J L West

Summary

Affiliation: Rice University
Country: USA

Publications

  1. ncbi request reprint Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeutics
    Jennifer L West
    Department of Bioengineering Rice University, Houston, Texas 77005 1892, USA
    Annu Rev Biomed Eng 5:285-92. 2003
  2. ncbi request reprint Proteolytically degradable hydrogels with a fluorogenic substrate for studies of cellular proteolytic activity and migration
    Soo Hong Lee
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, Texas 77251 1892, USA
    Biotechnol Prog 21:1736-41. 2005
  3. ncbi request reprint Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells
    Christie M Sayes
    Department of Chemistry, Rice University, Houston, TX, USA
    Toxicol Sci 92:174-85. 2006
  4. ncbi request reprint Synthetic biomimetic hydrogels incorporated with ephrin-A1 for therapeutic angiogenesis
    James J Moon
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, Texas 77251 1892, USA
    Biomacromolecules 8:42-9. 2007
  5. pmc Immunonanoshells for targeted photothermal ablation of tumor cells
    Amanda R Lowery
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Int J Nanomedicine 1:149-54. 2006
  6. pmc EphrinA I-targeted nanoshells for photothermal ablation of prostate cancer cells
    Andre M Gobin
    Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
    Int J Nanomedicine 3:351-8. 2008
  7. pmc Antibody-conjugated gold-gold sulfide nanoparticles as multifunctional agents for imaging and therapy of breast cancer
    Emily S Day
    Department of Bioengineering, Rice University, Houston, TX, USA
    Int J Nanomedicine 5:445-54. 2010
  8. ncbi request reprint Biofunctional materials for directing vascular development
    Jennifer E Saik
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Curr Vasc Pharmacol 10:331-41. 2012
  9. pmc Bioactive hydrogel substrates: probing leukocyte receptor-ligand interactions in parallel plate flow chamber studies
    Lakeshia J Taite
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Ann Biomed Eng 34:1705-11. 2006
  10. ncbi request reprint Applications of nanotechnology to biotechnology commentary
    J L West
    Department of Bioengineering, Rice University, Houston, TX 77005 1892, USA
    Curr Opin Biotechnol 11:215-7. 2000

Research Grants

Collaborators

  • Vicki L Colvin
  • Stephanie Nemir
  • Christie M Sayes
  • Naomi J Halas
  • D B Warheit
  • Charles Patrick
  • L R Hirsch
  • Rebekah A Drezek
  • William W Yu
  • Feng Liang
  • James J Moon
  • Malavosklish Bikram
  • Soo Hong Lee
  • Jordan S Miller
  • Andre M Gobin
  • Lakeshia J Taite
  • Andrea S Gobin
  • Jennifer E Saik
  • Solitaire A DeLong
  • Emily S Day
  • Amanda R Lowery
  • Ho Wook Jun
  • B K Mann
  • J S Stephens-Altus
  • Michael P Cuchiara
  • Ronald J Bernardi
  • Katie A Ruffino
  • Ying Ka Ingar Lau
  • Mariah S Hahn
  • Emmanuel Chang
  • Parul Natvar Patel
  • Elizabeth A Lipke
  • Kristyn S Bohl Masters
  • Rachael H Schmedlen
  • Kytai Truong Nguyen
  • Melissa K McHale
  • P Sundelacruz
  • M L Rowland
  • April A Smith
  • Nicholas S Riggall
  • Julia E Leslie-Barbick
  • Mary E Dickinson
  • Lissett R Bickford
  • Ross A Poche
  • Theodore M Chen
  • Alicia C B Allen
  • John H Slater
  • Patrick A Thompson
  • Peter Yang
  • Susan M Blaney
  • Alan R Davis
  • Rachel E Whitmire
  • John A Hipp
  • Francis Gannon
  • Elizabeth A Olmsted-Davis
  • Christine Fouletier-Dilling
  • Mariah Hahn
  • Bryan R E Smith
  • Michael B Lawrence
  • Maude L Rowland
  • Maude C Rowland
  • T Randall Lee
  • Mathilde I B├ęthencourt
  • Jiantang Sun
  • Laura A Poole-Warren
  • Paula Belem
  • S Joseph Leibovich
  • Kristyn S Masters
  • A T Tsai
  • A S Gobin
  • R H Schmedlen

