Christine B Ambrosone

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. doi request reprint Parity and breastfeeding among African-American women: differential effects on breast cancer risk by estrogen receptor status in the Women's Circle of Health Study
    Christine B Ambrosone
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Sts, Buffalo, NY, 14263, USA
    Cancer Causes Control 25:259-65. 2014
  2. pmc Rethinking sources of representative controls for the conduct of case-control studies in minority populations
    Elisa V Bandera
    The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08901, USA
    BMC Med Res Methodol 13:71. 2013
  3. pmc Epidemiology of breast cancer subtypes in two prospective cohort studies of breast cancer survivors
    Marilyn L Kwan
    Kaiser Permanente, Division of Research, Oakland, CA 94612, USA
    Breast Cancer Res 11:R31. 2009
  4. pmc Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival
    Robert C G Martin
    Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Breast Cancer Res 8:R45. 2006
  5. pmc Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897
    Christine B Ambrosone
    Roswell Park Cancer Institute, Department of Cancer Prevention and Control, Buffalo, NY 14263, USA
    J Clin Oncol 27:4973-9. 2009
  6. ncbi request reprint Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Res 65:1105-11. 2005
  7. pmc The promise and limitations of genome-wide association studies to elucidate the causes of breast cancer
    Christine B Ambrosone
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Breast Cancer Res 9:114. 2007
  8. doi request reprint Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysis
    Christine B Ambrosone
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 17:15-26. 2008
  9. ncbi request reprint Establishing a cancer center data bank and biorepository for multidisciplinary research
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 15:1575-7. 2006
  10. ncbi request reprint Sample collection, processing, and storage for large-scale studies: biorepositories to support cancer research
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 15:1574. 2006

Detail Information

Publications119 found, 100 shown here

  1. doi request reprint Parity and breastfeeding among African-American women: differential effects on breast cancer risk by estrogen receptor status in the Women's Circle of Health Study
    Christine B Ambrosone
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Sts, Buffalo, NY, 14263, USA
    Cancer Causes Control 25:259-65. 2014
    ..We evaluated these associations in a case-control study among African-American women in New York City and New Jersey...
  2. pmc Rethinking sources of representative controls for the conduct of case-control studies in minority populations
    Elisa V Bandera
    The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, 195 Little Albany Street, New Brunswick, NJ 08901, USA
    BMC Med Res Methodol 13:71. 2013
    ..Recruitment of controls remains a challenge in case-control studies and particularly in studies involving minority populations...
  3. pmc Epidemiology of breast cancer subtypes in two prospective cohort studies of breast cancer survivors
    Marilyn L Kwan
    Kaiser Permanente, Division of Research, Oakland, CA 94612, USA
    Breast Cancer Res 11:R31. 2009
    ....
  4. pmc Association between manganese superoxide dismutase promoter gene polymorphism and breast cancer survival
    Robert C G Martin
    Division of Surgical Oncology, Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Breast Cancer Res 8:R45. 2006
    ..The aim of our study was to investigate possible associations of the -102 C>T polymorphism with overall and relapse-free breast cancer survival in a hospital-based case-only study...
  5. pmc Myeloperoxidase genotypes and enhanced efficacy of chemotherapy for early-stage breast cancer in SWOG-8897
    Christine B Ambrosone
    Roswell Park Cancer Institute, Department of Cancer Prevention and Control, Buffalo, NY 14263, USA
    J Clin Oncol 27:4973-9. 2009
    ....
  6. ncbi request reprint Polymorphisms in genes related to oxidative stress (MPO, MnSOD, CAT) and survival after treatment for breast cancer
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Res 65:1105-11. 2005
    ..33; 95% confidence interval, 0.13-0.80; P = 0.01). These data indicate that gene variants that impact oxidative stress modify prognosis after treatment for breast cancer...
  7. pmc The promise and limitations of genome-wide association studies to elucidate the causes of breast cancer
    Christine B Ambrosone
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Breast Cancer Res 9:114. 2007
    ....
  8. doi request reprint Cigarette smoking, N-acetyltransferase 2 genotypes, and breast cancer risk: pooled analysis and meta-analysis
    Christine B Ambrosone
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 17:15-26. 2008
    ..Because slow NAT2 genotypes are present in 50% to 60% of Caucasian populations, smoking is likely to play an important role in breast cancer etiology...
  9. ncbi request reprint Establishing a cancer center data bank and biorepository for multidisciplinary research
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 15:1575-7. 2006
    ..In this report, we present an approach to developing a Data Bank and Biorepository at our own institution, with discussion of elements to be considered when establishing such a bank...
