David J Rademacher

Summary

Affiliation: Rosalind Franklin University of Medicine and Science
Country: USA

Publications

  1. pmc Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward
    David J Rademacher
    Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Road, Milwaukee, WI 53226 USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:633-41. 2007
  2. doi The effects of infusions of CART 55-102 into the basolateral amygdala on amphetamine-induced conditioned place preference in rats
    David J Rademacher
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Psychopharmacology (Berl) 208:499-509. 2010
  3. pmc Context modulates the expression of conditioned motor sensitization, cellular activation and synaptophysin immunoreactivity
    David J Rademacher
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Eur J Neurosci 26:2661-8. 2007
  4. ncbi Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Eur J Neurosci 21:1057-69. 2005
  5. ncbi Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice
    David J Rademacher
    Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuropharmacology 54:108-16. 2008
  6. ncbi Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition
    Jeanne L Seagard
    Zablocki Dept of Veterans Affairs Medical Center, Research Service 151, 5000 W National Ave, Milwaukee, WI 53295, USA
    Am J Physiol Heart Circ Physiol 286:H992-1000. 2004
  7. ncbi The neural substrates of amphetamine conditioned place preference: implications for the formation of conditioned stimulus-reward associations
    David J Rademacher
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Eur J Neurosci 24:2089-97. 2006
  8. ncbi The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Lipid Res 46:342-9. 2005
  9. pmc Amphetamine-associated contextual learning is accompanied by structural and functional plasticity in the basolateral amygdala
    David J Rademacher
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 30:4676-86. 2010
  10. ncbi U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance
    David J Rademacher
    Medical College of Wisconsin, Dept of Pharmacology and Toxicology, 8701 Watertown Plank Rd, Milwaukee, WI 53226 0509, USA
    Am J Physiol Heart Circ Physiol 288:H2694-701. 2005

