Nikunj S Patel

Summary

Affiliation: Roskamp Institute
Country: USA

Publications

  1. doi request reprint Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide
    Nikunj S Patel
    The Roskamp Institute, Sarasota, Florida 34243, USA
    Amyloid 15:5-19. 2008
  2. doi request reprint Alzheimer's beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2
    Nikunj S Patel
    Roskamp Institute, Sarasota, Florida, USA
    J Neurochem 112:66-76. 2010
  3. pmc Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    J Neuroinflammation 7:17. 2010
  4. ncbi request reprint Model of Alzheimer's disease amyloid-beta peptide based on a RNA binding protein
    Venkatarajan S Mathura
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Biochem Biophys Res Commun 332:585-92. 2005

Collaborators

Detail Information

Publications5

  1. doi request reprint Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptide
    Nikunj S Patel
    The Roskamp Institute, Sarasota, Florida 34243, USA
    Amyloid 15:5-19. 2008
    ..Using normal and mutated peptide fragments, we show that the sequence VHHQKLVFF is sufficient to exhibit potent anti-angiogenic effects. This small peptide may therefore have clinical relevance as an anti-angiogenic agent...
  2. doi request reprint Alzheimer's beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2
    Nikunj S Patel
    Roskamp Institute, Sarasota, Florida, USA
    J Neurochem 112:66-76. 2010
    ..Altogether, our data suggest that Abeta acts as an antagonist of VEGFR-2 and provide a mechanism explaining the anti-angiogenic activity of Abeta peptides...
  3. pmc Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    J Neuroinflammation 7:17. 2010
    ..We therefore explored whether the known NFkappaB inhibitor celastrol could represent a suitable compound for decreasing Abeta production and accumulation in vivo...
  4. ncbi request reprint Model of Alzheimer's disease amyloid-beta peptide based on a RNA binding protein
    Venkatarajan S Mathura
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Biochem Biophys Res Commun 332:585-92. 2005
    ..We hypothesize that in a similar fashion to AF-Sm1, RNA interacts with Abeta in the beta-hairpin (beta-turn-beta) structure and prevents fibril formation...