Rebekah A Drezek

Summary

Affiliation: Rice University
Country: USA

Publications

  1. doi Quantification of water solubilized CdSe/ZnS quantum dots in Daphnia magna
    Nastassja A Lewinski
    Department of Bioengineering, Rice University, Houston, Texas, USA
    Environ Sci Technol 44:1841-6. 2010
  2. pmc Lead sulfide near-infrared quantum dot bioconjugates for targeted molecular imaging
    Jiantang Sun
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Int J Nanomedicine 2:235-40. 2007
  3. pmc Gold nanoparticle delivery of modified CpG stimulates macrophages and inhibits tumor growth for enhanced immunotherapy
    Adam Yuh Lin
    Department of Bioengineering, Rice University, Houston, Texas, United States of America
    PLoS ONE 8:e63550. 2013
  4. pmc Rapid Stereomicroscopic Imaging of HER2 Overexpression in Ex Vivo Breast Tissue Using Topically Applied Silica-Based Gold Nanoshells
    Lissett R Bickford
    Department of Bioengineering, Rice University, 6100 Main Street, MS 142, Houston, TX 77005, USA School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA Department of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Oncol 2012:291898. 2012
  5. pmc High-density sub-100-nm peptide-gold nanoparticle complexes improve vaccine presentation by dendritic cells in vitro
    Adam Yuh Lin
    Department of Bioengineering, Rice University, 77005, Houston, TX USA
    Nanoscale Res Lett 8:72. 2013
  6. pmc Size-controlled synthesis of monodispersed gold nanoparticles via carbon monoxide gas reduction
    Joseph K Young
    Department of Electrical and Computer Engineering, Rice University, MS 366, 6100 Main St, Houston, TX 77005, USA
    Nanoscale Res Lett 6:428. 2011
  7. ncbi Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture
    Rebekah Drezek
    Rice University, Bioengineering Department, Houston, Texas 77251, USA
    J Biomed Opt 8:7-16. 2003
  8. ncbi Trophic transfer of amphiphilic polymer coated CdSe/ZnS quantum dots to Danio rerio
    Nastassja A Lewinski
    Department of Bioengineering, Rice University, MS 142, P O Box 1892, Houston, TX 77251, USA
    Nanoscale 3:3080-3. 2011
  9. doi A new era for cancer treatment: gold-nanoparticle-mediated thermal therapies
    Laura C Kennedy
    William Marsh Rice University, Dept of Bioengineering MS 142, 6100 Main St, Houston, TX 77005 1892, USA
    Small 7:169-83. 2011
  10. pmc Elimination of metastatic melanoma using gold nanoshell-enabled photothermal therapy and adoptive T cell transfer
    Adham S Bear
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital, Houston, Texas, United States of America
    PLoS ONE 8:e69073. 2013

Collaborators

Detail Information

Publications44

  1. doi Quantification of water solubilized CdSe/ZnS quantum dots in Daphnia magna
    Nastassja A Lewinski
    Department of Bioengineering, Rice University, Houston, Texas, USA
    Environ Sci Technol 44:1841-6. 2010
    ..Fluorescence microscopy and ICP-MS measurements revealed differences in uptake after 24 h of exposure which were attributed to particle surface coating and stability...
  2. pmc Lead sulfide near-infrared quantum dot bioconjugates for targeted molecular imaging
    Jiantang Sun
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Int J Nanomedicine 2:235-40. 2007
    ..Preliminary experimental results indicate that PbS-QD/antibody bioconjugates are promising candidates for targeted NIR molecular imaging and future in vivo NIR tissue imaging applications...
  3. pmc Gold nanoparticle delivery of modified CpG stimulates macrophages and inhibits tumor growth for enhanced immunotherapy
    Adam Yuh Lin
    Department of Bioengineering, Rice University, Houston, Texas, United States of America
    PLoS ONE 8:e63550. 2013
    ..These TEG modified CpG-AuNP complexes induced macrophage and dendritic cell tumor infiltration, significantly inhibited tumor growth, and promoted survival in mice when compared to treatments with free CpG...