  10. ncbi request reprint Sample collection, processing, and storage for large-scale studies: biorepositories to support cancer research
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 15:1574. 2006
  11. pmc Genetic predictors of acute toxicities related to radiation therapy following lumpectomy for breast cancer: a case-series study
    Christine B Ambrosone
    Department of Epidemiology, Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, New York, USA
    Breast Cancer Res 8:R40. 2006
    ..We hypothesized that polymorphisms encoding reduced or absent activity in the GSTs might result in greater risk for radiation-associated toxicity...
  12. pmc CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors
    Christine B Ambrosone
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Breast Cancer Res 5:R45-51. 2003
    ..We investigated the role of the MspAI genetic polymorphism in the 5' region of CYP17 on risk of breast cancer and as a modifier of reproductive risk factors...
  13. pmc Manganese superoxide dismutase polymorphism, treatment-related toxicity and disease-free survival in SWOG 8897 clinical trial for breast cancer
    Song Yao
    Department of Cancer and Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Sts, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 124:433-9. 2010
    ....
  14. ncbi request reprint Polymorphisms in genes related to oxidative stress (CAT, MnSOD, MPO, and eNOS) and acute toxicities from radiation therapy following lumpectomy for breast cancer
    Jiyoung Ahn
    Division of Cancer Prevention and Population Science, Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 12:7063-70. 2006
    ....
  15. doi request reprint Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk
    Yulin Li
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 30:777-84. 2009
    ..77, 95% CI = 1.05-2.99, P-interaction = 0.006). Our results support the hypothesis that there are joint effects of endogenous and exogenous antioxidants...
  16. pmc Nitric oxide synthase variants and disease-free survival among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial
    Ji Yeob Choi
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 15:5258-66. 2009
    ..We examined relationships between DFS and variants in NOS3, as well as NQO1, NQO2, and CBR3, among treated and untreated breast cancer patients in a Southwest Oncology Group clinical trial (S8897)...
  17. ncbi request reprint Associations between breast cancer risk and the catalase genotype, fruit and vegetable consumption, and supplement use
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Am J Epidemiol 162:943-52. 2005
    ..CC genotypes were prevalent in approximately 64% of controls; thus, the preventive potential for fruit consumption has widespread implications...
  18. pmc DNA promoter methylation in breast tumors: no association with genetic polymorphisms in MTHFR and MTR
    Meng Hua Tao
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, 270 Farber Hall, University at Buffalo, Buffalo, NY 14214, USA
    Cancer Epidemiol Biomarkers Prev 18:998-1002. 2009
    ..Overall, we found no evidence that these common polymorphisms of the MTHFR and MTR genes are associated with promoter methylation of E-cadherin, p16, and RAR-beta2 genes in breast cancer...
  19. pmc Iron intake, oxidative stress-related genes (MnSOD and MPO) and prostate cancer risk in CARET cohort
    Ji Yeob Choi
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 29:964-70. 2008
    ..These findings suggest that higher iron intake may be associated with risk of clinically aggressive prostate cancer, and that endogenous antioxidant capabilities may modify these associations...
  20. doi request reprint Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry
    Lei Quan
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY
    Int J Cancer 134:1408-21. 2014
    ..Our study systematically identified genetic variants in the adaptive immune response pathway associated with breast cancer risk, which appears to differ by ancestry groups, menopausal status and ER status...
  21. doi request reprint Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women
    Zhihong Gong
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY
    Int J Cancer 134:1422-35. 2014
    ..The finding of an increased risk observed among EA women with the highest intake of synthetic folate from fortified foods warrants further investigation...
  22. pmc Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    BMC Cancer 10:162. 2010
    ..Inverse associations between cruciferous vegetable intake and lung cancer risk have been consistently reported. However, associations within smoking status subgroups have not been consistently addressed...
  23. pmc Gene polymorphisms in cyclophosphamide metabolism pathway,treatment-related toxicity, and disease-free survival in SWOG 8897 clinical trial for breast cancer
    Song Yao
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 16:6169-76. 2010
    ..In an ancillary study to a SWOG (Southwest Oncology Group) trial (S8897), we investigated functional polymorphisms in 4 genes in CP pharmacokinetic pathways in relation to hematologic toxicity and disease-free survival (DFS)...
  24. ncbi request reprint Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer
    Chi Chen Hong
    Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 16:1784-94. 2007
    ....
