L B Rice

Summary

Country: USA

Publications

  1. doi request reprint Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE
    Louis B Rice
    J Infect Dis 197:1079-81. 2008
  2. ncbi request reprint Emerging issues in the management of infections caused by multi-drug-resistant, gram-negative bacilli
    Louis B Rice
    Medical Service 111, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio 44106, USA
    Surg Infect (Larchmt) 6:S-37-47. 2005
  3. ncbi request reprint Emerging issues in the management of infections caused by multidrug-resistant gram-negative bacteria
    Louis B Rice
    Louis Stokes Cleveland VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Cleve Clin J Med 74:S12-20. 2007
  4. ncbi request reprint Controlling antibiotic resistance in the ICU: different bacteria, different strategies
    Louis B Rice
    Louis Stokes Cleveland VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Cleve Clin J Med 70:793-800. 2003
  5. ncbi request reprint Do we really need new anti-infective drugs?
    Louis B Rice
    Medical Servicer 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Curr Opin Pharmacol 3:459-63. 2003
  6. ncbi request reprint Beta-lactam antibiotics and gastrointestinal colonization with vancomycin-resistant enterococci
    Louis B Rice
    Medical and Research Services, Louis Stokes Cleveland VA Medical Center, The Cleveland Veterans Affairs Research and Education Foundation, and Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 189:1113-8. 2004
  7. pmc Impact of specific pbp5 mutations on expression of beta-lactam resistance in Enterococcus faecium
    Louis B Rice
    Medical and Research Services, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 48:3028-32. 2004
  8. ncbi request reprint In vitro antienterococcal activity explains associations between exposures to antimicrobial agents and risk of colonization by multiresistant enterococci
    Louis B Rice
    Medical and Research Services, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio 44106, USA
    J Infect Dis 190:2162-6. 2004
  9. pmc Tn5386, a novel Tn916-like mobile element in Enterococcus faecium D344R that interacts with Tn916 to yield a large genomic deletion
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    J Bacteriol 187:6668-77. 2005
  10. ncbi request reprint Unmet medical needs in antibacterial therapy
    Louis B Rice
    Louis Stokes Cleveland VA Medical Center and Case Western Reserve University, Medical Service 111 W, 10701 East Blvd, Cleveland, OH 44106, USA
    Biochem Pharmacol 71:991-5. 2006

Collaborators

Detail Information

Publications67

  1. doi request reprint Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE
    Louis B Rice
    J Infect Dis 197:1079-81. 2008
  2. ncbi request reprint Emerging issues in the management of infections caused by multi-drug-resistant, gram-negative bacilli
    Louis B Rice
    Medical Service 111, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio 44106, USA
    Surg Infect (Larchmt) 6:S-37-47. 2005
    ..Infections caused by multi-drug-resistant, gram-negative bacilli lead, in many instances, to increased morbidity and mortality, prolonged hospital stays, and the use of broad-spectrum antibiotics...
  3. ncbi request reprint Emerging issues in the management of infections caused by multidrug-resistant gram-negative bacteria
    Louis B Rice
    Louis Stokes Cleveland VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Cleve Clin J Med 74:S12-20. 2007
    ....
  4. ncbi request reprint Controlling antibiotic resistance in the ICU: different bacteria, different strategies
    Louis B Rice
    Louis Stokes Cleveland VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Cleve Clin J Med 70:793-800. 2003
    ..Each strategy has theoretical benefits and limitations, but good data on their efficacy in controlling antimicrobial resistance are limited...
  5. ncbi request reprint Do we really need new anti-infective drugs?
    Louis B Rice
    Medical Servicer 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Curr Opin Pharmacol 3:459-63. 2003
    ....
