Andrei Gudkov

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. pmc Impact papers on aging in 2009
    Mikhail V Blagosklonny
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Aging (Albany NY) 2:111-21. 2010
  2. doi request reprint Mycoplasma infection suppresses p53, activates NF-kappaB and cooperates with oncogenic Ras in rodent fibroblast transformation
    D Y Logunov
    Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russia
    Oncogene 27:4521-31. 2008
  3. pmc Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure
    Vadim I Krivokrysenko
    Cleveland BioLabs, Inc, 73 High Street, Buffalo, NY 14203, USA
    J Pharmacol Exp Ther 343:497-508. 2012
  4. pmc Association of Mycoplasma hominis infection with prostate cancer
    Yulia A Barykova
    NF Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russia
    Oncotarget 2:289-97. 2011
  5. pmc Pathologies associated with the p53 response
    Andrei V Gudkov
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cold Spring Harb Perspect Biol 2:a001180. 2010
  6. pmc Radioprotection: smart games with death
    Andrei V Gudkov
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Clin Invest 120:2270-3. 2010
  7. ncbi request reprint Dangerous habits of a security guard: the two faces of p53 as a drug target
    Andrei V Gudkov
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Hum Mol Genet 16:R67-72. 2007
  8. pmc Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2)
    Alexander N Shakhov
    Cleveland BioLabs, Inc, Buffalo, New York, United States of America
    PLoS ONE 7:e33044. 2012
  9. ncbi request reprint Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin
    Susan A J Vaziri
    Experimental Therapeutics Program, Taussig Cancer Center, Cleveland Clinic Foundation, R40, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Mol Cancer Ther 4:1880-90. 2005
  10. ncbi request reprint Quinacrine inhibits the epidermal dendritic cell migration initiating T cell-mediated skin inflammation
    Anton V Gorbachev
    Department of Immunology, Cleveland Clinic, Cleveland, OH 44195 0001, USA
    Eur J Immunol 37:2257-67. 2007

Research Grants

  1. Diagnostic Therapeutic Targets in Prostate Cancer
    Andrei Gudkov; Fiscal Year: 2007
  2. MODULATORS OF P53 EXPRESSION AND FUNCTION
    Andrei Gudkov; Fiscal Year: 2007
  3. GENETIC ELEMENTS TRANSFORMING MOUSE FIBROBLASTS
    Andrei Gudkov; Fiscal Year: 2009
  4. STRESS INDUCED BYSTANDER EFFECT IN CANCER TREATMENT
    Andrei Gudkov; Fiscal Year: 2003
  5. GENETIC ELEMENTS TRANSFORMING MOUSE FIBROBLASTS
    Andrei Gudkov; Fiscal Year: 2003
  6. MODULATORS OF P53 EXPRESSION AND FUNCTION
    Andrei Gudkov; Fiscal Year: 2001
  7. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2010

