Research Topics
| David O WilliamsSummaryAffiliation: Rhode Island Hospital Country: USA Publications
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Publications
Outcomes of 6906 patients undergoing percutaneous coronary intervention in the era of drug-eluting stents: report of the DEScover RegistryDavid O Williams
Division of Cardiology, Department of Medicine Rhode Island Hospital, Medical School, Brown University, Providence, RI 02903, USA
Circulation 114:2154-62. 2006..The DEScover Registry was designed to characterize patients selected for drug-eluting stents (DES) in routine clinical practice and their outcomes in the United States...
Treatment delayed is treatment deniedDavid O Williams
Division of Cardiology, Department of Medicine, Brown Medical School, Providence, RI, USA
Circulation 109:1806-8. 2004
Outcomes of drug-eluting stents for protected left main coronary artery disease (from the Multicenter, United States DEScover registry)Joshua Leitner
Division of Cardiology, Rhode Island Hospital, Brown University, Providence, USA
Am J Cardiol 109:466-70. 2012..25, confidence interval 0.09 to 0.67, p = 0.006). In conclusion, status after CABG rather than PLM location increases the risk of repeat revascularization with PCI in DES-treated patients...
Temporal trends in patient-reported angina at 1 year after percutaneous coronary revascularization in the stent era: a report from the National Heart, Lung, and Blood Institute-sponsored 1997-2006 dynamic registryLakshmi Venkitachalam
Cardiovascular Institute, Department of Medicine, School of Medicine, Graduate School of Public Health, University of Pittsburgh, PA, USA
Circ Cardiovasc Qual Outcomes 2:607-15. 2009..Little, however, is known about the temporal impact on patient-reported symptoms and quality of life after PCI...
Percutaneous coronary intervention of moderate to severe calcified coronary lesions: insights from the National Heart, Lung, and Blood Institute Dynamic RegistrySripal Bangalore
Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
Catheter Cardiovasc Interv 77:22-8. 2011..To evaluate the efficacy and safety of drug eluting stents (DES) when compared with bare metal stents (BMS) in patients with moderate to severe calcified coronary lesions...
Twenty-year evolution of percutaneous coronary intervention and its impact on clinical outcomes: a report from the National Heart, Lung, and Blood Institute-sponsored, multicenter 1985-1986 PTCA and 1997-2006 Dynamic RegistriesLakshmi Venkitachalam
Cardiovascular Institute, Department of Medicine, School of Medicine, University of Pittsburgh, and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
Circ Cardiovasc Interv 2:6-13. 2009..Percutaneous coronary intervention (PCI) has undergone rapid progress, both in technology and adjunct therapy. However, documentation of long-term temporal trends in relation to contemporary practice is lacking...
Direct stenting compared to balloon predilation in drug-eluting stents: one-year outcomes from the DEScover RegistryJ Dawn Abbott
Division of Cardiology, Rhode Island Hospital, Brown University, Providence, Rhode Island 02903, USA
Catheter Cardiovasc Interv 79:84-9. 2012..We sought to examine the determinants and outcomes of direct stenting (DS) compared to predilation with drug-eluting stents (DES)...
Gender-based outcomes in percutaneous coronary intervention with drug-eluting stents (from the National Heart, Lung, and Blood Institute Dynamic Registry)J Dawn Abbott
Department of Cardiology, Rhode Island Hospital, Providence, Rhode Island, USA
Am J Cardiol 99:626-31. 2007..01) and men (relative risk 0.68, 95% confidence interval 0.51 to 0.91, p = 0.001). In conclusion, the widespread use of DESs is safe and has decreased clinically driven revascularization compared with BMSs equally in women and men...
Unrestricted use of drug-eluting stents compared with bare-metal stents in routine clinical practice: findings from the National Heart, Lung, and Blood Institute Dynamic RegistryJ Dawn Abbott
Department of Cardiology, Rhode Island Hospital, Providence, Rhode Island, USA
J Am Coll Cardiol 50:2029-36. 2007..We investigated the effectiveness and safety of drug-eluting stents (DES) as used in routine clinical practice...
Completeness of revascularization for multivessel coronary artery disease and its effect on one-year outcome: a report from the NHLBI Dynamic RegistryVankeepuram S Srinivas
Division of Cardiology, Montefiore Medical Center, New York, NY 10461, USA
J Interv Cardiol 20:373-80. 2007..In conclusion, despite the presence of more unfavorable characteristics, patients undergoing TR demonstrate 1-year outcomes equivalent to those having CR, supporting its continued use in selected patients...