Detail Information

Publications43

  1. ncbi request reprint Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeutics
    Jennifer L West
    Department of Bioengineering Rice University, Houston, Texas 77005 1892, USA
    Annu Rev Biomed Eng 5:285-92. 2003
    ..This review discusses applications that have been successfully demonstrated using nanomaterials including semiconductor nanocrystals, gold nanoparticles, gold nanoshells, and silver plasmon resonant particles...
  2. ncbi request reprint Proteolytically degradable hydrogels with a fluorogenic substrate for studies of cellular proteolytic activity and migration
    Soo Hong Lee
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, Texas 77251 1892, USA
    Biotechnol Prog 21:1736-41. 2005
    ..Cell migration and proteolytic activity were visualized using confocal microscopy. Proteolytic activity was concentrated near cell surfaces and remained present in the tracks where cell migration had occurred...
  3. ncbi request reprint Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells
    Christie M Sayes
    Department of Chemistry, Rice University, Houston, TX, USA
    Toxicol Sci 92:174-85. 2006
    ..The result highlights the important role that ex vivo measures of RS production can play in developing screens for cytotoxicity...
  4. ncbi request reprint Synthetic biomimetic hydrogels incorporated with ephrin-A1 for therapeutic angiogenesis
    James J Moon
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, Texas 77251 1892, USA
    Biomacromolecules 8:42-9. 2007
    ..The results of these studies demonstrate that pro-angiogenic properties of ephrin-A1 are preserved in hydrogels and suggest potential applications of this hydrogel system in regenerative medicine and tissue engineering...
  5. pmc Immunonanoshells for targeted photothermal ablation of tumor cells
    Amanda R Lowery
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Int J Nanomedicine 1:149-54. 2006
    ..Control nanoshells, conjugated with nonspecific anti-IgG or PEG, did not bind to either cell type, and cells continued to be viable after treatment with these control nanoshells and NIR irradiation...
  6. pmc EphrinA I-targeted nanoshells for photothermal ablation of prostate cancer cells
    Andre M Gobin
    Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
    Int J Nanomedicine 3:351-8. 2008
    ..We demonstrate selective photo-thermal destruction of these cells upon application of the NIR laser...
  7. pmc Antibody-conjugated gold-gold sulfide nanoparticles as multifunctional agents for imaging and therapy of breast cancer
    Emily S Day
    Department of Bioengineering, Rice University, Houston, TX, USA
    Int J Nanomedicine 5:445-54. 2010
    ..GGS-NPs are ideal multifunctional agents for cancer management because they offer the ability to pinpoint precise treatment sites and perform subsequent thermal ablation in a single setting...
  8. ncbi request reprint Biofunctional materials for directing vascular development
    Jennifer E Saik
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Curr Vasc Pharmacol 10:331-41. 2012
    ..Biomaterial scaffolds and their use as growth factor delivery systems are discussed, as well as other functional enhancement strategies to direct cellular responses for effective formation of a mature vascular network...
  9. pmc Bioactive hydrogel substrates: probing leukocyte receptor-ligand interactions in parallel plate flow chamber studies
    Lakeshia J Taite
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Ann Biomed Eng 34:1705-11. 2006
    ..This new system provides a unique polymer-based model for the study of interactions between leukocytes and endothelium as well as a platform to develop improved scaffolds for cardiovascular tissue engineering...
  10. ncbi request reprint Applications of nanotechnology to biotechnology commentary
    J L West
    Department of Bioengineering, Rice University, Houston, TX 77005 1892, USA
    Curr Opin Biotechnol 11:215-7. 2000
    ....
  11. doi request reprint Development of bioactive photocrosslinkable fibrous hydrogels
    J S Stephens-Altus
    Department of Bioengineering, Rice University, 6500 Main Street, Houston, Texas, USA
    J Biomed Mater Res A 98:167-76. 2011
    ..The ability to generate 3D fibrous architectures in hydrogel systems opens up new areas of investigation in cell-material interactions and tissue formation...
  12. pmc Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
    L R Hirsch
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, USA
    Proc Natl Acad Sci U S A 100:13549-54. 2003
    ..Tissues heated above the thermal damage threshold displayed coagulation, cell shrinkage, and loss of nuclear staining, which are indicators of irreversible thermal damage. Control tissues appeared undamaged...
  13. ncbi request reprint Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineering
    B K Mann
    Department of Bioengineering, Rice University, Houston, TX 77005-1892, USA
    Biomaterials 22:3045-51. 2001
    ..The biological activities of these materials can be tailored to meet the requirements of a given tissue engineering application by creating a mixture of various bioactive PEG derivatives prior to photopolymerization...
  14. ncbi request reprint A whole blood immunoassay using gold nanoshells
    L R Hirsch
    Department of Bioengineering, Rice University, P O Box 1892, Houston, Texas 77251 1892, USA
    Anal Chem 75:2377-81. 2003
    ..This system constitutes a simple immunoassay capable of detecting sub-nanogram-per-milliliter quantities of various analytes in different media within 10-30 min...
