R C Dart

Summary

Affiliation: Rocky Mountain Poison and Drug Center
Country: USA

Publications

  1. doi request reprint A randomized, double-blind, placebo-controlled trial of a highly purified equine F(ab)2 antibody black widow spider antivenom
    Richard C Dart
    Denver Health and Hospital Authority Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Ann Emerg Med 61:458-67. 2013
  2. doi request reprint Intravenous acetaminophen in the United States: iatrogenic dosing errors
    Richard C Dart
    Denver Health Medical Center, Rocky Mountain Poison and Drug Center, Denver, CO 80204, USA
    Pediatrics 129:349-53. 2012
  3. pmc Acetaminophen-cysteine adducts during therapeutic dosing and following overdose
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Gastroenterol 11:20. 2011
  4. pmc Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop
    Eric J Lavonas
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, Colorado, USA
    BMC Emerg Med 11:2. 2011
  5. doi request reprint The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study
    R C Dart
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, CO 80204, USA
    Aliment Pharmacol Ther 32:478-86. 2010
  6. ncbi request reprint Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial
    E K Kuffner
    Rocky Mountain Poison and Drug Center, 1010 Yosemite Cir, Denver, CO 80230, USA
    Arch Intern Med 161:2247-52. 2001
  7. ncbi request reprint Affinity-purified, mixed monospecific crotalid antivenom ovine Fab for the treatment of crotalid venom poisoning
    R C Dart
    Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Ann Emerg Med 30:33-9. 1997
  8. ncbi request reprint A randomized trial to determine the change in alanine aminotransferase during 10 days of paracetamol (acetaminophen) administration in subjects who consume moderate amounts of alcohol
    K Heard
    Rocky Mountain Poison and Drug Center, Division of Emergency Medicine, Department of Surgery, University of Colorado Denver and Health Sciences Center, Denver, CO, USA
    Aliment Pharmacol Ther 26:283-90. 2007
  9. pmc The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study
    E K Kuffner
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Med 5:13. 2007
  10. ncbi request reprint Neutralization of Latrodectus mactans and L. hesperus venom by redback spider (L. hasseltii) antivenom
    F F Daly
    Rocky Mountain Poison and Drug Center Denver Health Authority, Denver, Colorado, USA
    J Toxicol Clin Toxicol 39:119-23. 2001

