Rena Li

Summary

Affiliation: Roskamp Institute
Country: USA

Publications

  1. ncbi request reprint Brain sex matters: estrogen in cognition and Alzheimer's disease
    Rena Li
    Center for Hormone Advanced Science and Education CHASE, Roskamp Institute, Sarasota, FL 34243, United States Electronic address
    Mol Cell Endocrinol 389:13-21. 2014
  2. pmc Brain endogenous estrogen levels determine responses to estrogen replacement therapy via regulation of BACE1 and NEP in female Alzheimer's transgenic mice
    Rena Li
    Center for Hormone Advanced Science and Education, Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL 34243, USA
    Mol Neurobiol 47:857-67. 2013
  3. pmc Early reproductive experiences in females make differences in cognitive function later in life
    Rena Li
    Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243, USA
    J Alzheimers Dis 34:589-94. 2013
  4. pmc An old method facing a new challenge: re-visiting housekeeping proteins as internal reference control for neuroscience research
    Rena Li
    Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243, USA
    Life Sci 92:747-51. 2013
  5. pmc Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
    Hong Jiang
    Center for Advanced Therapeutic Strategies for Brain Disorders, Roskamp Institute, Sarasota, FL 34243, USA
    Mol Neurodegener 6:69. 2011
  6. ncbi request reprint Amyloid precursor protein mutation disrupts reproductive experience-enhanced normal cognitive development in a mouse model of Alzheimer's disease
    Jie Cui
    Center for Hormone Advanced Science and Education, Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL, 34243, USA
    Mol Neurobiol 49:103-12. 2014
  7. pmc Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces amyloidogenic processing of amyloid precursor protein in a mouse model of Alzheimer's disease
    Ping He
    Center for Advanced Therapeutic Strategies of Brain Disorders, Roskamp Institute, Sarasota, Florida, USA
    PLoS ONE 8:e58181. 2013
  8. pmc Estrogen synthesis and signaling pathways during aging: from periphery to brain
    Jie Cui
    Center for Hormone Advanced Science and Education CHASE, Roskamp Institute, Sarasota, FL 34243, USA
    Trends Mol Med 19:197-209. 2013
  9. ncbi request reprint Occludin deficiency with BACE1 elevation in cerebral amyloid angiopathy
    Xin Cheng
    From the Department of Neurology X C, Q D, Y S, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China Haldeman Laboratory of Molecular and Cellular Neurobiology X C, P H, Y S, Sun Health Research Institute, Sun City, AZ Center for Hormone Advanced Science and Education P H, R L and Center for Advanced Therapeutic Strategies for Brain Disorders P H, Y S, Roskamp Institute, Sarasota, FL and Department of Neurology Y S, University of Florida College of Medicine, Gainesville
    Neurology 82:1707-15. 2014
  10. pmc Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease
    Ping He
    Center for Advanced Therapeutic Strategies of Brain Disorders, Roskamp Institute, Sarasota, FL, USA
    PLoS ONE 8:e55091. 2013

Collaborators

  • Yong Shen
  • Nobuhiro Harada
  • Yuan Liu
  • Ping He
  • Jie Cui
  • Xin Cheng
  • Matthias Staufenbiel
  • Haibo Wang
  • Hong Jiang
  • Balaji Jothishankar
  • Hailan Yao
  • Qiang Dong
  • Qian Hua
  • Pengtao Li
  • Harald Hampel
  • David Prvulovic
  • Anders Wallin
  • Kaj Blennow