  4. pmc Rapid Stereomicroscopic Imaging of HER2 Overexpression in Ex Vivo Breast Tissue Using Topically Applied Silica-Based Gold Nanoshells
    Lissett R Bickford
    Department of Bioengineering, Rice University, 6100 Main Street, MS 142, Houston, TX 77005, USA School of Biomedical Engineering and Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA Department of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Oncol 2012:291898. 2012
    ....
  5. pmc High-density sub-100-nm peptide-gold nanoparticle complexes improve vaccine presentation by dendritic cells in vitro
    Adam Yuh Lin
    Department of Bioengineering, Rice University, 77005, Houston, TX USA
    Nanoscale Res Lett 8:72. 2013
    ..These high-peptide density AuNVs can stimulate CTLs better than free peptides and have great potential as carriers for various vaccine types...
  6. pmc Size-controlled synthesis of monodispersed gold nanoparticles via carbon monoxide gas reduction
    Joseph K Young
    Department of Electrical and Computer Engineering, Rice University, MS 366, 6100 Main St, Houston, TX 77005, USA
    Nanoscale Res Lett 6:428. 2011
    ..Upon synthesis, no excess reducing agent remains in solution eliminating the need for purification. The time necessary to synthesize AuNPs, using CO, is less than 2 min...
  7. ncbi Light scattering from cervical cells throughout neoplastic progression: influence of nuclear morphology, DNA content, and chromatin texture
    Rebekah Drezek
    Rice University, Bioengineering Department, Houston, Texas 77251, USA
    J Biomed Opt 8:7-16. 2003
    ..Understanding the quantitative relationships between nuclear features and scattering properties will aid in the development of noninvasive optical technologies for detection of precancerous conditions...
  8. ncbi Trophic transfer of amphiphilic polymer coated CdSe/ZnS quantum dots to Danio rerio
    Nastassja A Lewinski
    Department of Bioengineering, Rice University, MS 142, P O Box 1892, Houston, TX 77251, USA
    Nanoscale 3:3080-3. 2011
    ..004 respectively). The assimilation efficiency was 8% and 4% for adult and juvenile zebrafish respectively. This study is the first to examine the potential food chain transfer and biomagnification of QDs from zooplankton to zebrafish...
  9. doi A new era for cancer treatment: gold-nanoparticle-mediated thermal therapies
    Laura C Kennedy
    William Marsh Rice University, Dept of Bioengineering MS 142, 6100 Main St, Houston, TX 77005 1892, USA
    Small 7:169-83. 2011
    ..In this article, the rapidly evolving field of gold nanoparticle thermal therapy is reviewed, highlighting recent literature and describing current challenges to clinical translation of the technology...
  10. pmc Elimination of metastatic melanoma using gold nanoshell-enabled photothermal therapy and adoptive T cell transfer
    Adham S Bear
    Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital, Houston, Texas, United States of America
    PLoS ONE 8:e69073. 2013
    ..Hence, the combination of PTT and systemic immunotherapy prevented the adverse effects of PTT on metastatic tumor growth and optimized overall tumor control. ..
  11. pmc Antibody-conjugated gold-gold sulfide nanoparticles as multifunctional agents for imaging and therapy of breast cancer
    Emily S Day
    Department of Bioengineering, Rice University, Houston, TX, USA
    Int J Nanomedicine 5:445-54. 2010
    ..GGS-NPs are ideal multifunctional agents for cancer management because they offer the ability to pinpoint precise treatment sites and perform subsequent thermal ablation in a single setting...
  12. ncbi Measurement of immunotargeted plasmonic nanoparticles' cellular binding: a key factor in optimizing diagnostic efficacy
    Kun Fu
    Department of Bioengineering, Rice University, 6100 Main Street, MS 142, Houston, TX 77005, USA Department of Radiation Oncology, University of Texas, M D Anderson Cancer Center, Box 1202, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Nanotechnology 19:045103. 2008
    ..These results are also supported by dark-field microscopy images of the cells labeled with anti-HER2/nanoshell and anti-IgG/nanoshell bioconjugates...
