Kennon J Heard

Summary

Affiliation: Rocky Mountain Poison and Drug Center
Country: USA

Publications

  1. ncbi request reprint Acetylcysteine therapy for acetaminophen poisoning
    Kennon Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO 80204, USA
    Curr Pharm Biotechnol 13:1917-23. 2012
  2. pmc The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study
    E K Kuffner
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Med 5:13. 2007
  3. pmc Acetaminophen-cysteine adducts during therapeutic dosing and following overdose
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Gastroenterol 11:20. 2011
  4. pmc Knowledge of treatment group does not bias assessment of time to seizure in an animal model of cocaine poisoning
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Acad Emerg Med 17:e75-7. 2010
  5. doi request reprint Massive acetylcysteine overdose associated with cerebral edema and seizures
    Kennon Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    Clin Toxicol (Phila) 49:423-5. 2011
  6. doi request reprint Asymptomatic alanine aminotransferase elevations with therapeutic doses of acetaminophen
    Kennon Heard
    Rocky Mountain Poison Center, 990 Bannock St, Denver, CO 80262, USA
    Clin Toxicol (Phila) 49:90-3. 2011
  7. pmc The effect of olanzapine pretreatment on acute cocaine toxicity in mice
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO 80204, USA
    Clin Toxicol (Phila) 47:542-4. 2009
  8. pmc Case reports describing treatments in the emergency medicine literature: missing and misleading information
    Tiffany P Richason
    The Colorado Emergency Medicine Research Center, Division of Emergency Medicine, Department of Surgery, University of Colorado School Denver of Medicine, Aurora CO, USA
    BMC Emerg Med 9:10. 2009
  9. pmc Administration of ziprasidone for 10 days increases cocaine toxicity in mice
    K Heard
    Department of Surgery, Division of Emergency Medicine, University of Colorado School of Medicine, Denver, CO, USA
    Hum Exp Toxicol 27:499-503. 2008
  10. pmc Acetylcysteine for acetaminophen poisoning
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver 80208, USA
    N Engl J Med 359:285-92. 2008