Detail Information

Publications12

  1. ncbi request reprint Brain sex matters: estrogen in cognition and Alzheimer's disease
    Rena Li
    Center for Hormone Advanced Science and Education CHASE, Roskamp Institute, Sarasota, FL 34243, United States Electronic address
    Mol Cell Endocrinol 389:13-21. 2014
    ..This comprehensive review provides new insights into brain estrogens by presenting a better understanding of the tissue-specific estrogen effects and their roles in healthy ageing and cognitive function. ..
  2. pmc Brain endogenous estrogen levels determine responses to estrogen replacement therapy via regulation of BACE1 and NEP in female Alzheimer's transgenic mice
    Rena Li
    Center for Hormone Advanced Science and Education, Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL 34243, USA
    Mol Neurobiol 47:857-67. 2013
    ..Our results suggest that early and long-term usage of E2 and/or genistein may prevent AD pathologies in a dependent manner on endogenous brain estrogen levels in aged females...
  3. pmc Early reproductive experiences in females make differences in cognitive function later in life
    Rena Li
    Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243, USA
    J Alzheimers Dis 34:589-94. 2013
    ..In this mini review, we will focus on the effect of early motherhood on cognitive function later in life, which would provide insight on how reproductive experiences influence women's health during aging...
  4. pmc An old method facing a new challenge: re-visiting housekeeping proteins as internal reference control for neuroscience research
    Rena Li
    Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243, USA
    Life Sci 92:747-51. 2013
    ....
  5. pmc Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
    Hong Jiang
    Center for Advanced Therapeutic Strategies for Brain Disorders, Roskamp Institute, Sarasota, FL 34243, USA
    Mol Neurodegener 6:69. 2011
    ..These results suggest that TACE activity and soluble TNF receptors may be potential diagnostic candidate biomarkers in AD and MCI...
  6. ncbi request reprint Amyloid precursor protein mutation disrupts reproductive experience-enhanced normal cognitive development in a mouse model of Alzheimer's disease
    Jie Cui
    Center for Hormone Advanced Science and Education, Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL, 34243, USA
    Mol Neurobiol 49:103-12. 2014
    ....
  7. pmc Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces amyloidogenic processing of amyloid precursor protein in a mouse model of Alzheimer's disease
    Ping He
    Center for Advanced Therapeutic Strategies of Brain Disorders, Roskamp Institute, Sarasota, Florida, USA
    PLoS ONE 8:e58181. 2013
    ..The results suggest an inhibitory effect of TLJN on amyloidogenic APP processing by down-regulating the cleavage enzymes BACE1 and γ-secretase...
  8. pmc Estrogen synthesis and signaling pathways during aging: from periphery to brain
    Jie Cui
    Center for Hormone Advanced Science and Education CHASE, Roskamp Institute, Sarasota, FL 34243, USA
    Trends Mol Med 19:197-209. 2013
    ..This comprehensive review provides new insights into estrogens by giving a better understanding of the tissue-specific estrogen effects and their roles in various diseases...
  9. ncbi request reprint Occludin deficiency with BACE1 elevation in cerebral amyloid angiopathy
    Xin Cheng
    From the Department of Neurology X C, Q D, Y S, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China Haldeman Laboratory of Molecular and Cellular Neurobiology X C, P H, Y S, Sun Health Research Institute, Sun City, AZ Center for Hormone Advanced Science and Education P H, R L and Center for Advanced Therapeutic Strategies for Brain Disorders P H, Y S, Roskamp Institute, Sarasota, FL and Department of Neurology Y S, University of Florida College of Medicine, Gainesville
    Neurology 82:1707-15. 2014
    ..A significant cause of spontaneous hemorrhages in the elderly is cerebral amyloid angiopathy (CAA), which causes degeneration of cerebral vessels, but the mechanisms are unclear...
  10. pmc Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease
    Ping He
    Center for Advanced Therapeutic Strategies of Brain Disorders, Roskamp Institute, Sarasota, FL, USA
    PLoS ONE 8:e55091. 2013
    ..These results suggest that chronic thalidomide administration is an alternative approach for AD prevention and therapeutics...
  11. pmc β-Secretase: its biology as a therapeutic target in diseases
    Haibo Wang
    Center for Advanced Therapeutic Strategies for Brain Disorders, Roskamp Institute, Sarasota, FL 34203, USA
    Trends Pharmacol Sci 34:215-25. 2013
    ..Lastly, we discuss proposed strategies to control BACE1 activity for possible therapeutic application...

Research Grants3

  1. The role of estrogen receptors in Alzheimer?s disease
    Rena Li; Fiscal Year: 2009
    ..In this proposal, we will test the hypothesis that brain ER? and ER are involved in distinct signal transduction pathways against amyloid pathology and cognitive functions in the AD brain. ..
  2. The role of estrogen receptors in Alzheimer?s disease
    Rena Li; Fiscal Year: 2010
    ..In this proposal, we will test the hypothesis that brain ER? and ER are involved in distinct signal transduction pathways against amyloid pathology and cognitive functions in the AD brain. ..