  25. pmc Association between global DNA hypomethylation in leukocytes and risk of breast cancer
    Ji Yeob Choi
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 30:1889-97. 2009
    ..Global DNA hypomethylation may result in chromosomal instability and oncogene activation, and as a surrogate of systemic methylation activity, may be associated with breast cancer risk...
  26. ncbi request reprint Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer risk
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 27:1876-82. 2006
    ..These data indicate that GSTA1 genotypes related to reduced GSTA1 expression are associated with increased breast cancer primarily among women with lower consumption of cruciferous vegetables and among current smokers...
  27. pmc Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer
    Jie Shen
    Department of Cancer Prevention and Controls, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Carcinogenesis 33:604-12. 2012
    ..Further characterization of significant associations between microRNAs and risk alleles could facilitate the understanding of the functions of these GWAS discovered risk alleles in the genetic etiology of ovarian cancer...
  28. pmc Repeat polymorphisms in estrogen metabolism genes and prostate cancer risk: results from the Prostate Cancer Prevention Trial
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 32:1500-6. 2011
    ....
  29. pmc Dietary lignan intakes in relation to survival among women with breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study
    Susan E McCann
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 122:229-35. 2010
    ..In summary, our results suggest that higher lignan intakes may be associated with improved survival among postmenopausal women with breast cancer...
  30. ncbi request reprint MnSOD Val-9Ala genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New York
    Mia M Gaudet
    Department of Epidemiology, School of Public Health, University of North Carolina, CB 7435, Chapel Hill, NC 27599 7435, USA
    Cancer Causes Control 16:1225-34. 2005
    ..This study provides little evidence that variation in Val-9Ala polymorphism of MnSOD alone or through substantial interaction with key exposures believed to be pro- or anti-oxidant properties influences breast cancer risk...
  31. pmc Variants in the vitamin D pathway, serum levels of vitamin D, and estrogen receptor negative breast cancer among African-American women: a case-control study
    Song Yao
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Breast Cancer Res 14:R58. 2012
    ..We hypothesized that racial differences in 25OHD levels, as well as in inherited genetic variations, may contribute, in part, to the differences in tumor characteristics...
  32. pmc Racial disparities in posttraumatic stress after diagnosis of localized breast cancer: the BQUAL study
    Neomi Vin-Raviv
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    J Natl Cancer Inst 105:563-72. 2013
    ..This study examines changes in PTSD symptoms in the first 6 months after diagnosis and assesses racial/ethnic differences in PTSD symptomatology over time...
  33. pmc Noninitiation of adjuvant chemotherapy in women with localized breast cancer: the breast cancer quality of care study
    Alfred I Neugut
    Division of Medical Oncology, Columbia University Medical Center, 722 W 168th St, Room 725, New York, NY 10032, USA
    J Clin Oncol 30:3800-9. 2012
    ..For some women, adjuvant chemotherapy for nonmetastatic breast cancer decreases recurrences and increases survival; however, patient-physician decisions regarding chemotherapy receipt can be influenced by medical and nonmedical factors...
  34. pmc Non-steroidal anti-inflammatory drugs (NSAIDs) and breast cancer risk: differences by molecular subtype
    Theodore M Brasky
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA
    Cancer Causes Control 22:965-75. 2011
    ..28, 95% CI: 1.04-1.57), as well as luminal A or B breast cancers. These findings support the hypothesis of heterogeneous etiologies of breast cancer subtypes and that aspirin and ibuprofen vary in their effects...
  35. pmc Genetic variants in COX-2, non-steroidal anti-inflammatory drugs, and breast cancer risk: the Western New York Exposures and Breast Cancer (WEB) Study
    Theodore M Brasky
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA
    Breast Cancer Res Treat 126:157-65. 2011
    ..Better understanding of the role of COX-2 genetic variation and interaction with NSAID use in breast carcinogenesis has potential to inform prevention strategies...
  36. pmc Single-nucleotide polymorphisms in DNA repair genes and association with breast cancer risk in the web study
    Michelle R Roberts
    Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY 14214, USA
    Carcinogenesis 32:1223-30. 2011
    ..These results indicate that some of the variants in BER and NER genes may influence risk of postmenopausal breast cancer...
  37. ncbi request reprint Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New York
    Mia M Gaudet
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hil, NC 27516, USA
    Breast Cancer Res Treat 99:235-40. 2006
    ....
  38. ncbi request reprint Intakes of selected nutrients, foods, and phytochemicals and prostate cancer risk in western New York
    Susan E McCann
    Department of Epidemiology, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Nutr Cancer 53:33-41. 2005
    ..Nevertheless, our results support the hypothesis that a phytochemical-rich, plant-based diet is of importance in reducing risks of hormone-related neoplasms...