  6. ncbi request reprint Beta-lactam antibiotics and gastrointestinal colonization with vancomycin-resistant enterococci
    Louis B Rice
    Medical and Research Services, Louis Stokes Cleveland VA Medical Center, The Cleveland Veterans Affairs Research and Education Foundation, and Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 189:1113-8. 2004
    ..These data suggest that the risk of VRE colonization varies during exposure to different beta-lactam antimicrobial agents and that the risk is related to biliary concentration and antienterococcal activity of the specific beta-lactam...
  7. pmc Impact of specific pbp5 mutations on expression of beta-lactam resistance in Enterococcus faecium
    Louis B Rice
    Medical and Research Services, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 48:3028-32. 2004
    ..Affinity for penicillin generally correlated with beta-lactam MICs for the mutants, but these associations were not strictly proportional...
  8. ncbi request reprint In vitro antienterococcal activity explains associations between exposures to antimicrobial agents and risk of colonization by multiresistant enterococci
    Louis B Rice
    Medical and Research Services, Louis Stokes Cleveland VA Medical Center, Cleveland, Ohio 44106, USA
    J Infect Dis 190:2162-6. 2004
    ..These results support a model in which the impact that different beta -lactam agents have on colonization by VRE is related to the level of the beta -lactam agent's intrinsic antienterococcal activity against the colonizing strain...
  9. pmc Tn5386, a novel Tn916-like mobile element in Enterococcus faecium D344R that interacts with Tn916 to yield a large genomic deletion
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    J Bacteriol 187:6668-77. 2005
    ..Our data suggest that excision of Tn5386 can be catalyzed by the Tn916 integrase and that large genomic deletions may result from the interaction between these heterologous elements...
  10. ncbi request reprint Unmet medical needs in antibacterial therapy
    Louis B Rice
    Louis Stokes Cleveland VA Medical Center and Case Western Reserve University, Medical Service 111 W, 10701 East Blvd, Cleveland, OH 44106, USA
    Biochem Pharmacol 71:991-5. 2006
    ..Finally, the importance of indwelling devices as a nidus for nosocomial infections emphasizes the need for effective agents for treating biofilm-associated device infection both inside and outside of the hospital...
  11. pmc Enterococcus faecium low-affinity pbp5 is a transferable determinant
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 49:5007-12. 2005
    ..They also suggest that the spread of high-level ampicillin resistance among U.S. E. faecium strains is due in part to the transfer of low-affinity pbp5 between clinical isolates...
  12. ncbi request reprint Antibiotics and gastrointestinal colonization by vancomycin-resistant enterococci
    L B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center and Case Medical School, 10701 East Boulevard, Cleveland, OH 44106, USA
    Eur J Clin Microbiol Infect Dis 24:804-14. 2005
    ..Modification of antimicrobial prescribing practices may play an important role in facilitating successful infection control efforts to limit GRE in the nosocomial setting...
  13. ncbi request reprint Antimicrobial resistance in gram-positive bacteria
    Louis B Rice
    Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Am J Med 119:S11-9; discussion S62-70. 2006
    ....
  14. ncbi request reprint Antimicrobial resistance in gram-positive bacteria
    Louis B Rice
    Medical Service, Louis Stokes Cleveland VA Medical Center, Cleveland, OH 44106, USA
    Am J Infect Control 34:S11-9; discussion S64-73. 2006
    ....
  15. ncbi request reprint Challenges in identifying new antimicrobial agents effective for treating infections with Acinetobacter baumannii and Pseudomonas aeruginosa
    Louis B Rice
    Louis Stokes Cleveland VA Medical Center and Case Medical School, Cleveland, Ohio 44106, USA
    Clin Infect Dis 43:S100-5. 2006
    ..aeruginosa but has encouraging activity against many A. baumannii isolates. Resistance to tigecycline can emerge during therapy, however, and is due to expression of multidrug efflux pumps...
  16. pmc Interaction of related Tn916-like transposons: analysis of excision events promoted by Tn916 and Tn5386 integrases
    Louis B Rice
    Medicine and Research Services, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    J Bacteriol 189:3909-17. 2007
    ..These findings also raise interesting questions about the sequence specificities of the C terminals of Tn916-like integrases, which bind to the ends and facilitate strand exchange...
