Research Topics
Species | A R FalseySummaryAffiliation: Rochester General Hospital Country: USA Publications
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Publications
Detection of respiratory syncytial virus and human metapneumovirus by reverse transcription polymerase chain reaction in adults with and without respiratory illnessAnn R Falsey
Department of Medicine, Infectious Diseases Unit, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
J Clin Virol 35:46-50. 2006..No subject had a positive swab on days 14, 21 or 28. CONCLUSION: Asymptomatic carriage of RSV or hMPV is uncommon. RT-PCR should be a useful method for the diagnosis of these viral illnesses in adults...- Response of C-reactive protein and serum amyloid A to influenza A infection in older adultsA R Falsey
Department of Medicine, Rochester General Hospital, and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
J Infect Dis 183:995-9. 2001..It is possible that direct effects of CRP may exacerbate preexisting atherosclerotic lesions and may help explain cardiovascular events associated with acute influenza... - Novel coronavirus and severe acute respiratory syndromeAnn R Falsey
Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Lancet 361:1312-3. 2003 - Impact of rapid diagnosis on management of adults hospitalized with influenzaAnn R Falsey
Departments of Medicine, Rochester General Hospital and University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
Arch Intern Med 167:354-60. 2007..We compared the clinical management of patients with influenza whose rapid antigen test result was positive (Ag+) with the management of those whose rapid antigen test result was negative or the test was not performed (Ag0)... 
Comparison of the safety and immunogenicity of 2 respiratory syncytial virus (rsv) vaccines--nonadjuvanted vaccine or vaccine adjuvanted with alum--given concomitantly with influenza vaccine to high-risk elderly individualsAnn R Falsey
Department of Medicine, Rochester General Hospital, and University of Rochester School of Medicine, Rochester, NY 14621, USA
J Infect Dis 198:1317-26. 2008..Respiratory syncytial virus (RSV) has been recognized recently as an important adult pathogen...
Comparison of quantitative reverse transcription-PCR to viral culture for assessment of respiratory syncytial virus sheddingAnn R Falsey
Department of Medicine Infectious Disease Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
J Clin Microbiol 41:4160-5. 2003..Quantitative RT-PCR has an excellent correlation with viral titers, as measured by culture, and should be a useful tool for future studies addressing viral load and disease pathogenesis...- Human metapneumovirus infection in adultsAnn R Falsey
Department of Medicine, University of Rochester School of Medicine and Dentistry, and the Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
Pediatr Infect Dis J 27:S80-3. 2008..Although the true spectrum of adult hMPV remains to be defined, it is clear that hMPV can result in severe illness the frail elderly and adults with underlying diseases... - Detection of respiratory syncytial virus in adults with chronic obstructive pulmonary diseaseAnn R Falsey
Infectious Diseases Unit, Department of Medicine, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
Am J Respir Crit Care Med 173:639-43. 2006..These data raise the possibility of persistent low-grade infection in this population, which could have implications in COPD pathogenesis... - Long-term care facilities: a cornucopia of viral pathogensAnn R Falsey
Department of Medicine, Rochester General Hospital, Rochester, New York 14621, USA
J Am Geriatr Soc 56:1281-5. 2008..To determine the frequency and types of respiratory viruses circulating in Boston long-term care facilities (LTCFs) during a 3-year period... - Respiratory syncytial virus infection in elderly and high-risk adultsAnn R Falsey
Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
N Engl J Med 352:1749-59. 2005..Data on the epidemiology and clinical effects in community-dwelling elderly persons and high-risk adults can help in assessing the need for vaccine development... - Respiratory syncytial virus infection in elderly adultsAnn R Falsey
Department of Medicine, University of Rochester School of Medicine and Dentistry, and Rochester General Hospital, Rochester, New York, USA
Drugs Aging 22:577-87. 2005..An effective RSV vaccine has not yet been developed. Therefore, prevention of RSV is limited to standard infection control practices, such as hand washing and the use of gowns and gloves... - Community-acquired viral pneumoniaAnn R Falsey
