CLEMENT C IP

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. ncbi request reprint In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 60:2882-6. 2000
  2. ncbi request reprint New concepts in selenium chemoprevention
    Clement Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Metastasis Rev 21:281-9. 2002
  3. ncbi request reprint Control of rat mammary epithelium proliferation by conjugated linoleic acid
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Nutr Cancer 39:233-8. 2001
  4. ncbi request reprint Methylselenocysteine modulates proliferation and apoptosis biomarkers in premalignant lesions of the rat mammary gland
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Anticancer Res 21:863-7. 2001
  5. ncbi request reprint Chemoprevention with triphenylselenonium chloride in selenium-deficient rats
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Anticancer Res 20:4179-82. 2000
  6. ncbi request reprint Induction of apoptosis by conjugated linoleic acid in cultured mammary tumor cells and premalignant lesions of the rat mammary gland
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Epidemiol Biomarkers Prev 9:689-96. 2000
  7. ncbi request reprint Chemical speciation influences comparative activity of selenium-enriched garlic and yeast in mammary cancer prevention
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Agric Food Chem 48:2062-70. 2000
  8. ncbi request reprint Conjugated linoleic acid isomers and mammary cancer prevention
    Clement Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Nutr Cancer 43:52-8. 2002
  9. ncbi request reprint Monomethylated selenium inhibits growth of LNCaP human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA)
    Soo Ok Lee
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Prostate 66:1070-5. 2006
  10. ncbi request reprint Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling
    Yan Dong
    Departments of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 64:19-22. 2004