  17. ncbi request reprint Characterization of Tn5386, a Tn916-related mobile element
    Louis B Rice
    Medicine and Research Services, Case Western Reserve University, Cleveland, OH 44106, USA
    Plasmid 58:61-7. 2007
    ..Our results indicate that Tn5386 falls within the Tn916 family of transposons, and in place of tetM encodes a novel region that may confer resistance to lantibiotics...
  18. ncbi request reprint Association of different mobile elements to generate novel integrative elements
    L B Rice
    Medical Service 111 W, Louis Stokes VA Medical Center, 10701 East Blvd, Cleveland, Ohio 44106, USA
    Cell Mol Life Sci 59:2023-32. 2002
    ..The association of the elements with transferable elements or transposons may promote rapid dissemination among clinical strains, and create further opportunities for inclusion of additional resistance determinants...
  19. ncbi request reprint A potential virulence gene, hylEfm, predominates in Enterococcus faecium of clinical origin
    Louis B Rice
    Research and Medical Services, Louis Stokes Cleveland Veterans Affairs Medical Center and Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    J Infect Dis 187:508-12. 2003
    ..Differences in the prevalence of these strains may help explain variations in the clinical importance of multiresistant E. faecium across different continents...
  20. pmc High-level expression of chromosomally encoded SHV-1 beta-lactamase and an outer membrane protein change confer resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae
    L B Rice
    Medical Service, Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 44:362-7. 2000
    ....
  21. pmc Penicillin-binding protein 5 and expression of ampicillin resistance in Enterococcus faecium
    L B Rice
    Medical and Research Services, VA Medical Center, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 45:1480-6. 2001
    ..However, quantities of psr transcript were increased in D344-SRF(pCWR583) compared to D344-SRF(pCWR558), especially after growth in ampicillin; suggesting that PSR acts in some manner to activate its own transcription...
  22. pmc Emergence of vancomycin-resistant enterococci
    L B Rice
    VA Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Emerg Infect Dis 7:183-7. 2001
    ..Control of VRE will require better understanding of the mechanisms by which different classes of drugs promote gastrointestinal colonization...
  23. doi request reprint Antimicrobial pressure and the emergence and spread of multiresistant enterococci
    L B Rice
    Louis Stokes Veterans Administration Medical Center and Case Western Reserve University School of Medicine, 10701 East Boulevard, Cleveland, OH 44106, USA
    Postgrad Med 109:22-31. 2001
    ....
  24. ncbi request reprint Bacterial monopolists: the bundling and dissemination of antimicrobial resistance genes in gram-positive bacteria
    L B Rice
    Medical Service, Department of Veterans Affairs Medical Center, and the Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Clin Infect Dis 31:762-9. 2000
    ..An understanding of these mechanisms and their prevalence can improve our ability to treat clinical infections in hospitalized patients, as well as to predict and control the spread of resistant bacteria in the nosocomial environment...
  25. pmc Transfer of Tn5385, a composite, multiresistance chromosomal element from Enterococcus faecalis
    L B Rice
    Department of Veterans Affairs Medical Center, and Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Bacteriol 180:714-21. 1998
    ..They also suggest that chromosomal recombination is a mechanism of genetic exchange in enterococci...
  26. pmc Transferable, plasmid-mediated vanB-type glycopeptide resistance in Enterococcus faecium
    L B Rice
    Cleveland Department of Veterans Affairs Medical Center, Department of Medicine, Case Western Reserve University School of Medicine, Ohio 44106, USA
    Antimicrob Agents Chemother 42:963-4. 1998
    ..A similar plasmid has been observed in an unrelated E. faecium strain, suggesting that plasmid transfer of vanB operons occurs in nature and plays a role in the dissemination of VanB-type resistance among strains of E. faecium...
