Peter Demant

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. pmc MicroRNA genes are frequently located near mouse cancer susceptibility loci
    Cinzia Sevignani
    Department of Microbiology and Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 104:8017-22. 2007
  2. pmc Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system
    Martin Palus
    Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branisovska 31, České Budějovice CZ 37005, Czech Republic
    J Neuroinflammation 10:77. 2013
  3. pmc Comparative gene expression profiling in two congenic mouse strains following Bordetella pertussis infection
    Sander Banus
    Laboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    BMC Microbiol 7:88. 2007
  4. ncbi request reprint Cancer susceptibility in the mouse: genetics, biology and implications for human cancer
    Peter Demant
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nat Rev Genet 4:721-34. 2003
  5. ncbi request reprint The genetic factors in cancer development and their implications for cancer prevention and detection
    Peter Demant
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Radiat Res 164:462-6. 2005
  6. doi request reprint Susceptibility loci affecting ERBB2/neu-induced mammary tumorigenesis in mice
    Lei Quan
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Genes Chromosomes Cancer 51:631-43. 2012
  7. pmc Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats
    Lei Quan
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 6:e14727. 2011
  8. pmc A locus on chromosome 8 controlling tumor regionality-a new type of tumor diversity in the mouse lung
    Lei Quan
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Int J Cancer 126:2603-13. 2010
  9. ncbi request reprint Control of lymphocyte infiltration of lung tumors in mice by host's genes: mapping of four Lynf (lymphocyte infiltration) loci
    Neelima Kakarlapudi
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Immunol Immunother 57:217-25. 2008
  10. pmc Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice
    Vladimir Vladimirov
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Fleming, nám 2, 166 37 Prague 6, Czech Republic
    Infect Immun 71:2041-6. 2003

Collaborators

  • Remond J A Fijneman
  • Marie Lipoldová
  • Aldons Jake Lusis
  • Carlo Croce
  • T G Kimman
  • Thomas Drake
  • Robert Blank
  • Adele L Boskey
  • R J Vandebriel
  • W J Mooi
  • Lei Quan
  • Claudia A L Ruivenkamp
  • Alan Hutson
  • Neelima Kakarlapudi
  • Alphons P M Stassen
  • Martin Palus
  • Tom van Wezel
  • Nikos Tripodis
  • Sander Banus
  • Augustinus A M Hart
  • Cinzia Sevignani
  • Laurent Gouya
  • Gloria E Lopez Franco
  • Hugo Horlings
  • Vladimir Vladimirov
  • Alina Czarnomska
  • Anita M Klous
  • Tamás Csikós
  • Veronica V Colinayo
  • Antoon J M van Oosterhout
  • Jackie S Bodnar
  • Peter C Groot
  • Jan Kopecky
  • Daniel Ruzek
  • Jiri Salat
  • Jarmila Vojtísková
  • Libor Grubhoffer
  • Yuxun Zhou
  • Ashley Dittmar
  • Juanita H J Vernooy
  • Timo M Breit
  • Masayoshi Shimizu
  • Ramana V Davuluri
  • Jean Charles Deybach
  • Eric Couchi
  • Piet W Wester
  • Jeroen L A Pennings
  • Said Lyoumi
  • Barbara Hoebee
  • Anne Marie Robreau
  • Bernard Grandchamp
  • Terry Hyslop
  • Stephanie C Nnadi
  • Philippe Letteron
  • Carole Beaumont
  • Francoise Muzeau
  • Linda D Siracusa
  • Frits R Mooi
  • Henk J van Kranen
  • Herve Puy
  • Robert Fleming
  • George A Calin
  • Eric R Gremmer
  • Suzanne J Litscher
  • Michael Piette
  • Tyriina K O'Neil
  • Tomás Pilcík
  • Miroslawa Sitarz
  • Helena Havelková
  • Kazimiera Pysniak
  • Joanna Piskorowska
  • Hana Blazkova
  • Jana Badalova
  • Milena Svobodova
  • Elzbieta Krysiak
  • Michael Chu
  • Prescilla V Jeurink
  • Gert Scholten
  • Aurobindo Chatterjee
  • David B West
  • David A Ross
  • Gert Jan B van Ommen
  • Kelly Krass
  • Anastassis Perrakis
  • Gerrit A Meijjer
  • Kanti Charugundla
  • Carlo Zanon
  • Frans P Nijkamp
  • Lawrence W Castellani
  • Jian Hua Qiao

