A C Steere

Summary

Affiliation: Rhode Island Hospital
Country: USA

Publications

  1. ncbi request reprint Autoimmune mechanisms in antibiotic treatment-resistant lyme arthritis
    A C Steere
    Division of Rheumatology Immunology Medicine and the Department of Pathology, Tufts University School of Medicine, New England Medical Center, Boston, MA, USA
    J Autoimmun 16:263-8. 2001
  2. ncbi request reprint Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells
    C Trollmo
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 166:5286-91. 2001
  3. ncbi request reprint Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10-20 years after active Lyme disease
    R A Kalish
    Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Boston, MA 02111, USA
    Clin Infect Dis 33:780-5. 2001
  4. ncbi request reprint Differences in synovial fluid levels of matrix metalloproteinases suggest separate mechanisms of pathogenesis in Lyme arthritis before and after antibiotic treatment
    B Lin
    New England Medical Center, Tufts University School of Medicine, Tupper Research Institute, Department of Medicine, Boston, Massachusetts 02111, USA
    J Infect Dis 184:174-80. 2001
  5. pmc Recognition of multiple antibody epitopes throughout Borrelia burgdorferi p66, a candidate adhesin, in patients with early or late manifestations of Lyme disease
    H Ntchobo
    Division of Rheumatology and Immunology, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA
    Infect Immun 69:1953-6. 2001
  6. pmc Cellular and humoral immune responses to Borrelia burgdorferi antigens in patients with culture-positive early Lyme disease
    A Vaz
    Division of Rheumatology/Immunology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Infect Immun 69:7437-44. 2001
  7. pmc Expression of adhesion molecules in synovia of patients with treatment-resistant lyme arthritis
    E Akin
    Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
    Infect Immun 69:1774-80. 2001
  8. ncbi request reprint Host metalloproteinases in Lyme arthritis
    L T Hu
    New England Medical Center, Boston, Massachusetts, USA
    Arthritis Rheum 44:1401-10. 2001
  9. ncbi request reprint Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitis
    A Pohl-Koppe
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts, 02115, USA
    Cell Immunol 194:118-23. 1999
  10. ncbi request reprint Evaluation of study patients with Lyme disease, 10-20-year follow-up
    R A Kalish
    Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Tupper Research Institute, Boston, Massachusetts, USA
    J Infect Dis 183:453-60. 2001

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Autoimmune mechanisms in antibiotic treatment-resistant lyme arthritis
    A C Steere
    Division of Rheumatology Immunology Medicine and the Department of Pathology, Tufts University School of Medicine, New England Medical Center, Boston, MA, USA
    J Autoimmun 16:263-8. 2001
    ..Molecular mimicry between a dominant T cell epitope of OspA and hLFA-1 may be an important factor in the persistence of joint inflammation in genetically susceptible patients with treatment-resistant Lyme arthritis...
  2. ncbi request reprint Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1 alpha L is a partial agonist for outer surface protein A-reactive T cells
    C Trollmo
    Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 166:5286-91. 2001
    ..Our analysis at the clonal level demonstrates that human LFA-1alpha(L326-345) behaves as a partial agonist, perhaps playing a role in perpetuating symptoms of arthritis...
  3. ncbi request reprint Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10-20 years after active Lyme disease
    R A Kalish
    Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Boston, MA 02111, USA
    Clin Infect Dis 33:780-5. 2001
    ..IgM or IgG antibody responses to B. burgdorferi may persist for 10-20 years, but these responses are not indicative of active infection...
  4. ncbi request reprint Differences in synovial fluid levels of matrix metalloproteinases suggest separate mechanisms of pathogenesis in Lyme arthritis before and after antibiotic treatment
    B Lin
    New England Medical Center, Tufts University School of Medicine, Tupper Research Institute, Department of Medicine, Boston, Massachusetts 02111, USA
    J Infect Dis 184:174-80. 2001
    ..burgdorferi may be through CD14 and toll-like receptor-2, which were up-regulated in the presence of B. burgdorferi. These findings suggest different stimuli for MMP induction in untreated and antibiotic-resistant Lyme arthritis...
  5. pmc Recognition of multiple antibody epitopes throughout Borrelia burgdorferi p66, a candidate adhesin, in patients with early or late manifestations of Lyme disease
    H Ntchobo
    Division of Rheumatology and Immunology, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA
    Infect Immun 69:1953-6. 2001
    ..Among patients with later manifestations of the illness, antibody responses to the C-terminal portion of the protein were more prominent. These results demonstrate that Lyme disease patient sera recognize epitopes throughout p66...
  6. pmc Cellular and humoral immune responses to Borrelia burgdorferi antigens in patients with culture-positive early Lyme disease
    A Vaz
    Division of Rheumatology/Immunology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Infect Immun 69:7437-44. 2001
    ..We conclude that cellular and humoral responses to B. burgdorferi antigens are often found among patients with early Lyme disease. In contrast with the other antigens tested, cellular but not humoral reactivity was often found with OspA...
  7. pmc Expression of adhesion molecules in synovia of patients with treatment-resistant lyme arthritis
    E Akin
    Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
    Infect Immun 69:1774-80. 2001
    ..Upregulation of LFA-1 on lymphocytes in this lesion may be critical in the pathogenesis of treatment-resistant Lyme arthritis...
  8. ncbi request reprint Host metalloproteinases in Lyme arthritis
    L T Hu
    New England Medical Center, Boston, Massachusetts, USA
    Arthritis Rheum 44:1401-10. 2001
    ..burgdorferi. Inhibition of MMP activity prevents B. burgdorferi-induced cartilage degradation in vitro...
  9. ncbi request reprint Cross-reactivity of Borrelia burgdorferi and myelin basic protein-specific T cells is not observed in borrelial encephalomyelitis
    A Pohl-Koppe
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts, 02115, USA
    Cell Immunol 194:118-23. 1999
    ..burgdorferi and MBP, T-cell clones from these lines responded only to the antigen of the original stimulation. Thus, our data do not provide evidence for cross-reactivity between MBP and B. burgdorferi...
  10. ncbi request reprint Evaluation of study patients with Lyme disease, 10-20-year follow-up
    R A Kalish
    Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Tupper Research Institute, Boston, Massachusetts, USA
    J Infect Dis 183:453-60. 2001
    ..Thus, the overall current health status of each patient group was good, but sequelae were apparent primarily among patients with facial palsy who did not receive antibiotics for acute neuroborreliosis...
  11. ncbi request reprint Differential expression of cytokine mRNA in skin specimens from patients with erythema migrans or acrodermatitis chronica atrophicans
    R R Mullegger
    Division of Rheumatology Immunology, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA
    J Invest Dermatol 115:1115-23. 2000
    ..J Invest Dermatol 115:1115-1123 2000..
  12. ncbi request reprint Matrix metalloproteinases in the cerebrospinal fluid of patients with Lyme neuroborreliosis
    G Perides
    Tupper Research Institute, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts 02111, USA
    J Infect Dis 177:401-8. 1998
    ..001). This pattern of CSF gelatinase activity may be a useful marker for neuroborreliosis...
  13. ncbi request reprint Optic neuropathy in children with Lyme disease
    H Rothermel
    Division of Rheumatology/Immunology, Tufts University School of Medicine, New England Medical Center, Boston, MA 02111, USA
    Pediatrics 108:477-81. 2001
    ..If increased intracranial pressure persists despite antibiotic therapy, measures must be taken quickly to reduce the pressure...