  39. ncbi request reprint Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers
    Ji Yeob Choi
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Sts, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 16:1115-20. 2007
    ....
  40. pmc Pilot intervention outcomes of an educational program for biospecimen research participation
    Marc T Kiviniemi
    School of Public Health and Health Professions, State University of New York, Buffalo, NY, USA
    J Cancer Educ 28:52-9. 2013
    ..Accurate information and improved knowledge can reduce individual anxiety and concerns that serve as barriers to research participation...
  41. ncbi request reprint Genetic predictors of long-term toxicities after radiation therapy for breast cancer
    Nataliya Kuptsova
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Cancer 122:1333-9. 2008
    ..The application of genomics to outcomes following radiation therapy holds the promise of radiation dose adjustment to improve both cosmetic outcomes and quality of life for breast cancer patients...
  42. ncbi request reprint Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer
    Jun Yang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 28:1247-53. 2007
    ....
  43. pmc Supplement use during an intergroup clinical trial for breast cancer (S0221)
    Gary R Zirpoli
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 137:903-13. 2013
    ..Upon followup from the clinical trial, findings regarding supplement use and survival outcomes will better inform physician recommendations for patients on adjuvant chemotherapy...
  44. pmc Genetic predictors of taxane-induced neurotoxicity in a SWOG phase III intergroup adjuvant breast cancer treatment trial (S0221)
    Lara E Sucheston
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 130:993-1002. 2011
    ..If replicated, women with these genotypes should be closely monitored for toxicities and could be targeted for preventive measures or alternative therapeutic approaches...
  45. pmc Interpersonal influences and attitudes about adjuvant therapy treatment decisions among non-metastatic breast cancer patients: an examination of differences by age and race/ethnicity in the BQUAL study
    Rachel C Shelton
    Department of Sociomedical Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    Breast Cancer Res Treat 137:817-28. 2013
    ....
  46. pmc Non-steroidal anti-inflammatory drug (NSAID) use and breast cancer risk in the Western New York Exposures and Breast Cancer (WEB) Study
    Theodore M Brasky
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY 14214, USA
    Cancer Causes Control 21:1503-12. 2010
    ..Results of studies of non-steroidal anti-inflammatory drugs (NSAIDs) and breast cancer have been inconsistent. Timing of exposure and analysis of individual NSAIDs should be considered...
  47. pmc Intake of cruciferous vegetables modifies bladder cancer survival
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Carlton House Rm 365, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 19:1806-11. 2010
    ..Due to the potent antiproliferative effects of dietary isothiocyanates on bladder cancer in in vitro and in vivo models, cruciferous vegetable intake may also play a role in survival among patients with bladder cancer...
  48. ncbi request reprint No association between glutathione peroxidase Pro198Leu polymorphism and breast cancer risk
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 14:2459-61. 2005
  49. pmc A survey of breast cancer physicians regarding patient involvement in breast cancer treatment decisions
    Grace Clarke Hillyer
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 W 168th Street, New York, NY 10032, United States
    Breast 22:548-54. 2013
    ....
  50. doi request reprint Consumption of raw cruciferous vegetables is inversely associated with bladder cancer risk
    Li Tang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 17:938-44. 2008
    ..93, respectively). These data suggest that cruciferous vegetables, when consumed raw, may reduce the risk of bladder cancer, an effect consistent with the role of dietary isothiocyanates as chemopreventive agents against bladder cancer...
  51. pmc Use of nonsteroidal anti-inflammatory drugs and survival following breast cancer diagnosis
    Yanli Li
    Department of Social and Preventive Medicine, State University of New York at Buffalo, 265 Farber Hall, Buffalo, NY 14214, USA
    Cancer Epidemiol Biomarkers Prev 21:239-42. 2012
    ..While there is accumulating evidence that use of nonsteroidal anti-inflammatory drugs (NSAID) decreases breast cancer risk, little is known about the impact of NSAIDs on survival after breast cancer diagnosis...
  52. doi request reprint A functional polymorphism in the miR-146a gene and age of familial breast/ovarian cancer diagnosis
    Jie Shen
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 29:1963-6. 2008
    ....
  53. pmc PAH-DNA adducts, cigarette smoking, GST polymorphisms, and breast cancer risk
    Kathleen M McCarty
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Environ Health Perspect 117:552-8. 2009
    ..Few breast cancer studies have investigated the joint effects of multiple GSTs and a PAH biomarker...