Division of Infectious Diseases, Department of Medicine at Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA
Clin Geriatr Med 23:535-52, vi. 2007..Antiviral therapy is available for influenza A and B; specific viral diagnosis, particularly with the use of rapid antigen detection, may be useful for clinical management. Treatment for other viruses primarily is supportive... - Respiratory syncytial virus infection in adultsAnn R Falsey
Department of Medicine, Infectious Diseases Unit, Rochester General Hospital, Rochester, New York 14621, USA
Semin Respir Crit Care Med 28:171-81. 2007..Infection control measures are critical to limit spread of RSV. Currently, RSV vaccines are not available, but candidate vaccines are being developed... - Viral pneumonia in older adultsAnn R Falsey
Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
Clin Infect Dis 42:518-24. 2006..Because clinical features and periods of activity for many viruses overlap, laboratory confirmation of influenza is recommended for cases involving seriously ill or institutionalized patients... - Serum antibody decay in adults following natural respiratory syncytial virus infectionAnn R Falsey
Department of Medicine at Rochester General Hospital, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
J Med Virol 78:1493-7. 2006..In contrast, titers of uninfected subjects were relatively stable. The partial immunity resulting from a boost in serum antibody following natural RSV infection in adults appears to be short lived... - Human metapneumovirus infections in young and elderly adultsAnn R Falsey
Infectious Diseases Unit, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, 1425 Portland Avenue, Rochester, NY 14621, USA
J Infect Dis 187:785-90. 2003..In conclusion, hMPV infection occurs in adults of all ages and may account for a significant portion of persons hospitalized with respiratory infections during some years... - Respiratory syncytial virus infection in adultsA R Falsey
Rochester General Hospital and University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
Clin Microbiol Rev 13:371-84. 2000..An effective RSV vaccine has not yet been developed, and thus prevention of RSV infection is limited to standard infection control practices such as hand washing and the use of gowns and gloves... - Randomized, double-blind controlled phase 3 trial comparing the immunogenicity of high-dose and standard-dose influenza vaccine in adults 65 years of age and olderAnn R Falsey
Department of Medicine, Rochester General Hospital, Rochester, NY, USA
J Infect Dis 200:172-80. 2009..To improve the immunogenicity of influenza vaccine, a high-dose (HD) trivalent, inactivated influenza vaccine was developed... - Rhinovirus and coronavirus infection-associated hospitalizations among older adultsAnn R Falsey
Division of Infectious Diseases and Department of Medicine, University of Rochester School of Medicine and Dentistry, and Rochester General Hospital, Rochester, New York 14621, USA
J Infect Dis 185:1338-41. 2002..These data suggest that rhinoviruses and coronaviruses may be associated with serious respiratory illnesses in frail older adults... - Diagnosis of respiratory syncytial virus infection: comparison of reverse transcription-PCR to viral culture and serology in adults with respiratory illnessAnn R Falsey
Department of Medicine, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
J Clin Microbiol 40:817-20. 2002..The overall RT-PCR sensitivity was 73%, and specificity was 99%. These data indicate that RT-PCR is an excellent method for the diagnosis of acute RSV infection in adults... - Comparison of respiratory syncytial virus humoral immunity and response to infection in young and elderly adultsA R Falsey
Department of Medicine, Rochester General Hospital, Rochester, New York 14621, USA
J Med Virol 59:221-6. 1999..These data suggest that the severe clinical manifestations of RSV in the elderly are not due to a significant defect in humoral immunity... - Prothrombotic changes in hemostatic parameters and C-reactive protein in the elderly with winter acute respiratory tract infectionsJ T Horan
Department of Medicine, University of Rochester School of Medicine and Dentistry, NY, USA
Thromb Haemost 85:245-9. 2001..The associated increase in fibrinogen, an independent risk factor for ischemic heart disease, may be partly responsible for the excess winter vascular mortality... - Relationship of serum antibody to risk of respiratory syncytial virus infection in elderly adultsA R Falsey