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Acetylcysteine therapy for acetaminophen poisoning
    Kennon Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO 80204, USA
    Curr Pharm Biotechnol 13:1917-23. 2012
    ..The duration of treatment varies from 21 to 72 hours, depending on the protocol. Acetylcysteine also prevents death when administered to patients with hepatic failure from acetaminophen...
  2. pmc The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study
    E K Kuffner
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Med 5:13. 2007
    ..Our hypothesis was that common liver tests would be unaffected by administration of the maximum recommended daily dosage of acetaminophen for 3 consecutive days to newly-abstinent alcoholic subjects...
  3. pmc Acetaminophen-cysteine adducts during therapeutic dosing and following overdose
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Gastroenterol 11:20. 2011
    ..The objective of this study is to describe APAP-CYS concentrations in these clinical settings as well as to further characterize the concentrations observed following acetaminophen overdose...
  4. pmc Knowledge of treatment group does not bias assessment of time to seizure in an animal model of cocaine poisoning
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Acad Emerg Med 17:e75-7. 2010
    ..The necessity of blinded outcome assessment on animal studies is unknown. The authors determined the effect of knowledge of treatment group on assessment of time to seizure in an animal model of cocaine poisoning...
  5. doi request reprint Massive acetylcysteine overdose associated with cerebral edema and seizures
    Kennon Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    Clin Toxicol (Phila) 49:423-5. 2011
    ..Acetylcysteine is a safe and effective treatment for the prevention of hepatic injury due to acetaminophen poisoning. While dosing errors are common, in most cases, overdoses produce minimal clinical effects...
  6. doi request reprint Asymptomatic alanine aminotransferase elevations with therapeutic doses of acetaminophen
    Kennon Heard
    Rocky Mountain Poison Center, 990 Bannock St, Denver, CO 80262, USA
    Clin Toxicol (Phila) 49:90-3. 2011
    ..Toxicologists should consider therapeutic acetaminophen use as a cause of ALT elevation. Further study of the mechanism of ALT elevations may provide new insight into other causes of drug-induced liver injury and hepatic adaptation...
  7. pmc The effect of olanzapine pretreatment on acute cocaine toxicity in mice
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO 80204, USA
    Clin Toxicol (Phila) 47:542-4. 2009
    ..Olanzapine, an atypical antipsychotic medication, is an antagonist of these receptors. The objective of this study is to evaluate the efficacy of olanzapine pretreatment for attenuation of acute cocaine toxicity using a mouse model...
  8. pmc Case reports describing treatments in the emergency medicine literature: missing and misleading information
    Tiffany P Richason
    The Colorado Emergency Medicine Research Center, Division of Emergency Medicine, Department of Surgery, University of Colorado School Denver of Medicine, Aurora CO, USA
    BMC Emerg Med 9:10. 2009
    ..As a result, the information may be misleading to providers, and the clinical applications may be detrimental to patient care...
  9. pmc Administration of ziprasidone for 10 days increases cocaine toxicity in mice
    K Heard
    Department of Surgery, Division of Emergency Medicine, University of Colorado School of Medicine, Denver, CO, USA
    Hum Exp Toxicol 27:499-503. 2008
    ..However, our findings suggest that administration of an atypical antipsychotic for 10 days may increase the toxic effects of cocaine...
  10. pmc Acetylcysteine for acetaminophen poisoning
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver 80208, USA
    N Engl J Med 359:285-92. 2008
  11. ncbi request reprint A randomized trial to determine the change in alanine aminotransferase during 10 days of paracetamol (acetaminophen) administration in subjects who consume moderate amounts of alcohol
    K Heard
    Rocky Mountain Poison and Drug Center, Division of Emergency Medicine, Department of Surgery, University of Colorado Denver and Health Sciences Center, Denver, CO, USA
    Aliment Pharmacol Ther 26:283-90. 2007
    ..However, 14 days of therapeutic doses of paracetamol has been associated with an increase in serum transaminases...
  12. doi request reprint Benzodiazepines and antipsychotic medications for treatment of acute cocaine toxicity in animal models--a systematic review and meta-analysis
    Kennon Heard
    Rocky Mountain Poison and Drug Center, Denver, CO 80204, USA
    Hum Exp Toxicol 30:1849-54. 2011
    ..We conclude that both benzodiazepines and antipsychotic medications are effective for the prevention of lethality from cocaine toxicity in animal models...
  13. doi request reprint Anaphylaxis to black widow spider antivenom
    Christopher O Hoyte
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO 80204, USA
    Am J Emerg Med 30:836.e1-2. 2012
    ..Despite concern that the antivenom is an equine-derived whole IgG and can precipitate early hypersensitivity reactions, there is only 1 other reported case of anaphylaxis to the antivenom in the medical literature...
  14. pmc Serum alanine aminotransferase elevation during 10 days of acetaminophen use in nondrinkers
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, Colorado 80204, USA
    Pharmacotherapy 30:818-22. 2010
    ..To describe the changes in serum alanine aminotransferase (ALT) levels in nondrinkers receiving acetaminophen for 10 days...
  15. doi request reprint The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study
