G F Weber

Summary

Affiliation: Rhode Island Hospital
Country: USA

Publications

  1. ncbi Stress response genes: the genes that make cancer metastasize
    G F Weber
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Mol Med (Berl) 78:404-8. 2000
  2. pmc Differential roles of osteopontin/Eta-1 in early and late lpr disease
    G F Weber
    Department of Cancer Immunology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Clin Exp Immunol 126:578-83. 2001
  3. ncbi Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation
    Georg F Weber
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Binney Street, Boston, Massachusetts, USA
    J Leukoc Biol 72:752-61. 2002
  4. ncbi Molecular mechanisms of tumor dissemination in primary and metastatic brain cancers
    G F Weber
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA, USA
    Brain Res Bull 53:421-4. 2000
  5. ncbi Meeting report: the next interleukin?
    Georg F Weber
    Department of Radiation Oncology, New England Medical Center and Tufts University Medical School, NEMC 824, 750 Washington Street, Boston, MA 02111, USA
    Sci STKE 2002:pe37. 2002
  6. ncbi The metastasis gene osteopontin: a candidate target for cancer therapy
    G F Weber
    Department of Radiation Oncology, New England Medical Center and Tufts University Medical School, 750 Washington Street, NEMC 824, Boston, MA 02111, USA
    Biochim Biophys Acta 1552:61-85. 2001
  7. ncbi Absence of the CD44 gene prevents sarcoma metastasis
    Georg F Weber
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Cancer Res 62:2281-6. 2002
  8. ncbi Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity
    S Ashkar
    Laboratory for Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 287:860-4. 2000
  9. ncbi Costimulation by extracellular matrix proteins determines the response to TCR ligation
    B Adler
    Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Children's Hospital, Boston, Massachusetts 02115, USA
    Cell Immunol 210:30-40. 2001
  10. ncbi The immunology of Eta-1/osteopontin
    G F Weber
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cytokine Growth Factor Rev 7:241-8. 1996

Collaborators

  • B Adler
  • S R Rittling
  • Tak W Mak
  • D T Denhardt
  • Heike Weighardt
  • Lisa J Glickstein
  • Bin He
  • Mana Mirza
  • Kerry A Whalen
  • Caroline Schultheiss
  • B He
  • Cleo Mesa
  • Kathleen Craig-Mylius
  • Guoxin Zhang
  • S Ashkar
  • Elizabeth Shaughnessy
  • Brian S Schaffhausen
  • Thomas L Benjamin
  • John K Hurley
  • Gary A Pestano
  • Kristie A Vanpatten
  • H Cantor
  • Jeffrey A Knauf
  • Norisato Mitsutake
  • Craig Tomlinson
  • Markus Essler
  • Alexander Drzezga
  • M Mirza
  • Birgit Blechert
  • James A Fagin
  • Jan Mueller
  • Maureen Sartor
  • Enken Drecoll
  • Mario Medvedovic
  • Florian C Gaertner
  • Jenifer Coburn
  • X F Yang
  • M Jansson
  • V Panoutsakopoulou
  • M E Sanchirico
  • M J Glimcher
  • S Zawaideh

