David Mueller

Summary

Affiliation: Rosalind Franklin University of Medicine and Science
Country: USA

Publications

  1. pmc Structure of the c(10) ring of the yeast mitochondrial ATP synthase in the open conformation
    Jindrich Symersky
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, Chicago, Illinois, USA
    Nat Struct Mol Biol 19:485-91, S1. 2012
  2. ncbi request reprint Crystallization and preliminary crystallographic studies of the mitochondrial F1-ATPase from the yeast Saccharomyces cerevisiae
    David M Mueller
    Rosalind Franklin University of Medicine and Science, The Chicago Medical School, Department of Biochemistry and Molecular Biology, USA
    Acta Crystallogr D Biol Crystallogr 60:1441-4. 2004
  3. ncbi request reprint Ni-chelate-affinity purification and crystallization of the yeast mitochondrial F1-ATPase
    David M Mueller
    Department of Biochemistry and Molecular Biology, The Chicago Medical School, USA
    Protein Expr Purif 37:479-85. 2004
  4. pmc Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase
    Yamin Wang
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Biol Chem 282:8228-36. 2007
  5. ncbi request reprint Expression of bovine F1-ATPase with functional complementation in yeast Saccharomyces cerevisiae
    Neeti Puri
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Greenbay Road, North Chicago, IL 60064, USA
    J Biol Chem 280:22418-24. 2005
  6. pmc Novel features of the rotary catalytic mechanism revealed in the structure of yeast F1 ATPase
    Venkataraman Kabaleeswaran
    Department of Biochemistry and Molecular Biology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    EMBO J 25:5433-42. 2006
  7. pmc Introduction of the chloroplast redox regulatory region in the yeast ATP synthase impairs cytochrome c oxidase
    Hong Shen
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Biol Chem 283:32937-43. 2008
  8. pmc Asymmetric structure of the yeast F1 ATPase in the absence of bound nucleotides
    Venkataraman Kabaleeswaran
    Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Biol Chem 284:10546-51. 2009

Research Grants

  1. Structure Function of the ATP Synthase
    David Mueller; Fiscal Year: 2002
  2. Structure and Function of the Yeast ATPase
    David Mueller; Fiscal Year: 2009
  3. Structure and Function of the Yeast ATPase
    David Mueller; Fiscal Year: 2009
  4. Structure and Function of the Yeast ATPase
    David Mueller; Fiscal Year: 2007
  5. Structure and regulation of the ATP synthase
    David Mueller; Fiscal Year: 2006
  6. Structure Function of the ATP Synthase
    David Mueller; Fiscal Year: 2005
  7. Structure and regulation of the ATP synthase
    David Mueller; Fiscal Year: 2005
  8. Structure and regulation of the ATP synthase
    David Mueller; Fiscal Year: 2004
  9. Structure and regulation of the ATP synthase
    David Mueller; Fiscal Year: 2003
  10. Structure and Function of the Yeast ATPase
    DAVID MICHAEL MUELLER; Fiscal Year: 2010

Collaborators

  • John E Walker
  • Thomas Meier
  • D E Walters
  • Venkataraman Kabaleeswaran
  • Jindrich Symersky
  • Hong Shen
  • Neeti Puri
  • Andrew G W Leslie
  • Yamin Wang
  • José D Faraldo-Gómez
  • Alexander Krah
  • Vijayakanth Pagadala
  • Daniel Osowski
  • Usha Singh
  • Jie Lai-Zhang
  • Scott Meier