  15. ncbi request reprint Synthetic materials in the study of cell response to substrate rigidity
    Stephanie Nemir
    Department of Bioengineering, Rice University, 6100 Main St MS 142, Houston, TX 77005, USA
    Ann Biomed Eng 38:2-20. 2010
    ..This review will highlight past work in the field of cell response to substrate rigidity as well as areas for future study...
  16. ncbi request reprint Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro
    Christie M Sayes
    Department of Chemistry, Rice University, 1900 Rice Blvd, MS 60, Houston, TX 77005, USA
    Toxicol Lett 161:135-42. 2006
    ..e. the SWNTs in aqueous suspension precipitate out and selectively deposit on the membrane...
  17. ncbi request reprint Tissue engineering in the cardiovascular system: progress toward a tissue engineered heart
    B K Mann
    Rice University, Department of Bioengineering, Houston, Texas 77251-1892, USA
    Anat Rec 263:367-71. 2001
    ....
  18. ncbi request reprint Poly(ethylene glycol) hydrogels conjugated with a collagenase-sensitive fluorogenic substrate to visualize collagenase activity during three-dimensional cell migration
    Soo Hong Lee
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, USA
    Biomaterials 28:3163-70. 2007
    ..In summary, we have fabricated collagenase-sensitive hydrogels incorporated with CS-FS and successfully visualized the collagenase activity during three-dimensional cell migration...
  19. ncbi request reprint Effects of epidermal growth factor on fibroblast migration through biomimetic hydrogels
    Andrea S Gobin
    Department of Bioengineering, Rice University, Houston, Texas 77005 1892, USA
    Biotechnol Prog 19:1781-5. 2003
    ..These synthetic ECM analogues allow one to systematically control identities and concentrations of biomolecules and are useful tools to study mechanisms of cell migration...
  20. ncbi request reprint Protease-activated quantum dot probes
    Emmanuel Chang
    Rice University, Department of Bioengineering MS 142, P O Box 1892, Houston, TX 77251 1892, USA
    Biochem Biophys Res Commun 334:1317-21. 2005
    ..Initial studies observed a 52% rise in luminescence over 47 h of exposure to 0.2 mg/mL collagenase. These probes can be customized for targeted degradation simply by changing the sequence of the peptide linker...
  21. ncbi request reprint Localized delivery of nitric oxide from hydrogels inhibits neointima formation in a rat carotid balloon injury model
    Elizabeth A Lipke
    Department of Chemical Engineering, Rice University, 6100 Main Street, Houston, TX 77005, USA
    Acta Biomater 1:597-606. 2005
    ..These data indicate that localized delivery of NO from these hydrogels can significantly inhibit neointima formation in a rat carotid balloon injury model and suggest that these materials may be useful in preventing restenosis...
  22. ncbi request reprint Multilayer microfluidic PEGDA hydrogels
    Michael P Cuchiara
    Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, United States
    Biomaterials 31:5491-7. 2010
    ..This work has applications in the development of hydrogels as in vitro diagnostics and ultimately as regenerative medicine based therapeutics...
  23. ncbi request reprint Nano-C60 cytotoxicity is due to lipid peroxidation
    Christie M Sayes
    Department of Chemistry, 6100 Main St MS 60, Rice University, Houston, TX 77005, USA
    Biomaterials 26:7587-95. 2005
    ..With the addition of an antioxidant, L-ascorbic acid, the oxidative damage and resultant toxicity of nano-C60 was completely prevented...
  24. ncbi request reprint Metal nanoshells
    Leon R Hirsch
    Department of Bioengineering, Rice University, Box 1892, MS 144, Houston, TX 77251 1892, USA
    Ann Biomed Eng 34:15-22. 2006
    ..Several potential biomedical applications are under development, including immunoassays, modulated drug delivery, photothermal cancer therapy, and imaging contrast agents...
  25. ncbi request reprint Photolithographic patterning of polyethylene glycol hydrogels
    Mariah S Hahn
    Department of Bioengineering, Rice University, 6100 Main Street MS 142, Houston, TX 77005, USA
    Biomaterials 27:2519-24. 2006
    ..This patterning method may find use in tissue engineering, the elucidation of fundamental structure-function relationships, and the formation of immobilized cell and protein arrays for biotechnology...
  26. ncbi request reprint Photopolymerizable hydrogels for tissue engineering applications
    Kytai Truong Nguyen
    Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
    Biomaterials 23:4307-14. 2002
    ..Applications of photopolymerized hydrogels in tissue engineering that have been investigated are summarized...
  27. ncbi request reprint Photocrosslinkable polyvinyl alcohol hydrogels that can be modified with cell adhesion peptides for use in tissue engineering
    Rachael H Schmedlen
    Department of Bioengineering, Rice University, Houston, TX 77005 1892, USA
    Biomaterials 23:4325-32. 2002
    ..These results suggest that photopolymerizable PVA hydrogels are promising for tissue engineering applications...
  28. ncbi request reprint Temperature-sensitive hydrogels with SiO2-Au nanoshells for controlled drug delivery
    Malavosklish Bikram
    Department of Bioengineering, Rice University, 6100 Main Street, MS 144, Houston, TX 77005, USA
    J Control Release 123:219-27. 2007
    ....
  29. ncbi request reprint Thermo-responsive systems for controlled drug delivery
    Malavosklish Bikram