  27. ncbi request reprint Effect of parenteral antibiotic administration on the establishment of colonization with vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract
    C J Donskey
    Division of Infectious Diseases, Louis Stokes Dept of Veterans Affairs Medical Center, Cleveland, OH 44106
    J Infect Dis 181:1830-3. 2000
    ..Thus, in this mouse model, beta-lactam antibiotics with minimal anti-enterococcal activity promoted establishment of high-level VRE colonization, but Pip-Taz (a beta-lactam antibiotic with more potent activity against VRE) did not...
  28. ncbi request reprint Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients
    C J Donskey
    Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    N Engl J Med 343:1925-32. 2000
    ..In mice that have intestinal colonization with vancomycin-resistant enterococci, these agents promote high-density colonization, whereas antibiotics with minimal antianaerobic activity do not...
  29. ncbi request reprint An interventional program to improve antibiotic use
    Cynthia L Feucht
    Pharmacy Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA
    Ann Pharmacother 37:646-51. 2003
    ..Large volume and often inappropriate use of specific antimicrobial agents increase selective pressure for emergence of resistant bacteria and place strain on the pharmacy budget...
  30. pmc Identification of a new allelic variant of the Acinetobacter baumannii cephalosporinase, ADC-7 beta-lactamase: defining a unique family of class C enzymes
    Kristine M Hujer
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Case School of Medicine, 10701 East Blvd, Cleveland, Ohio 44016, USA
    Antimicrob Agents Chemother 49:2941-8. 2005
    ....
  31. ncbi request reprint Inhibition of vancomycin-resistant enterococci by an in vitro continuous-flow competitive exclusion culture containing human stool flora
    C J Donskey
    Infectious Diseases Section, Louis Stokes Cleveland Dept of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Infect Dis 184:1624-7. 2001
    ..These data support the hypothesis that the indigenous intestinal flora inhibit growth of VRE and suggest that CFCE cultures may be a useful means to study interactions between the indigenous flora and VRE...
  32. ncbi request reprint Emerging issues in antibiotic resistant infections in long-term care facilities
    R A Bonomo
    Division of Geriatrics, University Hospitals of Cleveland, Ohio, USA
    J Gerontol A Biol Sci Med Sci 54:B260-7. 1999
    ..The combined efforts of the medical directors, infection-control personnel, and administrators are needed to stem this problem...
  33. pmc Structure-activity relationships of different beta-lactam antibiotics against a soluble form of Enterococcus faecium PBP5, a type II bacterial transpeptidase
    Andrea M Hujer
    Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 49:612-8. 2005
    ....
  34. pmc In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin
    Andrea Endimiani
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 54:526-9. 2010
    ..Notably, 5 out of 6 extremely drug-resistant (tigecycline and colistin nonsusceptible) KpKPC were susceptible to fosfomycin. Compared to agar dilution, disk diffusion was more accurate than Etest...
  35. ncbi request reprint A clinical strain of Escherichia coli possessing CMY-2 plasmid-mediated amp C beta-lactamase: an emerging concern in pediatrics?
    Claudia M Hoyen
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Rainbow Babies and Childrens Hospital, Cleveland, OH 44106, USA
    Microb Drug Resist 8:329-33. 2002
    ..The transferable plasmid contained both blaCMY-2 and blaTEM-1b. Increasing reports of CMY-2 beta-lactamase in clinical isolates in children raise concerns about the empiric use of third-generation cephalosporins in this patient group...
  36. pmc Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA
    Andrea Endimiani
    Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Research Service, Cleveland, OH 44106, USA
    J Antimicrob Chemother 63:427-37. 2009
    ..Outbreaks in the Eastern USA have created serious treatment and infection control problems. A comparative multi-institutional analysis of these strains has not yet been performed...
  37. pmc Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States
    Andrea Endimiani
    Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 52:2680-2. 2008
    ..One isolate carried the bla(KPC-3) and qnrB19 genes on the same conjugative plasmid, whereas another carried the bla(KPC-3) and qnrA1 genes on separate plasmids...
