Peter J Quesenberry

Summary

Affiliation: Rhode Island Hospital
Country: USA

Publications

  1. pmc Homing and long-term engraftment of long- and short-term renewal hematopoietic stem cells
    Liansheng Liu
    Department of Medicine, Division of Hematology Oncology, Rhode Island Hospital, Providence, Rhode Island, United States of America
    PLoS ONE 7:e31300. 2012
  2. pmc Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis
    Todd M Savarese
    Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Breast Cancer Res 9:R29. 2007
  3. doi request reprint The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches, and microvesicles
    Peter J Quesenberry
    Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, RI, USA
    Stem Cell Rev 4:137-47. 2008
  4. doi request reprint Problems in the promised land: status of adult marrow stem cell biology
    Peter J Quesenberry
    Department of Medicine, Division of Hematology Oncology, Rhode Island Hospital, Providence, RI 02903, USA
    Exp Hematol 37:775-83. 2009
  5. pmc Cellular phenotype switching and microvesicles
    Peter J Quesenberry
    Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, USA
    Adv Drug Deliv Rev 62:1141-8. 2010
  6. pmc Expression of cell cycle-related genes with cytokine-induced cell cycle progression of primitive hematopoietic stem cells
    Peter J Quesenberry
    Rhode Island Hospital and the Brown Medical School, Division of Hematology Oncology, Department of Medicine, Providence, Rhode Island 02903, USA
    Stem Cells Dev 19:453-60. 2010
  7. ncbi request reprint The stem cell continuum: cell cycle, injury, and phenotype lability
    Peter J Quesenberry
    Division of Hematology and Oncology, Rhode Island Hospital, 593 Eddy Street, George 3, Providence, RI 02903, USA
    Ann N Y Acad Sci 1106:20-9. 2007
  8. pmc Murine allogeneic in vivo stem cell homing(,)
    Gerald A Colvin
    Department of Research, Roger Williams Medical Center, Providence, Rhode Island, USA
    J Cell Physiol 211:386-91. 2007
  9. doi request reprint Conversion potential of marrow cells into lung cells fluctuates with cytokine-induced cell cycle
    Mark S Dooner
    Department of Medical Oncology Research, Center for Stem Cell Biology Research, Rhode Island Hospital, Providence, RI 02903, USA
    Stem Cells Dev 17:207-19. 2008
  10. pmc Bone marrow production of lung cells: the impact of G-CSF, cardiotoxin, graded doses of irradiation, and subpopulation phenotype
    Jason M Aliotta
    Roger Williams Medical Center, Center for Stem Cell Biology, Providence, RI 02908, USA
    Exp Hematol 34:230-41. 2006

Research Grants

  1. Hematopoietic Circadian Rhythms
    Peter Quesenberry; Fiscal Year: 2005
  2. STEM CELLS HOMING AND MOTILITY
    Peter Quesenberry; Fiscal Year: 2002
  3. Challenges in the Era of Stem Cell Plasticity
    Peter Quesenberry; Fiscal Year: 2003
  4. Minimal Treatment Models of Stem Cell Engraftment
    Peter Quesenberry; Fiscal Year: 2004
  5. Cell Cycle Related Transdifferentiation into Lung Cells
    Peter Quesenberry; Fiscal Year: 2006

Collaborators

Detail Information

Publications72

  1. pmc Homing and long-term engraftment of long- and short-term renewal hematopoietic stem cells
    Liansheng Liu
    Department of Medicine, Division of Hematology Oncology, Rhode Island Hospital, Providence, Rhode Island, United States of America
    PLoS ONE 7:e31300. 2012
    ..The ST-HSC also gave secondary engraftment. These observations challenge current models of the stem cell hierarchy and suggest that stem cells are in a continuum of change...
  2. pmc Correlation of umbilical cord blood hormones and growth factors with stem cell potential: implications for the prenatal origin of breast cancer hypothesis
    Todd M Savarese
    Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Breast Cancer Res 9:R29. 2007
    ..We examined in umbilical cord blood the correlation of potential breast epithelial mitogens, including hormones and growth factors, with hematopoietic stem cell concentrations serving as surrogates of overall stem cell potential...
