Ghania Ait-Ghezala

Summary

Affiliation: Roskamp Institute
Country: USA

Publications

  1. doi request reprint Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's disease
    Ghania Ait-Ghezala
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Cytokine 44:283-7. 2008
  2. ncbi request reprint Genomic regulation after CD40 stimulation in microglia: relevance to Alzheimer's disease
    Ghania Ait-Ghezala
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Brain Res Mol Brain Res 140:73-85. 2005
  3. ncbi request reprint CD40 promotion of amyloid beta production occurs via the NF-kappaB pathway
    Ghania Ait-Ghezala
    The Roskamp Institute, Sarasota, FL 34243, USA
    Eur J Neurosci 25:1685-95. 2007
  4. ncbi request reprint Inhibition of Abeta production by NF-kappaB inhibitors
    Daniel Paris
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Neurosci Lett 415:11-6. 2007
  5. pmc Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    J Neuroinflammation 7:17. 2010
  6. doi request reprint Anatabine lowers Alzheimer's Aβ production in vitro and in vivo
    Daniel Paris
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Eur J Pharmacol 670:384-91. 2011
  7. pmc Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier
    Daniel Paris
    The Roskamp Institute, Sarasota, Florida 34243, United States of America
    Mol Med 17:149-62. 2011
  8. doi request reprint Serum beta-amyloid correlates with neuropsychological impairment
    Cheryl A Luis
    Roskamp Institute, Sarasota, FL, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 16:203-18. 2009
  9. ncbi request reprint Anti-angiogenic activity of the mutant Dutch A(beta) peptide on human brain microvascular endothelial cells
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Brain Res Mol Brain Res 136:212-30. 2005
  10. pmc Amelioration of experimental autoimmune encephalomyelitis by anatabine
    Daniel Paris
    Roskamp Institute, Sarasota, Florida, United States of America
    PLoS ONE 8:e55392. 2013