  38. pmc Effect of parenteral fluoroquinolone administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract
    Curtis J Donskey
    Research Service Medical Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 48:326-8. 2004
    ..Levofloxacin and ciprofloxacin did not promote colonization in comparison to saline controls, whereas moxifloxacin and gatifloxacin promoted persistent overgrowth in a dose-dependent fashion...
  39. pmc Enterococcal transposon Tn5384: evolution of a composite transposon through cointegration of enterococcal and staphylococcal plasmids
    M E Bonafede
    Department of Pediatrics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 41:1854-8. 1997
    ..These results implicate broad-host-range plasmids in the transfer of resistance determinants from staphylococci to enterococci...
  40. ncbi request reprint Inhibitor resistant class A beta-lactamases
    R A Bonomo
    Geriatric CARE Center, Cleveland, OH 44120, USA
    Front Biosci 4:e34-41. 1999
    ..Understanding the microbiologic and kinetic properties of these inhibitor resistant class A beta-lactamases can lead to the design of more potent beta-lactam compounds as well as more effective inhibitors...
  41. pmc Recombination proficiency influences frequency and locus of mutational resistance to linezolid in Enterococcus faecalis
    Michael Lobritz
    Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 47:3318-20. 2003
    ..UV202 resistance was associated with a G2505A mutation present in a single copy in mutants with different MICs...
  42. pmc Evaluation of a commercial microarray system for detection of SHV-, TEM-, CTX-M-, and KPC-type beta-lactamase genes in Gram-negative isolates
    Andrea Endimiani
    Research Service, Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    J Clin Microbiol 48:2618-22. 2010
    ..A total of 106 Gram-negative strains were tested. The following sensitivity and specificity results were recorded, respectively: for bla(SHV), 98.8% and 100%; for bla(TEM), 100% and 96.4%; and for bla(CTX-M) and bla(KPC), 100% and 100%...
  43. pmc Antibiotic-induced enterococcal expansion in the mouse intestine occurs throughout the small bowel and correlates poorly with suppression of competing flora
    Viera Lakticova
    Medical Service, Louis Stokes Cleveland VA Medical Center, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 50:3117-23. 2006
    ..Host or enterococcal factors induced by exposures to certain antibiotics may play a role in facilitating E. faecium colonization of the mammalian gastrointestinal tract...
  44. pmc Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis
    S H Marshall
    Research and Medical Services, Department of Veterans Affairs Medical Center and Division of Infectious Diseases, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 46:3334-6. 2002
    ..We analyzed nine clinical isolates of linezolid-resistant enterococci and showed a clear association between the number of 23S rRNA genes containing this mutation and the level of linezolid resistance expressed...
  45. pmc The KQ element, a complex genetic region conferring transferable resistance to carbapenems, aminoglycosides, and fluoroquinolones in Klebsiella pneumoniae
    Louis B Rice
    Department of Medicine, Medical and Research Services, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 52:3427-9. 2008
    ..This novel element represents a coalescence of genes conferring multidrug resistance in K. pneumoniae...
  46. pmc Emergence of linezolid-resistant Staphylococcus aureus after prolonged treatment of cystic fibrosis patients in Cleveland, Ohio
    Andrea Endimiani
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 55:1684-92. 2011
    ..Emergence of LRSA is a serious concern for CF patients who undergo prolonged courses of LZD therapy...
  47. doi request reprint Progress and challenges in implementing the research on ESKAPE pathogens
    Louis B Rice
    Medical Service, Louis Stokes Cleveland VA Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA
    Infect Control Hosp Epidemiol 31:S7-10. 2010
    ....
  48. pmc Multiple copies of functional, Tet(M)-encoding Tn916-like elements in a clinical Enterococcus faecium isolate
    Louis B Rice
    Medicine and Research Services, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Plasmid 64:150-5. 2010
    ..faecium recipient strain. These data indicate that nearly identical Tn916-like elements encoding Tet(M)-mediated tetracycline/minocycline resistance can coexist in clinical E. faecium isolates...
