R C Dart

Summary

Affiliation: Rocky Mountain Poison and Drug Center
Country: USA

Publications

  1. ncbi request reprint Efficacy, safety, and use of snake antivenoms in the United States
    R C Dart
    Rocky Mountain Poison and Drug Center, Denver Health Authority, and the Department of Surgery, Medicine and Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80230, USA
    Ann Emerg Med 37:181-8. 2001
  2. ncbi request reprint Evaluating patient compliance with nurse advice line recommendations and the impact on healthcare costs
    Gregory M Bogdan
    Rocky Mountain Poison and Drug Center, Denver, Colo 80204, USA
    Am J Manag Care 10:534-42. 2004
  3. doi request reprint Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care
    Richard C Dart
    Rocky Mountain Poison and Drug Center Denver Health, Denver, CO, USA
    Ann Emerg Med 54:386-394.e1. 2009
  4. ncbi request reprint The safety profile of sustained release paracetamol during therapeutic use and following overdose
    Richard C Dart
    Department of Surgery Emergency Medicine, Rocky Mountain Poison and Drug Center, Denver Health, University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    Drug Saf 28:1045-56. 2005
  5. doi request reprint Pediatric fatalities associated with over the counter (nonprescription) cough and cold medications
    Richard C Dart
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, CO 80204, USA
    Ann Emerg Med 53:411-7. 2009
  6. ncbi request reprint Does therapeutic use of acetaminophen cause acute liver failure?
    Richard C Dart
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, Colorado 80204, USA
    Pharmacotherapy 27:1219-30. 2007
  7. ncbi request reprint Monitoring risk: post marketing surveillance and signal detection
    Richard C Dart
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority and University of Colorado School of Medicine, Denver, CO 80204, USA
    Drug Alcohol Depend 105:S26-32. 2009
  8. ncbi request reprint A randomized multicenter trial of crotalinae polyvalent immune Fab (ovine) antivenom for the treatment for crotaline snakebite in the United States
    R C Dart
    Rocky Mountain Poison and Drug Center, 1010 Yosemite Cir, Denver, CO 80230, USA
    Arch Intern Med 161:2030-6. 2001
  9. ncbi request reprint Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial
    E K Kuffner
    Rocky Mountain Poison and Drug Center, 1010 Yosemite Cir, Denver, CO 80230, USA
    Arch Intern Med 161:2247-52. 2001
  10. ncbi request reprint A randomized trial to determine the change in alanine aminotransferase during 10 days of paracetamol (acetaminophen) administration in subjects who consume moderate amounts of alcohol
    K Heard
    Rocky Mountain Poison and Drug Center, Division of Emergency Medicine, Department of Surgery, University of Colorado Denver and Health Sciences Center, Denver, CO, USA
    Aliment Pharmacol Ther 26:283-90. 2007

