Joel Moake

Summary

Affiliation: Rice University
Country: USA

Publications

  1. ncbi request reprint Thrombotic thrombocytopenic purpura: the systemic clumping "plague"
    Joel L Moake
    Hematology Oncology Section, Department of Medicine, Baylor College of Medicine and Bioengineering Laboratory, Rice University, Houston, Texas 77030, USA
    Annu Rev Med 53:75-88. 2002
  2. ncbi request reprint Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome
    Joel L Moake
    Baylor College of Medicine and Rice University, Houston, Tex 77030, USA
    Arch Pathol Lab Med 126:1430-3. 2002
  3. ncbi request reprint Defective processing of unusually large von Willebrand factor multimers and thrombotic thrombocytopenic purpura
    J L Moake
    Baylor College of Medicine and Rice University, Houston, TX, USA
    J Thromb Haemost 2:1515-21. 2004
  4. ncbi request reprint Thrombotic microangiopathies
    Joel L Moake
    Baylor College of Medicine, Houston, USA
    N Engl J Med 347:589-600. 2002
  5. doi request reprint Thrombotic microangiopathies: multimers, metalloprotease, and beyond
    Joel Moake
    Rice University, Houston, Texas, USA
    Clin Transl Sci 2:366-73. 2009
  6. pmc Thrombotic thrombocytopenic purpura: survival by "giving a dam"
    Joel L Moake
    Medical Hematology Section The Methodist Hospital, Houston, Texas 77030, USA
    Trans Am Clin Climatol Assoc 115:201-19. 2004
  7. doi request reprint Thrombotic thrombocytopenia purpura (TTP) and other thrombotic microangiopathies
    Joel Moake
    Rice University, Department of Bioengineering, Houston, TX 77005, USA
    Best Pract Res Clin Haematol 22:567-76. 2009
  8. ncbi request reprint Journey in reverse: TTP from bedside to blood bank to bench
    Joel L Moake
    Baylor College of Medicine and Rice University, Houston, Texas 77005, USA
    J Clin Apher 22:37-49. 2007
  9. pmc Interaction of Shiga toxin with the A-domains and multimers of von Willebrand Factor
    Nathan C Lo
    From the Department of Bioengineering, Rice University, Houston, Texas 77005
    J Biol Chem 288:33118-23. 2013
  10. doi request reprint Human complement factor H is a reductase for large soluble von Willebrand factor multimers--brief report
    Leticia Nolasco
    From the Department of Bioengineering, Rice University, Houston, TX L N, J N, J M and Department of Pulmonary Medicine, M D Anderson Cancer Center, Houston, TX S F, V A K
    Arterioscler Thromb Vasc Biol 33:2524-8. 2013

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Thrombotic thrombocytopenic purpura: the systemic clumping "plague"
    Joel L Moake
    Hematology Oncology Section, Department of Medicine, Baylor College of Medicine and Bioengineering Laboratory, Rice University, Houston, Texas 77030, USA
    Annu Rev Med 53:75-88. 2002
    ..In neither condition is there a severe decrease in plasma vWf-cleaving metalloprotease activity...
  2. ncbi request reprint Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome
    Joel L Moake
    Baylor College of Medicine and Rice University, Houston, Tex 77030, USA
    Arch Pathol Lab Med 126:1430-3. 2002
    ....
  3. ncbi request reprint Defective processing of unusually large von Willebrand factor multimers and thrombotic thrombocytopenic purpura
    J L Moake
    Baylor College of Medicine and Rice University, Houston, TX, USA
    J Thromb Haemost 2:1515-21. 2004
  4. ncbi request reprint Thrombotic microangiopathies
    Joel L Moake
    Baylor College of Medicine, Houston, USA
    N Engl J Med 347:589-600. 2002
  5. doi request reprint Thrombotic microangiopathies: multimers, metalloprotease, and beyond
    Joel Moake
    Rice University, Houston, Texas, USA
    Clin Transl Sci 2:366-73. 2009
    ....
  6. pmc Thrombotic thrombocytopenic purpura: survival by "giving a dam"
    Joel L Moake
    Medical Hematology Section The Methodist Hospital, Houston, Texas 77030, USA
    Trans Am Clin Climatol Assoc 115:201-19. 2004
    ..Episodes of TTP are treated by "giving A DAM" (TS-13, that is) contained in normal plasma, either by infusion alone or in combination with plasmapheresis...
