Corbin Bachmeier

Summary

Affiliation: Roskamp Institute
Country: USA

Publications

  1. pmc Characterization and use of human brain microvascular endothelial cells to examine β-amyloid exchange in the blood-brain barrier
    Corbin Bachmeier
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL, 34243, USA
    Cytotechnology 62:519-29. 2010
  2. ncbi Role of the cannabinoid system in the transit of beta-amyloid across the blood-brain barrier
    Corbin Bachmeier
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA Electronic address
    Mol Cell Neurosci 56:255-62. 2013
  3. doi Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood-brain barrier
    Corbin Bachmeier
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL, 34243, USA
    J Mol Neurosci 49:270-6. 2013
  4. ncbi A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier
    Corbin Bachmeier
    The Roskamp Institute, Sarasota, FL 34243, USA
    Neurodegener Dis 11:13-21. 2013
  5. doi Epitope-dependent effects of Beta-amyloid antibodies on Beta-amyloid clearance in an in vitro model of the blood-brain barrier
    Corbin J Bachmeier
    The Roskamp Institute, Sarasota, Florida, USA
    Microcirculation 18:373-9. 2011
  6. doi Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier
    Corbin Bachmeier
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Eur J Pharmacol 659:124-9. 2011
  7. pmc Amelioration of experimental autoimmune encephalomyelitis by anatabine
    Daniel Paris
    Roskamp Institute, Sarasota, Florida, United States of America
    PLoS ONE 8:e55392. 2013
  8. pmc Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier
    Daniel Paris
    The Roskamp Institute, Sarasota, Florida 34243, United States of America
    Mol Med 17:149-62. 2011
  9. ncbi Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model
    Benoit C Mouzon
    Roskamp Institute, Sarasota, FL James A Haley Veterans Administration Medical Center, Tampa, FL Department of Life Sciences, Open University, Milton Keynes, United Kingdom
    Ann Neurol 75:241-54. 2014
  10. doi Alzheimer's beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2
    Nikunj S Patel
    Roskamp Institute, Sarasota, Florida, USA
    J Neurochem 112:66-76. 2010