Temporal variation in inhospital mortality with percutaneous coronary intervention: a report from the National Heart, Lung and Blood Institute Dynamic RegistryWarren K Laskey
Division of Cardiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Am Heart J 150:569-76. 2005..Whether such time dependence extends to the risk of procedural-related mortality after percutaneous coronary intervention (PCI) is presently unknown...
Marked improvements in outcomes of contemporary percutaneous coronary intervention in patients with diabetes mellitusAndrew M Freeman
Brown University, Rhode Island Hospital, Providence, Rhode Island 02903, USA
J Interv Cardiol 19:475-82. 2006..A combination of the use of stents and an increase in adjunctive medical therapy are likely responsible for the observed improvements in outcomes in contemporary PCI...
Recent trends in the percutaneous treatment of chronic total coronary occlusionsJ Dawn Abbott
Division of Cardiology, Rhode Island Hospital, Brown University, Providence, Rhode Island, USA
Am J Cardiol 97:1691-6. 2006....
Importance of the postdischarge interval in assessing major adverse clinical event rates following percutaneous coronary interventionWarren K Laskey
Division of Cardiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 0001, USA
Am J Cardiol 95:1135-9. 2005..Most postdischarge events derive from pathology related to the controlled vessel. A 30-day MACE rate may serve as a more comprehensive measurement of procedural outcome...
Impact of coronary collaterals on outcome following percutaneous coronary intervention (from the National Heart, Lung, and Blood Institute Dynamic Registry)J Dawn Abbott
Division of Cardiology, Brown University, Rhode Island Hospital, Providence, Rhode Island, USA
Am J Cardiol 96:676-80. 2005....
Safety and efficacy of drug-eluting stentsDavid O Williams
Department of Cardiology, Rhode Island Hospital, Providence, Rhode Island, USA
Rev Cardiovasc Med 6:S22-30. 2005..In addition, specific patient subsets, including those patients with multivessel coronary disease, will be evaluated...
Lessons learned in the drug-eluting stent eraJ Dawn Abbott
Division of Cardiology, Rhode Island Hospital and Brown Medical School, Providence, RI, USA
Am Heart Hosp J 5:169-72. 2007
Comparison of outcome in patients with ST-elevation versus non-ST-elevation acute myocardial infarction treated with percutaneous coronary intervention (from the National Heart, Lung, and Blood Institute Dynamic Registry)J Dawn Abbott
Division of Cardiology, Rhode Island Hospital, Brown University, Providence, Rhode Island, USA
Am J Cardiol 100:190-5. 2007..At 1 year, associated co-morbidities were strongly associated with death and MI, whereas only angiographic characteristics predicted the need for repeat revascularization...
Clinical presentation and predictors of target vessel revascularization after drug-eluting stent implantationHazem Al Muradi
Division of Cardiology, Rhode Island Hospital, Brown University, 593 Eddy St, Providence, RI 02903, USA
Cardiovasc Revasc Med 13:311-5. 2012..We sought to examine the predictors and presentations of patients with clinically driven TVR after DES...
Contemporary percutaneous coronary intervention versus balloon angioplasty for multivessel coronary artery disease: a comparison of the National Heart, Lung and Blood Institute Dynamic Registry and the Bypass Angioplasty Revascularization Investigation (BV S Srinivas
Department of Medicine, Division of Cardiovascular Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA
Circulation 106:1627-33. 2002..CONCLUSIONS: Among patients with multivessel disease, contemporary PCI resulted in safer and more durable revascularization. These results support the role of PCI for selected patients with multivessel coronary artery disease...
Hyperbaric oxygen solution infused into the anterior interventricular vein at reperfusion reduces infarct size in swineLynne L Johnson
Division of Cardiology, Rhode Island Hospital, Brown University, Providence, Rhode Island 02903, USA
Am J Physiol Heart Circ Physiol 287:H2234-40. 2004..001), midmyocardial (P=0.03), and endocardial (P <0.001) layers in AO 0 min. AO infused into the AIV immediately at Rep diffuses into the RR and reduces IS by reducing Rep injury associated with neutrophil activation...