  3. doi request reprint The paradoxical dynamism of marrow stem cells: considerations of stem cells, niches, and microvesicles
    Peter J Quesenberry
    Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, RI, USA
    Stem Cell Rev 4:137-47. 2008
    ..We propose that there is an interactive triangulated Venn diagram with continuously changing stem cells interacting with continuously changing areas of influence, both being modulated by transfer of genetic information by microvesicles...
  4. doi request reprint Problems in the promised land: status of adult marrow stem cell biology
    Peter J Quesenberry
    Department of Medicine, Division of Hematology Oncology, Rhode Island Hospital, Providence, RI 02903, USA
    Exp Hematol 37:775-83. 2009
    ....
  5. pmc Cellular phenotype switching and microvesicles
    Peter J Quesenberry
    Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, USA
    Adv Drug Deliv Rev 62:1141-8. 2010
    ..Additionally, vesicles have promise in the clinical arenas of disease biomarkers, tissue restoration and control of neoplastic cell growth...
  6. pmc Expression of cell cycle-related genes with cytokine-induced cell cycle progression of primitive hematopoietic stem cells
    Peter J Quesenberry
    Rhode Island Hospital and the Brown Medical School, Division of Hematology Oncology, Department of Medicine, Providence, Rhode Island 02903, USA
    Stem Cells Dev 19:453-60. 2010
    ..The alterations in multiple other cell cycle regulators were consistent with previous information obtained in other cell systems. The cycle regulatory mechanics appears to be preserved across broad ranges of cell types...
  7. ncbi request reprint The stem cell continuum: cell cycle, injury, and phenotype lability
    Peter J Quesenberry
    Division of Hematology and Oncology, Rhode Island Hospital, 593 Eddy Street, George 3, Providence, RI 02903, USA
    Ann N Y Acad Sci 1106:20-9. 2007
    ..Altogether, marrow appears to represent a highly flexible ever-changing cell system with the capacity to respond to products of injured cells and top repair a broad range of tissues...
  8. pmc Murine allogeneic in vivo stem cell homing(,)
    Gerald A Colvin
    Department of Research, Roger Williams Medical Center, Providence, Rhode Island, USA
    J Cell Physiol 211:386-91. 2007
    ..These data indicate a rapid homing into allogeneic recipients with a plateau at 1 h. The decline of secondary engraftability over time may indicate a phenotype alteration of homed cells...
  9. doi request reprint Conversion potential of marrow cells into lung cells fluctuates with cytokine-induced cell cycle
    Mark S Dooner
    Department of Medical Oncology Research, Center for Stem Cell Biology Research, Rhode Island Hospital, Providence, RI 02903, USA
    Stem Cells Dev 17:207-19. 2008
    ..The present study indicates that marrow stem cell production of nonhematopoietic cells also fluctuates on a continuum...
  10. pmc Bone marrow production of lung cells: the impact of G-CSF, cardiotoxin, graded doses of irradiation, and subpopulation phenotype
    Jason M Aliotta
    Roger Williams Medical Center, Center for Stem Cell Biology, Providence, RI 02908, USA
    Exp Hematol 34:230-41. 2006
    ..Previous studies have demonstrated the production of various types of lung cells from marrow cells under diverse experimental conditions. Our aim was to identify some of the variables that influence conversion in the lung...
  11. doi request reprint Heterogeneity of non-cycling and cycling synchronized murine hematopoietic stem/progenitor cells
    Gerald A Colvin
    Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Cell Physiol 222:57-65. 2010
    ..1964). Marrow stem cells may be most adequately defined on a population basis; stem cells existing in a continuum of reversible change rather than a hierarchy...
  12. pmc A new stem cell biology: the continuum and microvesicles
    Peter J Quesenberry
    Providence, RI
    Trans Am Clin Climatol Assoc 123:152-66; discussion 166. 2012
    ..The challenge of the future is to define the stem cell population, not purify the stem cell. We are at the beginning of elucidation of quantum stemomics...