  54. ncbi request reprint Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk
    Michael A Joseph
    Department of Oncological Sciences, Mt Sinai School of Medicine, New York, NY 10029, USA
    Nutr Cancer 50:206-13. 2004
    ....
  55. ncbi request reprint Associations between catalase phenotype and genotype: modification by epidemiologic factors
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 15:1217-22. 2006
    ..Associations between genotype and phenotype were modified by dietary factors, illustrating the biochemical complexity of studies of genetic polymorphisms and disease risk...
  56. ncbi request reprint Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk
    Jiyoung Ahn
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, New York, USA
    Cancer Res 64:7634-9. 2004
    ....
  57. pmc Case-only analyses of the associations between polymorphisms in the metastasis-modifying genes BRMS1 and SIPA1 and breast tumor characteristics, lymph node metastasis, and survival
    Michelle R Roberts
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 139:873-85. 2013
    ..Future evaluation of metastasis-modifying gene variants is necessary to better understand the biology of metastasis. ..
  58. pmc Polymorphisms in oxidative stress genes, physical activity, and breast cancer risk
    Lauren E McCullough
    Department of Epidemiology, University of North Carolina, CB 7435, McGavran Greenberg Hall, Chapel Hill, NC 27599 7435, USA
    Cancer Causes Control 23:1949-58. 2012
    ..Given the paradoxical effects of physical activity, the oxidative stress pathway is of interest. Genetic variation in CAT or antioxidant-related polymorphisms may mediate the physical activity-breast cancer association...
  59. pmc Non-initiation of adjuvant hormonal therapy in women with hormone receptor-positive breast cancer: The Breast Cancer Quality of Care Study (BQUAL)
    Alfred I Neugut
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Breast Cancer Res Treat 134:419-28. 2012
    ..Educational interventions to women about the benefits of hormonal therapy may decrease negative beliefs and increase hormone therapy initiation...
  60. pmc Common genetic variants are associated with accelerated bone mineral density loss after hematopoietic cell transplantation
    Song Yao
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 6:e25940. 2011
    ..Hypothesizing that genetic variants may influence post-HCT BMD loss, we conducted a prospective study to examine the associations of single nucleotide polymorphisms (SNP) in bone metabolism pathways and acute BMD loss after HCT...
  61. ncbi request reprint Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients
    Susan A Nowell
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Breast Cancer Res Treat 91:249-58. 2005
    ..These studies indicate that genetic variation in Phase II conjugating enzymes can influence the efficacy of tamoxifen therapy for breast cancer...
  62. pmc Enhanced statistical tests for GWAS in admixed populations: assessment using African Americans from CARe and a Breast Cancer Consortium
    Bogdan Pasaniuc
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    PLoS Genet 7:e1001371. 2011
    ..Our methods and our publicly available software are broadly applicable to GWAS in admixed populations...
  63. doi request reprint DNA hypermethylation and clinicopathological features in breast cancer: the Western New York Exposures and Breast Cancer (WEB) Study
    Meng Hua Tao
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, 270 Farber Hall, Buffalo, NY 14214, USA
    Breast Cancer Res Treat 114:559-68. 2009
    ..51; 95% CI, 1.01-2.32). Hypermethylation of RAR-beta(2) gene was inversely associated with histological and nuclear grade of breast cancer...
  64. doi request reprint Mitochondrial copy number and risk of breast cancer: a pilot study
    Jie Shen
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mitochondrion 10:62-8. 2010
    ..These results suggest the mtDNA copy number could be associated with risk of breast cancer, perhaps through an oxidative stress mechanism...
  65. pmc OSAT: a tool for sample-to-batch allocations in genomics experiments
    Li Yan
    Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    BMC Genomics 13:689. 2012
    ..Therefore, it is necessary to develop effective and handy tool to assign collected samples across batches in an appropriate way in order to minimize the impact of batch effects...
  66. pmc Pretreatment serum concentrations of 25-hydroxyvitamin D and breast cancer prognostic characteristics: a case-control and a case-series study
    Song Yao
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 6:e17251. 2011
    ..Results from epidemiologic studies on the relationship between vitamin D and breast cancer risk are inconclusive. It is possible that vitamin D may be effective in reducing risk only of specific subtypes due to disease heterogeneity...
  67. pmc NY-ESO-1 cancer testis antigen demonstrates high immunogenicity in triple negative breast cancer
    Foluso O Ademuyiwa
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 7:e38783. 2012
    ....