Detail Information

Publications8

  1. pmc Structure of the c(10) ring of the yeast mitochondrial ATP synthase in the open conformation
    Jindrich Symersky
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, Chicago, Illinois, USA
    Nat Struct Mol Biol 19:485-91, S1. 2012
    ..We propose that this new structure represents the functionally open form of the c subunit, which facilitates proton loading and release...
  2. ncbi request reprint Crystallization and preliminary crystallographic studies of the mitochondrial F1-ATPase from the yeast Saccharomyces cerevisiae
    David M Mueller
    Rosalind Franklin University of Medicine and Science, The Chicago Medical School, Department of Biochemistry and Molecular Biology, USA
    Acta Crystallogr D Biol Crystallogr 60:1441-4. 2004
    ..6, b = 294.2, c = 190.4 A, beta = 101.6 degrees. The asymmetric unit contains three molecules of yeast F1, with a corresponding volume per protein weight (VM) of 2.8 A3 Da(-1) and a solvent content of 55%...
  3. ncbi request reprint Ni-chelate-affinity purification and crystallization of the yeast mitochondrial F1-ATPase
    David M Mueller
    Department of Biochemistry and Molecular Biology, The Chicago Medical School, USA
    Protein Expr Purif 37:479-85. 2004
    ..The final enzyme is a homogeneous preparation with full activity and no apparent degradation products. This enzyme preparation has been used to obtain crystals that diffract to better than 2.8 A resolution...
  4. pmc Mitochondrial genome integrity mutations uncouple the yeast Saccharomyces cerevisiae ATP synthase
    Yamin Wang
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Biol Chem 282:8228-36. 2007
    ..These results indicate that residues within the mgi complementation group are necessary for efficient coupling of ATP synthase, possibly acting as a support to fix the axis of rotation of the central stalk...
  5. ncbi request reprint Expression of bovine F1-ATPase with functional complementation in yeast Saccharomyces cerevisiae
    Neeti Puri
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Greenbay Road, North Chicago, IL 60064, USA
    J Biol Chem 280:22418-24. 2005
    ....
  6. pmc Novel features of the rotary catalytic mechanism revealed in the structure of yeast F1 ATPase
    Venkataraman Kabaleeswaran
    Department of Biochemistry and Molecular Biology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    EMBO J 25:5433-42. 2006
    ....
  7. pmc Introduction of the chloroplast redox regulatory region in the yeast ATP synthase impairs cytochrome c oxidase
    Hong Shen
    Department of Biochemistry and Molecular Biology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Biol Chem 283:32937-43. 2008
    ..These results indicate that the chimeric ATP synthase containing cysteine, but not serine, decreases the expression or assembly of cytochrome c oxidase with little effect on the activity of the ATP synthase...
  8. pmc Asymmetric structure of the yeast F1 ATPase in the absence of bound nucleotides
    Venkataraman Kabaleeswaran
    Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Biol Chem 284:10546-51. 2009
    ..The adenine-binding pocket of the beta(TP) subunit is disrupted in the apoenzyme, suggesting that the beta(DP) subunit is responsible for unisite catalytic activity...

Research Grants14

  1. Structure Function of the ATP Synthase
    David Mueller; Fiscal Year: 2002
    ..abstract_text> ..
  2. Structure and Function of the Yeast ATPase
    David Mueller; Fiscal Year: 2009
    ..Future studies will target these regions for the development of antibiotics, which either perturb the coupling efficiency or block rotation of the gamma-subunit of the ATP synthase from pathogenic bacteria. ..
  3. Structure and Function of the Yeast ATPase
    David Mueller; Fiscal Year: 2009
    ..Future studies will target these regions for the development of antibiotics, which either perturb the coupling efficiency or block rotation of the gamma-subunit of the ATP synthase from pathogenic bacteria. ..
  4. Structure and Function of the Yeast ATPase
    David Mueller; Fiscal Year: 2007
    ..Future studies will target these regions for the development of antibiotics, which either perturb the coupling efficiency or block rotation of the gamma-subunit of the ATP synthase from pathogenic bacteria. ..
  5. Structure and regulation of the ATP synthase
    David Mueller; Fiscal Year: 2006
    ..abstract_text> ..
  6. Structure Function of the ATP Synthase
    David Mueller; Fiscal Year: 2005
    ..abstract_text> ..
  7. Structure and regulation of the ATP synthase
    David Mueller; Fiscal Year: 2005
    ..abstract_text> ..
  8. Structure and regulation of the ATP synthase
    David Mueller; Fiscal Year: 2004
    ..abstract_text> ..
  9. Structure and regulation of the ATP synthase
    David Mueller; Fiscal Year: 2003
    ..abstract_text> ..
  10. Structure and Function of the Yeast ATPase
    DAVID MICHAEL MUELLER; Fiscal Year: 2010
    ..Future studies will target these regions for the development of antibiotics, which either perturb the coupling efficiency or block rotation of the gamma-subunit of the ATP synthase from pathogenic bacteria. ..
  11. Structure Function of the ATP Synthase
    David Mueller; Fiscal Year: 2004
    ..abstract_text> ..
  12. Structure Function of the ATP Synthase
    David Mueller; Fiscal Year: 2003
    ..abstract_text> ..