Access site hematoma requiring blood transfusion predicts mortality in patients undergoing percutaneous coronary intervention: data from the National Heart, Lung, and Blood Institute Dynamic RegistryLeonid Yatskar
Department of Cardiology, New York University, New York, New York, USA
Catheter Cardiovasc Interv 69:961-6. 2007..To determine both the etiology of and outcomes associated with access site hematoma requiring transfusion (HRT) in patients undergoing percutaneous coronary intervention (PCI)...
Outcomes and complications associated with off-label and untested use of drug-eluting stentsNirat Beohar
Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
JAMA 297:1992-2000. 2007..Limited data exist regarding use of drug-eluting stents outside of approved indications in real-world settings...
The SIRIUS-DIRECT trial: a multi-center study of direct stenting using the sirolimus-eluting stent in patients with de novo native coronary artery lesionsJeffrey W Moses
New York Presbyterian Hospital, Columbia University and Cardiovascular Research Foundation, New York, USA
Catheter Cardiovasc Interv 70:505-12. 2007..To assess the safety and efficacy of direct stenting using the sirolimus-eluting BX Velocitytrade mark stent in patients with coronary lesions...
The problem with composite end points in cardiovascular studies: the story of major adverse cardiac events and percutaneous coronary interventionKevin E Kip
College of Nursing, University of South Florida, Tampa, Florida 33612, USA
J Am Coll Cardiol 51:701-7. 2008..Our purpose was to evaluate the heterogeneity and validity of composite end points, major adverse cardiac events (MACE) in particular, in cardiology research...
Thrombosis and drug-eluting stents: an objective appraisalDavid R Holmes
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55955, USA
J Am Coll Cardiol 50:109-18. 2007....
A comparison of bare-metal and drug-eluting stents for off-label indicationsOscar C Marroquin
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, USA
N Engl J Med 358:342-52. 2008..Recent reports suggest that off-label use of drug-eluting stents is associated with an increased incidence of adverse events. Whether the use of bare-metal stents would yield different results is unknown...
A decade of improvement in the clinical outcomes of percutaneous coronary intervention for multivessel coronary artery diseaseV S Srinivas
Circulation 107:e88. 2003
Comparison of in-hospital and one-year outcomes in patients with and without diabetes mellitus undergoing percutaneous catheter intervention (from the National Heart, Lung, and Blood Institute Dynamic Registry)Warren K Laskey
University of Maryland School of Medicine, Baltimore, Maryland, USA
Am J Cardiol 90:1062-7. 2002..73, 95% CI 0.61 to 0.88; adjusted RR in patients with diabetes 1.20, 95% CI 0.88 to 1.65). Beta blockers at the time of hospital discharge were significantly associated with reduced mortality rates at 1 year in both groups...
Comparison of in-hospital and one-year outcomes in patients with left ventricular ejection fractions <or=40%, 41% to 49%, and >or=50% having percutaneous coronary revascularizationPaul C Keelan
Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
Am J Cardiol 91:1168-72. 2003..Thus, significant LV dysfunction was still associated with increased in-hospital and 1-year mortality in patients having contemporary PCI...
Impact of age on procedural and 1-year outcome in percutaneous transluminal coronary angioplasty: a report from the NHLBI Dynamic RegistryHoward A Cohen
University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am Heart J 146:513-9. 2003..After PCI, the long-term relative risk of death is similar to that expected among persons of similar ages in the general population...
Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary arteryJeffrey W Moses
Cardiovascular Research Foundation and Lenox Hill Heart and Vascular Institute of New York, New York 10021, USA
N Engl J Med 349:1315-23. 2003..Preliminary reports of studies involving simple coronary lesions indicate that a sirolimus-eluting stent significantly reduces the risk of restenosis after percutaneous coronary revascularization...
A twist in our understanding of enzyme elevation after coronary interventionDavid O Williams
J Am Coll Cardiol 42:1906-8. 2003
Intracoronary brachytherapy: past, present, and futureDavid O Williams
Circulation 105:2699-700. 2002
Improved outcomes for women undergoing contemporary percutaneous coronary intervention: a report from the National Heart, Lung, and Blood Institute Dynamic registryAlice K Jacobs
Evans Memorial Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
J Am Coll Cardiol 39:1608-14. 2002..The goal of this study was to determine whether women undergoing contemporary percutaneous coronary intervention (PCI) remain at increased risk in comparison with men and whether the outcomes in women have improved...
Comparison of patients undergoing enhanced external counterpulsation and percutaneous coronary intervention for stable angina pectorisRichard Holubkov
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Cardiol 89:1182-6. 2002..Although PCI was associated with substantially lower rates of 1-year symptoms, EECP may be a safe treatment option for selected patients with obstructive coronary disease...
