Gloria Meredith

Summary

Affiliation: Rosalind Franklin University of Medicine and Science
Country: USA

Publications

  1. ncbi request reprint Amphetamine increases tyrosine kinase-B receptor expression in the dorsal striatum
    Gloria E Meredith
    Department of Cellular and Molecular Pharmacology, Chicago Medical School Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    Neuroreport 17:75-8. 2006
  2. pmc Impaired glutamate homeostasis and programmed cell death in a chronic MPTP mouse model of Parkinson's disease
    G E Meredith
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Exp Neurol 219:334-40. 2009
  3. pmc Modeling PD pathogenesis in mice: advantages of a chronic MPTP protocol
    Gloria E Meredith
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Parkinsonism Relat Disord 14:S112-5. 2008
  4. pmc Animal models of Parkinson's disease progression
    Gloria E Meredith
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Acta Neuropathol 115:385-98. 2008
  5. pmc The structural basis for mapping behavior onto the ventral striatum and its subdivisions
    Gloria E Meredith
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Brain Struct Funct 213:17-27. 2008
  6. ncbi request reprint Behavioral models of Parkinson's disease in rodents: a new look at an old problem
    Gloria E Meredith
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    Mov Disord 21:1595-606. 2006
  7. ncbi request reprint The neural substrates of amphetamine conditioned place preference: implications for the formation of conditioned stimulus-reward associations
    David J Rademacher
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Eur J Neurosci 24:2089-97. 2006
  8. ncbi request reprint MPTP administration in mice changes the ratio of splice isoforms of fosB and rgs9
    Judith A Potashkin
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Brain Res 1182:1-10. 2007
  9. pmc Context modulates the expression of conditioned motor sensitization, cellular activation and synaptophysin immunoreactivity
    David J Rademacher
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Eur J Neurosci 26:2661-8. 2007
  10. pmc Repeated amphetamine administration induces Fos in prefrontal cortical neurons that project to the lateral hypothalamus but not the nucleus accumbens or basolateral amygdala
    Maud M Morshedi
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    Psychopharmacology (Berl) 197:179-89. 2008

