Thaer Khoury

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. pmc CD138 (Syndecan-1) in thymic tumors: correlation with various World Health Organization types and clinical outcome
    Osama M Al-Agha
    Department of Pathology, State University of New York at Buffalo, Buffalo, NY, USA
    Int J Clin Exp Pathol 3:280-7. 2010
  2. doi request reprint Effect of delayed formalin fixation on estrogen and progesterone receptors in breast cancer: a study of three different clones
    Jingxin Qiu
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Am J Clin Pathol 134:813-9. 2010
  3. doi request reprint Delay to formalin fixation alters morphology and immunohistochemistry for breast carcinoma
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Appl Immunohistochem Mol Morphol 20:531-42. 2012
  4. pmc Aldehyde dehydrogenase 1A1 expression in breast cancer is associated with stage, triple negativity, and outcome to neoadjuvant chemotherapy
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Mod Pathol 25:388-97. 2012
  5. pmc Characteristics of Epstein-Barr virus-associated gastric cancer: a study of 235 cases at a comprehensive cancer center in U.S.A
    Camtu D Truong
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Exp Clin Cancer Res 28:14. 2009
  6. pmc The expression of TRMT2A, a novel cell cycle regulated protein, identifies a subset of breast cancer patients with HER2 over-expression that are at an increased risk of recurrence
    David G Hicks
    Clarient Inc, Aliso Veijo, California, USA
    BMC Cancer 10:108. 2010
  7. doi request reprint Breast carcinoma with amplified HER2: a gene expression signature specific for trastuzumab resistance and poor prognosis
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mod Pathol 23:1364-78. 2010
  8. doi request reprint Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Clin Lung Cancer 10:58-66. 2009
  9. doi request reprint Apoptosis-related (survivin, Bcl-2), tumor suppressor gene (p53), proliferation (Ki-67), and non-receptor tyrosine kinase (Src) markers expression and correlation with clinicopathologic variables in 60 thymic neoplasms
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Elm and Carlton St, Buffalo, NY 14203, USA
    Chest 136:220-8. 2009
  10. ncbi request reprint Delay to formalin fixation effect on breast biomarkers
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mod Pathol 22:1457-67. 2009

Collaborators

Detail Information

Publications43

  1. pmc CD138 (Syndecan-1) in thymic tumors: correlation with various World Health Organization types and clinical outcome
    Osama M Al-Agha
    Department of Pathology, State University of New York at Buffalo, Buffalo, NY, USA
    Int J Clin Exp Pathol 3:280-7. 2010
    ..However, more studies with larger cohort and longer follow-up are warranted to validate the clinical utility of CD138 to assess clinical behavior and prognosis of thymic tumors...
  2. doi request reprint Effect of delayed formalin fixation on estrogen and progesterone receptors in breast cancer: a study of three different clones
    Jingxin Qiu
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Am J Clin Pathol 134:813-9. 2010
    ..03). Based on our findings, it appears that regardless of the antibody clones evaluated, DFF has a negative effect on hormone receptors...
  3. doi request reprint Delay to formalin fixation alters morphology and immunohistochemistry for breast carcinoma
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Appl Immunohistochem Mol Morphol 20:531-42. 2012
    ..Delay to formalin fixation (DFF) also known as cold ischemia has been known to have an adverse effect on breast biomarkers. The aim of the study was to further evaluate the effect of DFF on tumor histomorphology and immunohistochemistry...
  4. pmc Aldehyde dehydrogenase 1A1 expression in breast cancer is associated with stage, triple negativity, and outcome to neoadjuvant chemotherapy
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Mod Pathol 25:388-97. 2012
    ..Moreover, we found that ALDH1A1 could be a useful marker to predict worse clinical outcome after chemotherapy in the neoadjuvant setting with substantial RCB. However, a larger cohort is required to verify our results...
  5. pmc Characteristics of Epstein-Barr virus-associated gastric cancer: a study of 235 cases at a comprehensive cancer center in U.S.A
    Camtu D Truong
    The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Exp Clin Cancer Res 28:14. 2009
    ..The aims of this study were to evaluate EBV-associated gastric cancer, to assess the distribution of EBV infected cells including all positive lymph nodes, and to define the characteristics of EBV-associated gastric cancer...
  6. pmc The expression of TRMT2A, a novel cell cycle regulated protein, identifies a subset of breast cancer patients with HER2 over-expression that are at an increased risk of recurrence
    David G Hicks
    Clarient Inc, Aliso Veijo, California, USA
    BMC Cancer 10:108. 2010
    ..Furthermore, the small but established risk of cardiac morbidity with trastuzumab therapy compels efforts towards the identification of biomarkers that might help stratify patients...
