Louis B Rice

Summary

Country: USA

Publications

  1. ncbi Antibiotic-resistant gram-negative organisms in pediatric chronic-care facilities
    Karen Lidsky
    Department of Pediatrics, Rainbow Babies and Children s Hospital of the University Hospitals of Cleveland, Cleveland, OH, 44106, USA
    Clin Infect Dis 34:760-6. 2002
  2. ncbi Tn5386, a novel Tn916-like mobile element in Enterococcus faecium D344R that interacts with Tn916 to yield a large genomic deletion
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    J Bacteriol 187:6668-77. 2005
  3. ncbi A novel peptidoglycan cross-linking enzyme for a beta-lactam-resistant transpeptidation pathway
    Jean Luc Mainardi
    INSERM, U655 Laboratoire de Recherche Moléculaire sur les Antibiotiques, Universite Pierre et Marie Curie, Paris, France
    J Biol Chem 280:38146-52. 2005
  4. ncbi Unmet medical needs in antibacterial therapy
    Louis B Rice
    Louis Stokes Cleveland VA Medical Center and Case Western Reserve University, Medical Service 111 W, 10701 East Blvd, Cleveland, OH 44106, USA
    Biochem Pharmacol 71:991-5. 2006
  5. ncbi Enterococcus faecium low-affinity pbp5 is a transferable determinant
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 49:5007-12. 2005
  6. ncbi Role of class A penicillin-binding proteins in the expression of beta-lactam resistance in Enterococcus faecium
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    J Bacteriol 191:3649-56. 2009
  7. ncbi Rapid diagnostics and appropriate antibiotic use
    Louis B Rice
    Louis Stokes Cleveland Veterans Affairs Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Clin Infect Dis 52:S357-60. 2011
  8. ncbi Multiple copies of functional, Tet(M)-encoding Tn916-like elements in a clinical Enterococcus faecium isolate
    Louis B Rice
    Medicine and Research Services, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Plasmid 64:150-5. 2010
  9. ncbi The clinical consequences of antimicrobial resistance
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Curr Opin Microbiol 12:476-81. 2009
  10. ncbi The Maxwell Finland Lecture: for the duration-rational antibiotic administration in an era of antimicrobial resistance and clostridium difficile
    Louis B Rice
    Medical Service, Louis Stokes Cleveland Veterans Affairs Medical Center, and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Infect Dis 46:491-6. 2008

Collaborators

Detail Information

Publications52

  1. ncbi Antibiotic-resistant gram-negative organisms in pediatric chronic-care facilities
    Karen Lidsky
    Department of Pediatrics, Rainbow Babies and Children s Hospital of the University Hospitals of Cleveland, Cleveland, OH, 44106, USA
    Clin Infect Dis 34:760-6. 2002
    ..Children residing in chronic-care facilities represent a large reservoir for resistant bacilli. Such colonization may be amenable to simple barrier infection-control procedures...
  2. ncbi Tn5386, a novel Tn916-like mobile element in Enterococcus faecium D344R that interacts with Tn916 to yield a large genomic deletion
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    J Bacteriol 187:6668-77. 2005
    ..Our data suggest that excision of Tn5386 can be catalyzed by the Tn916 integrase and that large genomic deletions may result from the interaction between these heterologous elements...
  3. ncbi A novel peptidoglycan cross-linking enzyme for a beta-lactam-resistant transpeptidation pathway
    Jean Luc Mainardi
    INSERM, U655 Laboratoire de Recherche Moléculaire sur les Antibiotiques, Universite Pierre et Marie Curie, Paris, France
    J Biol Chem 280:38146-52. 2005
    ..Ldt(fm) homologues are encountered sporadically among taxonomically distant bacteria, indicating that ld-transpeptidase-mediated resistance may emerge in various pathogens...
  4. ncbi Unmet medical needs in antibacterial therapy
    Louis B Rice
    Louis Stokes Cleveland VA Medical Center and Case Western Reserve University, Medical Service 111 W, 10701 East Blvd, Cleveland, OH 44106, USA
    Biochem Pharmacol 71:991-5. 2006
    ..Finally, the importance of indwelling devices as a nidus for nosocomial infections emphasizes the need for effective agents for treating biofilm-associated device infection both inside and outside of the hospital...