Collaborators

Detail Information

Publications43

  1. ncbi request reprint In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 60:2882-6. 2000
    ..Methylseleninic acid could be an excellent tool, especially for molecular mechanism studies in cell culture, and some of these attributes are discussed...
  2. ncbi request reprint New concepts in selenium chemoprevention
    Clement Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Metastasis Rev 21:281-9. 2002
    ..Based on this information, a number of signaling pathways are proposed that could potentially provide insight into how selenium might block cell cycle progression and induce cell death...
  3. ncbi request reprint Control of rat mammary epithelium proliferation by conjugated linoleic acid
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Nutr Cancer 39:233-8. 2001
    ..These observations suggest that the responsiveness of mammary epithelial cells to CLA intervention may be dependent on their proliferative status...
  4. ncbi request reprint Methylselenocysteine modulates proliferation and apoptosis biomarkers in premalignant lesions of the rat mammary gland
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Anticancer Res 21:863-7. 2001
    ..This is achieved by simultaneously modulating certain molecular pathways that are responsible for inhibiting cell proliferation and enhancing apoptosis...
  5. ncbi request reprint Chemoprevention with triphenylselenonium chloride in selenium-deficient rats
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Anticancer Res 20:4179-82. 2000
    ..Thus selenium chemoprevention efficacy can be separated experimentally from selenoprotein synthesis using this model system...
  6. ncbi request reprint Induction of apoptosis by conjugated linoleic acid in cultured mammary tumor cells and premalignant lesions of the rat mammary gland
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Epidemiol Biomarkers Prev 9:689-96. 2000
    ....
  7. ncbi request reprint Chemical speciation influences comparative activity of selenium-enriched garlic and yeast in mammary cancer prevention
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Agric Food Chem 48:2062-70. 2000
    ....
  8. ncbi request reprint Conjugated linoleic acid isomers and mammary cancer prevention
    Clement Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Nutr Cancer 43:52-8. 2002
    ..These confounding changes of the other unsaturated fatty acids in contributing to the effect of 10,12-CLA need to be clarified...
  9. ncbi request reprint Monomethylated selenium inhibits growth of LNCaP human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA)
    Soo Ok Lee
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Prostate 66:1070-5. 2006
    ..In this study, we tested whether selenium (methylselenocysteine (MSC)) affects tumor growth of human prostate cancer cells by targeting AR signaling in vivo...
  10. ncbi request reprint Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling
    Yan Dong
    Departments of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 64:19-22. 2004
    ....
  11. ncbi request reprint Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells
    Ke Zu
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 63:6988-95. 2003
    ..These two pathways may act in a cooperative manner to switch on the full force of the apoptotic machinery when cells are treated with both VES and MSA...
  12. ncbi request reprint Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival
    Yue Wu
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 30:3895-901. 2010
    ..Signaling between androgen receptor (AR) and mTOR may be crucial for prostate cancer cells to endure the low androgen and suboptimal nutrient conditions produced by androgen deprivation therapy...
  13. pmc Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response
    Lihui Ou
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Lipid Res 49:985-94. 2008
    ..In summary, our data demonstrate that apoptosis induced by t10,c12-CLA is mediated, at least in part, through an atypical ER stress response that culminates in the induction of CHOP and the cleavage of caspase-12...
  14. ncbi request reprint Up-regulation of c-Jun-NH2-kinase pathway contributes to the induction of mitochondria-mediated apoptosis by alpha-tocopheryl succinate in human prostate cancer cells
    Ke Zu
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 4:43-50. 2005
    ..Based on our findings, we propose a working model to capture the salient features of the apoptotic signaling circuitry of alpha-TOS...
  15. ncbi request reprint Doxorubicin and selenium cooperatively induce fas signaling in the absence of Fas/Fas ligand interaction
    Song Li
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 27:3075-82. 2007
    ..Mitochondrial activation of caspase-9 is in part responsible for the synergy. The present study aimed at examining the death receptor pathway in activating caspase-8 by the two-drug combination...
  16. ncbi request reprint Endoplasmic reticulum stress signal mediators are targets of selenium action
    Yue Wu
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 65:9073-9. 2005
    ..The present study thus provides strong evidence to support an important role of ER stress response in mediating the anticancer effect of selenium...
  17. ncbi request reprint Evidence of a field effect associated with mammary cancer chemoprevention by methylseleninic acid
    Yan Dong
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 22:27-32. 2002
    ....
  18. pmc Prx1 enhances androgen receptor function in prostate cancer cells by increasing receptor affinity to dihydrotestosterone
    Rishi Raj Chhipa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer Res 7:1543-52. 2009
    ..The above findings led us to believe that Prx1 may be a therapeutic target in blocking the transition of prostate cancer from an androgen-dependent to an androgen-refractory phenotype...
  19. ncbi request reprint Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates
    Song Li
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 6:1031-8. 2007
    ..The functional significance of Bim was confirmed by the observation that RNA interference of Bim markedly reduced the potency of selenium/doxorubicin to induce apoptosis...
  20. doi request reprint Survival advantage of AMPK activation to androgen-independent prostate cancer cells during energy stress
    Rishi Raj Chhipa
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, United States
    Cell Signal 22:1554-61. 2010
    ....
  21. ncbi request reprint Identification of molecular targets associated with selenium-induced growth inhibition in human breast cells using cDNA microarrays
    Yan Dong
    Department of Experimental Pathology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Res 62:708-14. 2002
    ....
  22. pmc Chemotherapeutic sensitization by endoplasmic reticulum stress: increasing the efficacy of taxane against prostate cancer
    Yue Wu
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Biol Ther 8:146-52. 2009
    ..Both the intrinsic and extrinsic apoptotic pathways were involved in the sensitization mechanism. Our study supports the idea that marshalling ER stress apoptotic response is conducive to chemotherapeutic sensitization...
  23. pmc Augmented suppression of androgen receptor signaling by a combination of alpha-tocopheryl succinate and methylseleninic acid
    Haitao Zhang
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer 107:2942-8. 2006
    ..The present study was designed to investigate whether a combination of alphaTS and MSA would produce an additive or a greater than additive effect in suppressing AR level, AR transactivation, and prostate-specific antigen (PSA)...
  24. ncbi request reprint Peroxiredoxin 1 interacts with androgen receptor and enhances its transactivation
    Soo Yeon Park
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 67:9294-303. 2007