  68. pmc Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: a Gynecologic Oncology Group study
    Chunqiao Tian
    Gynecologic Oncology Group Statistical and Data Center, Buffalo, NY 14263, USA
    Gynecol Oncol 124:575-81. 2012
    ..This study examined associations between functional variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes in patients with epithelial ovarian/primary peritoneal cancer (EOC/PPC) following platinum and taxane-based chemotherapy...
  69. pmc Dietary intakes of total and specific lignans are associated with clinical breast tumor characteristics
    Susan E McCann
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Nutr 142:91-8. 2012
    ..Future investigations are warranted to explore the strong associations observed with ER(-) cancer in premenopausal women...
  70. pmc Alcohol consumption and genetic variation in methylenetetrahydrofolate reductase and 5-methyltetrahydrofolate-homocysteine methyltransferase in relation to breast cancer risk
    Mary E Platek
    Department of Social and Preventive Medicine, State University of New York at Buffalo, Buffalo, NY, USA
    Cancer Epidemiol Biomarkers Prev 18:2453-9. 2009
    ..80; 95% CI, 1.03-3.28) compared with nondrinkers who were homozygote CC. Our findings indicate that among postmenopausal women, increased breast cancer risk with alcohol consumption may be as a result of effects on one-carbon metabolism...
  71. ncbi request reprint Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype
    Christine B Ambrosone
    Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Nutr 134:1134-8. 2004
    ..No significant effects of GST genotype on risk were observed in either menopausal group. These data indicate that cruciferous vegetables may play an important role in decreasing the risk of premenopausal breast cancer...
  72. pmc The Breast Cancer Quality of Care Study (BQUAL): a multi-center study to determine causes for noncompliance with breast cancer adjuvant therapy
    Alfred I Neugut
    Department of Medicine, and Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, School of Public Health, Columbia University Medical Center, 722 W 168th Street, New York, NY 10032, USA
    Breast J 18:203-13. 2012
    ..This information may be useful in planning interventions to improve quality of care...
  73. pmc IMA: an R package for high-throughput analysis of Illumina's 450K Infinium methylation data
    Dan Wang
    Department of Biostatistics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Bioinformatics 28:729-30. 2012
    ..The pipeline loads the data from Illumina platform and provides user-customized functions commonly required to perform exploratory methylation analysis for individual sites as well as annotated regions...
  74. ncbi request reprint Diet and alcohol consumption in relation to p53 mutations in breast tumors
    Jo L Freudenheim
    Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY 14214, USA
    Carcinogenesis 25:931-9. 2004
    ..For premenopausal women, alcohol consumption in the past was associated with p53 mutations...
  75. ncbi request reprint Concordance of pharmacogenetic polymorphisms in tumor and germ line DNA in adult patients with acute myeloid leukemia
    Joli R Weiss
    Department of Epidemiology and Cancer Prevention, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 16:1038-41. 2007
    ..Based on these data, genotypes derived from archived AML bone marrow samples were not likely to differ from those from genomic DNA, and archived bone marrow samples may be useful for the conduct of retrospective pharmacogenetic studies...
  76. ncbi request reprint Breast cancer in African-American women: differences in tumor biology from European-American women
    Kandace Amend
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, New York, USA
    Cancer Res 66:8327-30. 2006
    ..An overview of the current literature about racial differences in breast cancer prompts questions for future research to elucidate causes for the apparent disparities in tumor biology...
  77. pmc Serum estrogen levels and prostate cancer risk in the prostate cancer prevention trial: a nested case-control study
    Song Yao
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cancer Causes Control 22:1121-31. 2011
    ..Finasteride reduces prostate cancer risk by blocking the conversion of testosterone to dihydrotestosterone. However, whether finasteride affects estrogens levels or change in estrogens affects prostate cancer risk is unknown...
  78. doi request reprint Novel genetic variants in microRNA genes and familial breast cancer
    Jie Shen
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Int J Cancer 124:1178-82. 2009
    ..Our findings suggest that functional genetic variants in miRNA genes can potentially alter the regulation of key breast cancer genes. Whether they confer genetic susceptibility to breast cancer remains to be determined...
  79. doi request reprint A deletion polymorphism in glutathione-S-transferase mu (GSTM1) and/or theta (GSTT1) is associated with an increased risk of toxicity after autologous blood and marrow transplantation
    Theresa Hahn
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Biol Blood Marrow Transplant 16:801-8. 2010
    ..034) and mucositis (74% versus 55%, P = .006). GSTM1 and/or GSTT1 deletion polymorphisms were not associated with toxicity after allogeneic BMT. Future studies may allow for individualized genetic risk stratification...
