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Genomes and Genes | Daniel ParisSummaryAffiliation: Roskamp Institute Country: USA Publications
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Publications
Amelioration of experimental autoimmune encephalomyelitis by anatabineDaniel Paris
Roskamp Institute, Sarasota, Florida, United States of America
PLoS ONE 8:e55392. 2013..Altogether our data suggest that anatabine may be effective in the treatment of MS and should be piloted in clinical trials...
Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylationDaniel Paris
The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, Florida 34243, USA
Eur J Pharmacol 698:145-53. 2013..Overall our data show that the anti-inflammatory activity of anatabine in vitro and in vivo is mediated in part via an inhibition of STAT3 phosphorylation...- Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's diseaseDaniel Paris
The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
J Neuroinflammation 7:17. 2010..We therefore explored whether the known NFkappaB inhibitor celastrol could represent a suitable compound for decreasing Abeta production and accumulation in vivo... 
Inhibition of Abeta production by NF-kappaB inhibitorsDaniel Paris
Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Neurosci Lett 415:11-6. 2007..Altogether our data suggest that NF-kappaB inhibitors may be of therapeutic importance for the treatment of AD pathology not only by blocking inflammatory processes but also by directly inhibiting the production of Abeta peptides...- Impaired orthotopic glioma growth and vascularization in transgenic mouse models of Alzheimer's diseaseDaniel Paris
The Roskamp Institute, Sarasota, Florida 34243, USA
J Neurosci 30:11251-8. 2010.... - Anti-angiogenic activity of the mutant Dutch A(beta) peptide on human brain microvascular endothelial cellsDaniel Paris
The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Brain Res Mol Brain Res 136:212-30. 2005..Altogether, these data provide new molecular clues regarding the pathological activity of Dutch A(beta) peptide in the cerebrovasculature... - Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitorsDaniel Paris
The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Eur J Pharmacol 514:1-15. 2005..Altogether these data suggest that the gamma and beta-secretases play an essential role during angiogenesis and that inhibitors of the beta and gamma-secretases may constitute new classes of anti-angiogenic and anti-tumoral compounds... - Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrierDaniel Paris
The Roskamp Institute, Sarasota, Florida 34243, United States of America
Mol Med 17:149-62. 2011.... - Anatabine lowers Alzheimer's Aβ production in vitro and in vivoDaniel Paris
Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Eur J Pharmacol 670:384-91. 2011..Altogether our data suggest that anatabine may represent an interesting compound for regulating brain Aβ accumulation... - Nilvadipine antagonizes both Abeta vasoactivity in isolated arteries, and the reduced cerebral blood flow in APPsw transgenic miceDaniel Paris
The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Brain Res 999:53-61. 2004..All together, these data suggest that nilvadipine might be useful for the treatment of oligemia associated with AD... - Vasoactive effects of A beta in isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: role of inflammationDaniel Paris
Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Neurol Res 25:642-51. 2003..Altogether, our data suggest a link between inflammation and the compromised cerebral hemodynamics in AD... - Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's diseaseGhania Ait-Ghezala
Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Cytokine 44:283-7. 2008..Thus, we present preliminary evidence for potential usefulness for combination of plasma sCD40, sCD40L along with Abeta(1-40) and APOE epsilon4 in improving the clinical diagnosis of AD... - Alzheimer's beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2Nikunj S Patel
Roskamp Institute, Sarasota, Florida, USA
J Neurochem 112:66-76. 2010..Altogether, our data suggest that Abeta acts as an antagonist of VEGFR-2 and provide a mechanism explaining the anti-angiogenic activity of Abeta peptides... - CD40 promotion of amyloid beta production occurs via the NF-kappaB pathwayGhania Ait-Ghezala
The Roskamp Institute, Sarasota, FL 34243, USA
Eur J Neurosci 25:1685-95. 2007..Taken together, our results further suggest that CD40L stimulation may be a key component in AD pathology and that elements of the NF-kappaB pathway may be suitable targets for therapeutic approaches against AD... - Increased TNFalpha production and Cox-2 activity in organotypic brain slice cultures from APPsw transgenic miceAmita Quadros
Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Neurosci Lett 353:66-8. 2003..In conclusion, our data suggest that either activity or expression of Cox-2 is increased in TgAPPsw mice brains as a function of age, contributing to an increased production of pro-inflammatory eicosanoids and TNFalpha... - Inhibition of angiogenesis by Abeta peptidesDaniel Paris
The Roskamp Institute, Sarasota, Florida 34243, USA
Angiogenesis 7:75-85. 2004..Similarly to the intra-tumoral injection regimen, Abeta delivered intraperitoneally also suppressed the growth of human lung adenocarcinoma tumor xenografts. Altogether our data show that Abeta is an angiogenesis inhibitor... - Genomic regulation after CD40 stimulation in microglia: relevance to Alzheimer's diseaseGhania Ait-Ghezala
The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Brain Res Mol Brain Res 140:73-85. 2005..Taken together, our data also suggest that CD40 ligation in human microglia specifically perturbs many genes associated with APP processing... - Serum beta-amyloid correlates with neuropsychological impairmentCheryl A Luis
Roskamp Institute, Sarasota, FL, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 16:203-18. 2009.... - The granulocyte macrophage colony stimulating factor (GM-CSF) regulates amyloid beta (Abeta) productionClaude Henry Volmar
Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Cytokine 42:336-44. 2008..GM-CSF signaling may be a suitable therapeutic target against Abeta production in AD... - Potent anti-angiogenic motifs within the Alzheimer beta-amyloid peptideNikunj S Patel