    ..Based on the above information, we suggest that disrupting the interaction between Prx1 and AR may serve as a fruitful new target in the management of prostate cancer...
  25. ncbi request reprint Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers
    Yan Dong
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Cancer Ther 4:1047-55. 2005
    ..Our finding that MSA reduces androgen receptor availability by blocking androgen receptor transcription provides justification for a mechanism-driven intervention strategy in using selenium to control prostate cancer progression...
  26. ncbi request reprint Cellular and molecular effects of alpha-tocopheryloxybutyrate: lessons for the design of vitamin E analog for cancer prevention
    Yue Wu
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Anticancer Res 24:3795-802. 2004
    ..The future design of new anticancer tocopherol analogs should incorporate the ether linkage of the side chain for esterase resistance as well as other structural modifications for enhanced blocking of membrane signaling...
  27. ncbi request reprint Dietary intake of conjugated linoleic acids and risk of premenopausal and postmenopausal breast cancer, Western New York Exposures and Breast Cancer Study (WEB Study)
    Susan E McCann
    Department of Epidemiology, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Cancer Epidemiol Biomarkers Prev 13:1480-4. 2004
    ..40; 95% confidence interval, 0.16-1.01). Our findings suggest that, although CLA intake was not related to overall breast cancer risk, there may be associations with tumor biology at least among premenopausal women...
  28. ncbi request reprint Isomers of conjugated linoleic acid differ in their effects on angiogenesis and survival of mouse mammary adipose vasculature
    Patricia A Masso-Welch
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Nutr 134:299-307. 2004
    ..Moreover, we propose that each CLA isomer uniquely modifies the mammary stromal "soil" in a manner that is useful for chemoprevention of breast cancer...
  29. ncbi request reprint Prevention of mammary cancer with conjugated linoleic acid: role of the stroma and the epithelium
    Margot M Ip
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Mammary Gland Biol Neoplasia 8:103-18. 2003
    ..Together, the data suggest that CLA may be an excellent candidate for prevention of breast cancer...
  30. ncbi request reprint Inhibition of angiogenesis by the cancer chemopreventive agent conjugated linoleic acid
    Patricia A Masso-Welch
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 62:4383-9. 2002
    ..Both cis-9, trans-11 and trans-10, cis-12 CLA isomers were effective in inhibiting angiogenesis in vitro in a dose-dependent fashion. The ability of CLA to inhibit angiogenesis may contribute to its efficacy as a chemopreventive agent...
  31. pmc The t10,c12 isomer of conjugated linoleic acid stimulates mammary tumorigenesis in transgenic mice over-expressing erbB2 in the mammary epithelium
    Margot M Ip
    Department of Pharmacology and Therapeutics and Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 28:1269-76. 2007
    ..However, even though c9,t11-CLA was not efficacious in the erbB2 model, its ability to inhibit mammary tumor development in rat models suggests that it may have activity for prevention of some types of breast cancer...
  32. ncbi request reprint Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology
    Yun Jeong Kim
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 67:546-54. 2007
    ..The above information suggests that the Nrf2-Prx1 axis may be a fruitful target for intervention with respect to inhibiting the malignant progression and/or reducing the treatment resistance of cancer cells...
  33. ncbi request reprint Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array
    Yan Dong
    Department of Cancer Prevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 63:52-9. 2003
    ..The present study demonstrates the utility of a genome-wide analysis to elucidate the mechanism of selenium chemoprevention...
  34. ncbi request reprint Cell cycle arrest biomarkers in human lung cancer cells after treatment with selenium in culture
    Helen Swede
    Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Epidemiol Biomarkers Prev 12:1248-52. 2003
    ..Thus, the selection of selenium biomarkers for evaluation in an intervention trial must be based on empirical data derived from the cancer cell type of interest...
  35. ncbi request reprint Selenium disrupts estrogen signaling by altering estrogen receptor expression and ligand binding in human breast cancer cells
    Soo Ok Lee
    Department of Medicine, Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York, NY 14263, USA
    Cancer Res 65:3487-92. 2005
    ..Thus, differential regulation of ERalpha and ERbeta in breast cancer cells may represent a novel mechanism of selenium action and provide a rationale for selenium breast cancer prevention trial...
  36. ncbi request reprint Hypoxia increases androgen receptor activity in prostate cancer cells
    Soo Yeon Park
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 66:5121-9. 2006
    ..The AR-stimulatory effect of an unstable tissue oxygenation milieu of a tumor is likely to contribute to treatment resistance and the emergence of recurrent prostate cancer...
  37. ncbi request reprint Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells
    Yue Wu
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 5:246-52. 2006
    ..The finding suggests that selenium-mediated dephosphorylation of Akt via calcineurin is likely to be an additional mechanism in regulating the status of phospho-Akt...
  38. ncbi request reprint Prevention of breast cancer--present reality and future promise
    Clement Ip
    Dept of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Mammary Gland Biol Neoplasia 8:1-3. 2003
  39. ncbi request reprint Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2
    Weonsup Lee
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Biol Chem 282:22011-22. 2007
    ..These findings are consistent with the hypothesis that human Prx1 and Prx2 possess unique functions and regulatory mechanisms and that Cys(83) bestows a distinctive identity to Prx1...
  40. ncbi request reprint Prx1 suppresses radiation-induced c-Jun NH2-terminal kinase signaling in lung cancer cells through interaction with the glutathione S-transferase Pi/c-Jun NH2-terminal kinase complex
    Yun Jeong Kim
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 66:7136-42. 2006
    ..Our study provides new insight into the antiapoptotic function of Prx1 in modulating radiosensitivity and provides the impetus to monitor the influence of Prx1 levels in the management of lung cancer...
  41. pmc Conjugated linoleic acid induces apoptosis of murine mammary tumor cells via Bcl-2 loss
    Lihui Ou
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Biochem Biophys Res Commun 356:1044-9. 2007
    ..These results demonstrate that t10,c12-CLA triggers apoptosis of p53 mutant murine mammary tumor cells through the mitochondrial pathway by targeting Bcl-2...
  42. ncbi request reprint Analysis of protein redox modification by hypoxia
    Kyoung Soo Choi
    Department of Cellular Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Prep Biochem Biotechnol 36:65-79. 2006
    ..Our study proved that proteomics analysis employing the BIAM-labeling method can provide valuable information pertaining to global changes in the redox status of proteins in response to hypoxia...
  43. pmc High superoxide dismutase and low glutathione peroxidase activities in red blood cells predict susceptibility of lung cancer patients to radiation pneumonitis
    Eun Mi Park
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Free Radic Biol Med 42:280-7. 2007
    ..0046). Our results provide a strong rationale to monitor SOD and GPX activities of RBC to identify patients who are at risk of developing pneumonitis, and to implement a strategy of increasing the GPX/SOD ratio in order to lower the risk...