  13. pmc Optimization of PAMAM-gold nanoparticle conjugation for gene therapy
    Elizabeth R Figueroa
    Rice University, Department of Bioengineering, 6500 Main St, Houston, TX 77030, USA
    Biomaterials 35:1725-34. 2014
    ..AuPAMAM conjugates present attractive candidates for non-viral gene delivery due to their commercial availability, ease of fabrication and scale-up, high yield, high transfection efficiency and low cytotoxicity...
  14. doi Tunable nanostructures as photothermal theranostic agents
    Joseph K Young
    Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA
    Ann Biomed Eng 40:438-59. 2012
    ..These agents include hollow gold nanoshells, gold gold-sulfide nanoparticles, gold nanocages, carbon and titanium nanotubes, photothermal-based nanobubbles, polymeric nanoparticles and copper-based nanocrystals...
  15. doi Symmetry breaking in gold-silica-gold multilayer nanoshells
    Ying Hu
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    ACS Nano 4:1521-8. 2010
    ..We further demonstrate a trend of increasing absorption relative to scattering as the resonant wavelength red shifts in response to a larger core offset...
  16. doi Immunoconjugated gold nanoshell-mediated photothermal ablation of trastuzumab-resistant breast cancer cells
    Laura B Carpin
    Department of Bioengineering, Rice University, 6100 Main St, MS 142, Houston, TX 77005, USA
    Breast Cancer Res Treat 125:27-34. 2011
    ..This study suggests potential for applying gold nanoshell-mediated therapy to trastuzumab-resistant breast cancers in vivo...
  17. ncbi Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy
    Andre M Gobin
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    Nano Lett 7:1929-34. 2007
    ..Using these in a mouse model, we have demonstrated dramatic contrast enhancement for optical coherence tomography (OCT) and effective photothermal ablation of tumors...
  18. pmc Nanoshell-mediated photothermal therapy improves survival in a murine glioma model
    Emily S Day
    Department of Bioengineering, Rice University, 6100 Main Street MS 142, Houston, TX 77005, USA
    J Neurooncol 104:55-63. 2011
    ..3 days. The results of these studies suggest that nanoshell-mediated photothermal therapy represents a promising novel treatment strategy for malignant glioma...
  19. ncbi Metal nanoshells
    Leon R Hirsch
    Department of Bioengineering, Rice University, Box 1892, MS 144, Houston, TX 77251 1892, USA
    Ann Biomed Eng 34:15-22. 2006
    ..Several potential biomedical applications are under development, including immunoassays, modulated drug delivery, photothermal cancer therapy, and imaging contrast agents...
  20. doi Enhanced Raman scattering from nanoparticle-decorated nanocone substrates: a practical approach to harness in-plane excitation
    Ying S Hu
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    ACS Nano 4:5721-30. 2010
    ..Understanding and implementing the enhancing mechanism of structured metallic surfaces decorated with plasmonic nanoparticles open possibilities to substantially improve the SERS performance of the existing process-engineered substrates...
  21. doi The stabilization and targeting of surfactant-synthesized gold nanorods
    Betty C Rostro-Kohanloo
    Department of Physics and Astronomy, Rice University, Houston, TX 77005, USA
    Nanotechnology 20:434005. 2009
    ..This covalent strategy should be generally applicable to other biomedical applications of gold nanorods as well as other gold nanoparticles synthesized with CTAB...
  22. ncbi Gold nanoshell bioconjugates for molecular imaging in living cells
    Christopher Loo
    Department of Bioengineering, Rice University, MS 142, P O Box 1892, Houston, Texas 77251 1892, USA
    Opt Lett 30:1012-4. 2005
    ..We show that nanoshell bioconjugates can be used to effectively target and image human epidermal growth factor receptor 2 (HER2), a clinically relevant biomarker, in live human breast carcinoma cells...