  13. pmc Induction of pulmonary hypertensive changes by extracellular vesicles from monocrotaline-treated mice
    Jason M Aliotta
    Division of Hematology Oncology, Department of Medicine, Rhode Island Hospital, Providence, RI 02908, USA
    Cardiovasc Res 100:354-62. 2013
    ..In this study, we sought to determine whether LEV or plasma-derived EV (PEV) alter pulmonary vascular endothelial or marrow progenitor cell phenotype to induce pulmonary vascular remodelling...
  14. doi request reprint Nonengraftment haploidentical cellular immunotherapy for refractory malignancies: tumor responses without chimerism
    Gerald A Colvin
    Department of Medicine, Division of Hematology Oncology, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    Biol Blood Marrow Transplant 15:421-31. 2009
    ..Possible mechanisms contributing to its effectiveness include initial GVT kill, breaking of host tolerance to tumor through cross-reactive alloreactive responses, persistent nondetectable microchimerism, or some combination of these...
  15. pmc Alteration of marrow cell gene expression, protein production, and engraftment into lung by lung-derived microvesicles: a novel mechanism for phenotype modulation
    Jason M Aliotta
    Division of Hematology and Oncology, Rhode Island Hospital, 3rd Floor, George Building, 593 Eddy Street, Providence, Rhode Island 02903, USA
    Stem Cells 25:2245-56. 2007
    ..These findings demonstrate alterations of marrow cell phenotype by lung-derived microvesicles and suggest a novel mechanism for marrow cell-directed repair of injured tissue...
  16. pmc Progenitor/stem cell fate determination: interactive dynamics of cell cycle and microvesicles
    Jason M Aliotta
    Division of Hematology and Oncology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Stem Cells Dev 21:1627-38. 2012
    ..These data demonstrate that microvesicle modification of progenitor/stem cells is influenced by cell cycle and the treatment of the originator lung tissue...
  17. ncbi request reprint Lineage-negative bone marrow cells travel bidirectionally in the olfactory migratory stream but maintain hematopoietic phenotype
    Brian E Moore
    Center for Stem Cell Biology, Roger Williams Medical Center, Providence, Rhode Island, USA
    J Cell Physiol 202:147-52. 2005
    ..Antibody staining revealed that these cells did not take on a neural, glial, or endothelial phenotype, while largely retaining their hematopoietic lineage as demonstrated by CD45 positivity...
  18. ncbi request reprint Intrinsic hematopoietic stem cell/progenitor plasticity: Inversions
    Gerald A Colvin
    Roger Williams Medical Center, Department of Research, Adele Decof Cancer Center, Providence, Rhode Island 02908 4735, USA
    J Cell Physiol 199:20-31. 2004
    ..These studies indicate that primitive marrow cells reversibly shift from ESC to progenitors without differentiation occurring. They exist as a fluctuating continuum...
  19. doi request reprint Marrow cell genetic phenotype change induced by human lung cancer cells
    Michael Del Tatto
    Department of Medicine, Division of Hematology Oncology, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, USA
    Exp Hematol 39:1072-80. 2011
    ..They also suggest that the tissue environment may alter cancer cell gene expression...
  20. ncbi request reprint The chiaroscuro stem cell: a unified stem cell theory
    Peter J Quesenberry
    Center for Stem Cell Biology, Roger Williams Medical Center, Providence, RI 02908 4735, USA
    Blood 100:4266-71. 2002
    ..A general model indicates a marrow cell that can continually change its surface receptor expression and thus responds to external stimuli differently at different points in the cell cycle...
  21. pmc Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription
    Jason M Aliotta
    Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, Providence, RI 02903, USA
    Exp Hematol 38:233-45. 2010
    ..The present studies establish that entry of lung-derived microvesicles into marrow cells is a prerequisite for marrow expression of pulmonary epithelial cell-derived mRNA...
  22. ncbi request reprint Stem cell continuum: directed differentiation hotspots
    Gerald A Colvin
    Department of Research, Roger Williams Medical Center, Providence, RI 02908 4735, USA
    Exp Hematol 35:96-107. 2007
    ..The hypothesis was that stem cells would have different sensitivities to an identical inductive signal through cell-cycle transit and that this would affect the outcome of its progeny...
