Sreenivasulu Chintala

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. pmc Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition
    Sreenivasulu Chintala
    Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    BMC Cancer 12:293. 2012
  2. pmc Downregulation of cystine transporter xc by irinotecan in human head and neck cancer FaDu xenografts
    Sreenivasulu Chintala
    Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Chemotherapy 56:223-33. 2010
  3. pmc Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1alpha
    Sreenivasulu Chintala
    Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA
    Cancer Chemother Pharmacol 66:899-911. 2010
  4. doi request reprint The Vps33a gene regulates behavior and cerebellar Purkinje cell number
    Sreenivasulu Chintala
    Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Brain Res 1266:18-28. 2009
  5. pmc Hypoxia-specific drug tirapazamine does not abrogate hypoxic tumor cells in combination therapy with irinotecan and methylselenocysteine in well-differentiated human head and neck squamous cell carcinoma a253 xenografts
    Arup Bhattacharya
    Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Neoplasia 10:857-65. 2008
  6. ncbi request reprint Murine Hermansky-Pudlak syndrome genes: regulators of lysosome-related organelles
    Wei Li
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Bioessays 26:616-28. 2004
  7. pmc The Slc35d3 gene, encoding an orphan nucleotide sugar transporter, regulates platelet-dense granules
    Sreenivasulu Chintala
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Blood 109:1533-40. 2007
  8. ncbi request reprint The Hermansky-Pudlak syndrome 3 (cocoa) protein is a component of the biogenesis of lysosome-related organelles complex-2 (BLOC-2)
    Rashi Gautam
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Biol Chem 279:12935-42. 2004
  9. pmc Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells
    Sreenivasulu Chintala
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 102:10964-9. 2005
  10. pmc Double immunohistochemical staining method for HIF-1alpha and its regulators PHD2 and PHD3 in formalin-fixed paraffin-embedded tissues
    Mary M Vaughan
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Appl Immunohistochem Mol Morphol 18:375-81. 2010

Detail Information

Publications11

  1. pmc Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition
    Sreenivasulu Chintala
    Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    BMC Cancer 12:293. 2012
    ..This study was initiated to investigate the expression of PHDs, HIF-α, and VEGF-A in selected solid cancers, the mechanism of HIF-α inhibition by MSC, and to document antitumor activity of MSC against human ccRCC xenografts...
  2. pmc Downregulation of cystine transporter xc by irinotecan in human head and neck cancer FaDu xenografts
    Sreenivasulu Chintala
    Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Chemotherapy 56:223-33. 2010
    ....
  3. pmc Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1alpha
    Sreenivasulu Chintala
    Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA
    Cancer Chemother Pharmacol 66:899-911. 2010
    ..The aim of this study was to delineate the mechanism responsible for the observed efficacy targeting on HIF-1alpha and its transcriptionally regulated genes VEGF and CAIX...
  4. doi request reprint The Vps33a gene regulates behavior and cerebellar Purkinje cell number
    Sreenivasulu Chintala
    Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Brain Res 1266:18-28. 2009
    ..In general, the bf mutant may be a potentially new and useful model for understanding Purkinje cell development and function...
  5. pmc Hypoxia-specific drug tirapazamine does not abrogate hypoxic tumor cells in combination therapy with irinotecan and methylselenocysteine in well-differentiated human head and neck squamous cell carcinoma a253 xenografts
    Arup Bhattacharya
    Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Neoplasia 10:857-65. 2008
    ..CD31 immunostaining in A253 demonstrated disruption of tumor vessels by TPZ that could lower cytotoxic drug delivery to carbonic anhydrase IX-positive hypoxic tumor cells and may explain at least partially these unexpected results...
  6. ncbi request reprint Murine Hermansky-Pudlak syndrome genes: regulators of lysosome-related organelles
    Wei Li
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Bioessays 26:616-28. 2004
    ..Studies of the molecular functions of HPS proteins will reveal important details of vesicle trafficking and may lead to therapies for HPS...
  7. pmc The Slc35d3 gene, encoding an orphan nucleotide sugar transporter, regulates platelet-dense granules
    Sreenivasulu Chintala
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Blood 109:1533-40. 2007
    ..Unlike HPS or CHS genes, it has no apparent effect on other lysosome-related organelles such as melanosomes or lysosomes. The ash-Roswell mouse mutant is an appropriate model for human congenital-isolated delta-storage pool deficiency...
  8. ncbi request reprint The Hermansky-Pudlak syndrome 3 (cocoa) protein is a component of the biogenesis of lysosome-related organelles complex-2 (BLOC-2)
    Rashi Gautam
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    J Biol Chem 279:12935-42. 2004
    ..Interaction of the Hps5 and Hps6 proteins within BLOC-2 is abolished by the three-amino acid deletion in the Hps6(ru) mutant allele, indicating that these three amino acids are important for normal BLOC-2 complex formation...
  9. pmc Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells
    Sreenivasulu Chintala
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Proc Natl Acad Sci U S A 102:10964-9. 2005
    ..Thus, we have found that the Slc7a11 gene controls the production of pheomelanin pigment directly. Cells from sut mice provide a model for oxidative stress-related diseases and their therapies...
  10. pmc Double immunohistochemical staining method for HIF-1alpha and its regulators PHD2 and PHD3 in formalin-fixed paraffin-embedded tissues
    Mary M Vaughan
    Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Appl Immunohistochem Mol Morphol 18:375-81. 2010
    ..This new method defined the optimal conditions for detection of HIF-1alpha and PHDs in individual tumor cells and could have a diagnostic and therapeutic potential...
  11. ncbi request reprint Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6
    Qing Zhang
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Nat Genet 33:145-53. 2003
    ..Both genes are previously unknown and are found only in higher eukaryotes, and together represent a new class of genes that have evolved in higher organisms to govern the synthesis of highly specialized lysosome-related organelles...