  7. doi request reprint Thrombotic thrombocytopenia purpura (TTP) and other thrombotic microangiopathies
    Joel Moake
    Rice University, Department of Bioengineering, Houston, TX 77005, USA
    Best Pract Res Clin Haematol 22:567-76. 2009
    ....
  8. ncbi request reprint Journey in reverse: TTP from bedside to blood bank to bench
    Joel L Moake
    Baylor College of Medicine and Rice University, Houston, Texas 77005, USA
    J Clin Apher 22:37-49. 2007
    ..The discussion that follows was prepared in conjunction with the 2006 Francis Morrison, M.D., Memorial Lecture at the 27th Annual Meeting of the American Society for Apheresis...
  9. pmc Interaction of Shiga toxin with the A-domains and multimers of von Willebrand Factor
    Nathan C Lo
    From the Department of Bioengineering, Rice University, Houston, Texas 77005
    J Biol Chem 288:33118-23. 2013
    ..Stx-VWF interaction and the associated delay in ADAMTS-13-mediated cleavage of VWF may contribute to the pathophysiology of DHUS. ..
  10. doi request reprint Human complement factor H is a reductase for large soluble von Willebrand factor multimers--brief report
    Leticia Nolasco
    From the Department of Bioengineering, Rice University, Houston, TX L N, J N, J M and Department of Pulmonary Medicine, M D Anderson Cancer Center, Houston, TX S F, V A K
    Arterioscler Thromb Vasc Biol 33:2524-8. 2013
    ..Normal plasma contains a nonproteolytic reducing activity that subsequently rapidly diminishes the size of the large soluble vWF multimers...
  11. ncbi request reprint Platelets adhered to endothelial cell-bound ultra-large von Willebrand factor strings support leukocyte tethering and rolling under high shear stress
    A Bernardo
    Thrombosis Research Section, Department of Medicine, Houston, TX 77030, USA
    J Thromb Haemost 3:562-70. 2005
    ..The observed phenomenon delineates a mechanism for leukocytes to be tethered to arterial endothelial cells under high shear, providing a potential link between inflammation and thrombosis...
  12. ncbi request reprint Increased von Willebrand factor binding to platelets in single episode and recurrent types of thrombotic thrombocytopenic purpura
    T W Chow
    Cox Laboratory for Biomedical Engineering, Rice University, Houston, Texas 77251, USA
    Am J Hematol 57:293-302. 1998
    ..These results suggest that vWf-platelet interactions are involved in the platelet clumping process that characterizes TTP...
  13. ncbi request reprint Shear stress-induced binding of von Willebrand factor to platelets
    K Konstantopoulos
    Cox Lab for Biomedical Engineering, Rice University, Houston, Texas 77251 1892, USA
    Biorheology 34:57-71. 1997
    ..These data demonstrate that the binding of vWF to GPIb is likely to be the initial shear-induced platelet-ligand binding event...
  14. ncbi request reprint A novel flow cytometric analysis for platelet activation on immobilized von Willebrand factor or fibrillar collagen
    S Kao
    Cox Laboratory for Biomedical Engineering, Rice University, Houston, Texas 77251 1892, USA
    J Thromb Haemost 1:347-54. 2003
    ..Collagen fibrils, however, can activate adherent platelets sufficiently to promote the formation of large platelet aggregates...
  15. ncbi request reprint Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under flow
    N A Turner
    Department of Bioengineering, Rice University, Houston, TX 77251, USA
    Blood 98:3340-5. 2001
    ..Inhibitors of these pathways are potentially useful as antiarterial thrombotic agents...
  16. ncbi request reprint Fibrillin containing elastic microfibrils support platelet adhesion under dynamic shear conditions
    J M Ross
    Cox Laboratory for Biomedical Engineering, Rice University, Houston, TX, USA
    Thromb Haemost 79:155-61. 1998
    ..These results suggest roles for both collagen VI and fibrillin containing elastic microfibrils in modulating the platelet response to blood vessel injury...
  17. doi request reprint Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13
    Zhou Zhou
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Thromb Res 124:323-7. 2009
    ..ADAMTS-13 fits in the consensus of the ADAMTS family metalloproteases, but also contains two unique C- terminal CUB domains. Studying mutations in CUB domains could provide insights into the functional role of these domains...