  23. pmc Cellular immunotherapy for refractory hematological malignancies
    John L Reagan
    Division of Hematology Oncology, Rhode Island Hospital The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Transl Med 11:150. 2013
    ..The end goal of cellular therapy is not engraftment but instead is the purposeful rejection of donor cells so as to elicit a potent immune reaction that appears to break host tumor tolerance...
  24. pmc Marrow stem cells shift gene expression and engraftment phenotype with cell cycle transit
    Jean Francois Lambert
    Department of Research, Roger Williams Medical Center, 825 Chalkstone Ave, Providence, RI 02908, USA
    J Exp Med 197:1563-72. 2003
    ..These observations suggest stem cell gene expression shifts through cell cycle in relation to cell cycle related alterations of stem cell phenotype. The engraftment defect is related to a major phenotypic change of the stem cell...
  25. ncbi request reprint Developmental biology: Ignoratio elenchi: red herrings in stem cell research
    Peter J Quesenberry
    Department of Research, The Center for Stem Cell Biology, Providence, RI 02908 4735, USA
    Science 308:1121-2. 2005
  26. pmc Critical variables in the conversion of marrow cells to skeletal muscle
    Mehrdad Abedi
    Department of Research, Roger Williams Medical Center, 825 Chalkstone Ave, Providence, RI 02908 4735, USA
    Blood 106:1488-94. 2005
    ..These data may explain the differences in the literature for the frequency of marrow-to-skeletal muscle conversion and can set a platform for future models and perhaps clinical protocols...
  27. ncbi request reprint Gene expression fluctuations in murine hematopoietic stem cells with cell cycle progression
    Gerri J Dooner
    Department of Medical Oncology, Rhode Island Hospital, Providence, Rhode Island, 02903, USA
    J Cell Physiol 214:786-95. 2008
    ....
  28. ncbi request reprint The stem cell continuum
    Peter J Quesenberry
    Department of Research and Head, Cancer Center, Roger Williams Medical Center, 825 Chalkstone Ave, Providence, RI 02908 4735, USA
    Ann N Y Acad Sci 1044:228-35. 2005
    ..This could be considered plasticity squared. These data indicate that marrow stem cells are regulated on a continuum related to the cell cycle both as to hematopoietic and to nonhematopoietic differentiation...
  29. ncbi request reprint A specific heptapeptide from a phage display peptide library homes to bone marrow and binds to primitive hematopoietic stem cells
    Grzegorz S Nowakowski
    Division of Gene Therapy, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Stem Cells 22:1030-8. 2004
    ....
  30. ncbi request reprint Stem cell biology and the plasticity polemic
    Peter J Quesenberry
    Department of Research and the Adele R Decof Cancer Center, Roger Williams Medical Center, Providence, RI 02908, USA
    Exp Hematol 33:389-94. 2005
    ..We are at the beginning of an exciting and burgeoning field of research with great clinical potential...
  31. ncbi request reprint Stem cell plasticity: an overview
    Peter J Quesenberry
    Department of Research, The Center for Stem Cell Biology, Roger Williams Medical Center, Providence, RI 02908 4735, USA
    Blood Cells Mol Dis 32:1-4. 2004
    ..Overall, the therapeutic potential of adult marrow stem cells is very intriguing, and successful use therapeutically will probably depend on definition of the most appropriate transplant model and tissue injury...
  32. pmc Cellular immune therapy for refractory cancers: novel therapeutic strategies
    Karen K Ballen
    Division of Hematology Oncology, Massachusetts General Hospital, Boston, 02114, USA
    Exp Hematol 33:1427-35. 2005
    ..This review summarizes the field of cellular immune therapy using very-low-dose conditioning for refractory cancers...