  5. ncbi Enterococcus faecium low-affinity pbp5 is a transferable determinant
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 49:5007-12. 2005
    ..They also suggest that the spread of high-level ampicillin resistance among U.S. E. faecium strains is due in part to the transfer of low-affinity pbp5 between clinical isolates...
  6. ncbi Role of class A penicillin-binding proteins in the expression of beta-lactam resistance in Enterococcus faecium
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    J Bacteriol 191:3649-56. 2009
    ..Thus, susceptibility of Pbp5-mediated peptidoglycan cross-linking to different beta-lactam antibiotics differed as a function of its partner glycosyltransferase...
  7. ncbi Rapid diagnostics and appropriate antibiotic use
    Louis B Rice
    Louis Stokes Cleveland Veterans Affairs Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Clin Infect Dis 52:S357-60. 2011
    ..It is therefore critical that we develop rapid and reliable microbiological assays, evidence-based recommendations on appropriate durations of therapy, and accurate surrogate markers of infection resolution...
  8. ncbi Multiple copies of functional, Tet(M)-encoding Tn916-like elements in a clinical Enterococcus faecium isolate
    Louis B Rice
    Medicine and Research Services, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Plasmid 64:150-5. 2010
    ..faecium recipient strain. These data indicate that nearly identical Tn916-like elements encoding Tet(M)-mediated tetracycline/minocycline resistance can coexist in clinical E. faecium isolates...
  9. ncbi The clinical consequences of antimicrobial resistance
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Curr Opin Microbiol 12:476-81. 2009
    ....
  10. ncbi The Maxwell Finland Lecture: for the duration-rational antibiotic administration in an era of antimicrobial resistance and clostridium difficile
    Louis B Rice
    Medical Service, Louis Stokes Cleveland Veterans Affairs Medical Center, and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Infect Dis 46:491-6. 2008
    ..Studies are urgently needed to define minimal lengths of therapy to ensure that efforts at reduced use are safe and effective...
  11. ncbi Progress and challenges in implementing the research on ESKAPE pathogens
    Louis B Rice
    Medical Service, Louis Stokes Cleveland VA Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA
    Infect Control Hosp Epidemiol 31:S7-10. 2010
    ....
  12. ncbi Transferable capacity for gastrointestinal colonization in Enterococcus faecium in a mouse model
    Louis B Rice
    Medical and Research Services, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Infect Dis 199:342-9. 2009
    ..These results indicate that E. faecium clinical isolates express transmissible factors other than antimicrobial resistance that promote colonization of the mouse gastrointestinal tract...
  13. ncbi The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae
    Louis B Rice
    Department of Medicine, Medical and Research Services, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 52:3427-9. 2008
    ..This novel element represents a coalescence of genes conferring multidrug resistance in K. pneumoniae...
  14. ncbi Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA
    Andrea Endimiani
    Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Research Service, Cleveland, OH 44106, USA
    J Antimicrob Chemother 63:427-37. 2009
    ..Outbreaks in the Eastern USA have created serious treatment and infection control problems. A comparative multi-institutional analysis of these strains has not yet been performed...
  15. ncbi Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States
    Andrea Endimiani
    Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 52:2680-2. 2008
    ..One isolate carried the bla(KPC-3) and qnrB19 genes on the same conjugative plasmid, whereas another carried the bla(KPC-3) and qnrA1 genes on separate plasmids...
  16. ncbi Identification of a new allelic variant of the Acinetobacter baumannii cephalosporinase, ADC-7 beta-lactamase: defining a unique family of class C enzymes
    Kristine M Hujer
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Case School of Medicine, 10701 East Blvd, Cleveland, Ohio 44016, USA
    Antimicrob Agents Chemother 49:2941-8. 2005
    ....