Department of Medicine, University of Rochester School of Medicine and Dentistry and Rochester General Hospital, New York 14621, USA
J Infect Dis 177:463-6. 1998..1 +/- 2.1, vs. 10.3 +/- 1.5, P = .01). These results suggest that older adults with low titers of serum neutralizing antibody may be at greater risk of developing symptomatic RSV infection than those who have high antibody titers... - A simple and reproducible method for collecting nasal secretions in frail elderly adults, for measurement of virus-specific IgAE E Walsh
Division of Infectious Diseases, University of Rochester School of Medicine and Dentistry, Rochester General Hospital, Rochester, NY 14621, USA
J Infect Dis 179:1268-73. 1999.... - Reverse transcription polymerase chain reaction (RT-PCR) for diagnosis of respiratory syncytial virus infection in adults: use of a single-tube "hanging droplet" nested PCRE E Walsh
Department of Medicine, Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
J Med Virol 63:259-63. 2001..Use of a nested RT-PCR significantly improves the ability to detect RSV in respiratory samples and should improve the ability to rapidly diagnose RSV infection in adults, especially in the elderly... - Monoclonal antibody neutralization escape mutants of respiratory syncytial virus with unique alterations in the attachment (G) proteinE E Walsh
University of Rochester School of Medicine and Dentistry and Rochester General Hospital, New York 14621, USA
J Gen Virol 79:479-87. 1998..The predominant form of G produced by RSV-3 was found in infected cell supernatants, consistent with the size of secreted G... - Risk factors for respiratory failure associated with respiratory syncytial virus infection in adultsColey B Duncan
Department of Medicine, Rochester General Hospital, Rochester, New York 14621 3001, USA
J Infect Dis 200:1242-6. 2009..7 +/- 1.7 plaque-forming units (PFUs)/mL vs 2.4 +/- 1.1 PFUs/mL, P = .02), and high viral load was independently associated with respiratory failure... - Humoral immunity to human metapneumovirus infection in adultsAnn R Falsey
Department of Medicine, University of Rochester School of Medicine and Dentistry, United States
Vaccine 28:1477-80. 2010..Serum antibody may play a role in protection from hMPV infection supporting the development of an hMPV vaccine that stimulates humoral immunity... - Protein S declines during winter respiratory infectionsN K Kaba
University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Thromb Haemost 1:729-34. 2003.... - Respiratory syncytial virus infection in adultsYoshihiko Murata
Infectious Diseases Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester General Hospital, New York, USA
Antivir Ther 12:659-70. 2007..Vaccines against RSV remain an unachieved goal. Promising new agents that inhibit the virus-cell fusion, cell-cell fusion, or viral gene expression are currently in development... - Is clinical recognition of respiratory syncytial virus infection in hospitalized elderly and high-risk adults possible?Edward E Walsh
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA
J Infect Dis 195:1046-51. 2007..The clinical and radiographic features of respiratory syncytial virus (RSV) infection in elderly hospitalized persons have not been described in detail, to our knowledge, despite its relative frequent occurrence... - Humoral response to the central unglycosylated region of the respiratory syncytial virus attachment proteinYoshihiko Murata
Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry and Infectious Diseases Unit, Rochester General Hospital, 601 Elmwood Avenue Box 689, Rochester, NY 14642, USA Yoshihiko
Vaccine 28:6242-6. 2010..Our results have implications for RSV G-based serological diagnostics and vaccine development... - Circulating antibody-secreting cells during acute respiratory syncytial virus infection in adultsF Eun Hyung Lee
Division of Pulmonary and Critical Care Medicine, University of Rochester and Rochester General Hospital, Rochester, New York, USA
J Infect Dis 202:1659-66. 2010..The specificity and duration of circulating human antibody-secreting cells (ASCs) after vaccination have been well described, but characteristics of ASCs during acute respiratory infections have not been well studied... - Pulmonary complications of interpandemic influenza A in hospitalized adultsYoshihiko Murata
Department of Medicine, University of Rochester School of Medicine and Dentistry and Infectious Diseases Unit, Department of Medicine, Rochester General Hospital, Rochester, NY 14621, USA