  33. ncbi request reprint H2-mismatched transplantation with repetitive cell infusions and CD40 ligand antibody infusions without myeloablation
    Jean Francois Lambert
    Department of Research, Roger Williams Medical Center, Providence, and UMass Cancer Center, University of Massachusetts, Worcester, USA
    Br J Haematol 119:155-63. 2002
    ..This approach indicates that microchimaerism can tolerize for subsequent marrow infusions and produce macrochimaerism. This strategy could be applied in clinical human transplants...
  34. ncbi request reprint Differentiation hotspots: the deterioration of hierarchy and stochasm
    Gerald A Colvin
    Department of Research, Roger Williams Medical Center, Providence, RI 02908, USA
    Blood Cells Mol Dis 32:34-41. 2004
    ..This data inaugurates the end of a pure stochastic model. This work complements existing scientific work without discounting it and adds an additional dimension of complexity (or simplicity) to the process of hematopoiesis...
  35. pmc Marrow cell infusion attenuates vascular remodeling in a murine model of monocrotaline-induced pulmonary hypertension
    Jason M Aliotta
    Division of Hematology and Oncology, Sleep, and Critical Care Medicine, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, 593 Eddy Street, Providence, RI 02903, USA
    Stem Cells Dev 18:773-82. 2009
    ..In conclusion, WBM alone appears to increase RVPP and RV/BW in normal mice but the combination of WBM and TBI attenuates MCT-induced PH...
  36. ncbi request reprint Perspective: fundamental and clinical concepts on stem cell homing and engraftment: a journey to niches and beyond
    Peter J Quesenberry
    Department of Research, Roger Williams Medical Center, Providence, RI 02908 4735, USA
    Exp Hematol 33:9-19. 2005
    ..In this review, we will specifically focus on homing and engraftment to bone marrow because this is the best-studied and clinically applicable system...
  37. pmc Intercellular transfer of proteins as identified by stable isotope labeling of amino acids in cell culture
    Ming Li
    Laboratory of Retrovirology, Division of Infectious Diseases, Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Biol Chem 285:6285-97. 2010
    ..SILAC-generated data sets offer a valuable tool to identify and validate potential paracrine networks that may impact relevant biologic processes associated with phenotypic and genotypic signatures of health and disease...
  38. ncbi request reprint Future prospects for patient care utilizing autologous lymphoid and hematopoietic stem cells
    Lawrence G Lum
    Adele R Decof Cancer Center, Roger Williams Medical Center, 825 Chalkstone Avenue, Providence, RI 02908, USA
    Med Health R I 86:247-8. 2003
  39. ncbi request reprint The stem cell continuum: considerations on the heterogeneity and plasticity of marrow stem cells
    Peter J Quesenberry
    Department of Research, The Center for Stem Cell Biology, Roger Williams Medical Center, Providence, RI 02908 4735, USA
    Stem Cell Rev 1:29-36. 2005
    ..Final outcomes with this continuum model would be determined by the specific chromatin state of the cell and the presence of specific differentiation inducers...
  40. pmc RKIP phosphorylation and STAT3 activation is inhibited by oxaliplatin and camptothecin and are associated with poor prognosis in stage II colon cancer patients
    Sam Cross-Knorr
    Department of Medicine, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI 02903, USA
    BMC Cancer 13:463. 2013
    ....
  41. pmc The new stem cell biology
    Peter J Quesenberry
    Department of Research, Roger Williams Medical Center, 825 Chalkstone Avenue, Providence, RI 02908, USA
    Trans Am Clin Climatol Assoc 113:182-206; discussion 206-7. 2002
    ..These observations, along with progress in using low dose treatments and tolerization approaches, suggest many new therapeutic strategies involving stem cells and the creation of a new medical specialty; stemology...
  42. doi request reprint Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling
    Wentian Yang
    Department of Orthopaedics, Brown University Alpert Medical School and Rhode Island Hospital, Providence, Rhode Island 02903, USA
    Nature 499:491-5. 2013
    ....
  43. ncbi request reprint Stem cells and pulmonary metamorphosis: new concepts in repair and regeneration
    Jason M Aliotta
    Roger Williams Medical Center, Center for Stem Cell Biology, Providence, RI 02908, USA
    J Cell Physiol 204:725-41. 2005
    ....
