MARGOT IP

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Prevention of mammary cancer with conjugated linoleic acid: role of the stroma and the epithelium
    Margot M Ip
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Mammary Gland Biol Neoplasia 8:103-18. 2003
  2. pmc The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium
    Margot M Ip
    Department of Pharmacology and Therapeutics and Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 28:1269-76. 2007
  3. ncbi request reprint Inhibition of angiogenesis by the cancer chemopreventive agent conjugated linoleic acid
    Patricia A Masso-Welch
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 62:4383-9. 2002
  4. pmc Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response
    Lihui Ou
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Lipid Res 49:985-94. 2008
  5. pmc Conjugated linoleic acid induces mast cell recruitment during mouse mammary gland stromal remodeling
    Joshua S Russell
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Nutr 137:1200-7. 2007
  6. pmc t10,c12-Conjugated linoleic acid stimulates mammary tumor progression in Her2/ErbB2 mice through activation of both proliferative and survival pathways
    Xiaojing Meng
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 29:1013-21. 2008
  7. ncbi request reprint Dietary intake of conjugated linoleic acids and risk of premenopausal and postmenopausal breast cancer, Western New York Exposures and Breast Cancer Study (WEB Study)
    Susan E McCann
    Department of Epidemiology, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Cancer Epidemiol Biomarkers Prev 13:1480-4. 2004
  8. ncbi request reprint Isomers of conjugated linoleic acid differ in their effects on angiogenesis and survival of mouse mammary adipose vasculature
    Patricia A Masso-Welch
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Nutr 134:299-307. 2004
  9. ncbi request reprint Conjugated linoleic acid isomers and mammary cancer prevention
    Clement Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Nutr Cancer 43:52-8. 2002
  10. pmc Conjugated linoleic acid induces apoptosis of murine mammary tumor cells via Bcl-2 loss
    Lihui Ou
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Biochem Biophys Res Commun 356:1044-9. 2007

Research Grants

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Prevention of mammary cancer with conjugated linoleic acid: role of the stroma and the epithelium
    Margot M Ip
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Mammary Gland Biol Neoplasia 8:103-18. 2003
    ..Together, the data suggest that CLA may be an excellent candidate for prevention of breast cancer...
  2. pmc The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium
    Margot M Ip
    Department of Pharmacology and Therapeutics and Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 28:1269-76. 2007
    ..However, even though c9,t11-CLA was not efficacious in the erbB2 model, its ability to inhibit mammary tumor development in rat models suggests that it may have activity for prevention of some types of breast cancer...
  3. ncbi request reprint Inhibition of angiogenesis by the cancer chemopreventive agent conjugated linoleic acid
    Patricia A Masso-Welch
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 62:4383-9. 2002
    ..Both cis-9, trans-11 and trans-10, cis-12 CLA isomers were effective in inhibiting angiogenesis in vitro in a dose-dependent fashion. The ability of CLA to inhibit angiogenesis may contribute to its efficacy as a chemopreventive agent...
  4. pmc Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response
    Lihui Ou
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Lipid Res 49:985-94. 2008
    ..In summary, our data demonstrate that apoptosis induced by t10,c12-CLA is mediated, at least in part, through an atypical ER stress response that culminates in the induction of CHOP and the cleavage of caspase-12...
  5. pmc Conjugated linoleic acid induces mast cell recruitment during mouse mammary gland stromal remodeling
    Joshua S Russell
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Nutr 137:1200-7. 2007
    ....
  6. pmc t10,c12-Conjugated linoleic acid stimulates mammary tumor progression in Her2/ErbB2 mice through activation of both proliferative and survival pathways
    Xiaojing Meng
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 29:1013-21. 2008
    ....
  7. ncbi request reprint Dietary intake of conjugated linoleic acids and risk of premenopausal and postmenopausal breast cancer, Western New York Exposures and Breast Cancer Study (WEB Study)
    Susan E McCann
    Department of Epidemiology, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Cancer Epidemiol Biomarkers Prev 13:1480-4. 2004
    ..40; 95% confidence interval, 0.16-1.01). Our findings suggest that, although CLA intake was not related to overall breast cancer risk, there may be associations with tumor biology at least among premenopausal women...
  8. ncbi request reprint Isomers of conjugated linoleic acid differ in their effects on angiogenesis and survival of mouse mammary adipose vasculature
    Patricia A Masso-Welch
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Nutr 134:299-307. 2004
    ..Moreover, we propose that each CLA isomer uniquely modifies the mammary stromal "soil" in a manner that is useful for chemoprevention of breast cancer...
  9. ncbi request reprint Conjugated linoleic acid isomers and mammary cancer prevention
    Clement Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Nutr Cancer 43:52-8. 2002
    ..These confounding changes of the other unsaturated fatty acids in contributing to the effect of 10,12-CLA need to be clarified...
  10. pmc Conjugated linoleic acid induces apoptosis of murine mammary tumor cells via Bcl-2 loss
    Lihui Ou
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Biochem Biophys Res Commun 356:1044-9. 2007
    ..These results demonstrate that t10,c12-CLA triggers apoptosis of p53 mutant murine mammary tumor cells through the mitochondrial pathway by targeting Bcl-2...
  11. pmc NFkappaB1/p50 is not required for tumor necrosis factor-stimulated growth of primary mammary epithelial cells: implications for NFkappaB2/p52 and RelB
    Jiping Zhang
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Endocrinology 148:268-78. 2007
    ..In the absence of p50, p52 and RelB can compensate for p50 in TNF-stimulated growth and cyclin D1 induction in MEC...

Research Grants8

  1. TNF Modulation of Mammary Proliferation
    MARGOT IP; Fiscal Year: 2003
    ..Thus, as part of this aim, the efficacy of anti-TNF therapy vs. local TNF therapy against mammary tumors will be compared. ..
  2. MODULATION OF TNF--MAMMARY PROLIFERATION/DIFFERENTIATION
    MARGOT IP; Fiscal Year: 2002
    ..These studies will test the hypothesis that the activity of TNFa changes as cells become transformed. ..
  3. TNF Modulation of Mammary Proliferation
    MARGOT IP; Fiscal Year: 2006
    ..Thus, as part of this aim, the efficacy of anti-TNF therapy vs. local TNF therapy against mammary tumors will be compared. ..
  4. TNF Modulation of Mammary Proliferation
    MARGOT IP; Fiscal Year: 2007
    ..Thus, as part of this aim, the efficacy of anti-TNF therapy vs local TNF therapy against mammary tumors will be compared. ..