Research Topics
| David MuellerSummaryAffiliation: Rosalind Franklin University of Medicine and Science Country: USA Publications
Research Grants
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Detail Information
Publications
Crystallization and preliminary crystallographic studies of the mitochondrial F1-ATPase from the yeast Saccharomyces cerevisiaeDavid M Mueller
Rosalind Franklin University of Medicine and Science, The Chicago Medical School, Department of Biochemistry and Molecular Biology, USA
Acta Crystallogr D Biol Crystallogr 60:1441-4. 2004..6, b = 294.2, c = 190.4 A, beta = 101.6 degrees. The asymmetric unit contains three molecules of yeast F1, with a corresponding volume per protein weight (VM) of 2.8 A3 Da(-1) and a solvent content of 55%...- Ni-chelate-affinity purification and crystallization of the yeast mitochondrial F1-ATPaseDavid M Mueller
Department of Biochemistry and Molecular Biology, The Chicago Medical School, USA
Protein Expr Purif 37:479-85. 2004..The final enzyme is a homogeneous preparation with full activity and no apparent degradation products. This enzyme preparation has been used to obtain crystals that diffract to better than 2.8 A resolution... - Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthaseYamin Wang
Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
J Biol Chem 282:8228-36. 2007..These results indicate that residues within the mgi complementation group are necessary for efficient coupling of ATP synthase, possibly acting as a support to fix the axis of rotation of the central stalk... - Expression of bovine F1-ATPase with functional complementation in yeast Saccharomyces cerevisiaeNeeti Puri
Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Greenbay Road, North Chicago, IL 60064, USA
J Biol Chem 280:22418-24. 2005.... 
Novel features of the rotary catalytic mechanism revealed in the structure of yeast F1 ATPaseVenkataraman Kabaleeswaran
Department of Biochemistry and Molecular Biology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
EMBO J 25:5433-42. 2006....- Introduction of the chloroplast redox regulatory region in the yeast ATP synthase impairs cytochrome c oxidaseHong Shen
Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
J Biol Chem 283:32937-43. 2008..These results indicate that the chimeric ATP synthase containing cysteine, but not serine, decreases the expression or assembly of cytochrome c oxidase with little effect on the activity of the ATP synthase... - Asymmetric structure of the yeast F1 ATPase in the absence of bound nucleotidesVenkataraman Kabaleeswaran
Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
J Biol Chem 284:10546-51. 2009..The adenine-binding pocket of the beta(TP) subunit is disrupted in the apoenzyme, suggesting that the beta(DP) subunit is responsible for unisite catalytic activity...
Research Grants
- Structure and Function of the Yeast ATPaseDavid Mueller; Fiscal Year: 2009..Future studies will target these regions for the development of antibiotics, which either perturb the coupling efficiency or block rotation of the gamma-subunit of the ATP synthase from pathogenic bacteria. ..
- Structure and regulation of the ATP synthaseDavid Mueller; Fiscal Year: 2006..abstract_text> ..
- Structure Function of the ATP SynthaseDavid Mueller; Fiscal Year: 2005..abstract_text> ..
- Structure and Function of the Yeast ATPaseDAVID MICHAEL MUELLER; Fiscal Year: 2010..Future studies will target these regions for the development of antibiotics, which either perturb the coupling efficiency or block rotation of the gamma-subunit of the ATP synthase from pathogenic bacteria. ..