Michela Marinelli

..We will conclude by discussing how changes in the physiology of the dopamine neurons could participate in the development or exacerbation of psychiatric conditions such as drug addiction...

..They reported that the locomotor response to a novel environment does not predict responding for cocaine but reflects overall differences in the ability to learn operant tasks. ((c) 2005 APA, all rights reserved)...

..Furthermore, they suggest that activation of mGluR1 may represent a potential strategy for reducing cue-induced cocaine craving in abstinent cocaine addicts...

..It is unknown if individual differences in these neuroadaptive responses can account for naturally occurring differences in drug addiction liability...

..In conclusion, in adult rats, accumulation of synaptic CP-AMPARs in the NAc occurs after prolonged withdrawal from extended-access cocaine self-administration but not after prolonged withdrawal from noncontingent cocaine injections...

..In so far as such gene regulation is implicated in psychostimulant addiction, our findings suggest that SSRIs may enhance the addiction potential of methylphenidate...

..This elevation of firing rate during adolescence is consistent with it representing a vulnerable period for developing drug addiction...

..No difference between groups was evident with respect to autoreceptor sensitivity to quinpirole. CONCLUSIONS: Adolescent exposure to methylphenidate induces neuronal changes associated with increased addiction liability in rats...

..To date, no paradigm exists to model the common human situation in which stressors that are distinct from the experience of drugs can lead to relapse...

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..It is unclear whether these neuroadaptations play an important role in withdrawal-associated drug seeking...

..These results demonstrate that differences in the basal activity of DA neurons may be critically involved in determining individual vulnerability to drugs of abuse...

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..We conclude that selection of the age of the animals may be critically important in the design and interpretation of neurobiological studies...

..These findings suggest that differential Narp expression in the PFC may be involved in determining individual vulnerability to drugs of abuse, perhaps by influencing the activity of its excitatory projections...

..These data support a critical role for VTA Lepr in regulating feeding behavior and provide functional evidence for direct action of a peripheral metabolic signal on VTA dopamine neurons...

..This sensitized state, which can persist after the end of the stress, would render the subject more responsive to drugs of abuse and consequently more vulnerable to the development of addiction...

..Elevated dopamine enhanced performance in goal-directed operant responses. These data demonstrate that alterations in dopaminergic tone can scale the performance of a previously learned behavior in the absence of new learning...

..They also provide a possible underlying mechanism for the decreased reinforcing properties of drugs of abuse that was previously observed in mice lacking mu-opioid receptors...

..These results suggest that the stimulatory effect of AlloP on DA could mediate some of the behavioural effects of neurosteroids and, in particular, the interaction of these hormones with mood and motivation...

..Here we studied whether food deprivation would reinstate cocaine seeking and whether the stress hormone, corticosterone, is involved in this effect...

..In the long run, these findings will facilitate the development of new targeted therapeutic strategies for the treatment or prevention of cocaine addiction. ..

..In the long run, these studies will offer new insights into the development of treatment strategies that could prevent the development of addiction and relapse to drug taking. ..

..In the long run, these findings will facilitate the development of new targeted therapeutic strategies for the treatment or prevention of cocaine addiction. ..

..In the long run, these findings will facilitate the development of new targeted therapeutic strategies for the treatment or prevention of cocaine addiction. ..