  80. ncbi request reprint Gene-nutrient interactions in cancer etiology
    Susan A Nowell
    Department of Epidemiology, Roswell Park Cancer Institute, Elm Street, Buffalo, NY 14263, USA
    Nutr Rev 62:427-38. 2004
    ..The role of consumption of fruits and vegetables, as well as the role of genetic variants in oxidative stress genes, in the risk of breast cancer are also discussed...
  81. pmc Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X
    Ching Yu Cheng
    Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA
    PLoS Genet 5:e1000490. 2009
    ..27; genome-wide score = 3.46). Further mapping studies with dense sets of markers will be necessary to identify the alleles in these regions of chromosomes X and 5 that may be associated with variation in BMI...
  82. ncbi request reprint Polymorphisms in DNA repair genes and therapeutic outcomes of AML patients from SWOG clinical trials
    Nataliya Kuptsova
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Blood 109:3936-44. 2007
    ..With validation of results in larger samples, these findings could lead to optimizing individual chemotherapy options...
  83. pmc A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer
    Hua Zhao
    Department of Cancer Prevention and Controls, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 5:e13735. 2010
    ..The objective of this pilot study was to discover a panel of circulating miRNAs as potential novel breast cancer biomarkers...
  84. doi request reprint Molecular epidemiology to better predict lung cancer risk
    Mary E Reid
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Clin Lung Cancer 9:149-53. 2008
    ..It is likely that, by incorporating biomarkers of susceptibility, exposure, and effect, molecular epidemiologic approaches might better define factors that explain some of the variability in lung cancer risk...
  85. ncbi request reprint Hair dye use, meat intake, and tobacco exposure and presence of carcinogen-DNA adducts in exfoliated breast ductal epithelial cells
    Christine B Ambrosone
    Division of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Arch Biochem Biophys 464:169-75. 2007
    ..2, 95% CI=1.1-109.2) but not tobacco usage. These data indicate that women are exposed to several classes of dietary and environmental carcinogens and that metabolic genotype can be a susceptibility factor...
  86. pmc Serum oxidized protein and prostate cancer risk within the Prostate Cancer Prevention Trial
    Ashraful Hoque
    Division of Environmental Health Sciences, Columbia University, 630 West 168th Street, New York, NY 10032, USA
    Cancer Prev Res (Phila) 3:478-83. 2010
    ..The results of this large nested case-control study do not support the hypothesis that oxidative stress, at least as measured by protein carbonyl level, plays a role in prostate cancer...
  87. ncbi request reprint Exposures associated with serum organochlorine levels among postmenopausal women from western New York State
    Kirsten B Moysich
    Department of Cancer Prevention, Epidemiology and Biostatistics, Roswell Park Cancer Institute, Buffalo, NY 14226, USA
    Am J Ind Med 41:102-10. 2002
    ....
  88. ncbi request reprint Detection of epithelial ovarian cancer using 1H-NMR-based metabonomics
    Kunle Odunsi
    Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, NY 14261, USA
    Int J Cancer 113:782-8. 2005
    ..The metabonomic approach deserves further evaluation as a potential novel strategy for the early detection of epithelial ovarian cancer...
  89. ncbi request reprint Regular use of aspirin or acetaminophen and risk of non-Hodgkin lymphoma
    Julie A Baker
    Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Cancer Causes Control 16:301-8. 2005
    ..48--1.17). Other studies have demonstrated that acetaminophen is associated with transient decreases in DNA repair, and lymphocytes may be particularly susceptible to DNA damage, suggesting a mechanism for the elevated NHL risk observed...
  90. ncbi request reprint The role of genetic variability in drug metabolism pathways in breast cancer prognosis
    Ji Yeob Choi
    Roswell Park Cancer Institute, Department of Epidemiology, Elm and Carlton Sts, Buffalo, NY, 14263, USA
    Pharmacogenomics 7:613-24. 2006
    ..It is likely that the application of pharmacogenetics, particularly in the setting of randomized clinical trials, will contribute to findings that may result in individualized therapeutic dosing...
  91. ncbi request reprint New developments in the epidemiology of cancer prognosis: traditional and molecular predictors of treatment response and survival
    Christine B Ambrosone
    Department of Epidemiology Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Cancer Epidemiol Biomarkers Prev 15:2042-6. 2006
  92. doi request reprint Traumatic stress symptoms and breast cancer: the role of childhood abuse
    Rachel E Goldsmith
    Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY, USA
    Child Abuse Negl 34:465-70. 2010
    ..The present study investigated relations between reported childhood abuse and recent traumatic stress symptoms in women newly diagnosed with breast cancer (n=330)...
