Michela Marinelli

Summary

Affiliation: Rosalind Franklin University of Medicine and Science
Country: USA

Publications

  1. ncbi request reprint Excitability of dopamine neurons: modulation and physiological consequences
    M Marinelli
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science The Chicago Medical School, North Chicago, IL 60064, USA
    CNS Neurol Disord Drug Targets 5:79-97. 2006
  2. ncbi request reprint The many facets of the locomotor response to a novel environment test: theoretical comment on Mitchell, Cunningham, and Mark (2005)
    Michela Marinelli
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science The Chicago Medical School, North Chicago, IL 60064, USA
    Behav Neurosci 119:1144-51. 2005
  3. pmc Adolescents are more vulnerable to cocaine addiction: behavioral and electrophysiological evidence
    Wai Chong Wong
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 33:4913-22. 2013
  4. pmc Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 31:14536-41. 2011
  5. pmc Individual differences in dopamine cell neuroadaptations following cocaine self-administration
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    Biol Psychiatry 66:801-3. 2009
  6. pmc Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 31:5737-43. 2011
  7. pmc Selective serotonin reuptake inhibitor antidepressants potentiate methylphenidate (Ritalin)-induced gene regulation in the adolescent striatum
    Vincent Van Waes
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science The Chicago Medical School, North Chicago, IL 60064, USA
    Eur J Neurosci 32:435-47. 2010
  8. pmc Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization
    Xiaoting Wang
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 33:11012-22. 2013
  9. pmc Dopamine neurons in the ventral tegmental area fire faster in adolescent rats than in adults
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University, North Chicago, Illinois, USA
    J Neurophysiol 108:1620-30. 2012
  10. ncbi request reprint Adolescent exposure to methylphenidate alters the activity of rat midbrain dopamine neurons
    Cindy L Brandon
    Department of Anatomy and Cell Biology CLB, Finch University of Health Sciences The Chicago Medical School, North Chicago, Illinois 60048, USA
    Biol Psychiatry 54:1338-44. 2003

Research Grants

  1. Adolescent Cocaine Abuse: Electrophysiology & Behavior
    Michela Marinelli; Fiscal Year: 2009
  2. Adolescent Cocaine Abuse: Electrophysiology & Behavior
    Michela Marinelli; Fiscal Year: 2009
  3. Adolescent Cocaine Abuse: Electrophysiology & Behavior
    Michela Marinelli; Fiscal Year: 2009
  4. Adolescent Cocaine Abuse: Electrophysiology & Behavior
    Michela Marinelli; Fiscal Year: 2010

