Research Topics
| Rebekah A DrezekSummaryAffiliation: Rice University Country: USA Publications
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Detail Information
Publications
Quantification of water solubilized CdSe/ZnS quantum dots in Daphnia magnaNastassja A Lewinski
Department of Bioengineering, Rice University, Houston, Texas, USA
Environ Sci Technol 44:1841-6. 2010..Fluorescence microscopy and ICP-MS measurements revealed differences in uptake after 24 h of exposure which were attributed to particle surface coating and stability...
High-density sub-100-nm peptide-gold nanoparticle complexes improve vaccine presentation by dendritic cells in vitroAdam Yuh Lin
Department of Bioengineering, Rice University, 77005, Houston, TX USA
Nanoscale Res Lett 8:72. 2013..These high-peptide density AuNVs can stimulate CTLs better than free peptides and have great potential as carriers for various vaccine types...
Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin textureRebekah Drezek
Rice University, Bioengineering Department, Houston, Texas 77251, USA
J Biomed Opt 8:7-16. 2003..Understanding the quantitative relationships between nuclear features and scattering properties will aid in the development of noninvasive optical technologies for detection of precancerous conditions...- Size-controlled synthesis of monodispersed gold nanoparticles via carbon monoxide gas reductionJoseph K Young
Department of Electrical and Computer Engineering, Rice University, MS 366, 6100 Main St, Houston, TX 77005, USA
Nanoscale Res Lett 6:428. 2011..Upon synthesis, no excess reducing agent remains in solution eliminating the need for purification. The time necessary to synthesize AuNPs, using CO, is less than 2 min... - Trophic transfer of amphiphilic polymer coated CdSe/ZnS quantum dots to Danio rerioNastassja A Lewinski
Department of Bioengineering, Rice University, MS 142, P O Box 1892, Houston, TX 77251, USA
Nanoscale 3:3080-3. 2011..004 respectively). The assimilation efficiency was 8% and 4% for adult and juvenile zebrafish respectively. This study is the first to examine the potential food chain transfer and biomagnification of QDs from zooplankton to zebrafish... - A new era for cancer treatment: gold-nanoparticle-mediated thermal therapiesLaura C Kennedy
William Marsh Rice University, Dept of Bioengineering MS 142, 6100 Main St, Houston, TX 77005 1892, USA
Small 7:169-83. 2011..In this article, the rapidly evolving field of gold nanoparticle thermal therapy is reviewed, highlighting recent literature and describing current challenges to clinical translation of the technology... - Measurement of immunotargeted plasmonic nanoparticles' cellular binding: a key factor in optimizing diagnostic efficacyKun Fu
Department of Bioengineering, Rice University, 6100 Main Street, MS 142, Houston, TX 77005, USA Department of Radiation Oncology, University of Texas, M D Anderson Cancer Center, Box 1202, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Nanotechnology 19:045103. 2008..These results are also supported by dark-field microscopy images of the cells labeled with anti-HER2/nanoshell and anti-IgG/nanoshell bioconjugates... - Antibody-conjugated gold-gold sulfide nanoparticles as multifunctional agents for imaging and therapy of breast cancerEmily S Day
Department of Bioengineering, Rice University, Houston, TX, USA
Int J Nanomedicine 5:445-54. 2010..GGS-NPs are ideal multifunctional agents for cancer management because they offer the ability to pinpoint precise treatment sites and perform subsequent thermal ablation in a single setting... - Tunable nanostructures as photothermal theranostic agentsJoseph K Young
Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA
Ann Biomed Eng 40:438-59. 2012..These agents include hollow gold nanoshells, gold gold-sulfide nanoparticles, gold nanocages, carbon and titanium nanotubes, photothermal-based nanobubbles, polymeric nanoparticles and copper-based nanocrystals... - Symmetry breaking in gold-silica-gold multilayer nanoshellsYing Hu
Department of Bioengineering, Rice University, Houston, Texas 77005, USA
ACS Nano 4:1521-8. 2010..We further demonstrate a trend of increasing absorption relative to scattering as the resonant wavelength red shifts in response to a larger core offset... - Immunoconjugated gold nanoshell-mediated photothermal ablation of trastuzumab-resistant breast cancer cellsLaura B Carpin
Department of Bioengineering, Rice University, 6100 Main St, MS 142, Houston, TX 77005, USA
Breast Cancer Res Treat 125:27-34. 2011..This study suggests potential for applying gold nanoshell-mediated therapy to trastuzumab-resistant breast cancers in vivo... - Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapyAndre M Gobin
Department of Bioengineering, Rice University, Houston, Texas 77005, USA
Nano Lett 7:1929-34. 2007..Using these in a mouse model, we have demonstrated dramatic contrast enhancement for optical coherence tomography (OCT) and effective photothermal ablation of tumors... - Nanoshell-mediated photothermal therapy improves survival in a murine glioma modelEmily S Day
