Debra A Brock

Summary

Affiliation: Rice University
Country: USA

Publications

  1. doi request reprint Primitive agriculture in a social amoeba
    Debra A Brock
    Department of Ecology and Evolutionary Biology, Rice University, 6100 Main Street, Houston, Texas 77005, USA
    Nature 469:393-6. 2011
  2. pmc Cheating does not explain selective differences at high and low relatedness in a social amoeba
    Gerda Saxer
    Department of Ecology and Evolutionary Biology MS 170, Rice University, 6100 Main Street, Houston, TX 77005, USA
    BMC Evol Biol 10:76. 2010
  3. pmc The secreted Dictyostelium protein CfaD is a chalone
    Deenadayalan Bakthavatsalam
    Department of Biochemistry and Cell Biology, MS 140, Rice University, Houston, TX 77005 1892, USA
    J Cell Sci 121:2473-80. 2008
  4. pmc A cell number-counting factor regulates levels of a novel protein, SslA, as part of a group size regulation mechanism in Dictyostelium
    Tong Gao
    Howard Hughes Medical Institute, MS 140, Rice University, 6100 S Main Street, Houston, TX 77005 1892, USA
    Eukaryot Cell 6:1538-51. 2007
  5. pmc A 60-kilodalton protein component of the counting factor complex regulates group size in Dictyostelium discoideum
    Debra A Brock
    Howard Hughes Medical Institute, Rice University, 6100 S Main Street, Houston, Texas 77005 1892, USA
    Eukaryot Cell 5:1532-8. 2006
  6. ncbi request reprint A secreted factor represses cell proliferation in Dictyostelium
    Debra A Brock
    Howard Hughes Medical Institute and Department of Biochemistry and Cell Biology, MS 140, Rice University, 6100 South Main Street, Houston, TX 77005 1892, USA
    Development 132:4553-62. 2005
  7. ncbi request reprint Two components of a secreted cell number-counting factor bind to cells and have opposing effects on cAMP signal transduction in Dictyostelium
    Debra A Brock
    Howard Hughes Medical Institute, Rice University, Houston, Texas 77005 1892, USA
    J Biol Chem 278:52262-72. 2003
  8. ncbi request reprint Disruption of aldehyde reductase increases group size in dictyostelium
    Karen Ehrenman
    Howard Hughes Medical Institute and Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005 1892, USA
    J Biol Chem 279:837-47. 2004
  9. pmc CF45-1, a secreted protein which participates in Dictyostelium group size regulation
    Debra A Brock
    Howard Hughes Medical Institute, Rice University, Houston, Texas 77005 1892, USA
    Eukaryot Cell 2:788-97. 2003
  10. ncbi request reprint The different components of a multisubunit cell number-counting factor have both unique and overlapping functions
    Debra A Brock
    Howard Hughes Medical Institute, Rice University, 6100 South Main Street, Houston, TX 77005 1892, USA
    Development 129:3657-68. 2002

Collaborators

Detail Information

Publications11

  1. doi request reprint Primitive agriculture in a social amoeba
    Debra A Brock
    Department of Ecology and Evolutionary Biology, Rice University, 6100 Main Street, Houston, Texas 77005, USA
    Nature 469:393-6. 2011
    ..The striking convergent evolution between bacterial husbandry in social amoebas and fungus farming in social insects makes sense because multigenerational benefits of farming go to already established kin groups...
  2. pmc Cheating does not explain selective differences at high and low relatedness in a social amoeba
    Gerda Saxer
    Department of Ecology and Evolutionary Biology MS 170, Rice University, 6100 Main Street, Houston, TX 77005, USA
    BMC Evol Biol 10:76. 2010
    ..We expected that some strains would be out-competed in both treatments. In addition, we expected that low relatedness might allow the persistence of social cheaters as it provides opportunity to exploit other strains...
  3. pmc The secreted Dictyostelium protein CfaD is a chalone
    Deenadayalan Bakthavatsalam
    Department of Biochemistry and Cell Biology, MS 140, Rice University, Houston, TX 77005 1892, USA
    J Cell Sci 121:2473-80. 2008
    ..These results suggest that two interacting proteins may function together as a chalone signal in a negative feedback loop that slows Dictyostelium cell proliferation...
  4. pmc A cell number-counting factor regulates levels of a novel protein, SslA, as part of a group size regulation mechanism in Dictyostelium
    Tong Gao
    Howard Hughes Medical Institute, MS 140, Rice University, 6100 S Main Street, Houston, TX 77005 1892, USA
    Eukaryot Cell 6:1538-51. 2007
    ..sslA(CR11) does not significantly affect glucose levels, while glucose increases SslA levels. Together, the data suggest that SslA is a novel protein involved in part of a signal transduction pathway regulating group size...
  5. pmc A 60-kilodalton protein component of the counting factor complex regulates group size in Dictyostelium discoideum
    Debra A Brock
    Howard Hughes Medical Institute, Rice University, 6100 S Main Street, Houston, Texas 77005 1892, USA
    Eukaryot Cell 5:1532-8. 2006
    ..Together, the data suggest that CF60 is a component of CF, and thus this secreted signal has four different protein components...
  6. ncbi request reprint A secreted factor represses cell proliferation in Dictyostelium
    Debra A Brock
    Howard Hughes Medical Institute and Department of Biochemistry and Cell Biology, MS 140, Rice University, 6100 South Main Street, Houston, TX 77005 1892, USA
    Development 132:4553-62. 2005
    ..AprA may thus decrease the number of multinucleate cells and increase spore production. Together, the data suggest that AprA functions as part of a Dictyostelium chalone...
  7. ncbi request reprint Two components of a secreted cell number-counting factor bind to cells and have opposing effects on cAMP signal transduction in Dictyostelium
    Debra A Brock
    Howard Hughes Medical Institute, Rice University, Houston, Texas 77005 1892, USA
    J Biol Chem 278:52262-72. 2003
    ....
  8. ncbi request reprint Disruption of aldehyde reductase increases group size in dictyostelium
    Karen Ehrenman
    Howard Hughes Medical Institute and Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005 1892, USA
    J Biol Chem 279:837-47. 2004
    ..Together, our data suggest that disrupting alrA affects CF secretion, causes many effects on cellular metabolism, and has a major effect on group size...
  9. pmc CF45-1, a secreted protein which participates in Dictyostelium group size regulation
    Debra A Brock
    Howard Hughes Medical Institute, Rice University, Houston, Texas 77005 1892, USA
    Eukaryot Cell 2:788-97. 2003
    ..Like countin(-) and cf50(-) cells, cf45-1(-) cells have high levels of cytosolic glucose, high cell-cell adhesion, and low cell motility. Together, the data suggest that CF45-1 participates in group size regulation in Dictyostelium...
  10. ncbi request reprint The different components of a multisubunit cell number-counting factor have both unique and overlapping functions
    Debra A Brock
    Howard Hughes Medical Institute, Rice University, 6100 South Main Street, Houston, TX 77005 1892, USA
    Development 129:3657-68. 2002
    ..These observations indicate that unlike other known multisubunit factors, CF contains subunits with both overlapping and unique properties...
  11. ncbi request reprint Cells respond to and bind countin, a component of a multisubunit cell number counting factor
    Tong Gao
    Howard Hughes Medical Institute, Rice University, Houston, Texas 77005 1892, USA
    J Biol Chem 277:32596-605. 2002
    ..5 ng/ml or 60 pm. We hypothesize that countin regulates cell development through the same pathway as CF and that other proteins within the complex may modify the activity of countin and/or have independent size-regulating activities...