Collaborators

Detail Information

Publications21

  1. doi request reprint A randomized, double-blind, placebo-controlled trial of a highly purified equine F(ab)2 antibody black widow spider antivenom
    Richard C Dart
    Denver Health and Hospital Authority Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Ann Emerg Med 61:458-67. 2013
    ..We explore various efficacy measures for a novel F(ab)2 antivenom in patients with moderate to severe pain caused by black widow spider envenomation...
  2. doi request reprint Intravenous acetaminophen in the United States: iatrogenic dosing errors
    Richard C Dart
    Denver Health Medical Center, Rocky Mountain Poison and Drug Center, Denver, CO 80204, USA
    Pediatrics 129:349-53. 2012
    ..Health care providers are encouraged to contact their regional poison center (1-800-222-1222) so that dosing errors will be reported, and the experience with this new product can be accumulated...
  3. pmc Acetaminophen-cysteine adducts during therapeutic dosing and following overdose
    Kennon J Heard
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Gastroenterol 11:20. 2011
    ..The objective of this study is to describe APAP-CYS concentrations in these clinical settings as well as to further characterize the concentrations observed following acetaminophen overdose...
  4. pmc Unified treatment algorithm for the management of crotaline snakebite in the United States: results of an evidence-informed consensus workshop
    Eric J Lavonas
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, Denver, Colorado, USA
    BMC Emerg Med 11:2. 2011
    ..Treatment of crotaline envenomation is not standardized, and significant variation in practice exists...
  5. doi request reprint The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study
    R C Dart
    Rocky Mountain Poison and Drug Center, Denver Health and Hospital Authority, CO 80204, USA
    Aliment Pharmacol Ther 32:478-86. 2010
    ..Metabolism of paracetamol to its hepatotoxic metabolite is enhanced in patients who abuse alcohol, who also have compromised liver defences from depressed hepatic glutathione...
  6. ncbi request reprint Effect of maximal daily doses of acetaminophen on the liver of alcoholic patients: a randomized, double-blind, placebo-controlled trial
    E K Kuffner
    Rocky Mountain Poison and Drug Center, 1010 Yosemite Cir, Denver, CO 80230, USA
    Arch Intern Med 161:2247-52. 2001
    ..Millions of patients use acetaminophen; the prevalence of alcoholism in the United States is 5% to 10%...
  7. ncbi request reprint Affinity-purified, mixed monospecific crotalid antivenom ovine Fab for the treatment of crotalid venom poisoning
    R C Dart
    Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Ann Emerg Med 30:33-9. 1997
    ..To test the efficacy and safety of a new antivenom, affinity-purified, mixed monospecific crotalid antivenom ovine Fab, in human subjects with minimal or moderate crotalid envenomation...
  8. ncbi request reprint A randomized trial to determine the change in alanine aminotransferase during 10 days of paracetamol (acetaminophen) administration in subjects who consume moderate amounts of alcohol
    K Heard
    Rocky Mountain Poison and Drug Center, Division of Emergency Medicine, Department of Surgery, University of Colorado Denver and Health Sciences Center, Denver, CO, USA
    Aliment Pharmacol Ther 26:283-90. 2007
    ..However, 14 days of therapeutic doses of paracetamol has been associated with an increase in serum transaminases...
  9. pmc The effect of acetaminophen (four grams a day for three consecutive days) on hepatic tests in alcoholic patients--a multicenter randomized study
    E K Kuffner
    Rocky Mountain Poison and Drug Center, Denver Health, Denver, CO, USA
    BMC Med 5:13. 2007
    ..Our hypothesis was that common liver tests would be unaffected by administration of the maximum recommended daily dosage of acetaminophen for 3 consecutive days to newly-abstinent alcoholic subjects...
  10. ncbi request reprint Neutralization of Latrodectus mactans and L. hesperus venom by redback spider (L. hasseltii) antivenom
    F F Daly
    Rocky Mountain Poison and Drug Center Denver Health Authority, Denver, Colorado, USA
    J Toxicol Clin Toxicol 39:119-23. 2001
    ..To test the effectiveness of L. hasseltii (redback spider) antivenom in neutralizing the lethal effects of L. hesperus and L. mactans (North American black widow) venoms...
  11. ncbi request reprint Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity
    R S Horowitz
    Rocky Mountain Poison and Drug Center, Denver, Colorado 80220 6800, USA
    J Toxicol Clin Toxicol 35:447-51. 1997
    ..To determine whether the antidote for acetaminophen poisoning, N-acetylcysteine, administered to pregnant women with acetaminophen toxicity, crosses the placenta and can be measured in the newborn circulation following delivery...
  12. ncbi request reprint Efficacy, safety, and use of snake antivenoms in the United States
    R C Dart
    Rocky Mountain Poison and Drug Center, Denver Health Authority, and the Department of Surgery, Medicine and Pharmacy, University of Colorado Health Sciences Center, Denver, CO 80230, USA
    Ann Emerg Med 37:181-8. 2001
    ..Fab fragments enter solution quickly, thereby shortening the time to antivenom administration and are remarkably stable under extreme conditions of heat and handling...
  13. ncbi request reprint Calcium neutralizes fluoride bioavailability in a lethal model of fluoride poisoning
    K Heard
    Rocky Mountain Poison and Drug Center, Denver, Colorado, USA
    J Toxicol Clin Toxicol 39:349-53. 2001
    ..The purpose of this study is to evaluate the effect of calcium and magnesium to decrease the bioavailability of fluoride in a lethal model of fluoride poisoning...
  14. ncbi request reprint A single-arm clinical trial of a 48-hour intravenous N-acetylcysteine protocol for treatment of acetaminophen poisoning
    K Heard
    Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Clin Toxicol (Phila) 52:512-8. 2014
    ..This protocol delivers a higher dose of acetylcysteine which may be useful in selected cases involving very large overdoses. ..
  15. ncbi request reprint A randomized multicenter trial of crotalinae polyvalent immune Fab (ovine) antivenom for the treatment for crotaline snakebite in the United States
    R C Dart
    Rocky Mountain Poison and Drug Center, 1010 Yosemite Cir, Denver, CO 80230, USA
    Arch Intern Med 161:2030-6. 2001
    ..We compared the efficacy and safety of 2 dosing regimens with a new antivenom, Crotalinae polyvalent immune Fab (Fab AV)...
  16. ncbi request reprint Accidental, intravenous infusion of a peanut oil-based medication
    S A Seifert
    Rocky Mountain Poison and Drug Center, Denver, Colorado 80220 6800, USA
    J Toxicol Clin Toxicol 36:733-6. 1998
    ....
  17. ncbi request reprint Tricyclic antidepressants directly depress human myocardial mechanical function independent of effects on the conduction system
    K Heard
    Rocky Mountain Poison and Drug Center, Denver Health Authority, Denver, CO, USA
    Acad Emerg Med 8:1122-7. 2001
    ..To measure the effect of tricyclic antidepressant drugs (TCAs) on human myocardial contractility...
  18. ncbi request reprint Attenuation of verapamil-induced myocardial toxicity in an ex-vivo rat model using a verapamil-specific ovine immunoglobin
    R E Hill
    Rocky Mountain Poison and Drug Center, Denver Health Authority, Denver, CO 80230-6800, USA
    Acad Emerg Med 8:950-5. 2001
    ..9% (SD +/- 8.1) for verapamil alone (p < 0.05). There was no difference between the two control groups. CONCLUSION: Verapamil-specific IgG attenuated verapamil-induced reduction of developed tension in an ex-vivo rat model...
  19. ncbi request reprint Olanzapine overdose mimicking opioid intoxication
    G F O'Malley
    Rocky Mountain Poison and Drug Center, Denver, CO, USA
    Ann Emerg Med 34:279-81. 1999
    ..All 4 patients recovered with supportive care. Olanzapine should be added to opioid and alpha(2)-adrenergic agonist intoxication in the differential diagnosis of the patient with depressed mental status and miosis...
  20. ncbi request reprint Acute myocardial infarction associated with amphetamine use
    J Waksman
    Rocky Mountain Poison and Drug Center, Denver Health Authority, Colo 80230 6800, USA
    Mayo Clin Proc 76:323-6. 2001
    ..However, he subsequently experienced a non-Q-wave anterior wall myocardial infarction associated with the use of amphetamines...
  21. ncbi request reprint Clinical ergotism with lingual ischemia induced by clarithromycin-ergotamine interaction
    R S Horowitz
    Rocky Mountain Poison Center, Denver, Colo, USA
    Arch Intern Med 156:456-8. 1996
    ....