Affiliation: Roswell Park Cancer Institute
Kumar R, Bhat T, Walsh E, Chaudhary A, O Malley J, Rhim J, et al
. Cytochrome c-deficiency Confers Apoptosome and Mitochondrial Dysfunction in African-American Men with Prostate Cancer. Cancer Res. 2019;: pubmed publisher
..Overall, this study provides the first comprehensive experimental, mechanistic, and clinical evidence for apoptosome and mitochondrial dysfunction in PCa racial disparity. ..
Bhat T, Kumar S, Chaudhary A, Yadav N, Chandra D. Restoration of mitochondria function as a target for cancer therapy. Drug Discov Today. 2015;20:635-43 pubmed publisher
..Here, we summarize the key reasons contributing to mitochondria dysfunction in cancer cells and how restoration of mitochondrial function could be exploited for cancer therapeutics. ..
Ansari K, Arany P, Arama E, Larisch S, Birge R, Chandra D. International conference on Cell Death in Cancer and Toxicology 2018 (CDCT-2018). Cell Commun Signal. 2018;16:34 pubmed publisher
..Together, this highly interactive meeting showcased the rapid expansion in biomedical research in India and paved the way for future meetings on cell death and cancer throughout India. ..
Yadav N, Kumar S, Kumar R, Srivastava P, Sun L, Rapali P, et al
. Mechanism of neem limonoids-induced cell death in cancer: Role of oxidative phosphorylation. Free Radic Biol Med. 2016;90:261-71 pubmed publisher
..Together, we demonstrate that neem limonoids target OXPHOS system to induce cancer cell death, which does not require upregulation or activation of proapoptotic Bcl-2 family proteins. ..
Bhat T, Chaudhary A, Kumar S, O Malley J, Inigo J, Kumar R, et al
. Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer. Biochim Biophys Acta Rev Cancer. 2017;1867:58-66 pubmed publisher
..Here we review the connections between ER stress and mitochondrial apoptosis, describing potential cancer therapeutic targets. ..
Kumar S, Chaudhary A, Kumar R, O Malley J, Dubrovska A, Wang X, et al
. Combination therapy induces unfolded protein response and cytoskeletal rearrangement leading to mitochondrial apoptosis in prostate cancer. Mol Oncol. 2016;10:949-65 pubmed publisher
..Taken together, combination treatment with TXL and either APC or TG induces efficient apoptosis in both proliferating and cancer stem cells, suggesting this therapeutic combination may overcome drug resistance and recurrence in PCa. ..
Chaudhary A, O Malley J, Kumar S, Inigo J, Kumar R, Yadav N, et al
. Mitochondrial dysfunction and prostate cancer racial disparities among American men. Front Biosci (Schol Ed). 2017;9:154-164 pubmed
..Since defective cellular signaling is critical for prostate cancer cell survival, restoring mitochondrial function may provide strategies to alleviate prostate cancer disparities among American men. ..
O Malley J, Kumar R, Kuzmin A, Pliss A, Yadav N, Balachandar S, et al
. Lipid quantification by Raman microspectroscopy as a potential biomarker in prostate cancer. Cancer Lett. 2017;397:52-60 pubmed publisher
..Correlation between lipid accumulation and tumor stage provides quantitative marker for PCa diagnosis. Thus, Raman spectroscopy-based lipid quantification could be a sensitive and reliable tool for PCa diagnosis and staging. ..
Kumar S, Inigo J, Kumar R, Chaudhary A, O Malley J, Balachandar S, et al
. Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells. Cancer Lett. 2018;413:82-93 pubmed publisher
..Together, this study highlights the therapeutic potential of NL in mutant p53 expressing pancreatic cancer. ..