  49. doi request reprint The clinical consequences of antimicrobial resistance
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Curr Opin Microbiol 12:476-81. 2009
    ....
  50. pmc Role of class A penicillin-binding proteins in the expression of beta-lactam resistance in Enterococcus faecium
    Louis B Rice
    Medical Service 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    J Bacteriol 191:3649-56. 2009
    ..Thus, susceptibility of Pbp5-mediated peptidoglycan cross-linking to different beta-lactam antibiotics differed as a function of its partner glycosyltransferase...
  51. doi request reprint Transferable capacity for gastrointestinal colonization in Enterococcus faecium in a mouse model
    Louis B Rice
    Medical and Research Services, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Infect Dis 199:342-9. 2009
    ..These results indicate that E. faecium clinical isolates express transmissible factors other than antimicrobial resistance that promote colonization of the mouse gastrointestinal tract...
  52. doi request reprint The Maxwell Finland Lecture: for the duration-rational antibiotic administration in an era of antimicrobial resistance and clostridium difficile
    Louis B Rice
    Medical Service, Louis Stokes Cleveland Veterans Affairs Medical Center, and Case Western Reserve University, Cleveland, Ohio 44106, USA
    Clin Infect Dis 46:491-6. 2008
    ..Studies are urgently needed to define minimal lengths of therapy to ensure that efforts at reduced use are safe and effective...
  53. ncbi request reprint Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases
    David L Paterson
    Infectious Disease Section, VA Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Clin Infect Dis 39:31-7. 2004
    ..Antibiotic choice is particularly important in seriously ill patients with infections due to ESBL-producing K. pneumoniae...
  54. doi request reprint Rapid diagnostics and appropriate antibiotic use
    Louis B Rice
    Louis Stokes Cleveland Veterans Affairs Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Clin Infect Dis 52:S357-60. 2011
    ..It is therefore critical that we develop rapid and reliable microbiological assays, evidence-based recommendations on appropriate durations of therapy, and accurate surrogate markers of infection resolution...
  55. ncbi request reprint Rapid method of extraction and analysis of extended-spectrum beta-lactamases from clinical strains of Klebsiella pneumoniae
    D L Paterson
    Louis Stokes Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Clin Microbiol Infect 7:709-11. 2001
    ..Further studies are being undertaken to assess the method's applicability to other bacterial species...
  56. pmc Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance
    M A Ghannoum
    Center for Medical Mycology, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Clin Microbiol Rev 12:501-17. 1999
    ..For example, modification of enzymes which serve as targets for antimicrobial action and the involvement of membrane pumps in the extrusion of drugs are well characterized in both the eukaryotic and prokaryotic cells...
  57. ncbi request reprint Antibiotic-resistant gram-negative organisms in pediatric chronic-care facilities
    Karen Lidsky
    Department of Pediatrics, Rainbow Babies and Children s Hospital of the University Hospitals of Cleveland, Cleveland, OH, 44106, USA
    Clin Infect Dis 34:760-6. 2002
    ..Children residing in chronic-care facilities represent a large reservoir for resistant bacilli. Such colonization may be amenable to simple barrier infection-control procedures...
  58. ncbi request reprint Use of denaturing gradient gel electrophoresis for analysis of the stool microbiota of hospitalized patients
    Curtis J Donskey
    Infectious Diseases Section 111 W, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    J Microbiol Methods 54:249-56. 2003
    ..Thus, our findings are consistent with previous studies that utilized culture techniques, and suggest that DGGE is a useful technique for analysis of the stool microbiota of hospitalized patients...
  59. pmc Novel mechanism of resistance to glycopeptide antibiotics in Enterococcus faecium
    Julie Cremniter
    INSERM U655 LRMA, Centre de Recherches Biomedicales des Cordeliers, Universite Paris 6, 15 rue de l Ecole de Medecine, Paris 75270, France
    J Biol Chem 281:32254-62. 2006
    ..This novel mechanism of glycopeptide resistance was unrelated to the previously identified replacement of D-Ala(5) by D-Ser or D-lactate...
