Research Topics
| J L WestSummaryAffiliation: Rice University Country: USA Publications
Research Grants
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Detail Information
Publications
Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeuticsJennifer L West
Department of Bioengineering Rice University, Houston, Texas 77005 1892, USA
Annu Rev Biomed Eng 5:285-92. 2003..This review discusses applications that have been successfully demonstrated using nanomaterials including semiconductor nanocrystals, gold nanoparticles, gold nanoshells, and silver plasmon resonant particles...- Proteolytically degradable hydrogels with a fluorogenic substrate for studies of cellular proteolytic activity and migrationSoo-Hong Lee
Department of Bioengineering, Rice University, P.O. Box 1892, MS 142, Houston, Texas 77251-1892, USA
Biotechnol Prog 21:1736-41. 2005..Cell migration and proteolytic activity were visualized using confocal microscopy. Proteolytic activity was concentrated near cell surfaces and remained present in the tracks where cell migration had occurred... - Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cellsChristie M Sayes
Department of Chemistry, Rice University, Houston, TX, USA
Toxicol Sci 92:174-85. 2006..The result highlights the important role that ex vivo measures of RS production can play in developing screens for cytotoxicity... - Synthetic biomimetic hydrogels incorporated with ephrin-A1 for therapeutic angiogenesisJames J Moon
Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, Texas 77251 1892, USA
Biomacromolecules 8:42-9. 2007..The results of these studies demonstrate that pro-angiogenic properties of ephrin-A1 are preserved in hydrogels and suggest potential applications of this hydrogel system in regenerative medicine and tissue engineering... - Biofunctional materials for directing vascular developmentJennifer E Saik
Department of Bioengineering, Rice University, Houston, TX 77005, USA
Curr Vasc Pharmacol 10:331-41. 2012..Biomaterial scaffolds and their use as growth factor delivery systems are discussed, as well as other functional enhancement strategies to direct cellular responses for effective formation of a mature vascular network... 
Bioactive hydrogel substrates: probing leukocyte receptor-ligand interactions in parallel plate flow chamber studiesLakeshia J Taite
Department of Bioengineering, Rice University, Houston, TX 77005, USA
Ann Biomed Eng 34:1705-11. 2006..This new system provides a unique polymer-based model for the study of interactions between leukocytes and endothelium as well as a platform to develop improved scaffolds for cardiovascular tissue engineering...- Applications of nanotechnology to biotechnology commentaryJ L West
Department of Bioengineering, Rice University, Houston, TX 77005 1892, USA
Curr Opin Biotechnol 11:215-7. 2000.... 
Development of bioactive photocrosslinkable fibrous hydrogelsJ S Stephens-Altus
Department of Bioengineering, Rice University, 6500 Main Street, Houston, Texas, USA
J Biomed Mater Res A 98:167-76. 2011..The ability to generate 3D fibrous architectures in hydrogel systems opens up new areas of investigation in cell-material interactions and tissue formation...- Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: synthetic ECM analogs for tissue engineeringB K Mann
Department of Bioengineering, Rice University, Houston, TX 77005-1892, USA
Biomaterials 22:3045-51. 2001..The biological activities of these materials can be tailored to meet the requirements of a given tissue engineering application by creating a mixture of various bioactive PEG derivatives prior to photopolymerization... - Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidanceL R Hirsch
Department of Bioengineering, Rice University, P.O. Box 1892, MS-142, Houston, TX 77251-1892, USA
Proc Natl Acad Sci U S A 100:13549-54. 2003..Tissues heated above the thermal damage threshold displayed coagulation, cell shrinkage, and loss of nuclear staining, which are indicators of irreversible thermal damage. Control tissues appeared undamaged... - Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitroChristie M Sayes
Department of Chemistry, Rice University, 1900 Rice Blvd, MS 60, Houston, TX 77005, USA
Toxicol Lett 161:135-42. 2006..e. the SWNTs in aqueous suspension precipitate out and selectively deposit on the membrane... - Synthetic materials in the study of cell response to substrate rigidityStephanie Nemir
Department of Bioengineering, Rice University, 6100 Main St MS 142, Houston, TX 77005, USA
Ann Biomed Eng 38:2-20. 2010..This review will highlight past work in the field of cell response to substrate rigidity as well as areas for future study... - A whole blood immunoassay using gold nanoshellsL R Hirsch
Department of Bioengineering, Rice University, P O Box 1892, Houston, Texas 77251 1892, USA
Anal Chem 75:2377-81. 2003..This system constitutes a simple immunoassay capable of detecting sub-nanogram-per-milliliter quantities of various analytes in different media within 10-30 min... - Tissue engineering in the cardiovascular system: progress toward a tissue engineered heartB K Mann
Rice University, Department of Bioengineering, Houston, Texas 77251-1892, USA
Anat Rec 263:367-71. 2001.... - Protease-activated quantum dot probesEmmanuel Chang