    University of Houston, College of Pharmacy, Department of Pharmacological and Pharmaceutical Sciences, 1441 Moursund Street, Houston, TX 77030, USA
    Expert Opin Drug Deliv 5:1077-91. 2008
    ..The result has been the development of highly sophisticated systems, which demonstrate exquisite control over drug release and represent huge advances in biomedical research...
  30. ncbi request reprint Endothelialization of microporous YIGSR/PEG-modified polyurethaneurea
    Ho Wook Jun
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Tissue Eng 11:1133-40. 2005
    ..DNA content, hydroxyproline production, and cell migration were also significantly greater in peptide-modified scaffolds...
  31. pmc Biomimetic hydrogels with pro-angiogenic properties
    James J Moon
    Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
    Biomaterials 31:3840-7. 2010
    ..These results indicate that these hydrogels may be useful for applications in basic biological research, tissue engineering, and regenerative medicine...
  32. ncbi request reprint Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferation
    Parul Natvar Patel
    Department of Chemical Engineering, Rice University, Houston, Texas, USA
    Tissue Eng 11:1498-505. 2005
    ..Our results indicate that a scaffold system containing specific degradation sites and cell adhesion ligands permits cells to adhere and proliferate, thus providing a potential cell-scaffold system for adipogenesis...
  33. ncbi request reprint Effects of nitric oxide releasing poly(vinyl alcohol) hydrogel dressings on dermal wound healing in diabetic mice
    Kristyn S Bohl Masters
    Department of Chemical Engineering, Rice University, Houston, Texas, USA
    Wound Repair Regen 10:286-94. 2002
    ..The results of this study suggest that exogenous NO released from a hydrogel wound dressing has potential to modulate wound healing...
  34. ncbi request reprint Immunonanoshells for targeted photothermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell lines
    Ronald J Bernardi
    Texas Children s Cancer Center, Texas Children s Hospital, Baylor College of Medicine, Houston, TX, USA
    J Neurooncol 86:165-72. 2008
    ....
  35. ncbi request reprint Modification of materials with bioactive peptides
    Jennifer L West
    Department of Engineering, Rice University, Houston, TX, USA
    Methods Mol Biol 238:113-22. 2004
  36. ncbi request reprint Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migration
    Solitaire A DeLong
    Rice University, Department of Bioengineering, Houston, TX 77251 1892, USA
    J Control Release 109:139-48. 2005
    ..In addition, directed migration was further enhanced by increasing the RGDS gradient's slope. This hydrogel system is expected to be useful for directing cell migration to enhance the formation of engineered tissues...
  37. ncbi request reprint Laser-scanning lithography (LSL) for the soft lithographic patterning of cell-adhesive self-assembled monolayers
    Jordan S Miller
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, Texas 77251 1892, USA
    Biotechnol Bioeng 93:1060-8. 2006
    ....
  38. ncbi request reprint Overexpression of lysyl oxidase to increase matrix crosslinking and improve tissue strength in dermal wound healing
    Ying Ka Ingar Lau
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, USA
    Ann Biomed Eng 34:1239-46. 2006
    ..Addition of an inhibitor of LO abolished this increase. We applied this system in a rat dermal wound healing model and showed that treatment with LO-producing GAMs led to significantly enhanced mechanical strength of the wound site...
  39. ncbi request reprint Whole-blood immunoassay facilitated by gold nanoshell-conjugate antibodies
    Lee R Hirsch
    Department of Bioengineering, Rice University, Houston, TX, USA
    Methods Mol Biol 303:101-11. 2005
    ..Preparation of the antibody-nanoshell conjugates is described, along with the design and optimization of the whole-blood nanoshell-based immunoassay system...
  40. ncbi request reprint Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells
    Malavosklish Bikram
    Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA
    Ann Biomed Eng 35:796-807. 2007
    ..5 +/- 25.0 mm3 mineralized tissue and 31.8 +/- 7.8 mm3 for the cell-injected mice, and the bone was localized to the hydrogel surfaces. Histology revealed bone as well as cartilage for both hydrogel implanted and cell-injected animals...
  41. ncbi request reprint Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration
    Solitaire A DeLong
    Department of Bioengineering, Rice University, 6100 Main St, MS 142, Houston, TX 77005, USA
    Biomaterials 26:3227-34. 2005
    ..These hydrogel scaffolds may be useful for studying protein gradient effects on cell behavior and for directing cell migration in tissue-engineering applications...
  42. ncbi request reprint Nitric oxide-releasing polyurethane-PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion
    Lakeshia J Taite
    Department of Bioengineering, Rice University, Houston, Texas, USA
    J Biomed Mater Res B Appl Biomater 84:108-16. 2008
    ....
  43. ncbi request reprint Cell migration through defined, synthetic ECM analogs
    Andrea S Gobin
    Rice University, Department of Bioengineering, Houston, Texas 77005 1892, USA
    FASEB J 16:751-3. 2002
    ..Furthermore, both adhesive and proteolytically degradable sequences were required for cell migration to occur. These synthetic ECM analogues may be useful for 3-D mechanistic studies of many aspects of cell migration..