  17. ncbi In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin
    Andrea Endimiani
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 54:526-9. 2010
    ..Notably, 5 out of 6 extremely drug-resistant (tigecycline and colistin nonsusceptible) KpKPC were susceptible to fosfomycin. Compared to agar dilution, disk diffusion was more accurate than Etest...
  18. ncbi Evaluation of a commercial microarray system for detection of SHV-, TEM-, CTX-M-, and KPC-type beta-lactamase genes in Gram-negative isolates
    Andrea Endimiani
    Research Service, Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    J Clin Microbiol 48:2618-22. 2010
    ..A total of 106 Gram-negative strains were tested. The following sensitivity and specificity results were recorded, respectively: for bla(SHV), 98.8% and 100%; for bla(TEM), 100% and 96.4%; and for bla(CTX-M) and bla(KPC), 100% and 100%...
  19. ncbi Structure-activity relationships of different beta-lactam antibiotics against a soluble form of Enterococcus faecium PBP5, a type II bacterial transpeptidase
    Andrea M Hujer
    Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 49:612-8. 2005
    ....
  20. ncbi In vitro antienterococcal activity explains associations between exposures to antimicrobial agents and risk of colonization by multiresistant enterococci
    Louis B Rice
    Medical and Research Services, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio 44106, USA
    J Infect Dis 190:2162-6. 2004
    ..These results support a model in which the impact that different beta -lactam agents have on colonization by VRE is related to the level of the beta -lactam agent's intrinsic antienterococcal activity against the colonizing strain...
  21. ncbi Impact of specific pbp5 mutations on expression of beta-lactam resistance in Enterococcus faecium
    Louis B Rice
    Medical and Research Services, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 48:3028-32. 2004
    ..Affinity for penicillin generally correlated with beta-lactam MICs for the mutants, but these associations were not strictly proportional...
  22. ncbi Antimicrobial resistance in gram-positive bacteria
    Louis B Rice
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Med 119:S11-9; discussion S62-70. 2006
    ....
  23. ncbi Antibiotic-induced enterococcal expansion in the mouse intestine occurs throughout the small bowel and correlates poorly with suppression of competing flora
    Viera Lakticova
    Medical Service, Louis Stokes Cleveland VA Medical Center, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 50:3117-23. 2006
    ..Host or enterococcal factors induced by exposures to certain antibiotics may play a role in facilitating E. faecium colonization of the mammalian gastrointestinal tract...
  24. ncbi Emerging issues in the management of infections caused by multidrug-resistant gram-negative bacteria
    Louis B Rice
    Louis Stokes Cleveland VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Cleve Clin J Med 74:S12-20. 2007
    ....
  25. ncbi Emergence of linezolid-resistant Staphylococcus aureus after prolonged treatment of cystic fibrosis patients in Cleveland, Ohio
    Andrea Endimiani
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 55:1684-92. 2011
    ..Emergence of LRSA is a serious concern for CF patients who undergo prolonged courses of LZD therapy...
  26. ncbi A potential virulence gene, hylEfm, predominates in Enterococcus faecium of clinical origin
    Louis B Rice
    Research and Medical Services, Louis Stokes Cleveland Veterans Affairs Medical Center and Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    J Infect Dis 187:508-12. 2003
    ..Differences in the prevalence of these strains may help explain variations in the clinical importance of multiresistant E. faecium across different continents...
  27. ncbi Effect of parenteral fluoroquinolone administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract
    Curtis J Donskey
    Research Service Medical Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 48:326-8. 2004
    ..Levofloxacin and ciprofloxacin did not promote colonization in comparison to saline controls, whereas moxifloxacin and gatifloxacin promoted persistent overgrowth in a dose-dependent fashion...
  28. ncbi Beta-lactam antibiotics and gastrointestinal colonization with vancomycin-resistant enterococci
    Louis B Rice
    Medical and Research Services, Louis Stokes Cleveland VA Medical Center, The Cleveland Veterans Affairs Research and Education Foundation, and Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 189:1113-8. 2004
    ..These data suggest that the risk of VRE colonization varies during exposure to different beta-lactam antimicrobial agents and that the risk is related to biliary concentration and antienterococcal activity of the specific beta-lactam...