  44. pmc Stem cell plasticity revisited: the continuum marrow model and phenotypic changes mediated by microvesicles
    Peter J Quesenberry
    Division of Hematology and Oncology, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    Exp Hematol 38:581-92. 2010
    ..We further propose a stem cell population model in which the individual cell phenotypes continually change, but the population phenotype is relatively stable. This, in turn, is modulated by microvesicle and microenvironmental influences...
  45. ncbi request reprint The continuum model of marrow stem cell regulation
    Peter J Quesenberry
    Roger Williams Medical Center, Department of Research, Providence, Rhode Island 02908, USA
    Curr Opin Hematol 13:216-21. 2006
    ..A series of studies on purified lineage negative rhodamine low Hoechst low murine stem cells driven through cell cycle by cytokine exposure have shown that many phenotypic features show reversible changes with cycle progression...
  46. ncbi request reprint Targeting of Lin-Sca+ hematopoietic stem cells with bispecific antibodies to injured myocardium
    Lawrence G Lum
    Immunotherapy Program, Adele R Decof Cancer Center, Providence, RI 02908, USA
    Blood Cells Mol Dis 32:82-7. 2004
    ..These results suggest that stem cells retargeted with BiAb can be directly injected and retained by injured myocardium or targeted to injured myocardial tissues for tissue regeneration...
  47. pmc Cellular phenotype and extracellular vesicles: basic and clinical considerations
    Peter J Quesenberry
    1 Department of Medicine, Rhode Island Hospital, Providence, Rhode Island
    Stem Cells Dev 23:1429-36. 2014
    ..Extracellular vesicles offer an intriguing strategy for treating a number of diseases characterized by tissue injury. ..
  48. doi request reprint Spontaneous regression of chronic lymphocytic leukemia to a monoclonal B-lymphocytosis or to a normal phenotype
    Peter S Nakhla
    Department of Medicine, Rhode Island Hospital, Providence, RI, USA
    Leuk Lymphoma 54:1647-51. 2013
    ..03). This difference in the duration of CLL prior to remission could be due to a possible distinct pathophysiology for these events...
  49. pmc The Evi1, microRNA-143, K-Ras axis in colon cancer
    Jin Song Gao
    Division of Infectious Diseases, Department of Medicine, Miriam and Rhode Island Hospitals, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    FEBS Lett 585:693-9. 2011
    ..We find an indirect relationship between miRNA-143 and Evi1 expression. A complex molecular axis linking Evi1, miRNA-143 is operational in human colon cancer...
  50. ncbi request reprint Chromatin remodeling and stem cell theory of relativity
    Jan Cerny
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 201:1-16. 2004
    ..We are entering a new era of stem cell biology the era of "chromatinomics." We are one step closer to the practical use of cellular therapy for degenerative diseases...
  51. pmc Cryopreservation of hematopoietic stem cells
    David Berz
    Roger Williams Medical Center, Bone Marrow Transplant Unit, East Wing, Providence, Rhode Island 02908 4735, USA
    Am J Hematol 82:463-72. 2007
    ..Freezing efficiency has been proven repeatedly and the ability of long-term stored marrow to repopulate has been established. Standard approaches outlined here are used in many labs as the field continues to evolve...
  52. ncbi request reprint Advances in cellular therapy for the treatment of leukemia
    Kalyan Mantripragada
    Division of Hematology Oncology, Rhode Island Hospital, Warren Alpert School of Medicine, Brown University, Providence, Rhode Island 02903, USA
    Discov Med 17:15-24. 2014
    ..Significant responses and survival benefit have been reported with these modalities. Herein, we review the mechanisms for these newer adoptive immune therapies, clinical indications for their use, and potential future directions. ..
  53. pmc Low dose total body irradiation followed by allogeneic lymphocyte infusion for refractory hematologic malignancy--an updated review
    Karen K Ballen
    Division of Hematology Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Leuk Lymphoma 45:905-10. 2004
    ..The development of chimerism correlated with total previous myelotoxic chemotherapy (p < 0.001). This technique is now being extended into the haploidentical setting...
