Ruea Yea Huang

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. ncbi request reprint Genome-wide screen identifies genes whose inactivation confer resistance to cisplatin in Saccharomyces cerevisiae
    Ruea Yea Huang
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 65:5890-7. 2005
  2. ncbi request reprint Small ubiquitin-related modifier pathway is a major determinant of doxorubicin cytotoxicity in Saccharomyces cerevisiae
    Ruea Yea Huang
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, and Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 67:765-72. 2007
  3. pmc Elevated expression of the serine-arginine protein kinase 1 gene in ovarian cancer and its role in Cisplatin cytotoxicity in vitro
    Kunle Odunsi
    Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA
    PLoS ONE 7:e51030. 2012
  4. pmc Dysregulation of purine nucleotide biosynthesis pathways modulates cisplatin cytotoxicity in Saccharomyces cerevisiae
    David Kowalski
    Department of Cancer Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Pharmacol 74:1092-100. 2008
  5. ncbi request reprint Biologic contribution of P1 promoter-mediated expression of ST6Gal I sialyltransferase
    Michelle M Appenheimer
    The Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Glycobiology 13:591-600. 2003

Research Grants

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Genome-wide screen identifies genes whose inactivation confer resistance to cisplatin in Saccharomyces cerevisiae
    Ruea Yea Huang
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 65:5890-7. 2005
    ..The sensitivity of certain resistant strains to other cytotoxic agents suggests that our findings may point to particular drug combinations that can overcome resistance caused by inactivation of specific genes...
  2. ncbi request reprint Small ubiquitin-related modifier pathway is a major determinant of doxorubicin cytotoxicity in Saccharomyces cerevisiae
    Ruea Yea Huang
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, and Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Cancer Res 67:765-72. 2007
    ..Cumulatively, these results reveal that SUMO modification of proteins mediates the doxorubicin cytotoxicity in yeast, at least partially, by modification of septins and of proteins that control the intracellular drug concentration...
  3. pmc Elevated expression of the serine-arginine protein kinase 1 gene in ovarian cancer and its role in Cisplatin cytotoxicity in vitro
    Kunle Odunsi
    Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA
    PLoS ONE 7:e51030. 2012
    ..Together, these results suggest that elevated SRPK1 expression may play a role in ovarian tumorigenesis and SRPK1 may be a potential target for ovarian cancer therapy...
  4. pmc Dysregulation of purine nucleotide biosynthesis pathways modulates cisplatin cytotoxicity in Saccharomyces cerevisiae
    David Kowalski
    Department of Cancer Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Pharmacol 74:1092-100. 2008
    ..Taken together, our results indicate that dysregulation of the purine nucleotide biosynthesis pathways and the addition of exogenous purines can modulate cisplatin cytotoxicity in Saccharomyces cerevisiae...
  5. ncbi request reprint Biologic contribution of P1 promoter-mediated expression of ST6Gal I sialyltransferase
    Michelle M Appenheimer
    The Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Glycobiology 13:591-600. 2003
    ..Siat1deltaP1 mice also exhibit a greater bacterial burden in liver and spleen, accompanied by more pronounced spleno-/hepatomegaly and greater leukocyte infiltration into affected organs than their wild-type counterparts...

Research Grants1

  1. Identification of Novel Cisplatin Resistance Genes
    Ruea Yea Huang; Fiscal Year: 2005
    ..Evaluation of these targets may identify new biomarkers for pre-treatment screening of tumor samples for mutations that could allow for the identification of patients who are unlikely to benefit from cisplatin treatment. ..