- Dominant effector genetics in mammalian cellsX Xu
Rigel, Inc, San Francisco, California, USA
Nat Genet 27:23-9. 2001..Our data indicate that trans-dominant effector peptides can point to potential mechanisms by which signaling systems operate. Such tools may be useful in functional genomic analysis of signaling pathways in mammalian disease processes...
- Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaBP W Yu
Rigel, Inc 240 East Grand Ave, South San Francisco, California 94080, USA
Curr Biol 9:539-42. 1999..Overexpression of a dominant-negative mutant of RIP3 strongly inhibited the caspase activation but not the NFkappaB activation induced by TNFalpha. Therefore, RIP3 appears to function as an intermediary in TNFalpha-induced apoptosis...