Angina 1 year after percutaneous coronary intervention: a report from the NHLBI Dynamic RegistryRichard Holubkov
Department of Epidemiology, Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
Am Heart J 144:826-33. 2002..As percutaneous coronary intervention (PCI) is most commonly performed for relief of angina, it is important to identify factors associated with recurrence of anginal symptoms...
Et tu, bare metal stent?David O Williams
Circulation 116:2363-5. 2007
Relation of percutaneous coronary intervention of complex lesions to clinical outcomes (from the NHLBI Dynamic Registry)Robert L Wilensky
Cardiovascular Division, University of Pennsylvania, Philadelphia 19104, USA
Am J Cardiol 90:216-21. 2002..An increased in-hospital adverse clinical event rate was independently noted for thrombotic, bifurcation, and calcified lesions, and bifurcation lesions had worse long-term event rates...
Thrombolytic therapy vs primary percutaneous coronary intervention for myocardial infarction in patients presenting to hospitals without on-site cardiac surgery: a randomized controlled trialThomas Aversano
Blalock 524, Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21210, USA
JAMA 287:1943-51. 2002..Because PCI is often limited to hospitals that have on-site cardiac surgery programs, most acute MI patients do not have access to this therapy...
[Universal definition of the myocardial infarction.]Kristian Thygesen
Department of Medicine and Cardiology, Aarhus University Hospital, Dania
Kardiol Pol 66:47-62. 2008
Modeling and risk prediction in the current era of interventional cardiology: a report from the National Heart, Lung, and Blood Institute Dynamic RegistryDavid R Holmes
Mayo Clinic, 200 First Street SW, Rochester, Minn 55905, USA
Circulation 107:1871-6. 2003..Validation of in-hospital mortality models after percutaneous coronary interventions using multicenter data remains limited...
2007 focused update of the ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice guidelinesSpencer B King
J Am Coll Cardiol 51:172-209. 2008
2007 Focused Update of the ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines: 2007 Writing Group to Review New Evidence anSpencer B King
Circulation 117:261-95. 2008
Outcome of percutaneous coronary intervention in unstable angina pectoris versus stable angina pectoris in two different time periodsSrihari S Naidu
The Cardiovascular Division, Weill Cornell Medical Center, New York, New York, USA
Am J Cardiol 98:447-52. 2006....
The impact of ejection fraction on outcomes after percutaneous coronary intervention in patients with congestive heart failure: an analysis of the National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry and DynamiElizabeth M Holper
University of Chicago, Chicago, IL 60637, USA
Am Heart J 151:69-75. 2006..We studied the outcomes of patients with CHF who underwent PCI in the National Heart, Lung, and Blood Institute-sponsored Percutaneous Transluminal Coronary Angioplasty (PTCA) and Dynamic registries...
Development of systems of care for ST-elevation myocardial infarction patients: the primary percutaneous coronary intervention (ST-elevation myocardial infarction-receiving) hospital perspectiveChristopher B Granger
Circulation 116:e55-9. 2007
Bifurcation intervention: is it crush time yet?David O Williams
J Am Coll Cardiol 46:621-4. 2005
Ethnic differences in the presentation, treatment strategy, and outcomes of percutaneous coronary intervention (a report from the National Heart, Lung, and Blood Institute Dynamic Registry)James Slater
New York University Medical Center, New York, New York 1016 649, USA
Am J Cardiol 92:773-8. 2003....
The truth and consequences of the COURAGE trialDean J Kereiakes
Christ Hospital Heart and Vascular Center the Lindner Research Center, Cincinnati, Ohio 45219, USA
J Am Coll Cardiol 50:1598-603. 2007..An in-depth analysis of the COURAGE trial design and execution is provided...
Universal definition of myocardial infarctionKristian Thygesen
Circulation 116:2634-53. 2007
Comparison of the efficacy of direct coronary stenting with sirolimus-eluting stents versus stenting with predilation by intravascular ultrasound imaging (from the DIRECT trial)Atsushi Hirohata
Center for Research in Cardiovascular Intervention, Stanford University, Stanford, California, USA
Am J Cardiol 98:1464-7. 2006..This strategy appears to be associated with less neointimal hyperplasia near the distal stent edge...
What to do with patients receiving long-term clopidogrel: reload or relax?David O Williams
Circulation 118:1219-22. 2008