Collaborators

Detail Information

Publications39

  1. pmc Impact papers on aging in 2009
    Mikhail V Blagosklonny
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Aging (Albany NY) 2:111-21. 2010
    ..The emerging message in 2009 is that aging is not random but determined by a genetically-regulated longevity network and can be decelerated both genetically and pharmacologically...
  2. doi request reprint Mycoplasma infection suppresses p53, activates NF-kappaB and cooperates with oncogenic Ras in rodent fibroblast transformation
    D Y Logunov
    Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russia
    Oncogene 27:4521-31. 2008
    ....
  3. pmc Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure
    Vadim I Krivokrysenko
    Cleveland BioLabs, Inc, 73 High Street, Buffalo, NY 14203, USA
    J Pharmacol Exp Ther 343:497-508. 2012
    ....
  4. pmc Association of Mycoplasma hominis infection with prostate cancer
    Yulia A Barykova
    NF Gamaleya Research Institute for Epidemiology and Microbiology, Moscow, Russia
    Oncotarget 2:289-97. 2011
    ..hominis infection may be involved in PCa development and may, therefore, be a potential PCa marker and/or target for improved prevention and treatment of this disease...
  5. pmc Pathologies associated with the p53 response
    Andrei V Gudkov
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cold Spring Harb Perspect Biol 2:a001180. 2010
    ..Temporary reversible suppression of p53 by small molecules can be an effective and safe approach to reduce severity of p53-associated pathologies...
  6. pmc Radioprotection: smart games with death
    Andrei V Gudkov
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Clin Invest 120:2270-3. 2010
    ..The evidence indicates that this approach is likely to be specific for protection of normal cells and may, therefore, have clinical potential as an adjuvant in anticancer therapies...
  7. ncbi request reprint Dangerous habits of a security guard: the two faces of p53 as a drug target
    Andrei V Gudkov
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
    Hum Mol Genet 16:R67-72. 2007
    ..Here we briefly review specific aspects of this problem and discuss the ways of its pharmacological resolution based on detailed knowledge of molecular mechanisms of p53 regulation and activity...
  8. pmc Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2)
    Alexander N Shakhov
    Cleveland BioLabs, Inc, Buffalo, New York, United States of America
    PLoS ONE 7:e33044. 2012
    ..This study illustrates the strong potential of LP-based TLR2 agonists for anti-radiation prophylaxis and therapy in defense and medical scenarios...
  9. ncbi request reprint Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin
    Susan A J Vaziri
    Experimental Therapeutics Program, Taussig Cancer Center, Cleveland Clinic Foundation, R40, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Mol Cancer Ther 4:1880-90. 2005
    ..These results provide insights into the mechanisms by which inhibition of proteasome activity modulates DNA damage-induced apoptosis via a p53-dependent pathway...
  10. ncbi request reprint Quinacrine inhibits the epidermal dendritic cell migration initiating T cell-mediated skin inflammation
    Anton V Gorbachev
    Department of Immunology, Cleveland Clinic, Cleveland, OH 44195 0001, USA
    Eur J Immunol 37:2257-67. 2007
    ..These findings reveal a previously unrecognized mechanism of QC-mediated inhibition of inflammation...
  11. doi request reprint An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
    Lyudmila G Burdelya
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Science 320:226-30. 2008
    ..CBLB502 also showed radioprotective activity in lethally irradiated rhesus monkeys. Thus, TLR5 agonists could potentially improve the therapeutic index of cancer radiotherapy and serve as biological protectants in radiation emergencies...
  12. ncbi request reprint p53 is a suppressor of inflammatory response in mice
    Elena A Komarova
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    FASEB J 19:1030-2. 2005
    ....
  13. pmc Secreted transforming growth factor beta2 activates NF-kappaB, blocks apoptosis, and is essential for the survival of some tumor cells
    Tao Lu
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 101:7112-7. 2004
    ..These findings identify TGFbeta2 as a potential target for therapeutic strategies to inhibit the growth of tumor cells that depend on constitutively active NF-kappaB, or to sensitize them to treatment with cytotoxic drugs...
  14. ncbi request reprint Apoptosis inhibitor as a suppressor of tumor progression: expression of Bcl-2 eliminates selective advantages for p53-deficient cells in the tumor
    Katerina V Gurova
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer Biol Ther 1:39-44. 2002
    ....
  15. ncbi request reprint p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways
    Elena A Komarova
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    J Biol Chem 278:15465-8. 2003
    ..PFTalpha affected both signaling pathways in a p53-independent manner. These observations suggest that PFTalpha targets some unknown factor that is common for three major signal transduction pathways...
  16. ncbi request reprint Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice
    Elena A Komarova
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Oncogene 23:3265-71. 2004
    ....
  17. ncbi request reprint The role of p53 in determining sensitivity to radiotherapy
    Andrei V Gudkov
    Department of Molecular Biology, NC20, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Rev Cancer 3:117-29. 2003
    ..One of the key molecules involved in a cell's response to IR is p53. Understanding these mechanisms indicates new rational approaches to improving cancer treatment by IR...
  18. pmc Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65
    Tao Lu
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 107:46-51. 2010
    ..We conclude that reversible lysine methylation of NF-kappaB is an important element in the complex regulation of this key transcription factor...
  19. pmc Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications
    Nickolay Neznanov
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cell Cycle 8:3960-70. 2009
    ..These results reveal that QC is an inhibitor of HSF1-mediated HSR. As such, this compound has significant clinical potential as an adjuvant in therapeutic strategies aimed at exploiting the cytotoxic potential of proteotoxic stress...
  20. ncbi request reprint Paradoxical role of apoptosis in tumor progression
    Katerina V Gurova