  29. ncbi Characterization of Tn5386, a Tn916-related mobile element
    Louis B Rice
    Medicine and Research Services, Case Western Reserve University, Cleveland, OH 44106, USA
    Plasmid 58:61-7. 2007
    ..Our results indicate that Tn5386 falls within the Tn916 family of transposons, and in place of tetM encodes a novel region that may confer resistance to lantibiotics...
  30. ncbi A clinical strain of Escherichia coli possessing CMY-2 plasmid-mediated amp C beta-lactamase: an emerging concern in pediatrics?
    Claudia M Hoyen
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, OH 44106, USA
    Microb Drug Resist 8:329-33. 2002
    ..The transferable plasmid contained both blaCMY-2 and blaTEM-1b. Increasing reports of CMY-2 beta-lactamase in clinical isolates in children raise concerns about the empiric use of third-generation cephalosporins in this patient group...
  31. ncbi Analysis of PBP5 of early U.S. isolates of Enterococcus faecium: sequence variation alone does not explain increasing ampicillin resistance over time
    Jessica R Galloway-Peña
    Division of Infectious Disease, Department of Medicine, Center for the Study of Emerging and Re Emerging Pathogens, University of Texas Medical School, Houston, Texas 77030, USA
    Antimicrob Agents Chemother 55:3272-7. 2011
    ..Analysis of three other genes encoding cell wall/surface proteins also showed that there are two distinct evolutionary groups for each gene, but with occasional mixing of genes, consistent with a species that evolves by recombination...
  32. ncbi Interaction of related Tn916-like transposons: analysis of excision events promoted by Tn916 and Tn5386 integrases
    Louis B Rice
    Medicine and Research Services, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Bacteriol 189:3909-17. 2007
    ..These findings also raise interesting questions about the sequence specificities of the C terminals of Tn916-like integrases, which bind to the ends and facilitate strand exchange...
  33. ncbi Controlling antibiotic resistance in the ICU: different bacteria, different strategies
    Louis B Rice
    Louis Stokes Cleveland VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Cleve Clin J Med 70:793-800. 2003
    ..Each strategy has theoretical benefits and limitations, but good data on their efficacy in controlling antimicrobial resistance are limited...
  34. ncbi An interventional program to improve antibiotic use
    Cynthia L Feucht
    Pharmacy Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA
    Ann Pharmacother 37:646-51. 2003
    ....
  35. ncbi Use of denaturing gradient gel electrophoresis for analysis of the stool microbiota of hospitalized patients
    Curtis J Donskey
    Infectious Diseases Section 111 W, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    J Microbiol Methods 54:249-56. 2003
    ..Thus, our findings are consistent with previous studies that utilized culture techniques, and suggest that DGGE is a useful technique for analysis of the stool microbiota of hospitalized patients...
  36. ncbi Recombination proficiency influences frequency and locus of mutational resistance to linezolid in Enterococcus faecalis
    Michael Lobritz
    Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 47:3318-20. 2003
    ..UV202 resistance was associated with a G2505A mutation present in a single copy in mutants with different MICs...
  37. ncbi Challenges in identifying new antimicrobial agents effective for treating infections with Acinetobacter baumannii and Pseudomonas aeruginosa
    Louis B Rice
    Louis Stokes Cleveland VA Medical Center and Case Medical School, Cleveland, Ohio 44106, USA
    Clin Infect Dis 43:S100-5. 2006
    ..aeruginosa but has encouraging activity against many A. baumannii isolates. Resistance to tigecycline can emerge during therapy, however, and is due to expression of multidrug efflux pumps...
  38. ncbi Antimicrobial resistance in gram-positive bacteria
    Louis B Rice
    Medical Service, Louis Stokes Cleveland VA Medical Center, Cleveland, OH 44106, USA
    Am J Infect Control 34:S11-9; discussion S64-73. 2006
    ....
  39. ncbi Early insights into the interactions of different β-lactam antibiotics and β-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3
    Krisztina M Papp-Wallace
    Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 56:5687-92. 2012
    ..baumannii. Unraveling the contribution of PBPs to β-lactam susceptibility and resistance brings us one step closer to identifying which PBPs are the best targets for novel β-lactams...