Detail Information

Publications43

  1. ncbi request reprint Efficacy, safety, and use of snake antivenoms in the United States
    R C Dart
    Rocky Mountain Poison and Drug Center, Denver Health Authority, and the Department of Surgery, Medicine and Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80230, USA
    Ann Emerg Med 37:181-8. 2001
    ..Fab fragments enter solution quickly, thereby shortening the time to antivenom administration and are remarkably stable under extreme conditions of heat and handling...
  2. ncbi request reprint Evaluating patient compliance with nurse advice line recommendations and the impact on healthcare costs
    Gregory M Bogdan
    Rocky Mountain Poison and Drug Center, Denver, Colo 80204, USA
    Am J Manag Care 10:534-42. 2004
    ....
  3. doi request reprint Expert consensus guidelines for stocking of antidotes in hospitals that provide emergency care
    Richard C Dart
    Rocky Mountain Poison and Drug Center Denver Health, Denver, CO, USA
    Ann Emerg Med 54:386-394.e1. 2009
    ..We developed recommendations for antidote stocking at hospitals that provide emergency care...
  4. ncbi request reprint The safety profile of sustained release paracetamol during therapeutic use and following overdose
    Richard C Dart
    Department of Surgery Emergency Medicine, Rocky Mountain Poison and Drug Center, Denver Health, University of Colorado Health Sciences Center, Denver, Colorado 80204, USA
    Drug Saf 28:1045-56. 2005
    ..There were two deaths recorded in the TESS database: both were the result of multiple drug ingestion. No cases of death or unusual types of toxicity have been described from an overdose of paracetamol SR alone...
  5. doi request reprint Pediatric fatalities associated with over the counter (nonprescription) cough and cold medications
    Richard C Dart
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, CO 80204, USA
    Ann Emerg Med 53:411-7. 2009
    ..We evaluate the role of these medications in pediatric fatalities and identified factors that contributed to the death...
  6. ncbi request reprint Does therapeutic use of acetaminophen cause acute liver failure?
    Richard C Dart
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, Colorado 80204, USA
    Pharmacotherapy 27:1219-30. 2007
    ..To compare the reported occurrence of liver failure in subjects in prospective trials with that in patients in retrospective reports after repeated use of therapeutic dosages of acetaminophen...
  7. ncbi request reprint Monitoring risk: post marketing surveillance and signal detection
    Richard C Dart
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority and University of Colorado School of Medicine, Denver, CO 80204, USA
    Drug Alcohol Depend 105:S26-32. 2009
    ..While general risk management guidance has been developed by FDA, more specific analyses and guidance are needed to improve surveillance methodology for drugs which are misused, abused, diverted...
  8. ncbi request reprint A randomized multicenter trial of crotalinae polyvalent immune Fab (ovine) antivenom for the treatment for crotaline snakebite in the United States
    R C Dart
    Rocky Mountain Poison and Drug Center, 1010 Yosemite Cir, Denver, CO 80230, USA
    Arch Intern Med 161:2030-6. 2001
    ..We compared the efficacy and safety of 2 dosing regimens with a new antivenom, Crotalinae polyvalent immune Fab (Fab AV)...
  9. ncbi request reprint Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial
    E K Kuffner
    Rocky Mountain Poison and Drug Center, 1010 Yosemite Cir, Denver, CO 80230, USA
    Arch Intern Med 161:2247-52. 2001
    ..Millions of patients use acetaminophen; the prevalence of alcoholism in the United States is 5% to 10%...
  10. ncbi request reprint A randomized trial to determine the change in alanine aminotransferase during 10 days of paracetamol (acetaminophen) administration in subjects who consume moderate amounts of alcohol
    K Heard
    Rocky Mountain Poison and Drug Center, Division of Emergency Medicine, Department of Surgery, University of Colorado Denver and Health Sciences Center, Denver, CO, USA
    Aliment Pharmacol Ther 26:283-90. 2007
    ..However, 14 days of therapeutic doses of paracetamol has been associated with an increase in serum transaminases...
  11. ncbi request reprint Affinity-purified, mixed monospecific crotalid antivenom ovine Fab for the treatment of crotalid venom poisoning
    R C Dart
    Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Ann Emerg Med 30:33-9. 1997
    ..To test the efficacy and safety of a new antivenom, affinity-purified, mixed monospecific crotalid antivenom ovine Fab, in human subjects with minimal or moderate crotalid envenomation...
  12. doi request reprint The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study
    R C Dart
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, CO 80204, USA
    Aliment Pharmacol Ther 32:478-86. 2010
    ..Metabolism of paracetamol to its hepatotoxic metabolite is enhanced in patients who abuse alcohol, who also have compromised liver defences from depressed hepatic glutathione...
  13. pmc The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study