  23. ncbi Water-soluble quantum dots for biomedical applications
    William W Yu
    Department of Chemistry, Rice University, Houston, TX 77005, USA
    Biochem Biophys Res Commun 348:781-6. 2006
    ..Here, we discuss the recent development in making water-soluble quantum dots and related cytotoxicity for biomedical applications...
  24. doi Silica-gold nanoshells as potential intraoperative molecular probes for HER2-overexpression in ex vivo breast tissue using near-infrared reflectance confocal microscopy
    Lissett R Bickford
    Department of Bioengineering, Rice University, Houston, TX, 77005, USA
    Breast Cancer Res Treat 120:547-55. 2010
    ..This work supports the use of targeted silica-based gold nanoshells as potential real-time molecular probes for HER2-overexpression in human tissue...
  25. pmc T cells enhance gold nanoparticle delivery to tumors in vivo
    Laura C Kennedy
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Nanoscale Res Lett 6:283. 2011
    ..Thus, the use of T cell chaperones for AuNP delivery could enhance the efficacy of nanoparticle-based therapies and imaging applications by increasing AuNP tumor accumulation...
  26. ncbi Optically tunable nanoparticle contrast agents for early cancer detection: model-based analysis of gold nanoshells
    Alex W H Lin
    Rice University, Department of Bioengineering, PO Box 1892 MS 142, Houston, Texas 77251, USA
    J Biomed Opt 10:064035. 2005
    ..Characterizing the optical behavior of gold nanoshells in tissue will aid in developing nanoshells as contrast agents for optical diagnostics...
  27. doi Quantifying tumor-selective radiation dose enhancements using gold nanoparticles: a monte carlo simulation study
    Sean X Zhang
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1210, Houston, TX 77030, USA
    Biomed Microdevices 11:925-33. 2009
    ..Selective tumor labeling with gold nanospheres may be a strategy for clinically enhancing radiation effects...
  28. ncbi Optical imaging of the cervix
    Rebekah A Drezek
    Bioengineering Department, Rice University, Houston, Texas, USA
    Cancer 98:2015-27. 2003
    ..Applying the Littenberg assessment will help ensure that superior, not simply alternative, technologies are implemented...
  29. ncbi Nanoshell-enabled photonics-based imaging and therapy of cancer
    Christopher Loo
    Department of Bioengineering, Rice University, P O Box 1892, MS 142, Houston, TX 77030, USA
    Technol Cancer Res Treat 3:33-40. 2004
    ....
  30. ncbi Intraoperative techniques and tumor margin status--room for improvement for cervical cancer patients of childbearing age
    Lissett R Bickford
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Gynecol Oncol 107:S180-6. 2007
    ....
  31. ncbi Protease-activated quantum dot probes
    Emmanuel Chang
    Rice University, Department of Bioengineering MS 142, P O Box 1892, Houston, TX 77251 1892, USA
    Biochem Biophys Res Commun 334:1317-21. 2005
    ..Initial studies observed a 52% rise in luminescence over 47 h of exposure to 0.2 mg/mL collagenase. These probes can be customized for targeted degradation simply by changing the sequence of the peptide linker...
  32. ncbi Influence of fiber optic probe geometry on the applicability of inverse models of tissue reflectance spectroscopy: computational models and experimental measurements
    Jiantang Sun
    Rice University, Houston, TX 77005, USA
    Appl Opt 45:8152-62. 2006
    ..5-3 mm that is compatible with endoscopic specifications. The presented inversion method is computationally efficient for eventual real-time in vivo tissue diagnostics application...
  33. ncbi Reversible two-photon photoswitching and two-photon imaging of immunofunctionalized nanoparticles targeted to cancer cells
    Ming Qiang Zhu
    Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China
    J Am Chem Soc 133:365-72. 2011
    ..In comparison with single-photon NUV excitations, two-photon NIR laser excitations can potentially reduce absorption-related photodamage to living systems because cellular systems absorb much more weakly in the NIR...