Collaborators

Detail Information

Publications29

  1. doi request reprint Diagnostic utility of APOE, soluble CD40, CD40L, and Abeta1-40 levels in plasma in Alzheimer's disease
    Ghania Ait-Ghezala
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Cytokine 44:283-7. 2008
    ..Thus, we present preliminary evidence for potential usefulness for combination of plasma sCD40, sCD40L along with Abeta(1-40) and APOE epsilon4 in improving the clinical diagnosis of AD...
  2. ncbi request reprint Genomic regulation after CD40 stimulation in microglia: relevance to Alzheimer's disease
    Ghania Ait-Ghezala
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Brain Res Mol Brain Res 140:73-85. 2005
    ..Taken together, our data also suggest that CD40 ligation in human microglia specifically perturbs many genes associated with APP processing...
  3. ncbi request reprint CD40 promotion of amyloid beta production occurs via the NF-kappaB pathway
    Ghania Ait-Ghezala
    The Roskamp Institute, Sarasota, FL 34243, USA
    Eur J Neurosci 25:1685-95. 2007
    ..Taken together, our results further suggest that CD40L stimulation may be a key component in AD pathology and that elements of the NF-kappaB pathway may be suitable targets for therapeutic approaches against AD...
  4. ncbi request reprint Inhibition of Abeta production by NF-kappaB inhibitors
    Daniel Paris
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Neurosci Lett 415:11-6. 2007
    ..Altogether our data suggest that NF-kappaB inhibitors may be of therapeutic importance for the treatment of AD pathology not only by blocking inflammatory processes but also by directly inhibiting the production of Abeta peptides...
  5. pmc Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    J Neuroinflammation 7:17. 2010
    ..We therefore explored whether the known NFkappaB inhibitor celastrol could represent a suitable compound for decreasing Abeta production and accumulation in vivo...
  6. doi request reprint Anatabine lowers Alzheimer's Aβ production in vitro and in vivo
    Daniel Paris
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Eur J Pharmacol 670:384-91. 2011
    ..Altogether our data suggest that anatabine may represent an interesting compound for regulating brain Aβ accumulation...
  7. pmc Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier
    Daniel Paris
    The Roskamp Institute, Sarasota, Florida 34243, United States of America
    Mol Med 17:149-62. 2011
    ....
  8. doi request reprint Serum beta-amyloid correlates with neuropsychological impairment
    Cheryl A Luis
    Roskamp Institute, Sarasota, FL, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 16:203-18. 2009
    ....
  9. ncbi request reprint Anti-angiogenic activity of the mutant Dutch A(beta) peptide on human brain microvascular endothelial cells
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Brain Res Mol Brain Res 136:212-30. 2005
    ..Altogether, these data provide new molecular clues regarding the pathological activity of Dutch A(beta) peptide in the cerebrovasculature...
  10. pmc Amelioration of experimental autoimmune encephalomyelitis by anatabine
    Daniel Paris
    Roskamp Institute, Sarasota, Florida, United States of America
    PLoS ONE 8:e55392. 2013
    ..Altogether our data suggest that anatabine may be effective in the treatment of MS and should be piloted in clinical trials...
  11. doi request reprint Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, Florida 34243, USA
    Eur J Pharmacol 698:145-53. 2013
    ..Overall our data show that the anti-inflammatory activity of anatabine in vitro and in vivo is mediated in part via an inhibition of STAT3 phosphorylation...
  12. doi request reprint CD40 ligation mediates plaque-associated tau phosphorylation in beta-amyloid overproducing mice
    Vincent Laporte
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Brain Res 1231:132-42. 2008
    ..Together, our data suggest that CD40-CD40L interaction has an effect on tau phosphorylation independent of beta-amyloid pathology, and that this effect may occur through a decrease of cdk5 and p35/p25...
  13. ncbi request reprint The influence of diagnosis, intra- and inter-person variability on serum and plasma Abeta levels
    Laila Abdullah
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, United States
    Neurosci Lett 428:53-8. 2007
    ....
  14. doi request reprint Lipidomic profiling of phosphocholine containing brain lipids in mice with sensorimotor deficits and anxiety-like features after exposure to Gulf War agents
    Laila Abdullah
    Roskamp Institute, Sarasota, FL 34243, USA
    Neuromolecular Med 14:349-61. 2012
    ....
  15. pmc High serum Abeta and vascular risk factors in first-degree relatives of Alzheimer's disease patients
    Laila Abdullah
    Roskamp Institute, Sarasota, Florida 34243, USA
    Mol Med 15:95-100. 2009
    ..Longitudinal evaluation of blood Abeta in this cohort will provide a better understanding of the significance of this association in AD etiology...
  16. pmc Serum Abeta levels as predictors of conversion to mild cognitive impairment/Alzheimer disease in an ADAPT subcohort
    Laila Abdullah
    Roskamp Institute, Sarasota, Florida 34243, USA
    Mol Med 15:432-7. 2009
    ..In this subcohort of individuals at risk for AD, the association of Abeta with vascular risk factors and medications to treat these conditions did not interfere with Abeta's predictive value for MCI/AD...
  17. doi request reprint CD40/CD40L interaction induces Abeta production and increases gamma-secretase activity independently of tumor necrosis factor receptor associated factor (TRAF) signaling
    Claude Henry Volmar
    Roskamp Institute, Division of Genomics and Molecular Biology, Sarasota, FL 34243, USA
    Exp Cell Res 315:2265-74. 2009
    ..Taken together, our data suggest that CD40/CD40L interaction modulates APP processing independently of TRAF signaling...
  18. doi request reprint The granulocyte macrophage colony stimulating factor (GM-CSF) regulates amyloid beta (Abeta) production
    Claude Henry Volmar
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Cytokine 42:336-44. 2008
    ..GM-CSF signaling may be a suitable therapeutic target against Abeta production in AD...
  19. ncbi request reprint Model of Alzheimer's disease amyloid-beta peptide based on a RNA binding protein
    Venkatarajan S Mathura
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Biochem Biophys Res Commun 332:585-92. 2005
    ..We hypothesize that in a similar fashion to AF-Sm1, RNA interacts with Abeta in the beta-hairpin (beta-turn-beta) structure and prevents fibril formation...
  20. doi request reprint Proteomic CNS profile of delayed cognitive impairment in mice exposed to Gulf War agents
    Laila Abdullah
    Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243, USA
    Neuromolecular Med 13:275-88. 2011
    ..Evaluation of the potential role of these biological functions in GWI will be useful in identifying molecular pathways that can be targeted for the development of novel therapeutics against GWI...
  21. pmc Feasibility of Predicting MCI/AD Using Neuropsychological Tests and Serum β-Amyloid
    Cheryl A Luis
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    Int J Alzheimers Dis 2011:786264. 2011
    ....
  22. pmc Flavonoids lower Alzheimer's Aβ production via an NFκB dependent mechanism
    Daniel Paris
    Roskamp Institute, 2040 Whitfield Avenue, Sarasota, Florida 34243, USA
    Bioinformation 6:229-36. 2011
    ..Altogether, our data suggest that flavonoids inhibit Aβ and sAPPβ production by regulating BACE-1 expression and not by directly inhibiting BACE-1 activity...
  23. ncbi request reprint The cyclooxygenase 2 -765 C promoter allele is a protective factor for Alzheimer's disease
    Laila Abdullah
    Roskamp Institute, 2040 Whitfield Ave Sarasota, FL, USA
    Neurosci Lett 395:240-3. 2006
    ..464, CI = [.351-.885], p = .013). In this sample, the C allele of COX-2 -765 promoter polymorphism is associated with decreased risk of Alzheimer's disease, a finding which further supports the involvement of COX-2 in AD etiology...
  24. ncbi request reprint Inhibition of angiogenesis by Abeta peptides
    Daniel Paris
    The Roskamp Institute, Sarasota, Florida 34243, USA
    Angiogenesis 7:75-85. 2004
    ..Similarly to the intra-tumoral injection regimen, Abeta delivered intraperitoneally also suppressed the growth of human lung adenocarcinoma tumor xenografts. Altogether our data show that Abeta is an angiogenesis inhibitor...
  25. ncbi request reprint CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease
    Jun Tan
    Department of Psychiatry, Roskamp Institute, University of South Florida, 3515 E Fletcher Ave, Tampa, FL 33613, USA
    J Neuroimmunol 132:164-72. 2002
    ....
  26. ncbi request reprint Genomic analysis of response to traumatic brain injury in a mouse model of Alzheimer's disease (APPsw)
    Fiona C Crawford
    Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL 34243, USA
    Brain Res 1185:45-58. 2007
    ....
  27. ncbi request reprint Cocaine-induced oxidative stress precedes cell death in human neuronal progenitor cells
    H Fai Poon
    Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL 34243, United States
    Neurochem Int 50:69-73. 2007
    ..This may have implications for the consequences of cocaine abuse in situations where antioxidant capacity is compromised, as in the aging brain...
  28. ncbi request reprint Translocation breakpoint in two unrelated Tourette syndrome cases, within a region previously linked to the disorder
    Fiona C Crawford
    Department of Psychiatry, University of South Florida, 3515 E Fletcher Avenue, Tampa, FL 33613, USA
    Hum Genet 113:154-61. 2003
    ....
  29. ncbi request reprint Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production
    Ryan T Mott
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA
    Glia 46:369-79. 2004
    ..Furthermore, we show that neurons secrete CD22, which functions as an inhibitor of microglial proinflammatory cytokine production...