Edward Walsh

Summary

Affiliation: Rochester General Hospital
Country: USA

Publications

  1. ncbi request reprint A simple and reproducible method for collecting nasal secretions in frail elderly adults, for measurement of virus-specific IgA
    E E Walsh
    Division of Infectious Diseases, University of Rochester School of Medicine and Dentistry, Rochester General Hospital, Rochester, NY 14621, USA
    J Infect Dis 179:1268-73. 1999
  2. ncbi request reprint Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, and Department of Medicine, Rochester General Hospital, Rochester, New York, USA
    J Infect Dis 190:373-8. 2004
  3. ncbi request reprint Age related differences in humoral immune response to respiratory syncytial virus infection in adults
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Med Virol 73:295-9. 2004
  4. ncbi request reprint Risk factors for severe respiratory syncytial virus infection in elderly persons
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Infect Dis 189:233-8. 2004
  5. ncbi request reprint Is clinical recognition of respiratory syncytial virus infection in hospitalized elderly and high-risk adults possible?
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
    J Infect Dis 195:1046-51. 2007
  6. pmc Human metapneumovirus infections in adults: another piece of the puzzle
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Arch Intern Med 168:2489-96. 2008
  7. ncbi request reprint Clinical features of influenza A virus infection in older hospitalized persons
    Edward E Walsh
    Division of Infectious Diseases and Department of Medicine, and Department of Biostatistics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
    J Am Geriatr Soc 50:1498-503. 2002
  8. ncbi request reprint Detection of respiratory syncytial virus and human metapneumovirus by reverse transcription polymerase chain reaction in adults with and without respiratory illness
    Ann R Falsey
    Department of Medicine, Infectious Diseases Unit, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
    J Clin Virol 35:46-50. 2006
  9. pmc Humoral immunity to human metapneumovirus infection in adults
    Ann R Falsey
    Department of Medicine, University of Rochester School of Medicine and Dentistry, United States
    Vaccine 28:1477-80. 2010
  10. ncbi request reprint Effect of aging on cytokine production in response to respiratory syncytial virus infection
    Richard J Looney
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 695, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Infect Dis 185:682-5. 2002