Collaborators

Detail Information

Publications18

  1. pmc Characterization and use of human brain microvascular endothelial cells to examine β-amyloid exchange in the blood-brain barrier
    Corbin Bachmeier
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL, 34243, USA
    Cytotechnology 62:519-29. 2010
    ..These studies establish the HBMEC as a representative in vitro model of the BBB and offer a rapid fluorometric method of assessing Aβ exchange between the periphery and the brain...
  2. ncbi Role of the cannabinoid system in the transit of beta-amyloid across the blood-brain barrier
    Corbin Bachmeier
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA Electronic address
    Mol Cell Neurosci 56:255-62. 2013
    ..These findings provide insight into the mechanism by which cannabinoid treatment reduces Aβ burden in the AD brain and offer additional evidence on the utility of this pathway as a treatment for AD. ..
  3. doi Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood-brain barrier
    Corbin Bachmeier
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL, 34243, USA
    J Mol Neurosci 49:270-6. 2013
    ..Thus, RXR activation could mitigate Aβ brain burden by promoting both the metabolic and BBB clearance of Aβ, offering a novel approach to the treatment of AD...
  4. ncbi A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier
    Corbin Bachmeier
    The Roskamp Institute, Sarasota, FL 34243, USA
    Neurodegener Dis 11:13-21. 2013
    ..While apolipoprotein E4 (apoE4) is highly correlated with the development of Alzheimer's disease (AD), its role in AD pathology and, in particular, beta-amyloid (Aβ) removal from the brain, is not clearly defined...
  5. doi Epitope-dependent effects of Beta-amyloid antibodies on Beta-amyloid clearance in an in vitro model of the blood-brain barrier
    Corbin J Bachmeier
    The Roskamp Institute, Sarasota, Florida, USA
    Microcirculation 18:373-9. 2011
    ..To investigate the role of RAGE in the epitope-dependent effects of Aβ antibodies used as a peripheral sink therapy in AD...
  6. doi Selective dihydropyiridine compounds facilitate the clearance of β-amyloid across the blood-brain barrier
    Corbin Bachmeier
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Eur J Pharmacol 659:124-9. 2011
    ..This dual mechanism of action may be particularly effective in attenuating Aβ brain burden in Alzheimer's disease and could open the door to a new class of therapies for the treatment of this disease...
  7. pmc Amelioration of experimental autoimmune encephalomyelitis by anatabine
    Daniel Paris
    Roskamp Institute, Sarasota, Florida, United States of America
    PLoS ONE 8:e55392. 2013
    ..Altogether our data suggest that anatabine may be effective in the treatment of MS and should be piloted in clinical trials...
  8. pmc Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier
    Daniel Paris
    The Roskamp Institute, Sarasota, Florida 34243, United States of America
    Mol Med 17:149-62. 2011
    ....
  9. ncbi Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model
    Benoit C Mouzon
    Roskamp Institute, Sarasota, FL James A Haley Veterans Administration Medical Center, Tampa, FL Department of Life Sciences, Open University, Milton Keynes, United Kingdom
    Ann Neurol 75:241-54. 2014
    ..Traumatic brain injury (TBI) is a recognized risk factor for later development of neurodegenerative disease. However, the mechanisms contributing to neurodegeneration following TBI remain obscure...
  10. doi Alzheimer's beta-amyloid peptide blocks vascular endothelial growth factor mediated signaling via direct interaction with VEGFR-2
    Nikunj S Patel
    Roskamp Institute, Sarasota, Florida, USA
    J Neurochem 112:66-76. 2010
    ..Altogether, our data suggest that Abeta acts as an antagonist of VEGFR-2 and provide a mechanism explaining the anti-angiogenic activity of Abeta peptides...
  11. doi Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, Florida 34243, USA
    Eur J Pharmacol 698:145-53. 2013
    ..Overall our data show that the anti-inflammatory activity of anatabine in vitro and in vivo is mediated in part via an inhibition of STAT3 phosphorylation...
  12. doi Anatabine lowers Alzheimer's Aβ production in vitro and in vivo
    Daniel Paris
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Eur J Pharmacol 670:384-91. 2011
    ..Altogether our data suggest that anatabine may represent an interesting compound for regulating brain Aβ accumulation...
  13. doi Repetitive mild traumatic brain injury augments tau pathology and glial activation in aged hTau mice
    Joseph Olubunmi Ojo
    Roskamp Institute, Sarasota, Florida 34243, USA
    J Neuropathol Exp Neurol 72:137-51. 2013
    ....
  14. pmc Flavonoids lower Alzheimer's Aβ production via an NFκB dependent mechanism
    Daniel Paris
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, Florida 34243, USA
    Bioinformation 6:229-36. 2011
    ..Altogether, our data suggest that flavonoids inhibit Aβ and sAPPβ production by regulating BACE-1 expression and not by directly inhibiting BACE-1 activity...
  15. pmc Impaired orthotopic glioma growth and vascularization in transgenic mouse models of Alzheimer's disease
    Daniel Paris
    The Roskamp Institute, Sarasota, Florida 34243, USA
    J Neurosci 30:11251-8. 2010
    ....
  16. doi Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes
    Benoit Mouzon
    Roskamp Institute, Sarasota, Florida, USA
    J Neurotrauma 29:2761-73. 2012
    ..As such, this model may serve as a suitable platform with which to explore repetitive mTBI relevant to human brain injury...
  17. pmc A 3D-QSAR model based screen for dihydropyridine-like compound library to identify inhibitors of amyloid beta (Aβ) production
    Venkatarajan S Mathura
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Bioinformation 5:122-7. 2010
    ..We describe here our in silico model building strategy, model selection parameters and the chemical features that are useful for successful screening of DHP and DHP-like chemical libraries for Aβ inhibitors...
  18. pmc Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    J Neuroinflammation 7:17. 2010
    ..We therefore explored whether the known NFkappaB inhibitor celastrol could represent a suitable compound for decreasing Abeta production and accumulation in vivo...