Yurij Ionov

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. pmc Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: a model for identifying candidate breast-tumor suppressors
    Helena Zientek-Targosz
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mol Cancer 7:51. 2008
  2. pmc A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability
    Yurij Ionov
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 101:1273-8. 2004
  3. ncbi request reprint Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability
    Yurij Ionov
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Oncogene 23:639-45. 2004
  4. pmc A high throughput method for identifying personalized tumor-associated antigens
    Yurij Ionov
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Oncotarget 1:148-55. 2010
  5. ncbi request reprint Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells
    Michael R Rossi
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 163:123-9. 2005
  6. pmc Par-3 partitioning defective 3 homolog (C. elegans) and androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cells
    Dimiter Kunnev
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    BMC Cancer 9:318. 2009
  7. ncbi request reprint Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis
    Michael R Rossi
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 161:97-103. 2005
  8. ncbi request reprint Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects
    Yurij Ionov
    University of Colorado Health Sciences Center, Division of Medical Oncology, Denver, Colorado 80262, USA
    Anticancer Res 23:167-78. 2003

Research Grants

Collaborators

Detail Information

Publications8

  1. pmc Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: a model for identifying candidate breast-tumor suppressors
    Helena Zientek-Targosz
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Mol Cancer 7:51. 2008
    ..Identifying frequent mutations in cancer cells suggests the involvement of mutant genes in carcinogenesis...
  2. pmc A role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instability
    Yurij Ionov
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 101:1273-8. 2004
    ..These observations suggest that there is a selective growth/survival advantage to mutational inactivation of p300/CBP in cells with inactivated mismatch repair capabilities...
  3. ncbi request reprint Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability
    Yurij Ionov
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Oncogene 23:639-45. 2004
    ..When we applied this modified approach to the analysis of MSI-positive colon cancer cells, we identified mutations in the UVRAG and p300 genes...
  4. pmc A high throughput method for identifying personalized tumor-associated antigens
    Yurij Ionov
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA
    Oncotarget 1:148-55. 2010
    ..This observation confirms that personalized tumor-associated antigens can be identified by BLAST homology search following random peptide library screening on cancer patient's serum antibodies...
  5. ncbi request reprint Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells
    Michael R Rossi
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 163:123-9. 2005
    ..Inactivation of ACVR2 is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer...
  6. pmc Par-3 partitioning defective 3 homolog (C. elegans) and androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cells
    Dimiter Kunnev
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    BMC Cancer 9:318. 2009
    ..To distinguish between mRNA accumulations caused by stress response-induced transcription and nonsense-containing mRNA stabilizations is a challenge in identifying mutant genes using GINI...
  7. ncbi request reprint Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis
    Michael R Rossi
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Genet Cytogenet 161:97-103. 2005
    ..Two different heterozygous mutations in the Janus kinase 1 (JAK1) gene result in complete loss of the protein in several different prostate cancer cell lines...
  8. ncbi request reprint Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects
    Yurij Ionov
    University of Colorado Health Sciences Center, Division of Medical Oncology, Denver, Colorado 80262, USA
    Anticancer Res 23:167-78. 2003
    ..The Pim-1 33-kDa protein is a serine/threonine protein kinase that is capable of enhancing the rate of occurrence of c-Myc-induced lymphomas, and functions to block factor-withdrawal and genotoxic stress-induced apoptosis...

Research Grants5

  1. Using NMD to identify mutated genes in colon cancer
    Yurij Ionov; Fiscal Year: 2007
    ..Such an approach will help to identify metastasis suppressor genes in colon cancer. ..