Detail Information

Publications23

  1. ncbi Stress response genes: the genes that make cancer metastasize
    G F Weber
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    J Mol Med (Berl) 78:404-8. 2000
    ..In cancer, metastasis genes are dysregulated at the levels of expression or splicing. These genes constitute a unique group of cancer-related biomolecules...
  2. pmc Differential roles of osteopontin/Eta-1 in early and late lpr disease
    G F Weber
    Department of Cancer Immunology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Clin Exp Immunol 126:578-83. 2001
    ..These observations define two stages of Fas(lpr/lpr) disease with respect to osteopontin-dependent pathogenesis that should be taken into account in the design of therapeutic approaches to the clinical disease...
  3. ncbi Phosphorylation-dependent interaction of osteopontin with its receptors regulates macrophage migration and activation
    Georg F Weber
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Binney Street, Boston, Massachusetts, USA
    J Leukoc Biol 72:752-61. 2002
    ....
  4. ncbi Molecular mechanisms of tumor dissemination in primary and metastatic brain cancers
    G F Weber
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA, USA
    Brain Res Bull 53:421-4. 2000
    ..Consistent patterns of organ preference by malignancies of particular tissue origin suggest a necessary connection between loss of growth control and senescence genes and expression of genes mediating the dissemination of tumor cells...
  5. ncbi Meeting report: the next interleukin?
    Georg F Weber
    Department of Radiation Oncology, New England Medical Center and Tufts University Medical School, NEMC 824, 750 Washington Street, Boston, MA 02111, USA
    Sci STKE 2002:pe37. 2002
    ..A gene family with osteopontin as a member has been characterized...
  6. ncbi The metastasis gene osteopontin: a candidate target for cancer therapy
    G F Weber
    Department of Radiation Oncology, New England Medical Center and Tufts University Medical School, 750 Washington Street, NEMC 824, Boston, MA 02111, USA
    Biochim Biophys Acta 1552:61-85. 2001
    ....
  7. ncbi Absence of the CD44 gene prevents sarcoma metastasis
    Georg F Weber
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts, USA
    Cancer Res 62:2281-6. 2002
    ..This is in agreement with the role attributed to CD44 variants in the spread of cancer. Therefore, CD44 gene products are not essential for tumor incidence and growth but are important in regulating metastasis formation...
  8. ncbi Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity
    S Ashkar
    Laboratory for Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 287:860-4. 2000
    ..These findings identify Eta-1 as a key cytokine that sets the stage for efficient type-1 immune responses through differential regulation of macrophage IL-12 and IL-10 cytokine expression...
  9. ncbi Costimulation by extracellular matrix proteins determines the response to TCR ligation
    B Adler
    Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Children's Hospital, Boston, Massachusetts 02115, USA
    Cell Immunol 210:30-40. 2001
    ..The determination of elimination versus survival of activated T-cells by coligation of beta3-integrins may have bearing on the fundamental postthymic mechanisms that shape the T-cell repertoire...
  10. ncbi The immunology of Eta-1/osteopontin
    G F Weber
    Dana Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cytokine Growth Factor Rev 7:241-8. 1996
    ..Its biochemical characteristics suggest that Eta-1/osteopontin may be the T-lymphocyte suppressor factor. The apparently conflicting effects on individual immune functions may reflect homeostatic mechanisms...
  11. ncbi An osteopontin splice variant induces anchorage independence in human breast cancer cells
    B He
    Molecular Oncology Research Institute, New England Medical Center, Boston, MA, USA
    Oncogene 25:2192-202. 2006
    ..They also provide evidence for a bifunctional character of osteopontin, with the soluble form supporting invasiveness and the aggregated form promoting adhesion...
  12. pmc A novel Bcl-x isoform connected to the T cell receptor regulates apoptosis in T cells
    X F Yang
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 7:629-39. 1997
    ..Identification of Bcl-x gamma helps provide a molecular explanation of T cell activation and death after antigen engagement...
  13. ncbi Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response
    Kathleen Craig-Mylius
    Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, 149 13th Street, Room 8301, Charlestown, MA 02129, USA
    J Leukoc Biol 77:710-8. 2005
    ..burgdorferi to induce macrophages directly to produce proinflammatory cytokines...
  14. ncbi The absence of CD44 ameliorates Fas(lpr/lpr) disease
    Georg F Weber
    Department of Radiation Oncology, New England Medical Center, 750 Washington Street, NEMC 824, Boston, MA 02111, USA
    Autoimmunity 37:1-8. 2004
    ..The CD44 receptor may be a suitable therapeutic target for inhibition of lymphoproliferation in autoimmune diseases...
  15. pmc Growth factor signaling induces metastasis genes in transformed cells: molecular connection between Akt kinase and osteopontin in breast cancer
    Guoxin Zhang
    Department of Radiation Oncology, New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111, USA
    Mol Cell Biol 23:6507-19. 2003
    ..These studies define Akt kinase as a molecular bridge between cell cycle progression and dissemination...
  16. doi Molecular mechanisms of metastasis
    Georg F Weber
    University of Cincinnati Academic Health Center, College of Pharmacy, 3225 Eden Avenue, Cincinnati, OH 45267 0004, USA
    Cancer Lett 270:181-90. 2008
    ..The expression of metastasis genes is regulated by multi-subunit transcription factor complexes. The identification of genes that direct cancer metastasis implicates them as candidate drug targets...
  17. ncbi Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling
    Cleo Mesa
    Division of Endocrinology and Metabolism, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267, USA
    Cancer Res 66:6521-9. 2006
    ..The preferential induction of MMPs by BRAF could explain in part the more invasive behavior of thyroid cancers with BRAF mutations...
  18. ncbi In vivo characterization of endothelial cell activation in a transgenic mouse model of Alzheimer's disease
    Caroline Schultheiss
    Nuklearmedizinische Klinik und Poliklinik, Technische Universitat Munchen, Munchen, Germany
    Angiogenesis 9:59-65. 2006
    ..In conclusion our results indicate that amyloid deposition in the vasculature leads to endothelial cell apoptosis and endothelial cell activation, which can be modulated by anti-angiogenic drugs...
  19. ncbi IL-22-mediated tumor growth reduction correlates with inhibition of ERK1/2 and AKT phosphorylation and induction of cell cycle arrest in the G2-M phase
    Georg F Weber
    Chirurgische Klinik und Poliklinik der Technischen Universit√§t M√ľnchen, Ismaningerstrasse 22, 81675 Munich, Germany
    J Immunol 177:8266-72. 2006
    ..Therefore, IL-22 may play a role in the control of tumor growth and tumor progression...
  20. pmc Inhibition of interleukin-22 attenuates bacterial load and organ failure during acute polymicrobial sepsis
    Georg F Weber
    Department of Surgery, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Infect Immun 75:1690-7. 2007
    ..IL-22 therefore appears to play an important role in the regulation of inflammatory processes in vivo...
  21. ncbi Osteopontin-c is a selective marker of breast cancer
    Mana Mirza
    College of Pharmacy, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Int J Cancer 122:889-97. 2008
    ..In conjunction, osteopontin-c, ER and HER2 reliably predict grade 2-3 breast cancer. Hence, osteopontin-c is a diagnostic and prognostic marker that may have value in a diagnostic panel together with conventional breast cancer markers...
  22. pmc Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells
    Kerry A Whalen
    Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Virol 82:4946-54. 2008
    ..As critical PEA3 sites are also part of the polyomavirus enhancer, the same signaling important for viral replication also contributes to virally induced metastatic potential...
  23. ncbi Phosphorylation of NF-kappaB proteins by cyclic GMP-dependent kinase. A noncanonical pathway to NF-kappaB activation
    Bin He
    Department of Radiation Oncology, New England Medical Center, Boston, MA, USA
    Eur J Biochem 270:2174-85. 2003
    ..These observations may bear on mechanisms of programmed cell death in T-lymphocytes. They may also be relevant to ongoing efforts to induce cancer cell apoptosis through activation of PKG...