  54. ncbi request reprint Phase I/II study of treatment of stage IV breast cancer with OKT3 x trastuzumab-armed activated T cells
    Lawrence G Lum
    Immunotherapy and Blood and Stem Cell Transplantation Programs, Adele R Decof Cancer Center, Roger Williams Medical Center, Providence, RI 02908, USA
    Clin Breast Cancer 4:212-7. 2003
  55. pmc Nonengraftment haploidentical cellular therapy for hematologic malignancies
    John L Reagan
    Division of Hematology and Oncology, Rhode Island Hospital, The Warren Alpert Medical School, Providence, RI 02903, USA
    Adv Hematol 2012:784213. 2012
    ....
  56. ncbi request reprint Akt signaling regulates side population cell phenotype via Bcrp1 translocation
    Masaki Mogi
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 278:39068-75. 2003
    ..These data suggest that Akt signaling modulates the SP cell phenotype by regulating the expression of Bcrp1...
  57. ncbi request reprint Low-dose total body irradiation followed by allogeneic lymphocyte infusion may induce remission in patients with refractory hematologic malignancy
    Karen K Ballen
    Cancer Center and Department of Medicine, University of Massachusetts Memorial Health Care, Worcester, MA, USA
    Blood 100:442-50. 2002
    ..Low-dose TBI and allogeneic lymphocyte infusion may induce remission in patients with refractory hematologic malignancy...
  58. ncbi request reprint Circadian variations of bone marrow engraftability
    Lionel D'Hondt
    Centre Hospitalier Notre Dame et Reine Fabiola, Charleroi, Belgium
    J Cell Physiol 200:63-70. 2004
    ..Circadian variations of bone marrow engraftability are important and should be considered in bone marrow transplant strategies...
  59. ncbi request reprint A method for clonal analysis of epidermal growth factor-responsive neural progenitors
    Caron M Engstrom
    Department of Neurology, Cancer Center, University of Massachusetts Medical Center, Worcester, MA, USA
    J Neurosci Methods 117:111-21. 2002
    ..In individual colonies, oligodendrons predominated with a lesser presence of astroglial or neuronal cell types. This approach establishes a reliable and reproducible method for single cell cloning of neurosphere cells...
  60. ncbi request reprint Cytokine receptor repertoire and cytokine responsiveness of Ho(dull)/Rh(dull) stem cells with differing potentials for G1/S phase progression
    G Prem Veer Reddy
    Vattikuti Urology Institute, Henry Ford Health Sciences Center, Detroit, MI, USA
    Exp Hematol 30:792-800. 2002
    ....
  61. ncbi request reprint Cytokine modulation of murine stem cell engraftment: the role of adherence to plastic surfaces
    Stefan O Peters
    Medizinische Klinik I, Universitaet Luebeck, Germany
    Int J Hematol 76:84-90. 2002
    ..These data indicate that cytokine-treated engraftable stem cells do not show significant adherence to plastic surfaces...
  62. ncbi request reprint Transplanted clonal neural stem-like cells respond to remote photic stimulation following incorporation within the suprachiasmatic nucleus
    Piotr Zlomanczuk
    Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Exp Neurol 174:162-8. 2002
    ....
  63. ncbi request reprint Engraftment of post 5-fluorouracil murine marrow into minimally myeloablated (100 cGy) murine hosts
    Lionel D'Hondt
    Centre Hospitalier Notre Dame et Reine Fabiola, Charleroi, Belgium
    J Hematother Stem Cell Res 11:483-90. 2002
    ..Thus, these studies show transiently defective engraftment of 5-FU-treated marrow into submyeloablated hosts, which may be related to the cell cycle status of the stem cells...
  64. ncbi request reprint Studies on BrdU labeling of hematopoietic cells: stem cells and cell lines
    Lizhen Pang
    Cancer Center, University of Massachusetts, Worcester, Massachusetts, USA
    J Cell Physiol 197:251-60. 2003
    ..All together, while we cannot absolutely exclude damage/repair as contributing to stem cell BrdU labeling, the data indicate that primitive bone marrow stem cells are probably a cycling population...