  40. ncbi Intrinsic and acquired resistance mechanisms in enterococcus
    Brian L Hollenbeck
    Department of Medicine, Lifespan Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, USA
    Virulence 3:421-33. 2012
    ..This paper reviews the antibiotic resistance mechanisms in Enterococcus faecium and Enterococcus faecalis and discusses treatment options...
  41. ncbi Mechanisms of resistance and clinical relevance of resistance to β-lactams, glycopeptides, and fluoroquinolones
    Louis B Rice
    Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA
    Mayo Clin Proc 87:198-208. 2012
    ..As such, it is critical that we devise, test, and implement antimicrobial stewardship strategies that are effective at constraining and, ideally, reducing resistance in human pathogenic bacteria...
  42. ncbi Do we really need new anti-infective drugs?
    Louis B Rice
    Medical Servicer 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Curr Opin Pharmacol 3:459-63. 2003
    ....
  43. ncbi International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial Infections
    David L Paterson
    Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Ann Intern Med 140:26-32. 2004
    ..CONCLUSIONS: Production of ESBLs by Klebsiella pneumoniae is a widespread nosocomial problem. Appropriate infection control and antibiotic management strategies are needed to stem the spread of this emerging form of resistance...
  44. ncbi Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE
    Louis B Rice
    J Infect Dis 197:1079-81. 2008
  45. ncbi Extended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamases
    David L Paterson
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Antimicrob Agents Chemother 47:3554-60. 2003
    ..pneumoniae infections...
  46. ncbi Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases
    David L Paterson
    Infectious Disease Section, VA Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Clin Infect Dis 39:31-7. 2004
    ..Antibiotic choice is particularly important in seriously ill patients with infections due to ESBL-producing K. pneumoniae...
  47. ncbi Clinical-use-associated decrease in susceptibility of vancomycin-resistant Enterococcus faecium to linezolid: a comparison with quinupristin-dalfopristin
    Issam I Raad
    Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Antimicrob Agents Chemother 48:3583-5. 2004
    ..More than 6 months after their clinical use, a decrease in susceptibility was noted for only linezolid at 83%. This was related in part to a single G2576U gene mutation in domain V of the 23S rRNA gene...
  48. ncbi Novel mechanism of resistance to glycopeptide antibiotics in Enterococcus faecium
    Julie Cremniter
    INSERM U655-LRMA, , , , Paris 75270, France
    J Biol Chem 281:32254-62. 2006
    ..This novel mechanism of glycopeptide resistance was unrelated to the previously identified replacement of D-Ala(5) by D-Ser or D-lactate...
  49. ncbi Specificity of L,D-transpeptidases from gram-positive bacteria producing different peptidoglycan chemotypes
    Sophie Magnet
    INSERM, U655 LRMA F 75006 Paris France
    J Biol Chem 282:13151-9. 2007
    ..Blocking the assembly of the side chain could therefore be used to combat antibiotic resistance involving L,D-transpeptidases...
  50. ncbi Unexpected inhibition of peptidoglycan LD-transpeptidase from Enterococcus faecium by the beta-lactam imipenem
    Jean Luc Mainardi
    INSERM, U872, LRMA Pôle 4, Equipe 12 F 75006 Paris, France
    J Biol Chem 282:30414-22. 2007
    ..Combination therapy with imipenem and ampicillin could therefore be active against E. faecium strains having the dual capacity to manufacture peptidoglycan with transpeptidases of the LD- and DD-specificities...
  51. ncbi Empirical antibiotic choice for the seriously ill patient: are minimization of selection of resistant organisms and maximization of individual outcome mutually exclusive?
    David L Paterson
    Antibiotic Management Program, Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Clin Infect Dis 36:1006-12. 2003
    ..Computer-assisted antibiotic prescribing in ICUs may supplement or replace such strategies in the future...
  52. ncbi Collateral damage
    Louis B Rice
    Ann Intern Med 139:523-4. 2003