  7. doi request reprint Breast carcinoma with amplified HER2: a gene expression signature specific for trastuzumab resistance and poor prognosis
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mod Pathol 23:1364-78. 2010
    ....
  8. doi request reprint Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Clin Lung Cancer 10:58-66. 2009
    ..These results warrant further investigation to explore the value of eIF4E in identifying patients with aggressive disease for adjuvant treatments...
  9. doi request reprint Apoptosis-related (survivin, Bcl-2), tumor suppressor gene (p53), proliferation (Ki-67), and non-receptor tyrosine kinase (Src) markers expression and correlation with clinicopathologic variables in 60 thymic neoplasms
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Elm and Carlton St, Buffalo, NY 14203, USA
    Chest 136:220-8. 2009
    ..Our objective was to investigate the expression of survivin, Bcl-2, p53, Ki-67, and Src in thymic neoplasms and analyze their interrelationship with clinicopathologic variables...
  10. ncbi request reprint Delay to formalin fixation effect on breast biomarkers
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mod Pathol 22:1457-67. 2009
    ..03). To avoid delay to formalin fixation as a factor negatively affecting on breast biomarkers, we recommend not to delay formalin fixation for more than 1 h and not to store specimens overnight...
  11. pmc Foregut duplication cysts: a report of two cases with emphasis on embryogenesis
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, United States
    World J Gastroenterol 17:130-4. 2011
    ..Both cysts expressed thyroid transcription factor-1 (TTF-1) and surfactant. In this report, we explore the possible embryogenesis of these lesions in the light of TTF-1 and surfactant expression...
  12. doi request reprint Modified Alcian blue enhances the intraoperative diagnosis of sentinel lymph node metastasis in invasive lobular carcinoma: a prospective study
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Arch Pathol Lab Med 134:1513-9. 2010
    ..The sensitivity of an intraoperative diagnosis of sentinel lymph node metastasis of invasive lobular carcinoma using conventional staining is low...
  13. doi request reprint Breast hormonal receptors test should be repeated on excisional biopsy after negative core needle biopsy
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Breast J 17:180-6. 2011
    ..8%) cases and PR+ CNB/PR- EB in three (1.7%) cases. To avoid erroneous omission of life-saving endocrine therapy ER and PR should be repeated on the EB for patients whose CNB has negative hormonal receptors...
  14. doi request reprint HER2 testing: how to reach a high concordance rate between immunohistochemistry and fluorescence in situ hybridization
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Appl Immunohistochem Mol Morphol 19:424-30. 2011
    ..The concordance rate between immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) for human epidermal growth factor receptor-2 (HER2) is still a major clinical concern. We describe a new criteria evaluating HER2 IHC...
  15. pmc Tumour eosinophilia combined with an immunohistochemistry panel is useful in the differentiation of type B3 thymoma from thymic carcinoma
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Int J Exp Pathol 92:87-96. 2011
    ..Tumour eosinophilia combined with a panel of immunohistochemistry could differentiate type B3 thymoma from thymic carcinoma...
  16. doi request reprint ERBB2 juxtamembrane domain (trastuzumab binding site) gene mutation is a rare event in invasive breast cancers overexpressing the ERBB2 gene
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mod Pathol 24:1055-9. 2011
    ..Although it is unclear whether this substitution would result in trastuzumab target therapy resistance, this would not account for the relatively high frequency of this resistance encountered clinically...
  17. pmc TLE3 as a candidate biomarker of response to taxane therapy
    Swati A Kulkarni
    Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Breast Cancer Res 11:R17. 2009
    ..The addition of taxanes (Ts) to chemotherapeutic regimens has not demonstrated a consistent benefit in early-stage breast cancer. To date, no clinically relevant biomarkers that predict T response have been identified...
  18. pmc CD24 expression is an independent prognostic marker in cholangiocarcinoma
    Shefali Agrawal
    Department of Surgical Oncology, Roswell Park Cancer Institute, State University of New York, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Gastrointest Surg 11:445-51. 2007
    ..These findings may improve selection of patients for the appropriate treatment modality and the development of CD24-targeted therapy...
  19. ncbi request reprint Intestinal trefoil factor (TFF-3) and extracellular signal-regulated kinase (ERK) in cholangiocarcinoma
    Sikander Ailawadhi
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA
    Hepatogastroenterology 54:1339-44. 2007
    ..However, its role in biliary cancers is unknown. The biological effects of TFFs may result from EGFR, PI3 kinase, COX-2 and STAT-mediated signaling. We investigated the expression of TFF-3, Erk, Akt, EGFR and COX-2 in biliary cancer...