Research Grants

  1. Pathogenesis of RSV disease in the Elderly
    Edward Walsh; Fiscal Year: 2007

Collaborators

Detail Information

Publications36

  1. ncbi request reprint A simple and reproducible method for collecting nasal secretions in frail elderly adults, for measurement of virus-specific IgA
    E E Walsh
    Division of Infectious Diseases, University of Rochester School of Medicine and Dentistry, Rochester General Hospital, Rochester, NY 14621, USA
    J Infect Dis 179:1268-73. 1999
    ....
  2. ncbi request reprint Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, and Department of Medicine, Rochester General Hospital, Rochester, New York, USA
    J Infect Dis 190:373-8. 2004
    ..Multivariate analysis found that low RSV-specific nasal IgA was an independently significant risk factor for RSV infection...
  3. ncbi request reprint Age related differences in humoral immune response to respiratory syncytial virus infection in adults
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Med Virol 73:295-9. 2004
    ..The relationship of immune response to disease pathogenesis in older persons deserves further study...
  4. ncbi request reprint Risk factors for severe respiratory syncytial virus infection in elderly persons
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    J Infect Dis 189:233-8. 2004
    ..quot; These data suggest that the induction of neutralizing serum antibody with an RSV vaccine may potentially reduce disease severity in adult populations...
  5. ncbi request reprint Is clinical recognition of respiratory syncytial virus infection in hospitalized elderly and high-risk adults possible?
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
    J Infect Dis 195:1046-51. 2007
    ..The clinical and radiographic features of respiratory syncytial virus (RSV) infection in elderly hospitalized persons have not been described in detail, to our knowledge, despite its relative frequent occurrence...
  6. pmc Human metapneumovirus infections in adults: another piece of the puzzle
    Edward E Walsh
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Arch Intern Med 168:2489-96. 2008
    ..We describe the incidence and clinical impact of human metapneumovirus (HMPV), a newly identified virus, in adults...
  7. ncbi request reprint Clinical features of influenza A virus infection in older hospitalized persons
    Edward E Walsh
    Division of Infectious Diseases and Department of Medicine, and Department of Biostatistics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
    J Am Geriatr Soc 50:1498-503. 2002
    ..To determine the value of clinical parameters in predicting influenza in older persons and those with underlying cardiopulmonary conditions hospitalized with respiratory illnesses...
  8. ncbi request reprint Detection of respiratory syncytial virus and human metapneumovirus by reverse transcription polymerase chain reaction in adults with and without respiratory illness
    Ann R Falsey
    Department of Medicine, Infectious Diseases Unit, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
    J Clin Virol 35:46-50. 2006
    ..Respiratory syncytial virus (RSV) and human metapneumovirus (hMPV) are two viruses for which RT-PCR is now frequently used for diagnosis in adult disease...
  9. pmc Humoral immunity to human metapneumovirus infection in adults
    Ann R Falsey
    Department of Medicine, University of Rochester School of Medicine and Dentistry, United States
    Vaccine 28:1477-80. 2010
    ..Serum antibody may play a role in protection from hMPV infection supporting the development of an hMPV vaccine that stimulates humoral immunity...
  10. ncbi request reprint Effect of aging on cytokine production in response to respiratory syncytial virus infection
    Richard J Looney
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 695, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Infect Dis 185:682-5. 2002
    ..This defect in cellular immunity may be related to the increased morbidity observed with RSV infection in elderly persons...
  11. ncbi request reprint Serum antibody decay in adults following natural respiratory syncytial virus infection
    Ann R Falsey
    Department of Medicine at Rochester General Hospital, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
    J Med Virol 78:1493-7. 2006
    ..In contrast, titers of uninfected subjects were relatively stable. The partial immunity resulting from a boost in serum antibody following natural RSV infection in adults appears to be short lived...
  12. ncbi request reprint Impact of rapid diagnosis on management of adults hospitalized with influenza
    Ann R Falsey
    Departments of Medicine, Rochester General Hospital and University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
    Arch Intern Med 167:354-60. 2007
    ..We compared the clinical management of patients with influenza whose rapid antigen test result was positive (Ag+) with the management of those whose rapid antigen test result was negative or the test was not performed (Ag0)...
  13. ncbi request reprint Pulmonary complications of interpandemic influenza A in hospitalized adults
    Yoshihiko Murata
    Department of Medicine, University of Rochester School of Medicine and Dentistry and Infectious Diseases Unit, Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    J Infect Dis 195:1029-37. 2007
    ....
  14. pmc Risk factors for respiratory failure associated with respiratory syncytial virus infection in adults
    Coley B Duncan
    Department of Medicine, Rochester General Hospital, Rochester, New York 14621 3001, USA
    J Infect Dis 200:1242-6. 2009
    ..7 +/- 1.7 plaque-forming units (PFUs)/mL vs 2.4 +/- 1.1 PFUs/mL, P = .02), and high viral load was independently associated with respiratory failure...
  15. pmc Humoral response to the central unglycosylated region of the respiratory syncytial virus attachment protein
    Yoshihiko Murata
    Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry and Infectious Diseases Unit, Rochester General Hospital, 601 Elmwood Avenue Box 689, Rochester, NY 14642, USA Yoshihiko
    Vaccine 28:6242-6. 2010
    ..Our results have implications for RSV G-based serological diagnostics and vaccine development...
  16. doi request reprint Comparison of the safety and immunogenicity of 2 respiratory syncytial virus (rsv) vaccines--nonadjuvanted vaccine or vaccine adjuvanted with alum--given concomitantly with influenza vaccine to high-risk elderly individuals
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, and University of Rochester School of Medicine, Rochester, NY 14621, USA
    J Infect Dis 198:1317-26. 2008
    ..Respiratory syncytial virus (RSV) has been recognized recently as an important adult pathogen...
  17. ncbi request reprint Viral pneumonia in older adults
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    Clin Infect Dis 42:518-24. 2006
    ..Because clinical features and periods of activity for many viruses overlap, laboratory confirmation of influenza is recommended for cases involving seriously ill or institutionalized patients...
  18. pmc Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary disease
    Ann R Falsey
    Infectious Diseases Unit, Department of Medicine, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
    Am J Respir Crit Care Med 173:639-43. 2006
    ..These data raise the possibility of persistent low-grade infection in this population, which could have implications in COPD pathogenesis...
  19. pmc Circulating antibody-secreting cells during acute respiratory syncytial virus infection in adults
