DAVID A BORKHOLDER

Summary

Affiliation: Rochester Institute of Technology
Country: USA

Publications

  1. doi request reprint Round window membrane intracochlear drug delivery enhanced by induced advection
    DAVID A BORKHOLDER
    Department of Electrical and Microelectronic Engineering, Rochester Institute of Technology, Rochester 14623, USA Department of Microsystems Engineering, Rochester Institute of Technology, Rochester 14623, USA Department of Otolaryngology, University of Rochester Medical School, Rochester 14642, USA Department of Biomedical Engineering, University of Rochester Medical School, Rochester 14642, USA Electronic address
    J Control Release 174:171-6. 2014
  2. doi request reprint State-of-the-art mechanisms of intracochlear drug delivery
    DAVID A BORKHOLDER
    Department of Electrical Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA
    Curr Opin Otolaryngol Head Neck Surg 16:472-7. 2008
  3. pmc Murine intracochlear drug delivery: reducing concentration gradients within the cochlea
    DAVID A BORKHOLDER
    Department of Electrical and Microelectronic Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA
    Hear Res 268:2-11. 2010
  4. doi request reprint Noninvasive technique for monitoring drug transport through the murine cochlea using micro-computed tomography
    Masoumeh Haghpanahi
    Department of Electrical and Microelectronic Engineering, Rochester Institute of Technology, 79 Lomb Memorial Drive, Rochester, NY 14623, USA
    Ann Biomed Eng 41:2130-42. 2013
  5. ncbi request reprint Micro-molded cannulae for intracochlear infusions in small rodents
    Dean G Johnson
    Rochester Institute of Technology, Rochester, NY, 14623 USA
    Conf Proc IEEE Eng Med Biol Soc 2007:6617-20. 2007
  6. pmc In-plane biocompatible microfluidic interconnects for implantable microsystems
    Dean G Johnson
    Rochester Institute of Technology, Rochester, NY 14623, USA
    IEEE Trans Biomed Eng 58:943-8. 2011

Research Grants

Collaborators

  • Dean G Johnson
  • Masoumeh Haghpanahi
  • Robert D Frisina
  • Xiaoxia Zhu
  • Miriam B Gladstone

Detail Information

Publications6

  1. doi request reprint Round window membrane intracochlear drug delivery enhanced by induced advection
    DAVID A BORKHOLDER
    Department of Electrical and Microelectronic Engineering, Rochester Institute of Technology, Rochester 14623, USA Department of Microsystems Engineering, Rochester Institute of Technology, Rochester 14623, USA Department of Otolaryngology, University of Rochester Medical School, Rochester 14642, USA Department of Biomedical Engineering, University of Rochester Medical School, Rochester 14642, USA Electronic address
    J Control Release 174:171-6. 2014
    ..The B+C approach had more drug efficacy at lower frequencies, underscoring potential benefits for more precise control of delivery of inner ear therapeutic compounds. ..
  2. doi request reprint State-of-the-art mechanisms of intracochlear drug delivery
    DAVID A BORKHOLDER
    Department of Electrical Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA
    Curr Opin Otolaryngol Head Neck Surg 16:472-7. 2008
    ..This review examines recent developments in the field relevant to both clinical and animal research environments...
  3. pmc Murine intracochlear drug delivery: reducing concentration gradients within the cochlea
    DAVID A BORKHOLDER
    Department of Electrical and Microelectronic Engineering, Rochester Institute of Technology, Rochester, NY 14623, USA
    Hear Res 268:2-11. 2010
    ..Both the C+C approach and a flow rate increase were found to provide enhanced response for lower frequencies, with evidence suggesting the C+C approach reduces concentration gradients within the cochlea...
  4. doi request reprint Noninvasive technique for monitoring drug transport through the murine cochlea using micro-computed tomography
    Masoumeh Haghpanahi
    Department of Electrical and Microelectronic Engineering, Rochester Institute of Technology, 79 Lomb Memorial Drive, Rochester, NY 14623, USA
    Ann Biomed Eng 41:2130-42. 2013
    ..This may permit determination of spatially dependent diffusion and clearance parameters for enhanced models. ..
  5. ncbi request reprint Micro-molded cannulae for intracochlear infusions in small rodents
    Dean G Johnson
    Rochester Institute of Technology, Rochester, NY, 14623 USA
    Conf Proc IEEE Eng Med Biol Soc 2007:6617-20. 2007
    ..Histological evaluation revealed the cannula to be located correctly within the basal portion of scala tympani...
  6. pmc In-plane biocompatible microfluidic interconnects for implantable microsystems
    Dean G Johnson
    Rochester Institute of Technology, Rochester, NY 14623, USA
    IEEE Trans Biomed Eng 58:943-8. 2011
    ..9 N. Each interconnect consumes less than 0.018 mm3 (18 nL) of volume. The low added volume makes this an ideal interconnect technology for medical applications where implant volume is critical...

Research Grants2

  1. Improved Micro-Technologies for Inner Ear Drug Delivery
    DAVID BORKHOLDER; Fiscal Year: 2007
    ..The proposed research will provide information, tools, and new capabilities critical for the advancement of intra-cochlear gene-based therapy research. ..