Harold J Wanebo
Affiliation: Roger Williams Medical Center
- Meeting the biologic challenge of colorectal metastasesHarold J Wanebo
Division of Surgical Oncology, Landmark Medical Center, Woonsocket, RI, USA
Clin Exp Metastasis 29:821-39. 2012..Conclude the final lesson from this well presented mini symposium confirms the need for continued evaluation of the numerous discussion points by clinical trial...
- Targeting growth factors and angiogenesis; using small molecules in malignancyHarold J Wanebo
Department of Surgery, Division Surgical Oncology, Roger Williams Medical Center, Providence, RI, USA
Cancer Metastasis Rev 25:279-92. 2006....
- Surgical management of pelvic malignancy: role of extended abdominoperineal resection/exenteration/abdominal sacral resectionHarold J Wanebo
Boston University Medical School, MA 02118, USA
Surg Oncol Clin N Am 14:197-224. 2005
- Isolated chemotherapeutic perfusion of pelvis as neoadjuvant or palliative therapy for advanced cancer of the rectumHarold J Wanebo
Division of Surgical Oncology, Roger Williams Medical Center, Affiliated with Boston University, Providence, Rhode Island, USA
Ann Surg Oncol 15:1107-16. 2008..We currently report our results in 49 recurrent rectal cancer patients (26 had neoadjuvant IPP with intent to resect and 23 had IPP for palliation)...
- The neoadjuvant therapy of colorectal hepatic metastases and the role of biologic sensitizing and resistance factorsHarold J Wanebo
Division of Surgical Oncology, Landmark Medical Center, Woonsocket, Rhode Island, USA
J Surg Oncol 102:891-7. 2010..Here, we are discussing the role of biologic agents in the treatment of patients with liver metastases from CRC. We also discuss the role of biomarkers for response and resistance to such novel therapies...
- Selective organ preservation in operable locally advanced head and neck squamous cell carcinomas guided by primary site restaging biopsy: long-term results of two sequential brown university oncology group chemoradiotherapy studiesHarold J Wanebo
Division of Surgical Oncology, Landmark Medical Center, Woonsocket, RI, USA
Ann Surg Oncol 18:3479-85. 2011..The long-term outcomes of selective organ preservation in operable, locally advanced head and neck cancers in two sequential chemoradiotherapy (CRT) protocols (HN-53, HN-67) are reported...
- Weekly paclitaxel and carboplatin induction chemotherapy followed by concurrent chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neckNeal E Ready
Brown University Oncology Group, Providence, RI, USA
Am J Clin Oncol 35:6-12. 2012..To perform a phase II trial evaluating dose dense induction chemotherapy for locally advanced head and neck cancer...
- Concurrent chemoradiotherapy with weekly paclitaxel and carboplatin for locally advanced head and neck cancer: Long-term follow-up of a Brown University Oncology Group Phase II Study (HN-53)Prakash B Chougule
Department of Radiation Oncology, Rhode Island Hospital, Providence, Rhode Island, USA
Head Neck 30:289-96. 2008..A phase II study was conducted using concurrent paclitaxel, carboplatin, and external beam radiotherapy (RT) in patients with advanced head and neck cancer...
- Mucosal melanomasJohn Tomicic
Boston University, School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Surg Clin North Am 83:237-52. 2003..Until then, this aggressive tumor continues to have a poor prognosis, and surgical resection continues to be the mainstay of primary therapy...
- Pelvic perfusion for advanced colorectal cancersGiovanni Begossi
Roger Williams Medical Center, Boston University School of Medicine, 825 Chalkstone Avenue, Providence, RI 02908, USA
Surg Oncol Clin N Am 17:825-42, ix-x. 2008....
- Radical gastrectomy and lymphadenectomy: historic overview, surgical trends, and lessons from the pastMichael R DiSiena
Department of Surgery, Roger Williams Medical Center, 825 Chalkstone Avenue, Providence, RI 02908, USA
Surg Oncol Clin N Am 14:511-32, vi-vii. 2005
- An effective in vitro antitumor response against human pancreatic carcinoma with paclitaxel and daunorubicin by induction of both necrosis and apoptosisJames E Gervasoni
Roger Williams Hospital Boston University, 825 Chalkstone Ave, Providence, Rhode Island 02908, USA
Anticancer Res 24:2617-26. 2004..6 is more effectively killed following treatment with chemotherapeutic agents that cause death through at least two pathways, a caspase-dependent and caspase-independent apoptosis and necrosis...
- Salvage of pelvic recurrence of colorectal cancerKimberly A Varker
Division of Surgical Oncology, Comprehensive Cancer Center, The Ohio State University Medical Center, Columbus, Ohio, USA
J Surg Oncol 101:649-60. 2010..For patients with unresectable disease, isolated pelvic perfusion may provide effective palliation...
- Factors predictive of the status of sentinel lymph nodes in melanoma patients from a large multicenter databaseRichard L White
Department of General Surgery, Division of Surgical Oncology, Blumenthal Cancer Center, Carolinas Medical Center, Charlotte, NC, USA
Ann Surg Oncol 18:3593-600. 2011..This study investigated the significance of factors for predicting regional nodal disease in cutaneous melanoma using a large multicenter database...