    E K Kuffner
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Med 5:13. 2007
    ..Our hypothesis was that common liver tests would be unaffected by administration of the maximum recommended daily dosage of acetaminophen for 3 consecutive days to newly-abstinent alcoholic subjects...
  14. ncbi request reprint Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity
    R S Horowitz
    Rocky Mountain Poison and Drug Center, Denver, Colorado 80220 6800, USA
    J Toxicol Clin Toxicol 35:447-51. 1997
    ..To determine whether the antidote for acetaminophen poisoning, N-acetylcysteine, administered to pregnant women with acetaminophen toxicity, crosses the placenta and can be measured in the newborn circulation following delivery...
  15. ncbi request reprint Neutralization of Latrodectus mactans and L. hesperus venom by redback spider (L. hasseltii) antivenom
    F F Daly
    Rocky Mountain Poison and Drug Center Denver Health Authority, Denver, Colorado, USA
    J Toxicol Clin Toxicol 39:119-23. 2001
    ..To test the effectiveness of L. hasseltii (redback spider) antivenom in neutralizing the lethal effects of L. hesperus and L. mactans (North American black widow) venoms...
  16. doi request reprint The underrecognized toll of prescription opioid abuse on young children
    J Elise Bailey
    Rocky Mountain Poison and Drug Center Denver Health, Denver, CO 80204, USA
    Ann Emerg Med 53:419-24. 2009
    ..We hypothesize that poisoning of young children from prescription opioids occurs regularly in the United States and is associated with serious health events, including death...
  17. ncbi request reprint Overuse of over-the-counter analgesics by emergency department patients
    Kennon Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    Ann Emerg Med 48:315-8. 2006
    ..The purpose of this study is to determine the prevalence of over-the-counter analgesic overuse in a sample of emergency department (ED) patients...
  18. ncbi request reprint The effect of FDA approval of a generic competitor to OxyContin (oxycodone HCl controlled-release) tablets on the abuse of oxycodone
    J Elise Bailey
    Rocky Mountain Poison and Drug Center, Denver Health, CO, USA
    Drug Alcohol Depend 84:182-7. 2006
    ..These results did not vary when population rates or patient rates were used. PCC data indicate that approval of generic CR oxycodone was not followed by an immediate unfavorable effect on the misuse/abuse of oxycodone...
  19. doi request reprint Effects of clinical laboratory choice on study outcome: an interlaboratory evaluation of aminotransferase levels
    Jody L Green
    Research Department, Denver Health Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Pharmacotherapy 28:453-7. 2008
    ..To determine if laboratories with disparate alanine aminotransferase (ALT) reference ranges would report different rates of elevation greater than the upper limit of reference range (ULRR) and thus have the potential to alter study results...
  20. ncbi request reprint Active surveillance of abused and misused prescription opioids using poison center data: a pilot study and descriptive comparison
    Alice A Hughes
    Rocky Mountain Poison and Drug Center Denver Health and Hospital Authority, Denver, Colorado 80204, USA
    Clin Toxicol (Phila) 45:144-51. 2007
    ....
  21. pmc Acetaminophen-cysteine adducts during therapeutic dosing and following overdose
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Gastroenterol 11:20. 2011
    ..The objective of this study is to describe APAP-CYS concentrations in these clinical settings as well as to further characterize the concentrations observed following acetaminophen overdose...
  22. pmc Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop
    Eric J Lavonas
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, Colorado, USA
    BMC Emerg Med 11:2. 2011
    ..Treatment of crotaline envenomation is not standardized, and significant variation in practice exists...
  23. doi request reprint Therapeutic acetaminophen is not associated with liver injury in children: a systematic review
    Eric J Lavonas
    Rocky Mountain Poison and Drug Center, 777 Bannock St, MC 0180, Denver, CO 80204, USA
    Pediatrics 126:e1430-44. 2010
    ..Concern exists about the potential for liver injury with therapeutic dosing of acetaminophen in children...
  24. ncbi request reprint Prospective evaluation of repeated supratherapeutic acetaminophen (paracetamol) ingestion
    Frank F S Daly
    Rocky Mountain Poison and Drug Center Denver Health Authority, Denver, CO, USA
    Ann Emerg Med 44:393-8. 2004
    ..We provide the first prospective description of the characteristics, course, and outcome of patients with repeated supratherapeutic ingestion of acetaminophen...
  25. ncbi request reprint Calcium neutralizes fluoride bioavailability in a lethal model of fluoride poisoning
    K Heard
    Rocky Mountain Poison and Drug Center, Denver, Colorado, USA
    J Toxicol Clin Toxicol 39:349-53. 2001
    ..The purpose of this study is to evaluate the effect of calcium and magnesium to decrease the bioavailability of fluoride in a lethal model of fluoride poisoning...