    R C Dart
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, CO 80204, USA
    Aliment Pharmacol Ther 32:478-86. 2010
    ..Metabolism of paracetamol to its hepatotoxic metabolite is enhanced in patients who abuse alcohol, who also have compromised liver defences from depressed hepatic glutathione...
  16. doi request reprint An outbreak of exposure to a novel synthetic cannabinoid
    Andrew A Monte
    University of Colorado School of Medicine, Aurora, CO
    N Engl J Med 370:389-90. 2014
    ..Medical toxicologists and public health and law enforcement officials identified 263 cases of exposure to this novel substance. ..
  17. doi request reprint A characterization of synthetic cannabinoid exposures reported to the National Poison Data System in 2010
    Christopher O Hoyte
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    Ann Emerg Med 60:435-8. 2012
    ..We describe a series of exposures to products marketed as synthetic cannabinoids to better characterize the clinical effects in these patients...
  18. pmc Dental pain as a risk factor for accidental acetaminophen overdose: a case-control study
    Jody Vogel
    Denver Health Residency in Emergency Medicine, Denver, CO, USA
    Am J Emerg Med 29:1125-9. 2011
    ..Patients frequent take acetaminophen to treat dental pain. One previous study found a high rate of overuse of nonprescription analgesics in an emergency dental clinic...
  19. pmc Validity of a point of care device (Cholestech LDX) to monitor liver enzyme activity (aminotransferase measures) during a clinical trial
    Jody L Green
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO 80204, USA
    Contemp Clin Trials 31:279-82. 2010
    ..The use of a point of care device to monitor serum transaminases would allow immediate evaluation of this safety endpoint and may be less expensive than standard laboratory testing...
  20. doi request reprint The use of energy drinks, dietary supplements, and prescription medications by United States college students to enhance athletic performance
    Christopher O Hoyte
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, 990 Bannock Street, Denver, CO 80204, USA
    J Community Health 38:575-80. 2013
    ..5 %) and intermural (82.1 %) participants. The vast majority of survey respondents reported using energy drinks, dietary supplements, and prescription medications within the last year for athletic performance enhancement...
  21. pmc Oral and Intravenous Acetylcysteine for Treatment of Acetaminophen Toxicity: A Systematic Review and Meta-analysis
    Jody L Green
    Rocky Mountain Poison and Drug Center, Denver Health Medical Center, University of Colorado, Denver, Colorado Vanderbilt University School of Nursing, Nashville, Tennessee
    West J Emerg Med 14:218-26. 2013
    ..While it is difficult to disentangle the effects of dose and duration from route, our findings suggest that the rates of hepatotoxicity are similar for oral and IV administration...
  22. doi request reprint Survival after amphotericin B overdose treated with plasmapheresis
    George Sam Wang
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital, Denver, CO, USA
    Ann Pharmacother 47:e9. 2013
    ..To report a case of accidental amphotericin B overdose that was treated with plasmapheresis...
  23. pmc Observational studies of patients in the emergency department: a comparison of 4 sampling methods
    Morgan A Valley
    Department of Emergency Medicine, University of Colorado Denver School of Medicine, Aurora, CO, USA
    Ann Emerg Med 60:139-45.e1. 2012
    ..We evaluate the ability of 4 sampling methods to generate representative samples of the emergency department (ED) population...
  24. doi request reprint A US perspective of symptomatic Latrodectus spp. envenomation and treatment: a National Poison Data System review
    Andrew A Monte
    School of Medicine, University of Colorado Denver, Aurora, CO, USA
    Ann Pharmacother 45:1491-8. 2011
    ..Treatment has ranged from symptomatic care to administration of specific antivenom. Declining antivenom availability and, possibly, the fear of hypersensitivity allergic reactions, has limited antivenom use in the US...
  25. pmc Prediction of drug response and safety in clinical practice
    Andrew A Monte
    Rocky Mountain Poison and Drug Center, Denver, CO, USA
    J Med Toxicol 8:43-51. 2012
    ..New methods of metabolomics, proteomics, and transcriptomics that account for this complexity hold promise for translational researchers hoping to increase drug efficacy and decrease drug toxicity...
  26. pmc Types of studies used to support treatment recommendations in medical toxicology
    Ryan Chuang
    Rocky Mountain Poison and Drug Center, 777 Bannock St MC 0180, Denver, CO 80204 4507, USA
    J Med Toxicol 6:345-8. 2010
    ..Case reports and animal studies are commonly used as evidence to support treatment recommendations in medical toxicology textbooks...
  27. pmc Hepatic failure despite early acetylcysteine following large acetaminophen-diphenhydramine overdose
    George S Wang
    Section of Emergency Medicine, Children s Hospital, University of Colorado, Denver, Colorado, USA
    Pediatrics 127:e1077-80. 2011
    ..We suggest that elevated serum acetaminophen concentrations at the end of a standard 20-hour acetylcysteine infusion should be discussed with the local poison center...
  28. ncbi request reprint Olanzapine overdose mimicking opioid intoxication
    G F O'Malley
    Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Ann Emerg Med 34:279-81. 1999
    ..All 4 patients recovered with supportive care. Olanzapine should be added to opioid and alpha(2)-adrenergic agonist intoxication in the differential diagnosis of the patient with depressed mental status and miosis...