- Capacity of murine IL-12 to inhibit the development of primary melanoma tumors and to prevent lung metastases in the melanoma-challenged miceDavid P Shrayer
Departments of Surgery and Pathology, Roger Williams Medical Center, Brown University, 825 Chalkstone Avenue, Providence, RI 02908, USA
J Exp Ther Oncol 2:93-9. 2002..Evaluation of IL-12 therapy on primary tumor growth, mean diameters of primary tumors, survival rate, and development of lung metastases showed that the best results were observed using 300 ng/mouse (15 micrograms/kg) R mIL-12...
- Trojan-horse nanotube on-command intracellular drug deliveryChia Hsuan Wu
School of Engineering, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
Nano Lett 12:5475-80. 2012..Nanotube encapsulation permitted the drugs to be used at a 100-fold lower concentration compared to exogenous treatment yet achieve a comparable ~70% cancer kill rate...
- Changing patterns of failure of head and neck cancerCharu Taneja
Department of Surgery, Roger Williams Medical Center, 825 Chalkstone Ave, Providence, RI 02908, USA
Arch Otolaryngol Head Neck Surg 128:324-7. 2002..We reviewed the patterns of failure in cancers of the oral cavity, oropharynx, and larynx at our institution during the last decade...
- Preface. The evolution of regional therapy modalitiesHarold J Wanebo
Division of Surgical Oncology, Department of Surgery, Landmark Medical Center, 206 Cass Avenue, Woonsocket, RI 02895, USA
Surg Oncol Clin N Am 17:xvii-xix. 2008
- Regional chemotherapy: overviewJames H Muchmore
Department of Surgery, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
Surg Oncol Clin N Am 17:709-30, vii. 2008..Newer techniques demonstrate that the combination of regional therapies, hyperthermia, and surgery is essential in promoting improved patient outcomes...
- Clinical pharmacokinetics of isolated pelvic perfusionJames F Belliveau
Division of Surgical Oncology, Roger Williams Medical Center, Boston University School of Medicine, 825 Chalkstone Avenue, Providence, RI 02908, USA
Surg Oncol Clin N Am 17:773-84, viii. 2008..Pharmacokinetic modeling using empiric approximations for the kinetic rate constants is a convenient and novel way of fitting data using relatively simple mathematics and commercially available spreadsheets...
- Isolated pelvic perfusion: plasma pharmacokinetics depend primarily on drug dosage and not the type of drugJames F Belliveau
Department of Chemistry, Providence College, 549 River Avenue, Providence, RI, 02918, USA
Cancer Chemother Pharmacol 55:318-22. 2005..It appears that the pharmacokinetics are sufficiently defined as to predict plasma distribution curves for an additional drug with this protocol. Recent FDA approval of oxaliplatin allowed an evaluation of this premise...
- Synergistic effect of interleukin-2 and a vaccine of irradiated melanoma cells transfected to secrete staphylococcal enterotoxin ADavid P Schrayer
Department of Surgery and Pathology, University Medical Group Roger Williams Medical Center, Boston University School of Medicine, Providence, Rhode Island 02908, USA
Clin Exp Metastasis 19:43-53. 2002..The morphological and immunological effectiveness of the therapy was dose-dependent on IL-2...
- Cancers of the anal canal and anal marginJames E Gervasoni
Department of Surgery, Fox Chase Cancer Center at St Francis Medical Center, Trenton, New Jersey, USA
Cancer Invest 21:452-64. 2003
- Phase II study of external irradiation and weekly paclitaxel for nonmetastatic, unresectable pancreatic cancer: RTOG-98-12Tyvin Rich
Department of Radiation Oncology, University of Virginia Health Science Center, Charlottesville, Virginia 22908, USA
Am J Clin Oncol 27:51-6. 2004..These data provide the basis for a new Radiation Therapy Oncology Group trial using paclitaxel and irradiation combined with a second radiation sensitizer, gemcitabine, now under way...
- Editorial regarding use of modified femoral vein approach as method for implanting a totally implantable access port in patients with synchronous bilateral mastectomies (Chen et al.)Harold J Wanebo
J Surg Oncol 98:147. 2008
- Neoadjuvant therapy with high dose chemotherapy via isolated pelvic intra-abdominal perfusion with bone marrow stem cell support for advanced endometrial cancerMeghan Delaney
University of New England College of Osteopathic Medicine
Med Health R I 86:252-5. 2003
- Laparoscopic cholecystectomy: its effect on the prognosis of patients with gallbladder cancerXabier A de Aretxabala
Department of Surgery, Universidad de La Frontera, German Clinic Temuco, PO Box 54 D Temuco 4781176, Chile
World J Surg 28:544-7. 2004..Although there is a higher but insignificant recurrence rate among the patients who underwent LC, this is not translated into survival...
- Targeting small molecules in cancerHarold J Wanebo
Boston University, Boston, MA, USA
Cancer Treat Res 135:239-55. 2007