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Excitability of dopamine neurons: modulation and physiological consequences
    M Marinelli
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science The Chicago Medical School, North Chicago, IL 60064, USA
    CNS Neurol Disord Drug Targets 5:79-97. 2006
    ..We will conclude by discussing how changes in the physiology of the dopamine neurons could participate in the development or exacerbation of psychiatric conditions such as drug addiction...
  2. ncbi request reprint The many facets of the locomotor response to a novel environment test: theoretical comment on Mitchell, Cunningham, and Mark (2005)
    Michela Marinelli
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science The Chicago Medical School, North Chicago, IL 60064, USA
    Behav Neurosci 119:1144-51. 2005
    ..They reported that the locomotor response to a novel environment does not predict responding for cocaine but reflects overall differences in the ability to learn operant tasks. ((c) 2005 APA, all rights reserved)...
  3. pmc Adolescents are more vulnerable to cocaine addiction: behavioral and electrophysiological evidence
    Wai Chong Wong
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 33:4913-22. 2013
    ..In conclusion, adolescents show behavioral and electrophysiological traits of heightened addiction liability...
  4. pmc Group I mGluR activation reverses cocaine-induced accumulation of calcium-permeable AMPA receptors in nucleus accumbens synapses via a protein kinase C-dependent mechanism
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 31:14536-41. 2011
    ..Furthermore, they suggest that activation of mGluR1 may represent a potential strategy for reducing cue-induced cocaine craving in abstinent cocaine addicts...
  5. pmc Individual differences in dopamine cell neuroadaptations following cocaine self-administration
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois 60064, USA
    Biol Psychiatry 66:801-3. 2009
    ..It is unknown if individual differences in these neuroadaptive responses can account for naturally occurring differences in drug addiction liability...
  6. pmc Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 31:5737-43. 2011
    ..In conclusion, in adult rats, accumulation of synaptic CP-AMPARs in the NAc occurs after prolonged withdrawal from extended-access cocaine self-administration but not after prolonged withdrawal from noncontingent cocaine injections...
  7. pmc Selective serotonin reuptake inhibitor antidepressants potentiate methylphenidate (Ritalin)-induced gene regulation in the adolescent striatum
    Vincent Van Waes
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science The Chicago Medical School, North Chicago, IL 60064, USA
    Eur J Neurosci 32:435-47. 2010
    ..In so far as such gene regulation is implicated in psychostimulant addiction, our findings suggest that SSRIs may enhance the addiction potential of methylphenidate...
  8. pmc Kalirin-7 mediates cocaine-induced AMPA receptor and spine plasticity, enabling incentive sensitization
    Xiaoting Wang
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 33:11012-22. 2013
    ....
  9. pmc Dopamine neurons in the ventral tegmental area fire faster in adolescent rats than in adults
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University, North Chicago, Illinois, USA
    J Neurophysiol 108:1620-30. 2012
    ..This elevation of firing rate during adolescence is consistent with it representing a vulnerable period for developing drug addiction...
  10. ncbi request reprint Adolescent exposure to methylphenidate alters the activity of rat midbrain dopamine neurons
    Cindy L Brandon
    Department of Anatomy and Cell Biology CLB, Finch University of Health Sciences The Chicago Medical School, North Chicago, Illinois 60048, USA
    Biol Psychiatry 54:1338-44. 2003
    ..Thus we sought to determine whether repeated exposure to low-dose methylphenidate in adolescence alters dopamine neuronal excitability in adulthood...
  11. pmc Persistent increases in cocaine-seeking behavior after acute exposure to cold swim stress
    KELLY L CONRAD
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, North Chicago, Illinois, USA
    Biol Psychiatry 68:303-5. 2010
    ..To date, no paradigm exists to model the common human situation in which stressors that are distinct from the experience of drugs can lead to relapse...
  12. ncbi request reprint Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior
    Michela Marinelli
    Department of Cellular and Molecular Pharmacology, Finch University of Health Sciences, The Chicago Medical School, 3333 Green Bay Rd, North Chicago, IL 60064, USA
    Psychopharmacology (Berl) 168:84-98. 2003
    ..It is unclear whether these neuroadaptations play an important role in withdrawal-associated drug seeking...
  13. pmc Fluoxetine potentiates methylphenidate-induced gene regulation in addiction-related brain regions: concerns for use of cognitive enhancers?
    Heinz Steiner
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, Chicago Medical School, North Chicago, Illinois, USA
    Biol Psychiatry 67:592-4. 2010
    ....
  14. ncbi request reprint Enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons
    M Marinelli
    Department of Cellular and Molecular Pharmacology, Finch University of Health Sciences, The Chicago Medical School, North Chicago, Illinois 60064, USA
    J Neurosci 20:8876-85. 2000
    ..These results demonstrate that differences in the basal activity of DA neurons may be critically involved in determining individual vulnerability to drugs of abuse...
  15. pmc Age matters
    James Edgar McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, USA
    Eur J Neurosci 29:997-1014. 2009
    ..We conclude that selection of the age of the animals may be critically important in the design and interpretation of neurobiological studies...
  16. pmc Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
    KELLY L CONRAD
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    Nature 454:118-21. 2008
    ....
  17. ncbi request reprint Amphetamine and cocaine do not increase Narp expression in rat ventral tegmental area, nucleus accumbens or prefrontal cortex, but Narp may contribute to individual differences in responding to a novel environment
    W Lu
    Department of Neuroscience, The Chicago Medical School, North Chicago, IL 60064, USA
    Eur J Neurosci 15:2027-36. 2002
    ..These findings suggest that differential Narp expression in the PFC may be involved in determining individual vulnerability to drugs of abuse, perhaps by influencing the activity of its excitatory projections...
  18. ncbi request reprint Interaction between glucocorticoid hormones, stress and psychostimulant drugs
    Michela Marinelli
    INSERM U259, Universite de Bordeaux 2, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Eur J Neurosci 16:387-94. 2002
    ..This sensitized state, which can persist after the end of the stress, would render the subject more responsive to drugs of abuse and consequently more vulnerable to the development of addiction...
  19. ncbi request reprint Leptin receptor signaling in midbrain dopamine neurons regulates feeding
    Jonathan D Hommel
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Neuron 51:801-10. 2006
    ..These data support a critical role for VTA Lepr in regulating feeding behavior and provide functional evidence for direct action of a peripheral metabolic signal on VTA dopamine neurons...
  20. ncbi request reprint Decreased firing frequency of midbrain dopamine neurons in mice lacking mu opioid receptors
    Daniel S Mathon
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
    Eur J Neurosci 21:2883-6. 2005
    ..They also provide a possible underlying mechanism for the decreased reinforcing properties of drugs of abuse that was previously observed in mice lacking mu-opioid receptors...
  21. ncbi request reprint Dopamine scales performance in the absence of new learning
    Barbara Cagniard
    Department of Neurobiology, Pharmacology, and Physiology, The University of Chicago, Chicago, IL 60637, USA
    Neuron 51:541-7. 2006
    ..Elevated dopamine enhanced performance in goal-directed operant responses. These data demonstrate that alterations in dopaminergic tone can scale the performance of a previously learned behavior in the absence of new learning...
  22. ncbi request reprint The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens
    Francoise Rouge-Pont
    Psychobiologie des Comportements Adaptatifs, INSERM U259, Universite Victor Segalen Bordeaux 2, Domaine de Carreire, rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Eur J Neurosci 16:169-73. 2002
    ..These results suggest that the stimulatory effect of AlloP on DA could mediate some of the behavioural effects of neurosteroids and, in particular, the interaction of these hormones with mood and motivation...
  23. ncbi request reprint The role of corticosterone in food deprivation-induced reinstatement of cocaine seeking in the rat
    Uri Shalev
    Behavioral Neuroscience Branch, IRP NIDA NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 168:170-6. 2003
    ..Here we studied whether food deprivation would reinstate cocaine seeking and whether the stress hormone, corticosterone, is involved in this effect...

Research Grants7

  1. Adolescent Cocaine Abuse: Electrophysiology & Behavior
    Michela Marinelli; Fiscal Year: 2009
    ..In the long run, these findings will facilitate the development of new targeted therapeutic strategies for the treatment or prevention of cocaine addiction. ..
  2. Adolescent Cocaine Abuse: Electrophysiology & Behavior
    Michela Marinelli; Fiscal Year: 2009
    ..In the long run, these studies will offer new insights into the development of treatment strategies that could prevent the development of addiction and relapse to drug taking. ..
  3. Adolescent Cocaine Abuse: Electrophysiology & Behavior
    Michela Marinelli; Fiscal Year: 2009
    ..In the long run, these findings will facilitate the development of new targeted therapeutic strategies for the treatment or prevention of cocaine addiction. ..
  4. Adolescent Cocaine Abuse: Electrophysiology & Behavior
    Michela Marinelli; Fiscal Year: 2010
    ..In the long run, these findings will facilitate the development of new targeted therapeutic strategies for the treatment or prevention of cocaine addiction. ..