Nikolaos G Almyroudis

Summary

Affiliation: Roswell Park Cancer Institute
Country: USA

Publications

  1. doi request reprint Molecular epidemiology and risk factors for colonization by vancomycin-resistant Enterococcus in patients with hematologic malignancies
    N G Almyroudis
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA
    Infect Control Hosp Epidemiol 32:490-6. 2011
  2. ncbi request reprint Issues related to the design and interpretation of clinical trials of salvage therapy for invasive mold infection
    Nikolaos G Almyroudis
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Clin Infect Dis 43:1449-55. 2006
  3. doi request reprint Late infectious complications after cord blood stem cell transplantation
    N G Almyroudis
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Eur J Clin Microbiol Infect Dis 28:1405-8. 2009
  4. pmc Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice
    Melissa J Grimm
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 190:4175-84. 2013
  5. ncbi request reprint Broad-spectrum antifungal prophylaxis in patients with cancer at high risk for invasive mold infections: point
    Antonio V Gonzalez
    The Division of Infectious Diseases, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Natl Compr Canc Netw 6:175-82. 2008
  6. pmc Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense
    R Robert Vethanayagam
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 6:e28149. 2011
  7. ncbi request reprint Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Clin Infect Dis 44:402-9. 2007
  8. doi request reprint Antifungal prophylaxis and therapy in patients with hematological malignancies and hematopoietic stem cell transplant recipients
    Nikolaos G Almyroudis
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Expert Rev Anti Infect Ther 8:1451-66. 2010
  9. doi request reprint Infection control measures to prevent invasive mould diseases in hematopoietic stem cell transplant recipients
    Kimberly Partridge-Hinckley
    Division of Infection Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mycopathologia 168:329-37. 2009
  10. ncbi request reprint Antifungal agents in hematopoietic stem cell transplantation
    G Iyer Parameswaran
    Division of Infectious Diseases, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Curr Pharm Des 14:2011-21. 2008