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Cell Biochem 88:128-37. 2003
    ....
  21. ncbi request reprint Cellular quiescence caused by the Mdm2 inhibitor nutlin-3A
    Lioubov G Korotchkina
    Department of Cell Stress Biology, Roswell Park Cancer Institute, BLSC, Buffalo, NY, USA
    Cell Cycle 8:3777-81. 2009
    ..We discuss that Mdm antagonists could be used in combination with chemotherapy to reversibly arrest normal cells, thus protecting them during chemotherapy of cancer (cyclotherapy)...
  22. pmc Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB
    Tao Lu
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 106:16339-44. 2009
    ..Thus, we have used a powerful tool for mutagenesis of mammalian cells to reveal an aspect of the complex regulation of NFkappaB-dependent signaling...
  23. ncbi request reprint Dominant negative form of signal-regulatory protein-alpha (SIRPalpha /SHPS-1) inhibits tumor necrosis factor-mediated apoptosis by activation of NF-kappa B
    Nickolay Neznanov
    Department of Virology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio 44195, USA
    J Biol Chem 278:3809-15. 2003
    ..These data indicate that SIRPalpha/SHPS-1 is involved in negative regulation of NF-kappaB signaling...
  24. ncbi request reprint Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells
    Katerina V Gurova
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Cancer Res 63:2905-12. 2003
    ..These results indicate that two different p53 mutants that are separately rather weak can cooperate to generate p53 protein with anti-Fas function that is likely to provide additional selective advantages to the tumor...
  25. ncbi request reprint Expression of prostate specific antigen (PSA) is negatively regulated by p53
    Katerina V Gurova
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, OH 44195, USA
    Oncogene 21:153-7. 2002
    ..Thus, PSA is likely to be a tissue specific indicator of transformation-associated p53 suppression in prostate cells. This finding provides a plausible explanation for a frequent increase of PSA levels in advanced prostate cancer...
  26. pmc Prostate cancer cells tolerate a narrow range of androgen receptor expression and activity
    Natalia D Tararova
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Prostate 67:1801-15. 2007
    ..Our objective was to determine the importance of AR signaling for survival and growth of CaP cells, particularly those with a hormone-refractory phenotype...
  27. ncbi request reprint Melanoma cells can tolerate high levels of transcriptionally active endogenous p53 but are sensitive to retrovirus-transduced p53
    Julia V Kichina
    Department of Molecular Biology, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Oncogene 22:4911-7. 2003
    ..Hence, the p53 pathway in malignant melanomas can be considered for pharmacological targeting and anticancer gene therapy...
  28. ncbi request reprint The ability of protein tyrosine phosphatase SHP-1 to suppress NFkappaB can be inhibited by dominant negative mutant of SIRPalpha
    Nickolay Neznanov
    Department of Virology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    DNA Cell Biol 23:175-82. 2004
    ..The expression of dominant negative mutant of SIRPalpha has an effect similar to the expression of dominant negative PTP SHP-1 in the process of NFkappaB activation...
  29. ncbi request reprint Proteolytic cleavage of the p65-RelA subunit of NF-kappaB during poliovirus infection
    Nickolay Neznanov
    Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 280:24153-8. 2005
    ....
  30. ncbi request reprint Prospective therapeutic applications of p53 inhibitors
    Andrei V Gudkov
    Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Biochem Biophys Res Commun 331:726-36. 2005
    ....
  31. ncbi request reprint Poliovirus protein 3A binds and inactivates LIS1, causing block of membrane protein trafficking and deregulation of cell division
    Anna A Kondratova
    Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Cell Cycle 4:1403-10. 2005
    ....
  32. pmc Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-kappaB-dependent mechanism of p53 suppression in tumors
    Katerina V Gurova
    Department of Molecular Genetics, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Proc Natl Acad Sci U S A 102:17448-53. 2005
    ....
  33. pmc A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation
    Alexander D Boiko
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Genes Dev 20:236-52. 2006
    ..BTG2 expression was found to be significantly reduced in a large proportion of human kidney and breast carcinomas, suggesting that BTG2 is a tumor suppressor that links p53 and Rb pathways in human tumorigenesis...
  34. ncbi request reprint Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
    Evguenia Strom
    Cleveland BioLabs, Inc, 11000 Cedar Ave, Cleveland, Ohio 44106, USA
    Nat Chem Biol 2:474-9. 2006
    ..These results indicate that selective inhibition of the mitochondrial branch of the p53 pathway is sufficient for radioprotection in vivo...
  35. ncbi request reprint Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice
    Lyudmila G Burdelya
    Department of Molecular Genetics, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Cancer Res 66:9356-61. 2006
    ..Thus, reversible pharmacologic suppression of p53 may be a viable approach to improving anticancer treatment via an enhanced antiangiogenic effect of chemotherapy and radiotherapy...
  36. ncbi request reprint p53 pathway in renal cell carcinoma is repressed by a dominant mechanism
    Katerina V Gurova
    Department of Molecular Biology, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Cancer Res 64:1951-8. 2004
    ..Remarkably, cells of normal kidney epithelium also caused partial p53 repression in cell fusion experiments, suggesting that RCC-specific p53 repression may be based on an unknown dominant mechanism also acting in normal kidney tissue...
  37. pmc Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence
    Xianghong Zou
    Department of Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607, USA
    Genes Dev 16:2923-34. 2002
    ..Therefore, Cdk4 is essential for immortalization, and suppression of Cdk4 could be a prospective strategy to recruit cells with inactive Arf/p53 pathway to senescence...
  38. ncbi request reprint p53 determines multidrug sensitivity of childhood neuroblastoma
    Chengyuan Xue
    Children s Cancer Institute Australia for Medical Research, Randwick, New South Wales, Australia
    Cancer Res 67:10351-60. 2007
    ....
  39. ncbi request reprint Cancer drug discovery: the wisdom of imprecision
    Andrei V Gudkov
    Nat Med 10:1298-9. 2004