  18. ncbi request reprint von Willebrand factor in the pathophysiology of thrombotic thrombocytopenic purpura
    J L Moake
    Baylor College of Medicine, Houston, TX 77030, USA
    Clin Lab Sci 11:362-4. 1998
    ..Single episode and intermittent types of TTP in adults are, therefore, autoimmune processes of a short-term and recurrent nature, respectively...
  19. ncbi request reprint Increased von Willebrand factor (vWf) binding to platelets associated with impaired vWf breakdown in thrombotic thrombocytopenic purpura
    J L Moake
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    J Clin Apher 13:126-32. 1998
    ..Single episode and intermittent types of TTP in adults are likely to be short-term or recurrent autoimmune processes, respectively...
  20. pmc von Willebrand factor binding to platelet GpIb initiates signals for platelet activation
    M H Kroll
    Houston Veterans Affairs Medical Center, Baylor College of Medicine, Texas 77030
    J Clin Invest 88:1568-73. 1991
    ..This signal then causes PKC activation and increases of [Ca2+]i, which promote platelet secretion and potentiate aggregation...
  21. ncbi request reprint Platelet-derived VWF-cleaving metalloprotease ADAMTS-13
    L Liu
    Department of Medicine, Thrombosis Research Section, Baylor College of Medicine, Houston, TX 77030, USA
    J Thromb Haemost 3:2536-44. 2005
    ..This intrinsic activity may be physiologically important to prevent the sudden release of hyperactive ULVWF from platelets and serves as the second pool of ADAMTS-13 to encounter the increase in ULVWF release from endothelial cells...
  22. ncbi request reprint In vitro comparison of blood pump induced platelet microaggregates between a centrifugal and roller pump during cardiopulmonary bypass
    J Linneweber
    Baylor College of Medicine, Department of Surgery, Houston, TX, USA
    Int J Artif Organs 25:549-55. 2002
    ....
  23. pmc Assembly and activation of alternative complement components on endothelial cell-anchored ultra-large von Willebrand factor links complement and hemostasis-thrombosis
    Nancy A Turner
    Department of Bioengineering, Rice University, Houston, TX, USA
    PLoS ONE 8:e59372. 2013
    ..Our goal was to determine if EC-anchored ULVWF strings caused the assembly and activation of AP components, thereby linking two essential defense mechanisms...
  24. doi request reprint Generation and breakdown of soluble ultralarge von Willebrand factor multimers
    Nancy Turner
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    Semin Thromb Hemost 38:38-46. 2012
    ..New inhibitors of platelet adhesion to EC-anchored ULVWF multimeric strings and soluble ULVWF include an aptamer, a nanobody, and N-acetylcysteine...
  25. ncbi request reprint Conformational stability and domain unfolding of the Von Willebrand factor A domains
    Matthew Auton
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    J Mol Biol 366:986-1000. 2007
    ..The low stability of the A2 domain is likely to be important in regulating the exposure of the A2 domain cleavage site in response to shear stress, ULVWF platelet adherence, and the attachment of ADAMTS-13 to ULVWF...
  26. ncbi request reprint Thrombotic thrombocytopenic purpura associated with clopidogrel
    C L Bennett
    Veterans Affairs Chicago Healthcare System, Department of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, IL 60611, USA
    N Engl J Med 342:1773-7. 2000
    ..More than 3 million patients have received clopidogrel. We report the clinical and laboratory findings in 11 patients in whom thrombotic thrombocytopenic purpura developed during or soon after treatment with clopidogrel...
  27. pmc Covalent regulation of ULVWF string formation and elongation on endothelial cells under flow conditions
    Y Li
    Section of Thrombosis Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    J Thromb Haemost 6:1135-43. 2008
    ..On endothelial cells, freshly released ultra-large (UL) VWF multimers form long string-like structures to which platelets adhere...
  28. ncbi request reprint Novel ADAMTS-13 mutations in an adult with delayed onset thrombotic thrombocytopenic purpura
    Z Tao
    Section of Thrombosis Research, Baylor College of Medicine, Houston, TX 77030, USA
    J Thromb Haemost 4:1931-5. 2006
    ..Mutations throughout the ADAMTS13 gene have been identified in congenital TTP patients, most of whom have initial episodes during infancy or in early childhood...
  29. doi request reprint Protein phosphatase 2B inhibition promotes the secretion of von Willebrand factor from endothelial cells
    L H Nolasco
    Department of Bioengineering, Rice University, Houston, TX 77030, USA
    J Thromb Haemost 7:1009-18. 2009
    ..In comparison to protein kinases, a role for protein phosphatases in regulating endothelial exocytosis is undefined...