Rice University, Department of Bioengineering MS-142, P.O. Box 1892, Houston, TX 77251-1892, USA
Biochem Biophys Res Commun 334:1317-21. 2005..Initial studies observed a 52% rise in luminescence over 47 h of exposure to 0.2 mg/mL collagenase. These probes can be customized for targeted degradation simply by changing the sequence of the peptide linker... - Poly(ethylene glycol) hydrogels conjugated with a collagenase-sensitive fluorogenic substrate to visualize collagenase activity during three-dimensional cell migrationSoo Hong Lee
Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, USA
Biomaterials 28:3163-70. 2007..In summary, we have fabricated collagenase-sensitive hydrogels incorporated with CS-FS and successfully visualized the collagenase activity during three-dimensional cell migration... - Effects of epidermal growth factor on fibroblast migration through biomimetic hydrogelsAndrea S Gobin
Department of Bioengineering, Rice University, Houston, Texas 77005-1892, USA
Biotechnol Prog 19:1781-5. 2003..These synthetic ECM analogues allow one to systematically control identities and concentrations of biomolecules and are useful tools to study mechanisms of cell migration... - Photopolymerizable hydrogels for tissue engineering applicationsKytai Truong Nguyen
Department of Bioengineering, Rice University, Houston, TX 77251-1892, USA
Biomaterials 23:4307-14. 2002..Applications of photopolymerized hydrogels in tissue engineering that have been investigated are summarized... - Localized delivery of nitric oxide from hydrogels inhibits neointima formation in a rat carotid balloon injury modelElizabeth A Lipke
Department of Chemical Engineering, Rice University, 6100 Main Street, Houston, TX 77005, USA
Acta Biomater 1:597-606. 2005..These data indicate that localized delivery of NO from these hydrogels can significantly inhibit neointima formation in a rat carotid balloon injury model and suggest that these materials may be useful in preventing restenosis... - Metal nanoshellsLeon R Hirsch
Department of Bioengineering, Rice University, Box 1892, MS 144, Houston, TX 77251-1892, USA
Ann Biomed Eng 34:15-22. 2006..Several potential biomedical applications are under development, including immunoassays, modulated drug delivery, photothermal cancer therapy, and imaging contrast agents... - Nano-C60 cytotoxicity is due to lipid peroxidationChristie M Sayes
Department of Chemistry, 6100 Main St. MS-60, Rice University, Houston, TX 77005, USA
Biomaterials 26:7587-95. 2005..With the addition of an antioxidant, L-ascorbic acid, the oxidative damage and resultant toxicity of nano-C60 was completely prevented... - Photocrosslinkable polyvinyl alcohol hydrogels that can be modified with cell adhesion peptides for use in tissue engineeringRachael H Schmedlen
Department of Bioengineering, Rice University, Houston, TX 77005-1892, USA
Biomaterials 23:4325-32. 2002..These results suggest that photopolymerizable PVA hydrogels are promising for tissue engineering applications... - Multilayer microfluidic PEGDA hydrogelsMichael P Cuchiara
Department of Bioengineering, Rice University, 6100 Main Street, Houston, TX 77005, United States
Biomaterials 31:5491-7. 2010..This work has applications in the development of hydrogels as in vitro diagnostics and ultimately as regenerative medicine based therapeutics... - Photolithographic patterning of polyethylene glycol hydrogelsMariah S Hahn
Department of Bioengineering, Rice University, 6100 Main Street/MS 142, Houston, TX 77005, USA
Biomaterials 27:2519-24. 2006..This patterning method may find use in tissue engineering, the elucidation of fundamental structure-function relationships, and the formation of immobilized cell and protein arrays for biotechnology... - Temperature-sensitive hydrogels with SiO2-Au nanoshells for controlled drug deliveryMalavosklish Bikram
Department of Bioengineering, Rice University, 6100 Main Street, MS 144, Houston, TX 77005, USA
J Control Release 123:219-27. 2007.... - Thermo-responsive systems for controlled drug deliveryMalavosklish Bikram
University of Houston, College of Pharmacy, Department of Pharmacological and Pharmaceutical Sciences, 1441 Moursund Street, Houston, TX 77030, USA
Expert Opin Drug Deliv 5:1077-91. 2008..The result has been the development of highly sophisticated systems, which demonstrate exquisite control over drug release and represent huge advances in biomedical research... - EphrinA I-targeted nanoshells for photothermal ablation of prostate cancer cellsAndre M Gobin
Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
Int J Nanomedicine 3:351-8. 2008..We demonstrate selective photo-thermal destruction of these cells upon application of the NIR laser... - Immunonanoshells for targeted photothermal ablation of tumor cellsAmanda R Lowery
Department of Bioengineering, Rice University, Houston, TX 77005, USA
Int J Nanomedicine 1:149-54. 2006..Control nanoshells, conjugated with nonspecific anti-IgG or PEG, did not bind to either cell type, and cells continued to be viable after treatment with these control nanoshells and NIR irradiation... - Biomimetic hydrogels with pro-angiogenic propertiesJames J Moon
Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