Research Grants39

  1. Diagnostic Therapeutic Targets in Prostate Cancer
    Andrei Gudkov; Fiscal Year: 2007
    ....
  2. MODULATORS OF P53 EXPRESSION AND FUNCTION
    Andrei Gudkov; Fiscal Year: 2007
    ..Aim 4 addresses the safety concerns related to the p53 inhibitory approach and will result in estimation of a potential risk of carcinogenic effects of different classes of p53 inhibitors. ..
  3. GENETIC ELEMENTS TRANSFORMING MOUSE FIBROBLASTS
    Andrei Gudkov; Fiscal Year: 2009
    ..The success of the proposed study will indicate development of a powerful target discovery tool that will be applicable for ACTT identification in other types of cancer. ..
  4. STRESS INDUCED BYSTANDER EFFECT IN CANCER TREATMENT
    Andrei Gudkov; Fiscal Year: 2003
    ..abstract_text> ..
  5. GENETIC ELEMENTS TRANSFORMING MOUSE FIBROBLASTS
    Andrei Gudkov; Fiscal Year: 2003
    ..GSE database will be created and made available to biomedical researchers in the form of DNA hybridization arrays. ..
  6. MODULATORS OF P53 EXPRESSION AND FUNCTION
    Andrei Gudkov; Fiscal Year: 2001
    ..The expression patterns of the candidate proteins and their chromosome map positions are included in these aims. ..
  7. Controlling Radiation Injury by TLR5 Agonists
    Andrei V Gudkov; Fiscal Year: 2010
    ..The proposed experiments will provide essential mechanistic insight into the previously observed radio-protective and -mitigative effects of CBLB502. ..