Research Grants10

  1. NIR Absorbing Nanoparticles For Cancer Therapy
    Jennifer West; Fiscal Year: 2007
    ..We propose to evaluate biodistribution, biocompatibility and tumor ablation efficacy of these NIR-absorbing nanoparticles. The optimal particle formulation will be further examined in a model of medulloblastoma. ..
  2. BIOTECHNOLOGY RESEARCH TRAINING GRANT
    Jennifer West; Fiscal Year: 2007
    ..D. Anderson. ..
  3. DEGRADABLE SCAFFOLDS FOR GENETICALLY ENGINEERED GRAFTS
    Jennifer West; Fiscal Year: 2001
    ....
  4. DEGRADABLE SCAFFOLDS FOR GENETICALLY ENGINEERED GRAFTS
    Jennifer West; Fiscal Year: 1999
    ....
  5. DEGRADABLE SCAFFOLDS FOR GENETICALLY ENGINEERED GRAFTS
    Jennifer West; Fiscal Year: 2002
    ....
  6. DEGRADABLE SCAFFOLDS FOR GENETICALLY ENGINEERED GRAFTS
    Jennifer West; Fiscal Year: 2000
    ....
  7. SMC Differentiation During Vascular Graft Assembly
    Jennifer West; Fiscal Year: 2004
    ..Adult and embryonic flow conditions will be evaluated. This course of studies will be performed for each cell type. ..