  60. ncbi request reprint Specificity of L,D-transpeptidases from gram-positive bacteria producing different peptidoglycan chemotypes
    Sophie Magnet
    INSERM, U655 LRMA F 75006 Paris France
    J Biol Chem 282:13151-9. 2007
    ..Blocking the assembly of the side chain could therefore be used to combat antibiotic resistance involving L,D-transpeptidases...
  61. ncbi request reprint Empirical antibiotic choice for the seriously ill patient: are minimization of selection of resistant organisms and maximization of individual outcome mutually exclusive?
    David L Paterson
    Antibiotic Management Program, Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Clin Infect Dis 36:1006-12. 2003
    ..Computer-assisted antibiotic prescribing in ICUs may supplement or replace such strategies in the future...
  62. ncbi request reprint International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial Infections
    David L Paterson
    Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Ann Intern Med 140:26-32. 2004
    ..Commonly encountered nosocomially acquired gram-negative bacteria, especially Klebsiella pneumoniae, produce extended-spectrum beta-lactamases (ESBLs) as an antibiotic resistance mechanism...
  63. ncbi request reprint A novel peptidoglycan cross-linking enzyme for a beta-lactam-resistant transpeptidation pathway
    Jean Luc Mainardi
    INSERM, U655 Laboratoire de Recherche Moléculaire sur les Antibiotiques, Universite Pierre et Marie Curie, Paris, France
    J Biol Chem 280:38146-52. 2005
    ..Ldt(fm) homologues are encountered sporadically among taxonomically distant bacteria, indicating that ld-transpeptidase-mediated resistance may emerge in various pathogens...
  64. ncbi request reprint Unexpected inhibition of peptidoglycan LD-transpeptidase from Enterococcus faecium by the beta-lactam imipenem
    Jean Luc Mainardi
    INSERM, U872, LRMA Pôle 4, Equipe 12 F 75006 Paris, France
    J Biol Chem 282:30414-22. 2007
    ..Combination therapy with imipenem and ampicillin could therefore be active against E. faecium strains having the dual capacity to manufacture peptidoglycan with transpeptidases of the LD- and DD-specificities...
  65. pmc Extended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamases
    David L Paterson
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Antimicrob Agents Chemother 47:3554-60. 2003
    ..pneumoniae infections...
  66. pmc Clinical-use-associated decrease in susceptibility of vancomycin-resistant Enterococcus faecium to linezolid: a comparison with quinupristin-dalfopristin
    Issam I Raad
    Department of Infectious Diseases, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Antimicrob Agents Chemother 48:3583-5. 2004
    ..More than 6 months after their clinical use, a decrease in susceptibility was noted for only linezolid at 83%. This was related in part to a single G2576U gene mutation in domain V of the 23S rRNA gene...
  67. ncbi request reprint Collateral damage
    Louis B Rice
    Ann Intern Med 139:523-4. 2003

Research Grants9

  1. REGULATION OF AMPICILLIN RESISTANCE IN E FACEIUM
    Louis Rice; Fiscal Year: 2004
    ..They will also yield important new information on mechanisms of cell wall synthesis in E. faecium and other Gram-positive bacteria as well as on the mechanisms by which ampicillin resistance in E. faecium is regulated. ..
  2. Ampicillin resistance mechanisms in E. faecium
    Louis Rice; Fiscal Year: 2007
    ..abstract_text> ..
  3. Cell wall synthesis enzymes and beta-lactam resistance in Enterococcus faecium
    Louis B Rice; Fiscal Year: 2010
    ..This project aims to identify and characterize the complex and redundant mechanisms of ?-lactam resistance in an effort to better understand enterococcal physiology and promote identification of novel therapeutic targets. ..