  20. ncbi request reprint COX-2 expression in hepatocellular carcinoma is an initiation event; while EGF receptor expression with downstream pathway activation is a prognostic predictor of survival
    Jason Foster
    Department of Surgery, Roswell Park Cancer Institute, State University of New York at Buffalo, Elm and Carlton Streets, Buffalo, NY, USA
    Ann Surg Oncol 14:752-8. 2007
    ..In this study, we investigate the incidence and impact of activated EGFR downstream messengers phosphorylated akt (pakt) and/or phosphorylated MAPK (pMAPK) on survival in patients with HCC...
  21. pmc Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer
    Jun Yang
    Departments of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Ann Clin Lab Sci 38:105-12. 2008
    ..Further studies with larger sample size are needed to elucidate the role of this critical nuclear matrix protein in NSCLC prognosis...
  22. pmc Clinicopathologic significance of putative stem cell markers, CD44 and nestin, in gastric adenocarcinoma
    Sadhna Dhingra
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, United States
    Int J Clin Exp Pathol 4:733-41. 2011
    ..Their expression is also increased in intestinal metaplasia, a premalignant lesion. These findings suggest that CSCs may have a pathogenetic role in the pathway of intestinal metaplasia-intestinal type gastric adenocarcinoma...
  23. pmc Parity and breastfeeding among African-American women: differential effects on breast cancer risk by estrogen receptor status in the Women's Circle of Health Study
    Christine B Ambrosone
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Sts, Buffalo, NY, 14263, USA
    Cancer Causes Control 25:259-65. 2014
    ..We evaluated these associations in a case-control study among African-American women in New York City and New Jersey...
  24. pmc Associations between estrogen receptor-negative breast cancer and timing of reproductive events differ between African American and European American women
    Christine B Ambrosone
    Authors Affiliations Departments of Cancer Prevention and Control and Pathology, Roswell Park Cancer Institute, Buffalo Icahn School of Medicine at Mount Sinai, New York, New York University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania J Craig Venter Institute, Rockville, Maryland New Jersey State Cancer Registry, New Jersey Department of Health, Trenton Rutgers Cancer Institute of New Jersey, New Brunswick and Rutgers School of Public Health, Piscataway, New Jersey
    Cancer Epidemiol Biomarkers Prev 23:1115-20. 2014
    ..Cancer Epidemiol Biomarkers Prev; 23(6); 1115-20. ©2014 AACR. ..
  25. ncbi request reprint Akt expression may predict favorable prognosis in cholangiocarcinoma
    Milind M Javle
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Gastroenterol Hepatol 21:1744-51. 2006
    ..The aim of this clinicopathological study was to investigate the overexpression and co-expression of EGFR and related signaling proteins in cholangiocarcinoma and explore their relationship to clinical outcome...
  26. ncbi request reprint Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women
    Zhihong Gong
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY
    Int J Cancer 134:1422-35. 2014
    ..The finding of an increased risk observed among EA women with the highest intake of synthetic folate from fortified foods warrants further investigation...
  27. ncbi request reprint Expression of intestinal trefoil factor (TFF-3) in hepatocellular carcinoma
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Int J Gastrointest Cancer 35:171-7. 2005
    ..Intestinal trefoil peptide (TFF-3) expression has been demonstrated in benign hepatobiliary diseases, but there are limited data regarding its expression in HCC...
  28. ncbi request reprint Pleomorphic lobular carcinoma: a distinctive clinical and molecular breast cancer type
    Laketa Monhollen
    Department of Pathology Medicine Biostatistics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Histopathology 61:365-77. 2012
    ..Pleomorphic lobular carcinoma (PLC) is an aggressive variant of invasive lobular carcinoma. The aim of this study was to redefine PLC in terms of molecular classification...
  29. ncbi request reprint Morphoproteomic profile of mTOR, Ras/Raf kinase/ERK, and NF-kappaB pathways in human gastric adenocarcinoma
    Wei Feng
    Department of Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Ann Clin Lab Sci 38:195-209. 2008
    ....
  30. doi request reprint Expression of thyroid transcription factor-1 in colorectal carcinoma
    Bo Xu
    Department of Pathology and Laboratory Medicine, State University of New York at Buffalo, Buffalo, NY, USA
    Appl Immunohistochem Mol Morphol 18:244-9. 2010
    ..Positive nuclear TTF-1 in a metastatic carcinoma does not rule out CRC primary. Clinicopathologic correlation, tumor morphology, and a panel of immunohistochemical markers are essential to render the correct diagnosis...
  31. doi request reprint Neuroendocrine markers expression in pancreatic serous cystadenoma
    Kazunori Kanehira
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Appl Immunohistochem Mol Morphol 19:141-6. 2011
    ..Given the increased use of immunohistochemistry, we sought to investigate the expression of neuroendocrine markers in this entity and compare it with pancreatic neuroendocrine tumors (NETs)...