Department of Bioengineering, Rice University, 6100 Main Street MS 142, Houston, TX 77005, USA
J Neurooncol 104:55-63. 2011..3 days. The results of these studies suggest that nanoshell-mediated photothermal therapy represents a promising novel treatment strategy for malignant glioma... - Enhanced Raman scattering from nanoparticle-decorated nanocone substrates: a practical approach to harness in-plane excitationYing S Hu
Department of Bioengineering, Rice University, Houston, Texas 77005, USA
ACS Nano 4:5721-30. 2010..Understanding and implementing the enhancing mechanism of structured metallic surfaces decorated with plasmonic nanoparticles open possibilities to substantially improve the SERS performance of the existing process-engineered substrates... - The stabilization and targeting of surfactant-synthesized gold nanorodsBetty C Rostro-Kohanloo
Department of Physics and Astronomy, Rice University, Houston, TX 77005, USA
Nanotechnology 20:434005. 2009..This covalent strategy should be generally applicable to other biomedical applications of gold nanorods as well as other gold nanoparticles synthesized with CTAB... - Metal nanoshellsLeon R Hirsch
Department of Bioengineering, Rice University, Box 1892, MS 144, Houston, TX 77251-1892, USA
Ann Biomed Eng 34:15-22. 2006..Several potential biomedical applications are under development, including immunoassays, modulated drug delivery, photothermal cancer therapy, and imaging contrast agents... - Water-soluble quantum dots for biomedical applicationsWilliam W Yu
Department of Chemistry, Rice University, Houston, TX 77005, USA
Biochem Biophys Res Commun 348:781-6. 2006..Here, we discuss the recent development in making water-soluble quantum dots and related cytotoxicity for biomedical applications... - Gold nanoshell bioconjugates for molecular imaging in living cellsChristopher Loo
Department of Bioengineering, Rice University, MS 142, P O Box 1892, Houston, Texas 77251 1892, USA
Opt Lett 30:1012-4. 2005..We show that nanoshell bioconjugates can be used to effectively target and image human epidermal growth factor receptor 2 (HER2), a clinically relevant biomarker, in live human breast carcinoma cells... - Silica-gold nanoshells as potential intraoperative molecular probes for HER2-overexpression in ex vivo breast tissue using near-infrared reflectance confocal microscopyLissett R Bickford
Department of Bioengineering, Rice University, Houston, TX, 77005, USA
Breast Cancer Res Treat 120:547-55. 2010..This work supports the use of targeted silica-based gold nanoshells as potential real-time molecular probes for HER2-overexpression in human tissue... - T cells enhance gold nanoparticle delivery to tumors in vivoLaura C Kennedy
Department of Bioengineering, Rice University, Houston, TX 77005, USA
Nanoscale Res Lett 6:283. 2011..Thus, the use of T cell chaperones for AuNP delivery could enhance the efficacy of nanoparticle-based therapies and imaging applications by increasing AuNP tumor accumulation... - Optically tunable nanoparticle contrast agents for early cancer detection: model-based analysis of gold nanoshellsAlex W H Lin
Rice University, Department of Bioengineering, PO Box 1892-MS 142, Houston, Texas 77251, USA
J Biomed Opt 10:064035. 2005..Characterizing the optical behavior of gold nanoshells in tissue will aid in developing nanoshells as contrast agents for optical diagnostics... - Quantifying tumor-selective radiation dose enhancements using gold nanoparticles: a monte carlo simulation studySean X Zhang
Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1210, Houston, TX 77030, USA
Biomed Microdevices 11:925-33. 2009..Selective tumor labeling with gold nanospheres may be a strategy for clinically enhancing radiation effects... - Optical imaging of the cervixRebekah A Drezek
Bioengineering Department, Rice University, Houston, Texas, USA
Cancer 98:2015-27. 2003..Applying the Littenberg assessment will help ensure that superior, not simply alternative, technologies are implemented... - Nanoshell-enabled photonics-based imaging and therapy of cancerChristopher Loo
Department of Bioengineering, Rice University, P.O. Box 1892, MS-142, Houston, TX 77030, USA
Technol Cancer Res Treat 3:33-40. 2004.... - Protease-activated quantum dot probesEmmanuel Chang
Rice University, Department of Bioengineering MS-142, P.O. Box 1892, Houston, TX 77251-1892, USA
Biochem Biophys Res Commun 334:1317-21. 2005..Initial studies observed a 52% rise in luminescence over 47 h of exposure to 0.2 mg/mL collagenase. These probes can be customized for targeted degradation simply by changing the sequence of the peptide linker... - Influence of fiber optic probe geometry on the applicability of inverse models of tissue reflectance spectroscopy: computational models and experimental measurementsJiantang Sun
Rice University, Houston, TX 77005, USA