Research Grants23

  1. Molecular biomarkers of selenium chemoprevention
    Clement Ip; Fiscal Year: 2006
    ..The goal is to broaden our understanding of the significance of clonal suppression of early transformed cells in selenium protection of cancer. ..
  2. Selenium molecular signaling in human prostate cancer
    Clement Ip; Fiscal Year: 2007
    ..Aim 4 is to study the transcriptional control of GADD153 by selenium. The proposed research is thus designed to examine systemically the impact of GADD153 induction as a result of selenium treatment. ..
  3. MAMMARY CANCER PREVENTION BY CONJUGATED LINOLEIC ACID
    Clement Ip; Fiscal Year: 2007
    ..abstract_text> ..
  4. MAMMARY CANCER PREVENTION BY CONJUGATED LINOLEIC ACID
    Clement Ip; Fiscal Year: 2002
    ..These studies are designed to apply the in vitro information of Aims 1 and 2 to the in vivo model in order to validate the use of molecular surrogate endpoints in CLA intervention. ..
  5. CANCER PREVENTION BY SELENIUM-ENRICHED ALLIUM VEGETABLES
    Clement Ip; Fiscal Year: 2003
    ..The objective is to corroborate the significance of clonal suppression of preneoplastic lesions in selenium protection of cancer. ..