  32. ncbi request reprint Upregulation of the tissue inhibitor of metalloproteinase-1 protein is associated with progression of human non-small-cell lung cancer
    Ibrahim S Aljada
    Roswell Park Cancer Institute, State University of New York, Buffalo, Elm and Carlton Sts, Buffalo, NY 14263, USA
    J Clin Oncol 22:3218-29. 2004
    ....
  33. doi request reprint Primary intraplacental gestational choriocarcinoma: histologic and genetic analyses
    Kazunori Kanehira
    Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    Int J Gynecol Pathol 32:71-5. 2013
    ..The results suggest that the choriocarcinoma originated from the current placenta sharing exactly the same genotype of multiple polymorphic markers. It also excludes a nongestational choriocarcinoma, which is of germ cell origin...
  34. ncbi request reprint Retiform hemangioendothelioma: a case report and review of the literature
    Dongfeng Tan
    Department of Pathology and Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Cutan Pathol 32:634-7. 2005
    ..Retiform hemangioendothelioma (RH) is a rare, recently described vascular neoplasm of low malignant potential...
  35. ncbi request reprint Malignant glomus tumor: a case report and review of literature, focusing on its clinicopathologic features and immunohistochemical profile
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, State University of New York at Buffalo, Buffalo, New York 14263, USA
    Am J Dermatopathol 27:428-31. 2005
    ..Twelve of the forty-five cases developed metastasis. In this report, we emphasize the differential diagnosis of MGT in the skin and deep soft tissue...
  36. ncbi request reprint Activated Akt and Erk expression and survival after surgery in pancreatic carcinoma
    Krishdeep S Chadha
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Ann Surg Oncol 13:933-9. 2006
    ..The epidermal growth factor receptor (EGFR) and the phosphoinositol-3-kinase pathways are often activated in pancreatic cancer, and an understanding of their role in resected cases may help refine adjuvant therapy...
  37. doi request reprint Mammary Paget's disease and extra-mammary Paget's disease: two morphologically similar but biologically different diseases
    Weiguo Liu
    Department of Pathology, State University of New York at Buffalo, NY, USA
    J Cutan Pathol 37:1145-9. 2010
    ..The purpose of this study is to examine the expression of the human epidermal growth factor receptor 2 (HER2) pathway members in these two diseases...
  38. pmc Prostate derived Ets transcription factor and Carcinoembryonic antigen related cell adhesion molecule 6 constitute a highly active oncogenic axis in breast cancer
    Alka Mukhopadhyay
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Oncotarget 4:610-21. 2013
    ..Together, these findings show that PDEF-CEACAM6 is a highly active oncogenic axis in breast cancer and suggest that targeting of these molecules should provide novel treatments for most breast cancer patients...
  39. ncbi request reprint Presence of the BRAF V600E point mutation in morphologically benign appearing thyroid inclusions of cervical lymph nodes
    Wilfrido D Mojica
    Department of Pathology, University at Buffalo, The State University of New York, 100 High Street, Buffalo, NY 14203, USA
    Endocr Pathol 17:183-9. 2006
    ..Molecular analysis provided integral data indicating these morphologically bland thyroid inclusions were malignant, findings not readily apparent by morphologic examination alone...
  40. pmc Genetic variants in microRNAs and breast cancer risk in African American and European American women
    Song Yao
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
    Breast Cancer Res Treat 141:447-59. 2013
    ..Future studies are needed to validate our findings and to explore the underlying mechanisms. ..
  41. ncbi request reprint Pleomorphic lobular carcinoma in situ of the breast: clinicopathological review of 47 cases
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Histopathology 64:981-93. 2014
    ..The purpose of this study was to review a relatively large number of cases and to evaluate the risk of recurrence...
  42. doi request reprint Intracystic papillary carcinoma of breast: interrelationship with in situ and invasive carcinoma and a proposal of pathogenesis: array comparative genomic hybridization study of 14 cases
    Thaer Khoury
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Mod Pathol 27:194-203. 2014
    ..We offer herein a proposal of intracystic papillary carcinoma pathogenesis through its relation to invasive ductal carcinoma and ductal carcinoma in situ. ..
  43. ncbi request reprint Isolated extramedullary relapse of acute lymphoblastic leukemia in the breast of an adolescent girl: radiologic findings and discussion
    Prasanna R G Kumar
    Department of Radiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Pediatr Radiol 40:773-6. 2010
    ..Examination of tissue provided by US-guided core biopsy confirmed focal leukemic relapse. US is a commonly used diagnostic tool in children and adolescents with a breast mass, for both characterization and guided biopsy...