Appl Opt 45:8152-62. 2006..5-3 mm that is compatible with endoscopic specifications. The presented inversion method is computationally efficient for eventual real-time in vivo tissue diagnostics application... - Reversible two-photon photoswitching and two-photon imaging of immunofunctionalized nanoparticles targeted to cancer cellsMing Qiang Zhu
Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China
J Am Chem Soc 133:365-72. 2011..In comparison with single-photon NUV excitations, two-photon NIR laser excitations can potentially reduce absorption-related photodamage to living systems because cellular systems absorb much more weakly in the NIR... - Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnosticsDana E Gheorghe
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Texas Medical Center Campus, 1441 Moursund St, Houston, TX 77030, USA
Nanoscale Res Lett 6:554. 2011..Thus, these nanoshells have the potential to be utilized for tumor cell ablation because of their absorption as well as an imaging agent... - Intraoperative techniques and tumor margin status--room for improvement for cervical cancer patients of childbearing ageLissett R Bickford
Department of Bioengineering, Rice University, Houston, TX 77005, USA
Gynecol Oncol 107:S180-6. 2007.... - Lead sulfide near-infrared quantum dot bioconjugates for targeted molecular imagingJiantang Sun
Department of Bioengineering, Rice University, Houston, TX 77005, USA
Int J Nanomedicine 2:235-40. 2007..Preliminary experimental results indicate that PbS-QD/antibody bioconjugates are promising candidates for targeted NIR molecular imaging and future in vivo NIR tissue imaging applications... - Evaluation of quantum dot cytotoxicity based on intracellular uptakeEmmanuel Chang
Rice University, Department of Bioengineering MS-142, PO Box 1892, Houston, TX 77251-1892, USA
Small 2:1412-7. 2006 - Forming biocompatible and nonaggregated nanocrystals in water using amphiphilic polymersWilliam W Yu
Department of Chemistry, Rice University, Houston, Texas 77005, USA
J Am Chem Soc 129:2871-9. 2007..In the particular case of semiconductor nanocrystals (e.g., quantum dots), the materials in water have the same optical spectra as well as quantum yield as those formed initially in organic solutions... - Novel siRNA-based molecular beacons for dual imaging and therapyEmmanuel Chang
Rice University, Department of Bioengineering, Houston, Texas, USA
Biotechnol J 2:422-5. 2007.... - Immunotargeted nanoshells for integrated cancer imaging and therapyChristopher Loo
Department of Bioengineering, Rice University, P.O. Box 1892, Houston, Texas 77251-1892, USA
Nano Lett 5:709-11. 2005..In a proof of principle experiment, dual imaging/therapy immunotargeted nanoshells are used to detect and destroy breast carcinoma cells that overexpress HER2, a clinically relevant cancer biomarker... - Cytotoxicity of nanoparticlesNastassja Lewinski
Department of Bioengineering MS 142, Rice University, PO Box 1892, Houston, TX 77251 1892, USA
Small 4:26-49. 2008.... - Experimental evaluation of angularly variable fiber geometry for targeting depth-resolved reflectance from layered epithelial tissue phantomsAdrien Wang
Rice University, Department of Bioengineering, Houston, Texas 77251 1892, USA
J Biomed Opt 12:044011. 2007..Conversely, the orthogonal fibers are found to be more sensitive to changes in the stromal phantom layer... - Contrast agents for confocal microscopy: how simple chemicals affect confocal images of normal and cancer cells in suspensionAndres F Zuluaga
The University of Texas at Austin, Department of Electrical and Computer Engineering, Austin, Texas 78712, USA
J Biomed Opt 7:398-403. 2002..This can further confocal microscopy's ability to assess disease in cells and tissues... - Analytical model to describe fluorescence spectra of normal and preneoplastic epithelial tissue: comparison with Monte Carlo simulations and clinical measurementsSung K Chang
Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
J Biomed Opt 9:511-22. 2004..Future work will explore the use of this model to extract information about changes in epithelial and stromal optical properties from clinical measurements and the diagnostic value of these parameters... - Microanatomical and biochemical origins of normal and precancerous cervical autofluorescence using laser-scanning fluorescence confocal microscopyIna Pavlova
Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA
Photochem Photobiol 77:550-5. 2003..These changes can explain differences in in vivo fluorescence spectra of normal and precancerous cervical tissue... - Calcium-induced alterations in mitochondrial morphology quantified in situ with optical scatter imagingNada N Boustany
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
Biophys J 83:1691-700. 2002..Our data show that changes in OSIR correlate with mitochondrial morphology change in situ. OSI provides a new tool for subcellular imaging and complements other microscopy methods, such as fluorescence...