The Roskamp Institute, Sarasota, Florida 34243, USA
Amyloid 15:5-19. 2008..Using normal and mutated peptide fragments, we show that the sequence VHHQKLVFF is sufficient to exhibit potent anti-angiogenic effects. This small peptide may therefore have clinical relevance as an anti-angiogenic agent... - Pro-inflammatory effect of freshly solubilized beta-amyloid peptides in the brainDaniel Paris
The Roskamp Institute, University of South Florida, Tampa 33613, USA
Prostaglandins Other Lipid Mediat 70:1-12. 2002..Our data provide evidence that fsAbeta triggers a pro-inflammatory reaction in rat brain, and suggest that the cerebrovasculature may constitute an important source of pro-inflammatory eicosanoids... - Serum Abeta levels as predictors of conversion to mild cognitive impairment/Alzheimer disease in an ADAPT subcohortLaila Abdullah
Roskamp Institute, Sarasota, Florida 34243, USA
Mol Med 15:432-7. 2009..In this subcohort of individuals at risk for AD, the association of Abeta with vascular risk factors and medications to treat these conditions did not interfere with Abeta's predictive value for MCI/AD... - Impaired angiogenesis in a transgenic mouse model of cerebral amyloidosisDaniel Paris
The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Neurosci Lett 366:80-5. 2004..In addition, Tg APPsw mice show a reduction in vascular density in the cortex and hippocampus compared to control littermates. Altogether, our data suggest that the over expression of APPsw in the vasculature may oppose angiogenesis... - A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrierCorbin Bachmeier
The Roskamp Institute, Sarasota, FL 34243, USA
Neurodegener Dis 11:13-21. 2013..While apolipoprotein E4 (apoE4) is highly correlated with the development of Alzheimer's disease (AD), its role in AD pathology and, in particular, beta-amyloid (Aβ) removal from the brain, is not clearly defined... - The influence of diagnosis, intra- and inter-person variability on serum and plasma Abeta levelsLaila Abdullah
Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, United States
Neurosci Lett 428:53-8. 2007.... - Model of Alzheimer's disease amyloid-beta peptide based on a RNA binding proteinVenkatarajan S Mathura
Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Biochem Biophys Res Commun 332:585-92. 2005..We hypothesize that in a similar fashion to AF-Sm1, RNA interacts with Abeta in the beta-hairpin (beta-turn-beta) structure and prevents fibril formation... - High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer's disease patientsLaila Abdullah
Roskamp Institute, Sarasota, Florida 34243, USA
Mol Med 15:95-100. 2009..Longitudinal evaluation of blood Abeta in this cohort will provide a better understanding of the significance of this association in AD etiology... - Flavonoids lower Alzheimer's Aβ production via an NFκB dependent mechanismDaniel Paris
Roskamp Institute, 2040 Whitfield Avenue, Sarasota, Florida 34243, USA
Bioinformation 6:229-36. 2011..Altogether, our data suggest that flavonoids inhibit Aβ and sAPPβ production by regulating BACE-1 expression and not by directly inhibiting BACE-1 activity... - Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrierCorbin Bachmeier
The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Eur J Pharmacol 659:124-9. 2011..This dual mechanism of action may be particularly effective in attenuating Aβ brain burden in Alzheimer's disease and could open the door to a new class of therapies for the treatment of this disease... - Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortaeDaniel Paris
Department of Psychiatry, The Roskamp Institute, University of South Florida, 3515 E Fletcher Avenue, Tampa, FL 33613, USA
Atherosclerosis 161:293-9. 2002..Taken together these data show that statins can antagonize the effect of A beta in different assays and provide new clues to understand the prophylactic action of the statins against Alzheimer's disease... - Stimulation of the retinoid x receptor facilitates Beta-amyloid clearance across the blood-brain barrierCorbin Bachmeier
The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL, 34243, USA
J Mol Neurosci 49:270-6. 2013..Thus, RXR activation could mitigate Aβ brain burden by promoting both the metabolic and BBB clearance of Aβ, offering a novel approach to the treatment of AD... - Epitope-dependent effects of Beta-amyloid antibodies on Beta-amyloid clearance in an in vitro model of the blood-brain barrierCorbin J Bachmeier
The Roskamp Institute, Sarasota, Florida, USA
Microcirculation 18:373-9. 2011..To investigate the role of RAGE in the epitope-dependent effects of Aβ antibodies used as a peripheral sink therapy in AD... - A 3D-QSAR model based screen for dihydropyridine-like compound library to identify inhibitors of amyloid beta (Aβ) productionVenkatarajan S Mathura
Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
Bioinformation 5:122-7. 2010..We describe here our in silico model building strategy, model selection parameters and the chemical features that are useful for successful screening of DHP and DHP-like chemical libraries for Aβ inhibitors... - A novel physico-chemical property based model for studying the effects of mutation on the aggregation of peptidesVenkatarajan S Mathura
Roskamp Institute, 2040, Whitfield Avenue, Sarasota, FL 34243, USA
Protein Pept Lett 16:991-8. 2009..We also show that sequences containing beta-sheet classes of Structural Classification of Proteins (SCOP) have a higher propensity for aggregation... - Characterization and use of human brain microvascular endothelial cells to examine β-amyloid exchange in the blood-brain barrierCorbin Bachmeier
The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL, 34243, USA
Cytotechnology 62:519-29. 2010..These studies establish the HBMEC as a representative in vitro model of the BBB and offer a rapid fluorometric method of assessing Aβ exchange between the periphery and the brain... - Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptorJiazhi Sun
Drug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Cancer Res 64:3586-92. 2004..Taken together, these results demonstrate that a synthetic molecule capable of disrupting the binding of VEGF to its receptor selectively inhibits VEGF-dependent signaling and suppresses angiogenesis and tumorigenesis...