Detail Information

Publications25

  1. pmc MicroRNA genes are frequently located near mouse cancer susceptibility loci
    Cinzia Sevignani
    Department of Microbiology and Immunology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 104:8017-22. 2007
    ..These data provide a catalog of miRNA genes in inbred strains that could represent genes involved in the development and penetrance of solid tumors...
  2. pmc Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system
    Martin Palus
    Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branisovska 31, České Budějovice CZ 37005, Czech Republic
    J Neuroinflammation 10:77. 2013
    ..Despite the medical importance of this disease, some crucial steps in the development of encephalitis remain poorly understood. In particular, the basis of the disease severity is largely unknown...
  3. pmc Comparative gene expression profiling in two congenic mouse strains following Bordetella pertussis infection
    Sander Banus
    Laboratory for Infectious Diseases and Screening, National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    BMC Microbiol 7:88. 2007
    ..pertussis inoculation. Twelve and a half percent of the genomes of these mice are from a different genetic background...
  4. ncbi request reprint Cancer susceptibility in the mouse: genetics, biology and implications for human cancer
    Peter Demant
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nat Rev Genet 4:721-34. 2003
    ..In future, this unique approach is likely to provide important insights into the pathways of tumour development and might ultimately lead to more effective individually targeted cancer-prevention strategies...
  5. ncbi request reprint The genetic factors in cancer development and their implications for cancer prevention and detection
    Peter Demant
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Radiat Res 164:462-6. 2005
    ..Therefore, genetic testing of persons in danger of being exposed to carcinogenic factors should be an important part of the personnel selection...
  6. doi request reprint Susceptibility loci affecting ERBB2/neu-induced mammary tumorigenesis in mice
    Lei Quan
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Genes Chromosomes Cancer 51:631-43. 2012
    ..These results expand the knowledge of ERBB2 tumorigenesis and point to a combined control of specific tumor phenotypes by germ-line polymorphisms and somatic alterations...
  7. pmc Most lung and colon cancer susceptibility genes are pair-wise linked in mice, humans and rats
    Lei Quan
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 6:e14727. 2011
    ..Comparison of molecular mechanisms of susceptibility genes that are organ-specific and those with trans-organ effects can provide a new dimension in understanding individual cancer susceptibility...
  8. pmc A locus on chromosome 8 controlling tumor regionality-a new type of tumor diversity in the mouse lung
    Lei Quan
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Int J Cancer 126:2603-13. 2010
    ..The identification of genes controlling lung tumor regionality will provide novel insights into the biology of lung tumors and potentially improve the possibilities of individualized prognosis and treatment in human lung cancer...
  9. ncbi request reprint Control of lymphocyte infiltration of lung tumors in mice by host's genes: mapping of four Lynf (lymphocyte infiltration) loci
    Neelima Kakarlapudi
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Immunol Immunother 57:217-25. 2008
    ..Such prediction of probability of tumor infiltration in individual cancer patients could help considerably to assess their prognosis and to decide about the application and the type of immunotherapy...
  10. pmc Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice
    Vladimir Vladimirov
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Fleming, nám 2, 166 37 Prague 6, Czech Republic
    Infect Immun 71:2041-6. 2003
    ..It indicates organ-specific control of antiparasite responses. The definition of genes controlling these responses will permit a better understanding of pathways and genetic diversity underlying the different disease phenotypes...
  11. ncbi request reprint Genetic study of variation in normal mouse iron homeostasis reveals ceruloplasmin as an HFE-hemochromatosis modifier gene
    Laurent Gouya
    INSERM U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Universite Paris 7 Denis Diderot, site Bichat, Paris, France
    Gastroenterology 132:679-86. 2007
    ..However, penetrance of this mutation is incomplete, suggesting that other genetic and environmental factors contribute to its differential biologic or clinical expression...
  12. ncbi request reprint Genetic analysis of macrophage characteristics as a tool to identify tumor susceptibility genes: mapping of three macrophage-associated risk inflammatory factors, marif1, marif2, and marif3
    Remond J A Fijneman
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Cancer Res 64:3458-64. 2004
    ..These studies provide a novel approach to investigate the genetics of microenvironmental influence on predisposition to tumorigenesis, thereby contributing to development of new strategies that aim to prevent or treat cancer...