    F Eun Hyung Lee
    Division of Pulmonary and Critical Care Medicine, University of Rochester and Rochester General Hospital, Rochester, New York, USA
    J Infect Dis 202:1659-66. 2010
    ..The specificity and duration of circulating human antibody-secreting cells (ASCs) after vaccination have been well described, but characteristics of ASCs during acute respiratory infections have not been well studied...
  20. pmc Diagnosis of respiratory syncytial virus infection: comparison of reverse transcription-PCR to viral culture and serology in adults with respiratory illness
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
    J Clin Microbiol 40:817-20. 2002
    ..The overall RT-PCR sensitivity was 73%, and specificity was 99%. These data indicate that RT-PCR is an excellent method for the diagnosis of acute RSV infection in adults...
  21. ncbi request reprint Rhinovirus and coronavirus infection-associated hospitalizations among older adults
    Ann R Falsey
    Division of Infectious Diseases and Department of Medicine, University of Rochester School of Medicine and Dentistry, and Rochester General Hospital, Rochester, New York 14621, USA
    J Infect Dis 185:1338-41. 2002
    ..These data suggest that rhinoviruses and coronaviruses may be associated with serious respiratory illnesses in frail older adults...
  22. ncbi request reprint Human metapneumovirus infections in young and elderly adults
    Ann R Falsey
    Infectious Diseases Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, 1425 Portland Avenue, Rochester, NY 14621, USA
    J Infect Dis 187:785-90. 2003
    ..In conclusion, hMPV infection occurs in adults of all ages and may account for a significant portion of persons hospitalized with respiratory infections during some years...
  23. ncbi request reprint Novel coronavirus and severe acute respiratory syndrome
    Ann R Falsey
    Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Lancet 361:1312-3. 2003
  24. ncbi request reprint Lack of sensitivity of rapid antigen tests for the diagnosis of respiratory syncytial virus infection in adults
    Aida E Casiano-Colón
    ViaHealth Clinical Laboratories and Pathology, Rochester, NY, USA
    J Clin Virol 28:169-74. 2003
    ..DFA detected 14 (23%), VIDAS detected 12 (20%) and BD detected only 6 (10%) of the RSV infected persons. Rapid antigen detection tests for the diagnosis of RSV respiratory illness in adults are of limited value...
  25. pmc Comparison of quantitative reverse transcription-PCR to viral culture for assessment of respiratory syncytial virus shedding
    Ann R Falsey
    Department of Medicine Infectious Disease Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
    J Clin Microbiol 41:4160-5. 2003
    ..Quantitative RT-PCR has an excellent correlation with viral titers, as measured by culture, and should be a useful tool for future studies addressing viral load and disease pathogenesis...
  26. ncbi request reprint Respiratory syncytial virus infection in elderly and high-risk adults
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
    N Engl J Med 352:1749-59. 2005
    ..Data on the epidemiology and clinical effects in community-dwelling elderly persons and high-risk adults can help in assessing the need for vaccine development...
  27. ncbi request reprint Respiratory syncytial virus infection in elderly adults
    Ann R Falsey
    Department of Medicine, University of Rochester School of Medicine and Dentistry, and Rochester General Hospital, Rochester, New York, USA
    Drugs Aging 22:577-87. 2005
    ..An effective RSV vaccine has not yet been developed. Therefore, prevention of RSV is limited to standard infection control practices, such as hand washing and the use of gowns and gloves...
  28. pmc Microneutralization assay for the measurement of neutralizing antibodies to human metapneumovirus
    Ann R Falsey
    Department of Medicine, Rochester General Hospital, Rochester, NY 14621 3001, USA
    J Clin Virol 46:314-7. 2009
    ..Human metapneumovirus (hMPV) is a newly discovered virus which causes respiratory illness in persons of all ages...
  29. ncbi request reprint Human infant respiratory syncytial virus (RSV)-specific type 1 and 2 cytokine responses ex vivo during primary RSV infection
    F Eun Hyung Lee
    David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Infect Dis 195:1779-88. 2007
    ..Illness severity is likely multifactorial; however, unlike other viral infections, both type 1 and type 2 cytokine responses have been implicated in severe disease...
  30. ncbi request reprint Experimental infection of humans with A2 respiratory syncytial virus
    F Eun Hyung Lee
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 689, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Antiviral Res 63:191-6. 2004
    ..This model provides a safe and efficient mechanism for proof-of-concept studies of anti-viral agents and RSV vaccines, as well as for investigation of immune responses to infection...
  31. pmc Antigenic presentation of heterologous epitopes engineered into the outer surface-exposed helix 4 loop region of human papillomavirus L1 capsomeres
    Yoshihiko Murata
    Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Virol J 6:81. 2009
    ..We sought to utilize HPV L1 capsomeres as a vaccine platform by engineering heterologous epitopes within L1 derivatives deleted for h4 domain...
  32. pmc Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunization
    Jessica L Halliley
    Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Vaccine 28:3582-7. 2010
    ..The kinetics of this response and the relationship of circulating ASCs to protective antibody titers have not been completely explored...
  33. pmc Identification of and human serum reactogenicity to neutralizing epitopes within the central unglycosylated region of the respiratory syncytial virus attachment protein
    Yoshihiko Murata
    Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA
    Clin Vaccine Immunol 17:695-7. 2010
    ..In approximately 40% of hospitalized and outpatient adults infected with RSV subtype A, these contiguous residues are the target of > or =4-fold increases in IgG response between acute- and convalescent-phase sera...
  34. ncbi request reprint The balance between influenza- and RSV-specific CD4 T cells secreting IL-10 or IFNgamma in young and healthy-elderly subjects
    F Eun Hyung Lee
    David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
    Mech Ageing Dev 126:1223-9. 2005
    ..A similar trend was seen for influenza. IFNgamma-secreting CD4 T cells contributed significantly more to anti-RSV than anti-influenza responses in both groups...
  35. ncbi request reprint Influenza: evolving strategies in treatment and prevention
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, and Hospitalists, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 28:144-58. 2007
    ..e., the elderly or patients with comorbidities), and expanding the use of vaccines to healthy children and adults reduces the incidence of influenza, pneumonia, and hospitalizations due to respiratory illnesses in the community...
  36. pmc Serosurvey of human metapneumovirus infection in Croatia
    Suncanica Ljubin Sternak
    Virology Department, Croatian, National Institute of Public Health, Zagreb, Croatia
    Croat Med J 47:878-81. 2006
    ..To assess the seroprevalence of human metapneumovirus (hMPV) in Croatia...

Research Grants6

  1. Pathogenesis of RSV disease in the Elderly
    Edward Walsh; Fiscal Year: 2007
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