Rena Li

Summary

Affiliation: Roskamp Institute
Country: USA

Publications

  1. pmc Brain endogenous estrogen levels determine responses to estrogen replacement therapy via regulation of BACE1 and NEP in female Alzheimer's transgenic mice
    Rena Li
    Center for Hormone Advanced Science and Education, Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL 34243, USA
    Mol Neurobiol 47:857-67. 2013
  2. pmc Early reproductive experiences in females make differences in cognitive function later in life
    Rena Li
    Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243, USA
    J Alzheimers Dis 34:589-94. 2013
  3. pmc An old method facing a new challenge: re-visiting housekeeping proteins as internal reference control for neuroscience research
    Rena Li
    Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243, USA
    Life Sci 92:747-51. 2013
  4. pmc Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
    Hong Jiang
    Center for Advanced Therapeutic Strategies for Brain Disorders, Roskamp Institute, Sarasota, FL 34243, USA
    Mol Neurodegener 6:69. 2011
  5. pmc Chronic Administration of Anti-Stroke Herbal Medicine TongLuoJiuNao Reduces Amyloidogenic Processing of Amyloid Precursor Protein in a Mouse Model of Alzheimer's Disease
    Ping He
    Center for Advanced Therapeutic Strategies of Brain Disorders, Roskamp Institute, Sarasota, Florida, United States of America
    PLoS ONE 8:e58181. 2013
  6. pmc Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease
    Ping He
    Center for Advanced Therapeutic Strategies of Brain Disorders, Roskamp Institute, Sarasota, FL, USA
    PLoS ONE 8:e55091. 2013
  7. pmc Estrogen synthesis and signaling pathways during aging: from periphery to brain
    Jie Cui
    Center for Hormone Advanced Science and Education CHASE, Roskamp Institute, Sarasota, FL 34243, USA
    Trends Mol Med 19:197-209. 2013
  8. pmc β-Secretase: its biology as a therapeutic target in diseases
    Haibo Wang
    Center for Advanced Therapeutic Strategies for Brain Disorders, Roskamp Institute, Sarasota, FL 34203, USA
    Trends Pharmacol Sci 34:215-25. 2013

Research Grants

Collaborators

  • Yong Shen
  • Ping He
  • Matthias Staufenbiel
  • Jie Cui
  • Haibo Wang
  • Hong Jiang
  • Yuan Liu
  • Xin Cheng
  • Qian Hua
  • Pengtao Li
  • Anders Wallin
  • Kaj Blennow
  • Harald Hampel
  • David Prvulovic

Detail Information

Publications8

  1. pmc Brain endogenous estrogen levels determine responses to estrogen replacement therapy via regulation of BACE1 and NEP in female Alzheimer's transgenic mice
    Rena Li
    Center for Hormone Advanced Science and Education, Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL 34243, USA
    Mol Neurobiol 47:857-67. 2013
    ..Our results suggest that early and long-term usage of E2 and/or genistein may prevent AD pathologies in a dependent manner on endogenous brain estrogen levels in aged females...
  2. pmc Early reproductive experiences in females make differences in cognitive function later in life
    Rena Li
    Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243, USA
    J Alzheimers Dis 34:589-94. 2013
    ..In this mini review, we will focus on the effect of early motherhood on cognitive function later in life, which would provide insight on how reproductive experiences influence women's health during aging...
  3. pmc An old method facing a new challenge: re-visiting housekeeping proteins as internal reference control for neuroscience research
    Rena Li
    Center for Hormone Advanced Science and Education, Roskamp Institute, Sarasota, FL 34243, USA
    Life Sci 92:747-51. 2013
    ....
  4. pmc Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
    Hong Jiang
    Center for Advanced Therapeutic Strategies for Brain Disorders, Roskamp Institute, Sarasota, FL 34243, USA
    Mol Neurodegener 6:69. 2011
    ..These results suggest that TACE activity and soluble TNF receptors may be potential diagnostic candidate biomarkers in AD and MCI...
  5. pmc Chronic Administration of Anti-Stroke Herbal Medicine TongLuoJiuNao Reduces Amyloidogenic Processing of Amyloid Precursor Protein in a Mouse Model of Alzheimer's Disease
    Ping He
    Center for Advanced Therapeutic Strategies of Brain Disorders, Roskamp Institute, Sarasota, Florida, United States of America
    PLoS ONE 8:e58181. 2013
    ..The results suggest an inhibitory effect of TLJN on amyloidogenic APP processing by down-regulating the cleavage enzymes BACE1 and γ-secretase...
  6. pmc Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease
    Ping He
    Center for Advanced Therapeutic Strategies of Brain Disorders, Roskamp Institute, Sarasota, FL, USA
    PLoS ONE 8:e55091. 2013
    ..These results suggest that chronic thalidomide administration is an alternative approach for AD prevention and therapeutics...
  7. pmc Estrogen synthesis and signaling pathways during aging: from periphery to brain
    Jie Cui
    Center for Hormone Advanced Science and Education CHASE, Roskamp Institute, Sarasota, FL 34243, USA
    Trends Mol Med 19:197-209. 2013
    ..This comprehensive review provides new insights into estrogens by giving a better understanding of the tissue-specific estrogen effects and their roles in various diseases...
  8. pmc β-Secretase: its biology as a therapeutic target in diseases
    Haibo Wang
    Center for Advanced Therapeutic Strategies for Brain Disorders, Roskamp Institute, Sarasota, FL 34203, USA
    Trends Pharmacol Sci 34:215-25. 2013
    ..Lastly, we discuss proposed strategies to control BACE1 activity for possible therapeutic application...

Research Grants3

  1. The role of estrogen receptors in Alzheimer?s disease
    Rena Li; Fiscal Year: 2010
    ..In this proposal, we will test the hypothesis that brain ER? and ER are involved in distinct signal transduction pathways against amyloid pathology and cognitive functions in the AD brain. ..