  26. ncbi request reprint A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning
    K Heard
    Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Clin Toxicol (Phila) 52:512-8. 2014
    ..This protocol delivers a higher dose of acetylcysteine which may be useful in selected cases involving very large overdoses. ..
  27. ncbi request reprint Tricyclic antidepressants directly depress human myocardial mechanical function independent of effects on the conduction system
    K Heard
    Rocky Mountain Poison and Drug Center, Denver Health Authority, Denver, CO, USA
    Acad Emerg Med 8:1122-7. 2001
    ..To measure the effect of tricyclic antidepressant drugs (TCAs) on human myocardial contractility...
  28. ncbi request reprint Attenuation of verapamil-induced myocardial toxicity in an ex-vivo rat model using a verapamil-specific ovine immunoglobin
    R E Hill
    Rocky Mountain Poison and Drug Center, Denver Health Authority, Denver, CO 80230-6800, USA
    Acad Emerg Med 8:950-5. 2001
    ..9% (SD +/- 8.1) for verapamil alone (p < 0.05). There was no difference between the two control groups. CONCLUSION: Verapamil-specific IgG attenuated verapamil-induced reduction of developed tension in an ex-vivo rat model...
  29. ncbi request reprint Accidental, intravenous infusion of a peanut oil-based medication
    S A Seifert
    Rocky Mountain Poison and Drug Center, Denver, Colorado 80220 6800, USA
    J Toxicol Clin Toxicol 36:733-6. 1998
    ....
  30. ncbi request reprint Clinical ergotism with lingual ischemia induced by clarithromycin-ergotamine interaction
    R S Horowitz
    Rocky Mountain Poison Center, Denver, Colo, USA
    Arch Intern Med 156:456-8. 1996
    ....
  31. ncbi request reprint Acute myocardial infarction associated with amphetamine use
    J Waksman
    Rocky Mountain Poison and Drug Center, Denver Health Authority, Colo 80230 6800, USA
    Mayo Clin Proc 76:323-6. 2001
    ..However, he subsequently experienced a non-Q-wave anterior wall myocardial infarction associated with the use of amphetamines...
  32. pmc The effect of amiodarone pretreatment on survival of mice with cocaine toxicity
    Christopher R DeWitt
    Medical Toxicology Fellow, Rocky Mountain Poison and Drug Center and Denver Health Medical Center, Denver, CO
    J Med Toxicol 1:11-8. 2005
    ..However, the effects amiodarone in the setting of cocaine toxicity are unknown and unstudied. The purpose of this study was to evaluate the safety and efficacy of amiodarone pretreatment in a murine model of acute cocaine toxicity...
  33. ncbi request reprint New developments in antidotes
    Nicole L Ries
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO 80204, USA
    Med Clin North Am 89:1379-97. 2005
    ..The timely and judicious use of an antidote can prevent death and shorten hospitalization as well as reduce the patient's pain and suffering. Although their importance is recognized, sufficient stocking of antidotes remains a problem...
  34. ncbi request reprint Patient-tailored acetylcysteine administration
    Richard C Dart
    Ann Emerg Med 50:280-1. 2007
  35. ncbi request reprint Alcohol and acetaminophen hepatotoxicity
    Richard C Dart
    Arch Intern Med 163:244-5. 2003
  36. ncbi request reprint Acetaminophen poisoning: an evidence-based consensus guideline for out-of-hospital management
    Richard C Dart
    American Association of Poison Control Centers, Washington, District of Columbia 20016, USA
    Clin Toxicol (Phila) 44:1-18. 2006
    ..However, the effects of other drugs might require referral to an emergency department in accordance with the poison center's normal triage criteria. 2) The use of cimetidine as an antidote is not recommended (Grade A)...
  37. ncbi request reprint The development of a comprehensive risk-management program for prescription opioid analgesics: researched abuse, diversion and addiction-related surveillance (RADARS)
    Theodore J Cicero
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Pain Med 8:157-70. 2007
    ..Thus, its major focus was the detection of abuse of OxyContin and other commonly prescribed opioid analgesics at the three-digit ZIP code level across the country utilizing a number of different detection systems...
  38. ncbi request reprint Prescribing methadone as an analgesic
    Richard C Dart
    Ann Intern Med 143:620. 2005
  39. ncbi request reprint Inhalational abuse of methanol products: elevated methanol and formate levels without vision loss
    Vikhyat S Bebarta
    Department of Emergency Medicine, Wilford Hall Medical Center, San Antonio, TX, USA
    Am J Emerg Med 24:725-8. 2006
    ....
  40. ncbi request reprint A 20-hour treatment for acute acetaminophen overdose
    Luke Yip
    N Engl J Med 348:2471-2. 2003
  41. ncbi request reprint Coma, metabolic acidosis and normal liver function in a child with a large serum acetaminophen level
    Carrie D Mendoza
    Ann Emerg Med 48:637. 2006
  42. ncbi request reprint Osteoarthritis of the knee
    Raymond S Koff
    N Engl J Med 354:2508-9; author reply 2508-9. 2006
  43. pmc The use of visual analog pain scales in black widow spider envenomation
    Jody J Rogers
    J Med Toxicol 2:46-7. 2006