Research Grants

Detail Information

Publications25

  1. ncbi request reprint Amphetamine increases tyrosine kinase-B receptor expression in the dorsal striatum
    Gloria E Meredith
    Department of Cellular and Molecular Pharmacology, Chicago Medical School Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    Neuroreport 17:75-8. 2006
    ..These findings indicate that changes in striatal tyrosine kinase-B signaling could play a role in neuroadaptations and behavioral changes induced by amphetamine treatment...
  2. pmc Impaired glutamate homeostasis and programmed cell death in a chronic MPTP mouse model of Parkinson's disease
    G E Meredith
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Exp Neurol 219:334-40. 2009
    ..These data suggest that increased glutamate signaling could be an important mechanism for the death of dopaminergic neurons and trigger the induction of programmed cell death in the chronic MPTP/probenecid model...
  3. pmc Modeling PD pathogenesis in mice: advantages of a chronic MPTP protocol
    Gloria E Meredith
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Parkinsonism Relat Disord 14:S112-5. 2008
    ..These data support the validity of the MPTP/p model for unravelling the degenerative processes in PD and testing therapies that slow their progress...
  4. pmc Animal models of Parkinson's disease progression
    Gloria E Meredith
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Acta Neuropathol 115:385-98. 2008
    ..This review critically evaluates these in vivo models and the roles they play in mimicking the progression of PD...
  5. pmc The structural basis for mapping behavior onto the ventral striatum and its subdivisions
    Gloria E Meredith
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Brain Struct Funct 213:17-27. 2008
    ..This review is focused on evaluating the structural differences in nucleus accumbens core and shell neurons and discusses how such different morphologies could underlie distinguishable behavioral processes...
  6. ncbi request reprint Behavioral models of Parkinson's disease in rodents: a new look at an old problem
    Gloria E Meredith
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    Mov Disord 21:1595-606. 2006
    ....
  7. ncbi request reprint The neural substrates of amphetamine conditioned place preference: implications for the formation of conditioned stimulus-reward associations
    David J Rademacher
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Eur J Neurosci 24:2089-97. 2006
    ..These data therefore suggest that the formation of conditioned stimulus-reward associations requires, at least in part, activation of amygdalar-hippocampal circuits...
  8. ncbi request reprint MPTP administration in mice changes the ratio of splice isoforms of fosB and rgs9
    Judith A Potashkin
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Brain Res 1182:1-10. 2007
    ..The data indicate that the pattern of splice isoforms of fosB and rgs9 reflects the brain's immediate and long-term responses to the physiological stress associated with Parkinsonism...
  9. pmc Context modulates the expression of conditioned motor sensitization, cellular activation and synaptophysin immunoreactivity
    David J Rademacher
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Eur J Neurosci 26:2661-8. 2007
    ..These data indicate that the basolateral amygdala-nucleus accumbens core pathway is necessary for the context-elicited conditioned motor responses, while the hippocampus encodes the spatial context...
  10. pmc Repeated amphetamine administration induces Fos in prefrontal cortical neurons that project to the lateral hypothalamus but not the nucleus accumbens or basolateral amygdala
    Maud M Morshedi
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    Psychopharmacology (Berl) 197:179-89. 2008
    ..These projections are clearly important for the progressive enhancement of the behavioral response during drug administration that persists through withdrawal...
  11. pmc Differential laminar effects of amphetamine on prefrontal parvalbumin interneurons
    M M Morshedi
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    Neuroscience 149:617-24. 2007
    ..They also suggest that a sensitizing amphetamine regimen directs medial prefrontal cortex (mPFC) outflow, via changes in inhibitory neuron activation, toward subcortical centers important in reward...
  12. ncbi request reprint Astroglial plasticity and glutamate function in a chronic mouse model of Parkinson's disease
    Adrian G Dervan
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Exp Neurol 190:145-56. 2004
    ....
  13. pmc Amphetamine-associated contextual learning is accompanied by structural and functional plasticity in the basolateral amygdala
    David J Rademacher
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 30:4676-86. 2010
    ..Thus, context-drug associations are accompanied by structural and functional plasticity in the BLA, findings that have important implications for drug-seeking behavior...
  14. pmc Increased synapses in the medial prefrontal cortex are associated with repeated amphetamine administration
    Maud M Morshedi
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    Synapse 63:126-35. 2009
    ..Therefore, behavioral sensitization as a result of repeated exposure to AMPH is accompanied by the increased formation of spine, but not dendritic, synapses onto pyramidal neurons in the mPFC...
  15. ncbi request reprint A critical review of the development and importance of proteinaceous aggregates in animal models of Parkinson's disease: new insights into Lewy body formation
    Gloria E Meredith
    Department of Cellular and Molecular Pharmacology, Chicago Medical School, Finch University of Health Sciences, 3333 Green Bay Road, North Chicago, IL 60054, USA
    Parkinsonism Relat Disord 10:191-202. 2004
    ..Elucidating the common mechanisms in animal models is a first step towards understanding the role of Lewy bodies and their formation in Parkinson's disease...
  16. ncbi request reprint The role of oxidative stress in the dysregulation of gene expression and protein metabolism in neurodegenerative disease
    Judith A Potashkin
    Department of Cellular and Molecular Pharmacology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA
    Antioxid Redox Signal 8:144-51. 2006
    ....
  17. ncbi request reprint 'Rejuvenation' protects neurons in mouse models of Parkinson's disease
    C Savio Chan
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Nature 447:1081-6. 2007
    ..Such blocking ('rejuvenation') protects these neurons in both in vitro and in vivo models of Parkinson's disease, pointing to a new strategy that could slow or stop the progression of the disease...
  18. ncbi request reprint Amphetamine-induced place preference and conditioned motor sensitization requires activation of tyrosine kinase receptors in the hippocampus
    Fei Shen
    Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago Medical Center, Maywood, Illinois 60153, USA
    J Neurosci 26:11041-51. 2006
    ....
  19. ncbi request reprint BDNF heterozygous mice demonstrate age-related changes in striatal and nigral gene expression
    Alicia J Saylor
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Exp Neurol 199:362-72. 2006
    ....
  20. ncbi request reprint Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's disease
    Jinghua Jin
    Department of Pathology, School of Medicine, University of Washington, Seattle, WA 98104, USA
    Brain Res Mol Brain Res 134:119-38. 2005
    ..In addition, DJ-1 was present in the halo but not in the core of classical LBs in patients with PD. Our findings suggested that DJ-1 might play an important role in mitochondrial dysfunction, as well as LB formation in PD...
  21. ncbi request reprint Elevated neuronal nitric oxide synthase expression in chronic haloperidol-treated rats
    Yuen Sum Lau
    Division of Pharmacology, School of Pharmacy, University of Missouri Kansas City, 2411 Holmes St M3 111, Kansas City, MO, USA
    Neuropharmacology 45:986-94. 2003
    ..Furthermore, the toxic effect of chronic haloperidol on NOS system selectivity takes place in the neostriatum...
  22. ncbi request reprint From drugs of abuse to parkinsonism. The MPTP mouse model of Parkinson's disease
    Yuen Sum Lau
    Division of Pharmacology, University of Missouri Kansas City, School of Pharmacy, Kansas City, MO, USA
    Methods Mol Med 79:103-16. 2003
  23. ncbi request reprint Brain-derived neurotrophic factor expression is increased in the rat amygdala, piriform cortex and hypothalamus following repeated amphetamine administration
    Gloria E Meredith
    Department of Basic Medical Science, University of Missouri Kansas City, School of Medicine, 2411 Holmes Rd, Kansas City, MO 64108, USA
    Brain Res 949:218-27. 2002
    ..These results suggest that the upregulation of BDNF expression and protein in the basolateral nucleus of the amygdala and its targets could be an important part of the neuroadaptive response to psychostimulants...
  24. ncbi request reprint The ultrastructural distribution of alpha-synuclein-like protein in normal mouse brain
    Susan Totterdell
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Brain Res 1004:61-72. 2004
    ..Nevertheless alpha-synuclein is also found in terminals of neurons which have not been reported to accumulate the protein in neurodegenerative disorders...
  25. ncbi request reprint Relationship of orofacial movements to behavioural repertoire as assessed topographically over the course of 6-month haloperidol treatment followed by 4-month withdrawal
    Ian E J De Souza
    Department of Anatomy, Royal College of Surgeons in Ireland, St Stephen s Green, Dublin 2, Ireland
    Psychopharmacology (Berl) 169:28-34. 2003
    ..Given their common action to block dopamine D2-like receptors, VCMs may be related to changes in dopaminergic function; if so, other typical dopamine-mediated behaviours might be altered also...

Research Grants14

  1. Mechanisms underlying reward-related synaptogenesis
    Gloria Meredith; Fiscal Year: 2007
    ..Finally, in Aim 3, we will examine the influence of BDNF on synaptic strength in BL by chronically infusing this factor and studying the physiological and anatomical synaptic responses. ..
  2. Synaptic Proteins, Trophic Factors and Neurodegeneration
    Gloria Meredith; Fiscal Year: 2004
    ..The findings of this research should shed light on target areas where neuroprotection strategies can be implemented. ..
  3. Mechanisms underlying reward-related synaptogenesis
    Gloria E Meredith; Fiscal Year: 2010
    ..abstract_text> ..