  93. ncbi request reprint Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients
    Jenny Chang-Claude
    Division of Clinical Epidemiology and Toxicology, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:4802-9. 2005
    ..We evaluated the association of six polymorphisms in the DNA repair genes: XRCC1 (Arg194Trp, Arg280His, and Arg399Gln), APE1 (Asp148Glu), and XPD (Lys751Gln and Asp312Asn), with the risk of acute skin reactions following radiotherapy...
  94. ncbi request reprint Association between TP53 and p21 genetic polymorphisms and acute side effects of radiotherapy in breast cancer patients
    Xiang Lin Tan
    Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Breast Cancer Res Treat 97:255-62. 2006
    ..In conclusion, the TP53 72Pro variant may be associated with the development of acute skin toxicity after radiotherapy in patients with normal weight. Large clinical studies are needed to clearly confirm this association...
  95. ncbi request reprint Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy
    Susan Nowell
    S Nowell, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, USA
    J Natl Cancer Inst 94:1635-40. 2002
    ..We investigated the hypothesis that that high sulfation activity would increase the elimination of 4-OH TAM by examining whether the presence of this polymorphism affects the efficacy of tamoxifen therapy...
  96. ncbi request reprint p53 Mutation analysis in breast tumors by a DNA microarray method
    Meredith Tennis
    Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057 1465, USA
    Cancer Epidemiol Biomarkers Prev 15:80-5. 2006
    ..We have shown the utility of the Affymetrix GeneChip method under these challenging conditions and provided new data for the mutational spectra of breast cancer in a population-based study...
  97. ncbi request reprint Lifestyle factors and survival in women with breast cancer
    Lawrence H Kushi
    Division of Research, Kaiser Permanente, Oakland, CA, USA
    J Nutr 137:236S-242S. 2007
    ..This and other studies promise to provide some of the first objective information regarding diet and breast cancer prognosis and serve as models for studies of diet and prognosis of other cancers...
  98. ncbi request reprint Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men
    Jong Park
    Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
    Cancer Epidemiol Biomarkers Prev 15:1473-8. 2006
    ..The purpose of this study was to determine if the deletion polymorphism is associated with susceptibility to prostate cancer...
  99. ncbi request reprint The risk of breast cancer associated with dietary lignans differs by CYP17 genotype in women
    Susan E McCann
    Department of Social and Preventive Medicine, University at Buffalo, NY 14214, USA
    J Nutr 132:3036-41. 2002
    ..12, 95% CI 0.03-0.50). Our results suggest that CYP17 genotype may be important in modifying the effect on breast cancer risk of exogenous estrogens, particularly for premenopausal women...
  100. ncbi request reprint Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk
    Susan Nowell
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
    Mutat Res 506:175-85. 2002
    ....
  101. ncbi request reprint Genetic polymorphisms in the DNA double-strand break repair genes XRCC3, XRCC2, and NBS1 are not associated with acute side effects of radiotherapy in breast cancer patients
    Odilia Popanda
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 15:1048-50. 2006

Research Grants18

  1. Antioxidant supplements, genetics, and chemotherapy outcomes
    Christine Ambrosone; Fiscal Year: 2009
    ....
  2. Antioxidant supplements, genetics and chemotherapy outcomes
    Christine Ambrosone; Fiscal Year: 2007
    ....
  3. Lung cancer molecular markers by sex: intergroup study
    Christine Ambrosone; Fiscal Year: 2007
    ..Results from this study, the largest to date to evaluate biomarkers of susceptibility and effect, will likely elucidate reasons for the rise in lung cancer, particularly adenocarcinomas, in smoking and non-smoking women. ..
  4. Race & Risk Factors for Early/Aggressive Breast Cancer
    Christine Ambrosone; Fiscal Year: 2007
    ..Results from this study will provide much-needed answers as to why African-American women are more likely than Caucasians to be diagnosed with more aggressive disease at an earlier age. ..
  5. Pharmacogenetics: Breast Cancer Treatment and Prognosis
    Christine Ambrosone; Fiscal Year: 2005
    ..Individualized dosing according to genotype could contribute to increased efficacy and decreased toxicity among patients being treated for cancer. ..
  6. DNA Methylation: a Mechanism for Aggressive Breast Cancer in African-American Wom
    Michael J Higgins; Fiscal Year: 2010
    ..As such, it could provide insight into factors related to the aggressive breast cancers observed in African-American women. Because methylation is reversible, it may also provide new directions for prevention and therapeutics. ..