J Infect Dis 195:1029-37. 2007.... - Human metapneumovirus infections in adults: another piece of the puzzleEdward E Walsh
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Arch Intern Med 168:2489-96. 2008..We describe the incidence and clinical impact of human metapneumovirus (HMPV), a newly identified virus, in adults... - Antivirals for influenza: what is their role in the older patient?Ghinwa Dumyati
Rochester General Hospital, University of Rochester School of Medicine and Dentistry, Rochester, New York 14261, USA
Drugs Aging 19:777-86. 2002..However, they are costly. Early identification and diagnosis of influenza illnesses are crucial since treatment with antiviral agents should be started within 48 hours of the beginning of illness... - Clinical features of influenza A virus infection in older hospitalized personsEdward E Walsh
Division of Infectious Diseases and Department of Medicine, and Department of Biostatistics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, USA
J Am Geriatr Soc 50:1498-503. 2002..To determine the value of clinical parameters in predicting influenza in older persons and those with underlying cardiopulmonary conditions hospitalized with respiratory illnesses... - Lack of sensitivity of rapid antigen tests for the diagnosis of respiratory syncytial virus infection in adultsAida E Casiano-Colón
ViaHealth Clinical Laboratories and Pathology, Rochester, NY, USA
J Clin Virol 28:169-74. 2003..DFA detected 14 (23%), VIDAS detected 12 (20%) and BD detected only 6 (10%) of the RSV infected persons. Rapid antigen detection tests for the diagnosis of RSV respiratory illness in adults are of limited value... - Risk factors for severe respiratory syncytial virus infection in elderly personsEdward E Walsh
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
J Infect Dis 189:233-8. 2004..quot; These data suggest that the induction of neutralizing serum antibody with an RSV vaccine may potentially reduce disease severity in adult populations... - Age related differences in humoral immune response to respiratory syncytial virus infection in adultsEdward E Walsh
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
J Med Virol 73:295-9. 2004..The relationship of immune response to disease pathogenesis in older persons deserves further study... - Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adultsEdward E Walsh
Department of Medicine, University of Rochester School of Medicine and Dentistry, and Department of Medicine, Rochester General Hospital, Rochester, New York, USA
J Infect Dis 190:373-8. 2004..Multivariate analysis found that low RSV-specific nasal IgA was an independently significant risk factor for RSV infection... - Respiratory syncytial virus infection in elderly and high-risk adultsA R Falsey
General Hospital, Rochester, NY, USA
Exp Lung Res 31:77. 2005 - Respiratory syncytial virus infection in older personsA R Falsey
Department of Medicine, Rochester General Hospital, NY 14621, USA
Vaccine 16:1775-8. 1998..PFP-2, a candidate RSV subunit vaccine, has been evaluated in healthy and institutionalized elderly and been found to be safe and immunogenic... - Hepatitis B immunization of healthy elderly adults: relationship between naïve CD4+ T cells and primary immune response and evaluation of GM-CSF as an adjuvantR J Looney
Department of Medicine, University of Rochester School of Medicine and Dentistry, New York, USA
J Clin Immunol 21:30-6. 2001..73 due to the increase in age but only 0.40 due to the decrease in naive CD4 T cells. Thus, there was a large effect of age that could not be explained by the quantitative change in the naïve T-helper cells... - Experimental infection of humans with A2 respiratory syncytial virusF Eun-Hyung Lee
Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 689, 601 Elmwood Avenue, Rochester, NY 14642, USA
Antiviral Res 63:191-6. 2004..This model provides a safe and efficient mechanism for proof-of-concept studies of anti-viral agents and RSV vaccines, as well as for investigation of immune responses to infection... - Human infant respiratory syncytial virus (RSV)-specific type 1 and 2 cytokine responses ex vivo during primary RSV infectionF Eun Hyung Lee
David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
J Infect Dis 195:1779-88. 2007..Illness severity is likely multifactorial; however, unlike other viral infections, both type 1 and type 2 cytokine responses have been implicated in severe disease... - Microneutralization assay for the measurement of neutralizing antibodies to human metapneumovirusAnn R Falsey
Department of Medicine, Rochester General Hospital, Rochester, NY 14621 3001, USA