  65. ncbi request reprint Rhythmicity of engraftment and altered cell cycle kinetics of cytokine-cultured murine marrow in simulated microgravity compared with static cultures
    Gerald A Colvin
    University of Massachusetts Cancer Center, Worcester, MA 01655, USA
    In Vitro Cell Dev Biol Anim 38:343-51. 2002
    ..This is the first study of engraftable stem cells under microgravity conditions, and the differences between microgravity and normal gravity cultures may present opportunities for unique future stem cell expansion strategies...
  66. ncbi request reprint Discrete stem cells: subsets or a continuum?
    Mark A Kirkland
    Blood 108:3949; author reply 3950. 2006
  67. ncbi request reprint Association of fetal hormone levels with stem cell potential: evidence for early life roots of human cancer
    Inkyung Baik
    Cancer Research Center and Department of Cancer Biology, ILAT Steroid RIA Laboratory, University of Massachusetts Medical School, Worchester, MA 01605, USA
    Cancer Res 65:358-63. 2005
    ....
  68. ncbi request reprint Stem cells and prenatal origin of breast cancer
    Inkyung Baik
    Cancer Research Center and Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cancer Causes Control 15:517-30. 2004
    ..We conclude by outlining a feasible population-based study that measures stem cell potential to explore mechanisms mediating the relation between in utero exposure to pregnancy hormones and breast cancer risk in the offspring...
  69. ncbi request reprint A combination chemotherapy protocol with dose intensification and autologous bone marrow transplant (VELCAP-HDC) for canine lymphoma
    Angela E Frimberger
    Tufts University School of Veterinary Medicine, North Grafton, MA 01536, USA
    J Vet Intern Med 20:355-64. 2006
    ..027). Median survival time for dogs in group 3 was 139 weeks, compared with 43 weeks and 68 weeks for dogs in groups 1 and 2, respectively...
  70. ncbi request reprint Coexpression of oncostatin M and its receptors and evidence for STAT3 activation in human ovarian carcinomas
    Todd M Savarese
    Cytokine Cytokine Receptor LINK Laboratory, Cancer Center, University of Massachusetts Medical School, Worcester, 01655, USA
    Cytokine 17:324-34. 2002
    ..Oncostatin M and its receptors may be part of a network of cytokine systems within ovarian carcinomas that may act to maintain STAT3 in its activated form, a phenomenon associated with the malignant phenotype...
  71. doi request reprint Stem cell plasticity: clinical implications
    Peter J Quesenberry
    Exp Hematol 36:669-71. 2008
  72. ncbi request reprint Quantitative tissue stem cell modeling
    Ingo Roeder
    Blood 102:1143-4; author reply 1144-5. 2003

Research Grants5

  1. Hematopoietic Circadian Rhythms
    Peter Quesenberry; Fiscal Year: 2005
    ..Transgenic Pert-luc rats and mice will be available at University of Virginia, and the array/informatic studies done at Princeton. ..
  2. STEM CELLS HOMING AND MOTILITY
    Peter Quesenberry; Fiscal Year: 2002
    ..The influence of cytokines on the appearance, localization, and function of cell processes and distribution of adhesion receptors on both stem cells and stromal cells will also be examined. ..
  3. Challenges in the Era of Stem Cell Plasticity
    Peter Quesenberry; Fiscal Year: 2003
    ..Participants will include investigators in the basic biology of stem cells, clinical transplanters, and clinician investigators. The workshops and symposium will be held in Providence, Rhode Island on April 8, 9, 10 & 11, 2003 ..
  4. Minimal Treatment Models of Stem Cell Engraftment
    Peter Quesenberry; Fiscal Year: 2004
    ..These studies should shed light on the stem cell/accessory cell mechanism involved in both syngeneic and allogeneic transplantation and provide approaches to minimize toxicity in both types of transplantation. ..
  5. Cell Cycle Related Transdifferentiation into Lung Cells
    Peter Quesenberry; Fiscal Year: 2006
    ..This could then lead to therapies of various lung disorders such as acute respiratory distress syndrome. ..