Detail Information

Publications25

  1. pmc Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward
    David J Rademacher
    Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Road, Milwaukee, WI 53226 USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:633-41. 2007
    ..The findings of the present study indicate that the CB(1)/endocannabinoid signaling system is an important allostatic mediator that both modulates the responses of mice to stress and is itself modulated by stress...
  2. doi The effects of infusions of CART 55-102 into the basolateral amygdala on amphetamine-induced conditioned place preference in rats
    David J Rademacher
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Psychopharmacology (Berl) 208:499-509. 2010
    ..The formation of context-drug associations produces either conditioned place preference (CPP) or conditioned place aversion (CPA)...
  3. pmc Context modulates the expression of conditioned motor sensitization, cellular activation and synaptophysin immunoreactivity
    David J Rademacher
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Eur J Neurosci 26:2661-8. 2007
    ..These data indicate that the basolateral amygdala-nucleus accumbens core pathway is necessary for the context-elicited conditioned motor responses, while the hippocampus encodes the spatial context...
  4. ncbi Inhibition of restraint stress-induced neural and behavioural activation by endogenous cannabinoid signalling
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Eur J Neurosci 21:1057-69. 2005
    ....
  5. ncbi Effects of acute and repeated restraint stress on endocannabinoid content in the amygdala, ventral striatum, and medial prefrontal cortex in mice
    David J Rademacher
    Medical College of Wisconsin, Department of Pharmacology and Toxicology, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuropharmacology 54:108-16. 2008
    ..These studies are consistent with the hypothesis that stress exposure alters endocannabinoid signaling in the brain and that alterations in endocannabinoid signaling occur during habituation to stress...
  6. ncbi Anandamide content and interaction of endocannabinoid/GABA modulatory effects in the NTS on baroreflex-evoked sympathoinhibition
    Jeanne L Seagard
    Zablocki Dept of Veterans Affairs Medical Center, Research Service 151, 5000 W National Ave, Milwaukee, WI 53295, USA
    Am J Physiol Heart Circ Physiol 286:H992-1000. 2004
    ....
  7. ncbi The neural substrates of amphetamine conditioned place preference: implications for the formation of conditioned stimulus-reward associations
    David J Rademacher
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Eur J Neurosci 24:2089-97. 2006
    ..These data therefore suggest that the formation of conditioned stimulus-reward associations requires, at least in part, activation of amygdalar-hippocampal circuits...
  8. ncbi The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA
    J Lipid Res 46:342-9. 2005
    ..These data demonstrate that FAAH activity differentially affects AEA and OEA/PEA contents postmortem and suggest that AEA formation specifically occurs via an ethanolamine-dependent route postmortem...
  9. pmc Amphetamine-associated contextual learning is accompanied by structural and functional plasticity in the basolateral amygdala
    David J Rademacher
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 30:4676-86. 2010
    ..Thus, context-drug associations are accompanied by structural and functional plasticity in the BLA, findings that have important implications for drug-seeking behavior...
  10. ncbi U-46619 but not serotonin increases endocannabinoid content in middle cerebral artery: evidence for functional relevance
    David J Rademacher
    Medical College of Wisconsin, Dept of Pharmacology and Toxicology, 8701 Watertown Plank Rd, Milwaukee, WI 53226 0509, USA
    Am J Physiol Heart Circ Physiol 288:H2694-701. 2005
    ..These results suggest that MCA production of eCBs is not regulated by constriction per se but likely via a signaling pathway that is specific for TXA(2) receptors and not 5-HT receptors...
  11. ncbi Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Endocrinology 145:5431-8. 2004
    ....
  12. ncbi Waterborne lead exposure affects brain endocannabinoid content in male but not female fathead minnows (Pimephales promelas)
    David J Rademacher
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neurotoxicology 26:9-15. 2005
    ..As eCBs serve as activity-dependent retrograde inhibitors of neurotransmitter release, the increase in brain eCB content would accentuate Pb2+-induced decreases in evoked neurotransmitter release in male but not female fathead minnows...
  13. pmc Retrieval of contextual memories increases activity-regulated cytoskeleton-associated protein in the amygdala and hippocampus
    David A Figge
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA
    Brain Struct Funct 218:1177-96. 2013
    ..Thus, the retrieval of contextual memories increases Arc in the amygdala and hippocampus, an effect that could be important for approach behavior to a drug-associated context. ..
  14. pmc The general anesthetic propofol increases brain N-arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Br J Pharmacol 139:1005-13. 2003
    ....
  15. ncbi Production of hydroxyeicosatetraenoic acids and prostaglandins by a novel rat microglial cell line
    David J Rademacher
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Neuroimmunol 149:130-41. 2004
    ..RTMGL1 synthesize 5-HETE from arachidonic acid (AA) likely via a 5-lipoxygenase (LO). Thus, RTMGL1 have morphological and histological characteristics of primary microglia and metabolize AA via both COX and LO pathways...
  16. ncbi Differential regulation of the endocannabinoids anandamide and 2-arachidonylglycerol within the limbic forebrain by dopamine receptor activity
    Sachin Patel
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Pharmacol Exp Ther 306:880-8. 2003
    ....
  17. pmc Increased synapses in the medial prefrontal cortex are associated with repeated amphetamine administration
    Maud M Morshedi
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    Synapse 63:126-35. 2009
    ..Therefore, behavioral sensitization as a result of repeated exposure to AMPH is accompanied by the increased formation of spine, but not dendritic, synapses onto pyramidal neurons in the mPFC...
  18. ncbi Microinjection of a cannabinoid receptor antagonist into the NTS increases baroreflex duration in dogs
    David J Rademacher
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226 0509, USA
    Am J Physiol Heart Circ Physiol 284:H1570-6. 2003
    ..Microinjection of WIN-55212-2 had no effect on the baroreflex. These data suggest that endocannabinoids can modulate the excitability of NTS neurons involved in the baroreceptor reflex, leading to modulation of baroreflex regulation...
  19. pmc Aberrant restoration of spines and their synapses in L-DOPA-induced dyskinesia: involvement of corticostriatal but not thalamostriatal synapses
    Yiyue Zhang
    Department of Pharmaceutical Sciences, College of Pharmacy, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    J Neurosci 33:11655-67. 2013
    ..Such alterations could substantially impair the ability of striatal neurons to gate cortically driven signals and contribute to the loss of bidirectional synaptic plasticity. ..
  20. ncbi Effects of the selective mu(1)-opioid receptor antagonist, naloxonazine, on cocaine-induced conditioned place preference and locomotor behavior in rats
    David J Rademacher
    Department of Psychology, University of Wisconsin Milwaukee, 224 Garland Hall, 2441 East Hartford Avenue, Milwaukee, WI 53211, USA
    Neurosci Lett 332:159-62. 2002
    ..These findings indicate that the rewarding effects of cocaine can be blocked solely by mu(1)-opioid receptor antagonism and are consistent with the view that the locomotor and rewarding effects of drugs can be dissociated...
  21. pmc MPTP mouse models of Parkinson's disease: an update
    Gloria E Meredith
    Department of Pharmaceutical Sciences, College of Pharmacy, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Parkinsons Dis 1:19-33. 2011
    ....
  22. ncbi Effects of dietary lead and/or dimercaptosuccinic acid exposure on regional serotonin and serotonin metabolite content in rainbow trout (Oncorhynchus mykiss)
    David J Rademacher
    Department of Psychology, University of Wisconsin Milwaukee, 224 Garland Hall, 2441 East Hartford Avenue, Milwaukee, WI 53211, USA
    Neurosci Lett 339:156-60. 2003
    ..DMSA increased 5-HIAA content in all three brain regions and increased 5-HT content only the optic tectum. Treatment with DMSA may be more effective than removal of Pb from the diet in reversing Pb-induced alterations in 5-HT...
  23. ncbi Effects of cocaine and putative atypical antipsychotics on rat social behavior: an ethopharmacological study
    David J Rademacher
    Department of Psychology, University of Wisconsin Milwaukee, 224 Garland Hall, 2441 East Hartford Avenue, Milwaukee, WI 53211, USA
    Pharmacol Biochem Behav 73:769-78. 2002
    ..Amperozide, clozapine and olanzapine have anticonflict and anxiolytic effects, as well as potent and specific antiaggressive effects...
  24. ncbi Acute effects of amperozide and paroxetine on social cohesion in male conspecifics
    David J Rademacher
    Department of Psychology, University of Wisconsin Milwaukee, Milwaukee, WI, USA
    Brain Res Bull 58:187-91. 2002
    ..Amperozide may prove to be a more effective treatment for social anxiety disorder than paroxetine, which is supported by our results...
  25. ncbi Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress
    Matthew N Hill
    Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Neuropsychopharmacology 30:508-15. 2005
    ....