Grace Stutzmann

Summary

Affiliation: Rosalind Franklin University of Medicine and Science
Country: USA

Publications

  1. ncbi request reprint The pathogenesis of Alzheimers disease is it a lifelong "calciumopathy"?
    Grace E Stutzmann
    Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, IL 60064, USA
    Neuroscientist 13:546-59. 2007
  2. pmc Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease
    Grace E Stutzmann
    Department of Neuroscience, Rosalind Franklin University The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Pharmacol Rev 63:700-27. 2011
  3. doi request reprint Seeing the brain in action: how multiphoton imaging has advanced our understanding of neuronal function
    Grace Stutzmann
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Microsc Microanal 14:482-91. 2008
  4. ncbi request reprint Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models
    Grace E Stutzmann
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Ann N Y Acad Sci 1097:265-77. 2007
  5. ncbi request reprint Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice
    Grace E Stutzmann
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697 4550, USA
    J Neurosci 26:5180-9. 2006
  6. doi request reprint Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice
    Shreaya Chakroborty
    Department of Neuroscience, Rosalind Franklin University, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 29:9458-70. 2009
  7. ncbi request reprint Calcium dysregulation, IP3 signaling, and Alzheimer's disease
    Grace E Stutzmann
    Department of Neurobiology and Behavior, 1146 McGaugh Hall, University of California Irvine, Irvine, CA 92697, USA
    Neuroscientist 11:110-5. 2005
  8. ncbi request reprint Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability
    Grace E Stutzmann
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697 4550, USA
    J Neurosci 24:508-13. 2004
  9. pmc NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice
    Ivan Goussakov
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 30:12128-37. 2010
  10. pmc Calcium signaling and amyloid toxicity in Alzheimer disease
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA
    J Biol Chem 285:12463-8. 2010

Research Grants

Collaborators

Detail Information

Publications11

  1. ncbi request reprint The pathogenesis of Alzheimers disease is it a lifelong "calciumopathy"?
    Grace E Stutzmann
    Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, IL 60064, USA
    Neuroscientist 13:546-59. 2007
    ..Therefore, "Calcinists" do not necessarily reject betaAptist or Tauist doctrine, but rather believe that their genesis is associated with earlier calcium signaling dysregulations...
  2. pmc Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease
    Grace E Stutzmann
    Department of Neuroscience, Rosalind Franklin University The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Pharmacol Rev 63:700-27. 2011
    ..Preclinical investigations suggest a therapeutic potential for use of agents that target ER Ca(2+) handling systems of excitable cells in disorders ranging from cardiac arrhythmias and skeletal muscle myopathies to Alzheimer disease...
  3. doi request reprint Seeing the brain in action: how multiphoton imaging has advanced our understanding of neuronal function
    Grace Stutzmann
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Microsc Microanal 14:482-91. 2008
    ..In order to better appreciate recent contributions of multiphoton microscopy to our current and future understanding of biological systems, an historical awareness of past microscopy applications is useful...
  4. ncbi request reprint Enhanced ryanodine-mediated calcium release in mutant PS1-expressing Alzheimer's mouse models
    Grace E Stutzmann
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Ann N Y Acad Sci 1097:265-77. 2007
    ..Our results highlight the critical roles of RyR-mediated Ca(2+) signaling in both neuronal physiology and pathophysiology, and point to presenilin-linked disruptions in RyR signaling as an important genetic factor in AD...
  5. ncbi request reprint Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice
    Grace E Stutzmann
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697 4550, USA
    J Neurosci 26:5180-9. 2006
    ..We conclude that lifelong ER Ca2+ disruptions in AD are related to a modulation of RyR signaling associated with PS1 mutations and represent a discrete "calciumopathy," not merely an acceleration of normal aging...
  6. doi request reprint Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice
    Shreaya Chakroborty
    Department of Neuroscience, Rosalind Franklin University, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 29:9458-70. 2009
    ..These early signaling alterations may underlie the later synaptic breakdown and cognitive deficits characteristic of later stage AD...
  7. ncbi request reprint Calcium dysregulation, IP3 signaling, and Alzheimer's disease
    Grace E Stutzmann
    Department of Neurobiology and Behavior, 1146 McGaugh Hall, University of California Irvine, Irvine, CA 92697, USA
    Neuroscientist 11:110-5. 2005
    ..The author discusses recent findings in both the physiological functioning of the IP(3)-signaling pathway in neurons and the involvement of ERCa(2+) disruptions in the pathogenesis of AD...
  8. ncbi request reprint Dysregulated IP3 signaling in cortical neurons of knock-in mice expressing an Alzheimer's-linked mutation in presenilin1 results in exaggerated Ca2+ signals and altered membrane excitability
    Grace E Stutzmann
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697 4550, USA
    J Neurosci 24:508-13. 2004
    ..Even in young animals, PS1 mutations have profound effects on neuronal Ca2+ and electrical signaling: cumulatively, these disruptions may contribute to the long-term pathophysiology of AD...
  9. pmc NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice
    Ivan Goussakov
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 30:12128-37. 2010
    ..We propose that presenilin-linked disruptions in RyR signaling and subsequent CICR via NMDAR-mediated calcium influx alters synaptic function and serves as an early pathogenic factor in AD...
  10. pmc Calcium signaling and amyloid toxicity in Alzheimer disease
    Angelo Demuro
    Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA
    J Biol Chem 285:12463-8. 2010
    ..Although no cause or cure is currently known, targeting Ca(2+) dyshomeostasis as an underlying and integral component of AD pathology may result in novel and effective treatments for AD...
  11. ncbi request reprint Ca2+ signaling in mouse cortical neurons studied by two-photon imaging and photoreleased inositol triphosphate
    Grace E Stutzmann
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697 4550, USA
    J Neurosci 23:758-65. 2003
    ..Metabotropic signaling via the phosphoinositide pathway thus serves as a powerful and sustained modulator of excitability in cortical neurons and displays complex reciprocal interactions between electrical and chemical signals...

Research Grants3

  1. Neuronal Calcium Dysregulation in Aging and Alzheimer's disease
    Grace Stutzmann; Fiscal Year: 2009
    ..Benefits to public health include the prospect for earlier AD diagnosis and novel therapeutic intervention, long before the onset of cognitive decline and irreversible histopathology. ..
  2. Neuronal Calcium Dysregulation in Aging and Alzheimer's disease
    Grace E Stutzmann; Fiscal Year: 2010
    ..Benefits to public health include the prospect for earlier AD diagnosis and novel therapeutic intervention, long before the onset of cognitive decline and irreversible histopathology. ..