  30. ncbi request reprint Direct detection of red blood cell fragments: a new flow cytometric method to evaluate hemolysis in blood pumps
    J Linneweber
    Baylor College of Medicine, Department of Surgery, Houston, Texas 77030, USA
    ASAIO J 47:533-6. 2001
    ..Flow cytometry can be used for the rapid, sensitive, hemoglobin independent evaluation of pump induced RBC trauma...
  31. ncbi request reprint ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions
    Jing Fei Dong
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Blood 100:4033-9. 2002
    ..These results suggest that cleavage of EC-derived ULVWF multimers by ADAMTS-13 is a rapid physiologic process that occurs on endothelial cell surfaces...
  32. ncbi request reprint Case series of thrombotic thrombocytopenic purpura in children and adolescents
    Terzah M Horton
    Department of Pediatrics, Baylor College of Medicine, Texas Children s Hospital, Houston, Texas 77030, USA
    J Pediatr Hematol Oncol 25:336-9. 2003
    ..Although rare, TTP is a life-threatening illness that does occur in children and should be considered in the differential diagnosis of thrombocytopenia with hemolytic anemia...
  33. ncbi request reprint Enhanced platelet adhesion and aggregation by endothelial cell-derived unusually large multimers of von Willebrand factor
    R Anand Kumar
    Department of Bioengineering, Rice University, Houston, TX, USA
    Biorheology 43:681-91. 2006
    ..ULVWF is also significantly more potent than P-VWF in mediating both shear-induced platelet aggregation and ristocetin-mediated platelet agglutination...
  34. ncbi request reprint von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura
    Joel L Moake
    Baylor College of Medicine, Houston, TX, USA
    Semin Hematol 41:4-14. 2004
    ..Established, evolving, and some of the unresolved issues in TTP pathophysiology will be summarized...
  35. ncbi request reprint Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group
    Tapani Ruutu
    Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Haematologica 92:95-100. 2007
    ..An International Working Group was formed to develop a consensus formulation of criteria for diagnosing clinically significant TAM...
  36. ncbi request reprint Measurement of the binding forces between von Willebrand factor and variants of platelet glycoprotein Ibalpha using optical tweezers
    Maneesh Arya
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    Lasers Surg Med 30:306-12. 2002
    ..The adhesion of different leucine-rich repeats was studied using optical tweezers in order to determine which ones were critical for the vWf/GP Ibalpha interaction...
  37. ncbi request reprint Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers
    Maneesh Arya
    Department of Bioengineering, Rice University, Houston, TX, USA
    Blood 99:3971-7. 2002
    ..Therefore, we suggest that the conformational state of ULVWF multimers is more critical than their size for interaction with platelets...
  38. ncbi request reprint Characterization of von Willebrand factor interaction with collagens in real time using surface plasmon resonance
    Feng Li
    Cox Laboratory for Biomedical Engineering, Institute of Bioscience and Bioengineering, Rice University, Houston, TX 77251 1892, USA
    Ann Biomed Eng 30:1107-16. 2002
    ..Our results demonstrate that the vWf dissociation rates are dependent on the vWf molecular mass and the duration of interactions. We conclude that vWf-collagen binding interactions involve multiple bond processes...
  39. pmc Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions
    Zhenyin Tao
    Thrombosis Research Section, Department of Medicine, BCM286, N1319, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Blood 106:4139-45. 2005
    ..These results suggest that the CUB-1 domain may serve as the docking site for ADAMTS13 to bind ULVWF under flow, a critical step to initiate ULVWF proteolysis...
  40. pmc Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers
    Leticia H Nolasco
    Hematology Research Section, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Blood 106:4199-209. 2005
    ..These processes may contribute to the evolution of glomerular occlusion by platelet and fibrin thrombi in diarrhea-associated HUS...
  41. ncbi request reprint P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface
    Arnoldo Padilla
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Blood 103:2150-6. 2004
    ..Finally, the strength of the minimal ULVWF-P-selectin bond was measured to be 7.2 pN. We, therefore, conclude that P-selectin may anchor ULVWF strings to endothelial cells and facilitate their cleavage by ADAMTS13...
  42. ncbi request reprint ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor
    Jing Fei Dong
    Thrombosis Research Section, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:29633-9. 2003
    ..Once released, these cleaved VWF fragments become inaccessible for the metalloprotease to prevent further cleavage...