  34. pmc Gold-silver alloy nanoshells: a new candidate for nanotherapeutics and diagnostics
    Dana E Gheorghe
    Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Texas Medical Center Campus, 1441 Moursund St, Houston, TX 77030, USA
    Nanoscale Res Lett 6:554. 2011
    ..Thus, these nanoshells have the potential to be utilized for tumor cell ablation because of their absorption as well as an imaging agent...
  35. ncbi Immunotargeted nanoshells for integrated cancer imaging and therapy
    Christopher Loo
    Department of Bioengineering, Rice University, P O Box 1892, Houston, Texas 77251 1892, USA
    Nano Lett 5:709-11. 2005
    ..In a proof of principle experiment, dual imaging/therapy immunotargeted nanoshells are used to detect and destroy breast carcinoma cells that overexpress HER2, a clinically relevant cancer biomarker...
  36. ncbi Forming biocompatible and nonaggregated nanocrystals in water using amphiphilic polymers
    William W Yu
    Department of Chemistry, Rice University, Houston, Texas 77005, USA
    J Am Chem Soc 129:2871-9. 2007
    ..In the particular case of semiconductor nanocrystals (e.g., quantum dots), the materials in water have the same optical spectra as well as quantum yield as those formed initially in organic solutions...
  37. ncbi Evaluation of quantum dot cytotoxicity based on intracellular uptake
    Emmanuel Chang
    Rice University, Department of Bioengineering MS 142, PO Box 1892, Houston, TX 77251 1892, USA
    Small 2:1412-7. 2006
  38. ncbi Novel siRNA-based molecular beacons for dual imaging and therapy
    Emmanuel Chang
    Rice University, Department of Bioengineering, Houston, Texas, USA
    Biotechnol J 2:422-5. 2007
    ....
  39. ncbi Experimental evaluation of angularly variable fiber geometry for targeting depth-resolved reflectance from layered epithelial tissue phantoms
    Adrien Wang
    Rice University, Department of Bioengineering, Houston, Texas 77251 1892, USA
    J Biomed Opt 12:044011. 2007
    ..Conversely, the orthogonal fibers are found to be more sensitive to changes in the stromal phantom layer...
  40. doi Cytotoxicity of nanoparticles
    Nastassja Lewinski
    Department of Bioengineering MS 142, Rice University, PO Box 1892, Houston, TX 77251 1892, USA
    Small 4:26-49. 2008
    ....
  41. ncbi Contrast agents for confocal microscopy: how simple chemicals affect confocal images of normal and cancer cells in suspension
    Andres F Zuluaga
    The University of Texas at Austin, Department of Electrical and Computer Engineering, Austin, Texas 78712, USA
    J Biomed Opt 7:398-403. 2002
    ..This can further confocal microscopy's ability to assess disease in cells and tissues...
  42. ncbi Analytical model to describe fluorescence spectra of normal and preneoplastic epithelial tissue: comparison with Monte Carlo simulations and clinical measurements
    Sung K Chang
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    J Biomed Opt 9:511-22. 2004
    ..Future work will explore the use of this model to extract information about changes in epithelial and stromal optical properties from clinical measurements and the diagnostic value of these parameters...
  43. ncbi Microanatomical and biochemical origins of normal and precancerous cervical autofluorescence using laser-scanning fluorescence confocal microscopy
    Ina Pavlova
    Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA
    Photochem Photobiol 77:550-5. 2003
    ..These changes can explain differences in in vivo fluorescence spectra of normal and precancerous cervical tissue...
  44. pmc Calcium-induced alterations in mitochondrial morphology quantified in situ with optical scatter imaging
    Nada N Boustany
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Biophys J 83:1691-700. 2002
    ..Our data show that changes in OSIR correlate with mitochondrial morphology change in situ. OSI provides a new tool for subcellular imaging and complements other microscopy methods, such as fluorescence...