Detail Information

Publications21

  1. doi request reprint Molecular epidemiology and risk factors for colonization by vancomycin-resistant Enterococcus in patients with hematologic malignancies
    N G Almyroudis
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA
    Infect Control Hosp Epidemiol 32:490-6. 2011
    ..To study the molecular epidemiology of vancomycin-resistant Enterococcus (VRE) colonization and to identify modifiable risk factors among patients with hematologic malignancies...
  2. ncbi request reprint Issues related to the design and interpretation of clinical trials of salvage therapy for invasive mold infection
    Nikolaos G Almyroudis
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Clin Infect Dis 43:1449-55. 2006
    ..Given that randomized studies are unrealistic, studies involving carefully selected, matched, contemporaneous control subjects are likely to be the most useful alternative...
  3. doi request reprint Late infectious complications after cord blood stem cell transplantation
    N G Almyroudis
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Eur J Clin Microbiol Infect Dis 28:1405-8. 2009
    ..In conclusion, survival beyond day 100 following cord bloodstem cell transplantation is associated with a considerable risk of infections in our single center experience...
  4. pmc Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice
    Melissa J Grimm
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Immunol 190:4175-84. 2013
    ..Taken together, our studies identify a central role for monocyte/macrophage NADPH oxidase in controlling fungal infection and in limiting acute lung inflammation...
  5. ncbi request reprint Broad-spectrum antifungal prophylaxis in patients with cancer at high risk for invasive mold infections: point
    Antonio V Gonzalez
    The Division of Infectious Diseases, Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Natl Compr Canc Netw 6:175-82. 2008
    ....
  6. pmc Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense
    R Robert Vethanayagam
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, United States of America
    PLoS ONE 6:e28149. 2011
    ..cepacia, whereas the proteases we evaluated were dispensable. Our results indicate that NADPH oxidase dependent pathways separate from neutrophil serine protease activation are required for host defense against specific pathogens...
  7. ncbi request reprint Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Clin Infect Dis 44:402-9. 2007
    ..Finally, we discuss the implications of newer antifungal agents and diagnostic adjuncts in the design of future clinical trials to evaluate prophylaxis and early prevention strategies...
  8. doi request reprint Antifungal prophylaxis and therapy in patients with hematological malignancies and hematopoietic stem cell transplant recipients
    Nikolaos G Almyroudis
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Expert Rev Anti Infect Ther 8:1451-66. 2010
    ..Here, we review the pharmacological data and major clinical trials that guide the use of antifungals, as well as areas of uncertainty and future perspectives...
  9. doi request reprint Infection control measures to prevent invasive mould diseases in hematopoietic stem cell transplant recipients
    Kimberly Partridge-Hinckley
    Division of Infection Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mycopathologia 168:329-37. 2009
    ....
  10. ncbi request reprint Antifungal agents in hematopoietic stem cell transplantation
    G Iyer Parameswaran
    Division of Infectious Diseases, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Curr Pharm Des 14:2011-21. 2008
    ..Finally there has been increasing interest on combination therapy for invasive aspergillosis due to the high rate of failure of the currently available antifungals, especially in the profoundly immunocompromised host...
  11. pmc Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Infect Dis 47:674-83. 2008
    ..We also discuss potential pitfalls in assessing outcome, such as conflicting clinical, radiological, and/or mycological data and gaps in knowledge...
  12. ncbi request reprint Prevention and treatment of invasive fungal diseases in neutropenic patients
    Nikolaos G Almyroudis
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Curr Opin Infect Dis 22:385-93. 2009
    ..Despite advances in the diagnosis and management, invasive fungal diseases contribute substantially to the morbidity and mortality of patients with prolonged neutropenia...
  13. pmc NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury
    Nikolaos G Almyroudis
    Division of Infectious Diseases, Department of Medicine, University at Buffalo School of Medicine Buffalo, NY, USA Department of Medicine, Roswell Park Cancer Institute Buffalo, NY, USA
    Front Immunol 4:45. 2013
    ..Recent work supports a role for NETosis in both acute lung injury and in autoimmunity. Knowledge gained about mechanisms that modulate NETosis may lead to novel therapeutic approaches to limit inflammation-associated injury...
  14. doi request reprint Role of NADPH oxidase in host defense against aspergillosis
    Melissa J Grimm
    Department of Medicine, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Med Mycol 49:S144-9. 2011
    ....
  15. ncbi request reprint Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis
    Minoo Battiwalla
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York 14202, USA
    Biol Blood Marrow Transplant 13:765-70. 2007
    ..Collectively, these results show that ganciclovir suppresses T-lymphocyte proliferation in vitro by inhibiting DNA synthesis; with implications for T-lymphocyte function following allogeneic BMT...
  16. pmc In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents
    Nikolaos G Almyroudis
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA
    Antimicrob Agents Chemother 51:2587-90. 2007
    ..The significant in vitro activity of posaconazole against several species appears to support its reported clinical efficacy. Decreased susceptibility to amphotericin B was noted with Cunninghamella bertholletiae...
  17. ncbi request reprint Review of epidemiology, diagnosis, and treatment of invasive mould infections in allogeneic hematopoietic stem cell transplant recipients
    Zahida Bhatti
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA
    Mycopathologia 162:1-15. 2006
    ..We review the epidemiology, diagnosis, and management of invasive mould infection in HSCT, with a focus on allogeneic recipients. We also discuss options for prevention and early treatment of invasive mould infections...
  18. ncbi request reprint Immunotherapy for fungal infections
    Brahm H Segal
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Clin Infect Dis 42:507-15. 2006
    ..g., vaccines). Immunotherapy must be tailored to specific immunocompromised states. Challenges exist in bringing promising immunotherapies from the laboratory to clinical trials...
  19. doi request reprint Acyclovir prophylaxis against varicella zoster virus reactivation in multiple myeloma patients treated with bortezomib-based therapies: a retrospective analysis of 100 patients
    Abhisek Swaika
    Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York, USA
    J Support Oncol 10:155-9. 2012
    ..Previous studies have indicated that, in patients with multiple myeloma (MM), bortezomib is associated with an increased incidence of herpes zoster, resulting from reactivation of latent varicella zoster virus (VZV)...
  20. ncbi request reprint Antibacterial prophylaxis in patients with cancer and neutropenia
    Nikolaos G Almyroudis
    N Engl J Med 354:90-4; author reply 90-4. 2006
  21. ncbi request reprint Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt
    Elias J Anaissie
    Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Clin Infect Dis 43:1031-9. 2006