J Clin Virol 46:314-7. 2009..Human metapneumovirus (hMPV) is a newly discovered virus which causes respiratory illness in persons of all ages... - Effect of aging on cytokine production in response to respiratory syncytial virus infectionRichard J Looney
Department of Medicine, University of Rochester School of Medicine and Dentistry, Box 695, 601 Elmwood Avenue, Rochester, NY 14642, USA
J Infect Dis 185:682-5. 2002..This defect in cellular immunity may be related to the increased morbidity observed with RSV infection in elderly persons... - Identification of and human serum reactogenicity to neutralizing epitopes within the central unglycosylated region of the respiratory syncytial virus attachment proteinYoshihiko Murata
Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA
Clin Vaccine Immunol 17:695-7. 2010..In approximately 40% of hospitalized and outpatient adults infected with RSV subtype A, these contiguous residues are the target of > or =4-fold increases in IgG response between acute- and convalescent-phase sera... - Peak frequencies of circulating human influenza-specific antibody secreting cells correlate with serum antibody response after immunizationJessica L Halliley
Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Vaccine 28:3582-7. 2010..The kinetics of this response and the relationship of circulating ASCs to protective antibody titers have not been completely explored... - Clinical and immunologic predictors of influenza illness among vaccinated older adultsZainab Shahid
Division of Infectious Diseases, Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
Vaccine 28:6145-51. 2010..ILI subjects (p=0.03). The cell-mediated immune response to influenza distinguishes A/H3N2 LCI from other ILI in older adults, and suggests a link between cell-mediated immunity and influenza illness severity in vaccinated older adults... - The balance between influenza- and RSV-specific CD4 T cells secreting IL-10 or IFNgamma in young and healthy-elderly subjectsF Eun Hyung Lee
David H Smith Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
Mech Ageing Dev 126:1223-9. 2005..A similar trend was seen for influenza. IFNgamma-secreting CD4 T cells contributed significantly more to anti-RSV than anti-influenza responses in both groups... - The diagnosis of viral respiratory disease in older adultsH Keipp Talbot
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Clin Infect Dis 50:747-51. 2010.... - New emerging technologies and the intradermal route: the novel way to immunize against influenzaAnn R Falsey
Rochester General Hospital, NY 14621, USA
Vaccine 28:D24-32. 2010..In addition, these methods of delivery may increase acceptability in children and persons with needle phobias, thus addressing some of the present barriers to influenza immunization... - RSV 2007: recent advances in respiratory syncytial virus researchWhitney W Stevens
The Carter Immunology Center, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA
Viral Immunol 21:133-40. 2008..Additionally, there were two posters sessions displaying more than one hundred abstracts. The following summary provides a review of the proceedings from each session... - Detection of genetic lineages of human metapneumovirus in Croatia during the winter season 2005/2006Suncanica Ljubin-Sternak
Department of Virology, Collaborating Centre WHO for Virology, Croatian National Institute of Public Health, Zagreb, Croatia
J Med Virol 80:1282-7. 2008..It also showed the existence of two sublineages within the group B (B1 and B2) and three subclusters within lineage A (A1, A2a and A2b). Further molecular analysis revealed point mutations in HMPV strains of sublineage B1... - Respiratory syncytial virus and other pneumoviruses: a review of the international symposium--RSV 2003Alexander C Schmidt
Department of Pediatric Pulmonology and Immunology, Charite University Hospital, Berlin, Germany
Virus Res 106:1-13. 2004..Chanock Award for lifetime achievement in RSV research, an award named in honor of the person who started the field of RSV research by recovering the first human RS virus from infants with severe bronchiolitis in 1956... - Serosurvey of human metapneumovirus infection in CroatiaSuncanica Ljubin Sternak
Virology Department, Croatian, National Institute of Public Health, Zagreb, Croatia
Croat Med J 47:878-81. 2006..To assess the seroprevalence of human metapneumovirus (hMPV) in Croatia...
Research Grants
- Sixth International Respiratory Syncytial Virus SymposiumANN FALSEY; Fiscal Year: 2007..abstract_text> ..