  13. ncbi request reprint Genetic characterization of the Dyscalc locus
    Veronica V Colinayo
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 90095, USA
    Mamm Genome 13:283-8. 2002
    ..The congenic strains exhibit little or no myocardial or vascular calcification, unlike the background HcB C3H strain, and the calcification segregated as a Mendelian factor, allowing finer mapping of Dyscalc...
  14. ncbi request reprint Mouse genetic model for clinical and immunological heterogeneity of leishmaniasis
    Marie Lipoldová
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Fleming nám 2, 16637 Prague, Czech Republic
    Immunogenetics 54:174-83. 2002
    ..Combining functional and clinical information with multilocus genotyping may improve our ability to predict the progression of the disease and to optimize the treatment...
  15. ncbi request reprint Spectroscopically determined collagen Pyr/deH-DHLNL cross-link ratio and crystallinity indices differ markedly in recombinant congenic mice with divergent calculated bone tissue strength
    Robert D Blank
    Research Division, The Hospital for Special Surgery, New York, New York, USA
    Connect Tissue Res 44:134-42. 2003
    ..The data illustrate the importance of material properties in addition to mineral quantity to bone tissue strength...
  16. ncbi request reprint Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis
    Marie Lipoldová
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Fleming nám 2, 166 37 Prague, Czech Republic
    Nat Rev Genet 7:294-305. 2006
    ..Several of these QTLs probably also influence susceptibility to other infections, indicating that their characterization will contribute to our understanding of susceptibility to infectious disease in general...
  17. ncbi request reprint Lung tumor location and lymphocyte infiltration in mice are genetically determined
    Hugo Horlings
    Division of Pathology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    Exp Lung Res 31:513-25. 2005
    ..The definition of genes controlling these traits will provide novel insights into the determination of tumor phenotype...
  18. ncbi request reprint Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function and lung tumor susceptibility
    Marie Lipoldová
    Laboratory of Molecular and Cellular Immunology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Praha, Czech Republic
    Int J Cancer 114:394-9. 2005
    ..The possible relevance of these QTL associations in several different sites of the genome for the immune response, inflammation and tumorigenesis has to be elucidated...
  19. ncbi request reprint Dual energy X ray absorptiometry of ex vivo HcB/Dem mouse long bones: left are denser than right
    Gloria E Lopez Franco
    Section of Endocrinology, Department of Medicine, University of Wisconsin Medical School, 600 Highland Ave, Madison, WI, 53792, USA
    Calcif Tissue Int 76:26-31. 2005
    ..These observations may represent the densitometric manifestation of behavioral and neuroanatomical lateralization in laboratory mice...
  20. ncbi request reprint Five new mouse susceptibility to colon cancer loci, Scc11-Scc15
    Claudia A L Ruivenkamp
    Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands
    Oncogene 22:7258-60. 2003
    ..We confirmed all five originally described Scc loci and detected five additional new Scc loci; Scc11-Scc15. All these loci were detected in two-way interactions...
  21. ncbi request reprint Opposite effects of modifiers of the ApcMin mutation in intestine and mammary gland
    Alina Czarnomska
    Department of Genetics and Laboratory Animal Breeding, Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    Cancer Res 63:4533-7. 2003
    ....
  22. ncbi request reprint Genetic analysis of three-dimensional shape of mouse lung tumors reveals eight lung tumor shape-determining (Ltsd) loci that are associated with tumor heterogeneity and symmetry
    Nikos Tripodis
    Division of Molecular Genetics, The Netherlands Cancer Institute, 1066CX Amsterdam, The Netherlands
    Cancer Res 63:125-31. 2003
    ..This is the first set of loci that affects qualitative aspects of lung tumors and may provide biologically and clinically interesting indicators of lung tumor progression...
  23. ncbi request reprint Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers
    Claudia A L Ruivenkamp
    Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nat Genet 31:295-300. 2002
    ..Our data suggest that PTPRJ is relevant to the development of several different human cancers...
  24. ncbi request reprint Genetic analysis of antigen-induced airway manifestations of asthma using recombinant congenic mouse strains
    Antoon J M van Oosterhout
    Department of Pharmacology and Pathophysiology, Faculty of Pharmacy, Utrecht University, Utrecht, Netherlands
    Chest 121:13S. 2002
  25. pmc Positional cloning of the combined hyperlipidemia gene Hyplip1
    Jackie S Bodnar
    Department of Medicine, University of California, Los Angeles, 47 123 CHS, UCLA School of Medicine, Los Angeles, California 90095, USA
    Nat Genet 30:110-6. 2002
    ..These results reveal a new pathway of potential clinical significance that contributes to plasma lipid metabolism...

Research Grants7