Biomaterials 31:3840-7. 2010..These results indicate that these hydrogels may be useful for applications in basic biological research, tissue engineering, and regenerative medicine... - Nitric oxide-releasing polyurethane-PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesionLakeshia J Taite
Department of Bioengineering, Rice University, Houston, Texas, USA
J Biomed Mater Res B Appl Biomater 84:108-16. 2008.... - Immunonanoshells for targeted photothermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell linesRonald J Bernardi
Texas Children s Cancer Center, Texas Children s Hospital, Baylor College of Medicine, Houston, TX, USA
J Neurooncol 86:165-72. 2008.... - Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cellsMalavosklish Bikram
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, 1441 Moursund Street, Houston, TX 77030, USA
Ann Biomed Eng 35:796-807. 2007..5 +/- 25.0 mm3 mineralized tissue and 31.8 +/- 7.8 mm3 for the cell-injected mice, and the bone was localized to the hydrogel surfaces. Histology revealed bone as well as cartilage for both hydrogel implanted and cell-injected animals... - Effects of nitric oxide releasing poly(vinyl alcohol) hydrogel dressings on dermal wound healing in diabetic miceKristyn S Bohl Masters
Department of Chemical Engineering, Rice University, Houston, Texas, USA
Wound Repair Regen 10:286-94. 2002..The results of this study suggest that exogenous NO released from a hydrogel wound dressing has potential to modulate wound healing... - Modification of materials with bioactive peptidesJennifer L West
Department of Engineering, Rice University, Houston, TX, USA
Methods Mol Biol 238:113-22. 2004 - Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migrationSolitaire A DeLong
Department of Bioengineering, Rice University, 6100 Main St, MS 142, Houston, TX 77005, USA
Biomaterials 26:3227-34. 2005..These hydrogel scaffolds may be useful for studying protein gradient effects on cell behavior and for directing cell migration in tissue-engineering applications... - Whole-blood immunoassay facilitated by gold nanoshell-conjugate antibodiesLee R Hirsch
Department of Bioengineering, Rice University, Houston, TX, USA
Methods Mol Biol 303:101-11. 2005..Preparation of the antibody-nanoshell conjugates is described, along with the design and optimization of the whole-blood nanoshell-based immunoassay system... - Poly(ethylene glycol) hydrogel system supports preadipocyte viability, adhesion, and proliferationParul Natvar Patel
Department of Chemical Engineering, Rice University, Houston, Texas, USA
Tissue Eng 11:1498-505. 2005..Our results indicate that a scaffold system containing specific degradation sites and cell adhesion ligands permits cells to adhere and proliferate, thus providing a potential cell-scaffold system for adipogenesis... - Covalent immobilization of RGDS on hydrogel surfaces to direct cell alignment and migrationSolitaire A DeLong
Rice University, Department of Bioengineering, Houston, TX 77251-1892, USA
J Control Release 109:139-48. 2005..In addition, directed migration was further enhanced by increasing the RGDS gradient's slope. This hydrogel system is expected to be useful for directing cell migration to enhance the formation of engineered tissues... - Endothelialization of microporous YIGSR/PEG-modified polyurethaneureaHo-Wook Jun
Department of Bioengineering, Rice University, Houston, TX 77005, USA
Tissue Eng 11:1133-40. 2005..DNA content, hydroxyproline production, and cell migration were also significantly greater in peptide-modified scaffolds... - Laser-scanning lithography (LSL) for the soft lithographic patterning of cell-adhesive self-assembled monolayersJordan S Miller
Department of Bioengineering, Rice University, P.O. Box 1892, MS-142, Houston, Texas 77251-1892, USA
Biotechnol Bioeng 93:1060-8. 2006.... - Overexpression of lysyl oxidase to increase matrix crosslinking and improve tissue strength in dermal wound healingYing Ka Ingar Lau
Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77251 1892, USA
Ann Biomed Eng 34:1239-46. 2006..Addition of an inhibitor of LO abolished this increase. We applied this system in a rat dermal wound healing model and showed that treatment with LO-producing GAMs led to significantly enhanced mechanical strength of the wound site... - Cell migration through defined, synthetic ECM analogsAndrea S Gobin
Rice University, Department of Bioengineering, Houston, Texas 77005-1892, USA
FASEB J 16:751-3. 2002..Furthermore, both adhesive and proteolytically degradable sequences were required for cell migration to occur. These synthetic ECM analogues may be useful for 3-D mechanistic studies of many aspects of cell migration..
Research Grants
- NIR Absorbing Nanoparticles For Cancer TherapyJennifer West; Fiscal Year: 2007..We propose to evaluate biodistribution, biocompatibility and tumor ablation efficacy of these NIR-absorbing nanoparticles. The optimal particle formulation will be further examined in a model of medulloblastoma. ..
- BIOTECHNOLOGY RESEARCH TRAINING GRANTJennifer West; Fiscal Year: 2007..D. Anderson. ..
- SMC Differentiation During Vascular Graft AssemblyJennifer West; Fiscal Year: 2004..Adult and embryonic flow conditions will be evaluated. This course of studies will be performed for each cell type. ..
- DEGRADABLE SCAFFOLDS FOR GENETICALLY ENGINEERED GRAFTSJennifer West; Fiscal Year: 2002....