James L Clements

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. pmc Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint
    Gustavo Pedraza-Alva
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
    EMBO J 25:763-73. 2006
  2. ncbi request reprint Impaired thymic selection in mice expressing altered levels of the SLP-76 adaptor protein
    Kimberley Ramsey
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Leukoc Biol 83:419-29. 2008
  3. ncbi request reprint Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1
    Shinu A John
    Department of Biochemistry, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:951-62. 2008
  4. ncbi request reprint Known and potential functions for the SLP-76 adapter protein in regulating T-cell activation and development
    James L Clements
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Immunol Rev 191:211-9. 2003
  5. ncbi request reprint Impaired generation of CD8+ thymocytes in Ets-1-deficient mice
    James L Clements
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Immunol 177:905-12. 2006
  6. ncbi request reprint Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease
    Duncheng Wang
    Department of Biochemistry, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA
    Int Immunol 17:1179-91. 2005
  7. ncbi request reprint The Src homology 2 domain-containing leukocyte protein of 76-kDa adaptor links integrin ligation with p44/42 MAPK phosphorylation and podosome distribution in murine dendritic cells
    Nancy A Luckashenak
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 177:5177-85. 2006
  8. pmc The immunogenicity of L1210 lymphoma clones correlates with their ability to function as antigen-presenting cells
    Kelly A Cycon
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Immunology 128:e641-51. 2009
  9. ncbi request reprint Signaling through the murine T cell receptor induces IL-17 production in the absence of costimulation, IL-23 or dendritic cells
    Xikui K Liu
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    Mol Cells 20:339-47. 2005
  10. pmc Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection
    Jonathan S Maltzman
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 202:893-900. 2005

Research Grants

  1. SLP-76 and ADAP dependent dendritic cell function
    James Clements; Fiscal Year: 2004

Collaborators

  • Lee Ann Garrett-Sinha
  • Shawn P Murphy
  • Sarah L Gaffen
  • Gary Koretzky
  • Shinu A John
  • Gustavo Pedraza-Alva
  • Kelly A Cycon
  • Tina M Thornton
  • Kimberley Ramsey
  • Mercedes Rincon
  • Nancy A Luckashenak
  • Duncheng Wang
  • Xikui K Liu
  • Jonathan S Maltzman
  • Renae Holtz
  • Hiroshi Fuji
  • Roger J Davis
  • C David Wood
  • Dwight E Matthews
  • Bradley Doble
  • Lisa M Russell
  • Nancy Luckashenak
  • Alexander Aronshtam
  • Bin Deng
  • Guadalupe Sabio
  • Rebecca L Ryszkiewicz
  • Miroslav Koulnis
  • Tina Thornton
  • Kimberley D Ramsey
  • Colette Charland
  • Mark S Schlissel
  • Lisa Kovoor
  • Kevin P Barton
  • Dean H Percy

Detail Information

Publications11

  1. pmc Activation of p38 MAP kinase by DNA double-strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint
    Gustavo Pedraza-Alva
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405, USA
    EMBO J 25:763-73. 2006
    ..We propose that p38 MAP kinase is activated by V(D)J-mediated DSBs and induces a p53-mediated G2/M checkpoint to allow DNA repair and prevent cellular transformation...
  2. ncbi request reprint Impaired thymic selection in mice expressing altered levels of the SLP-76 adaptor protein
    Kimberley Ramsey
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Leukoc Biol 83:419-29. 2008
    ....
  3. ncbi request reprint Ets-1 regulates plasma cell differentiation by interfering with the activity of the transcription factor Blimp-1
    Shinu A John
    Department of Biochemistry, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 283:951-62. 2008
    ..These results reveal a previously unknown mechanism for the control of Blimp-1 activity by Ets-1 and suggest that expression of Ets-1 must be down-regulated before plasmacytic differentiation can occur...
  4. ncbi request reprint Known and potential functions for the SLP-76 adapter protein in regulating T-cell activation and development
    James L Clements
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Immunol Rev 191:211-9. 2003
    ..A potential role for this critical signaling intermediate in integrating signals leading to positive and negative selection of the peripheral T-cell repertoire is also discussed...
  5. ncbi request reprint Impaired generation of CD8+ thymocytes in Ets-1-deficient mice
    James L Clements
    Department of Immunology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Immunol 177:905-12. 2006
    ..These data identify Ets-1 as a key transcription factor regulating thymocyte positive selection and lineage commitment of MHC class I-restricted thymocytes...
  6. ncbi request reprint Ets-1 deficiency leads to altered B cell differentiation, hyperresponsiveness to TLR9 and autoimmune disease
    Duncheng Wang
    Department of Biochemistry, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA
    Int Immunol 17:1179-91. 2005
    ..Hence, our studies establish Ets-1 as an important regulator of peripheral B cell differentiation and B cell responses to TLR9 activation...
  7. ncbi request reprint The Src homology 2 domain-containing leukocyte protein of 76-kDa adaptor links integrin ligation with p44/42 MAPK phosphorylation and podosome distribution in murine dendritic cells
    Nancy A Luckashenak
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 177:5177-85. 2006
    ....
  8. pmc The immunogenicity of L1210 lymphoma clones correlates with their ability to function as antigen-presenting cells
    Kelly A Cycon
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Immunology 128:e641-51. 2009
    ..Therefore, the immunogenicity of L1210 cells directly correlates (i) with their ability to stimulate naïve T cells, and (ii) with the concomitant expression of MHCII, B7-1, B7-2, and CD40...
  9. ncbi request reprint Signaling through the murine T cell receptor induces IL-17 production in the absence of costimulation, IL-23 or dendritic cells
    Xikui K Liu
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY 14214, USA
    Mol Cells 20:339-47. 2005
    ....
  10. pmc Conditional deletion reveals a cell-autonomous requirement of SLP-76 for thymocyte selection
    Jonathan S Maltzman
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Exp Med 202:893-900. 2005
    ..These studies show for the first time that SLP-76 is required for signal transduction through the mature alphabeta TCR in primary cells of the T lineage...
  11. pmc Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation
    Tina M Thornton
    Department of Medicine Immunobiology Program, University of Vermont, Burlington, VT 05405 0068, USA
    Science 320:667-70. 2008
    ..Activation of beta-catenin-mediated signaling through GSK3beta inhibition provides a potential mechanism for p38 MAPK-mediated survival in specific tissues...

Research Grants1

  1. SLP-76 and ADAP dependent dendritic cell function
    James Clements; Fiscal Year: 2004
    ..abstract_text> ..