BRIAN RICHARD OTT

Summary

Affiliation: Rhode Island Hospital
Country: USA

Publications

  1. doi request reprint Assessment of driving-related skills prediction of unsafe driving in older adults in the office setting
    Brian R Ott
    Department of Neurology, Warren Alpert Medical School, Brown University and Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Am Geriatr Soc 61:1164-9. 2013
  2. pmc Naturalistic validation of an on-road driving test of older drivers
    Brian R Ott
    Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Hum Factors 54:663-74. 2012
  3. pmc Computerized maze navigation and on-road performance by drivers with dementia
    Brian R Ott
    Department of Clinical Neurosciences, Brown University, Providence, Rhode Island, USA
    J Geriatr Psychiatry Neurol 21:18-25. 2008
  4. ncbi request reprint Open label, multicenter, 28-week extension study of the safety and tolerability of memantine in patients with mild to moderate Alzheimer's disease
    Brian R Ott
    The Alzheimer s Disease and Memory Disorders Center, Rhode Island Hospital APC 6, 593 Eddy Street, Providence, Rhode Island 02903, and Department of Psychiatry, Northwestern University, Chicago, IL 60611, USA
    J Neurol 254:351-8. 2007
  5. pmc Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer's disease
    Brian R Ott
    Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Alzheimers Dis 20:647-57. 2010
  6. pmc A longitudinal study of drivers with Alzheimer disease
    B R Ott
    Department of Clinical Neurosciences, Brown University, Providence, RI, USA
    Neurology 70:1171-8. 2008
  7. ncbi request reprint Neuroimaging correlates of dementia rating scale performance at baseline and 12-month follow-up among patients with vascular dementia
    Lawrence H Sweet
    Brown University Medical School, Miriam Hospital, Providence, RI 20903, USA
    J Geriatr Psychiatry Neurol 16:240-4. 2003
  8. pmc Neuropsychological deficits associated with driving performance in Parkinson's and Alzheimer's disease
    Janet Grace
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA
    J Int Neuropsychol Soc 11:766-75. 2005
  9. ncbi request reprint Clinical correlates of cognitive decline in vascular dementia
    Robert H Paul
    Brown Medical School, Providence, Rhode Island 20903, USA
    Cogn Behav Neurol 16:40-6. 2003
  10. ncbi request reprint Is donepezil therapy associated with reduced mortality in nursing home residents with dementia?
    Mason C Gasper
    Department of Clinical Neurosciences, Brown University, Providence, Rhode Island, USA
    Am J Geriatr Pharmacother 3:1-7. 2005

Detail Information

Publications49

  1. doi request reprint Assessment of driving-related skills prediction of unsafe driving in older adults in the office setting
    Brian R Ott
    Department of Neurology, Warren Alpert Medical School, Brown University and Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Am Geriatr Soc 61:1164-9. 2013
    ....
  2. pmc Naturalistic validation of an on-road driving test of older drivers
    Brian R Ott
    Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Hum Factors 54:663-74. 2012
    ..The objective was to compare a standardized road test to naturalistic driving by older people who may have cognitive impairment to define improvements that could potentially enhance the validity of road testing in this population...
  3. pmc Computerized maze navigation and on-road performance by drivers with dementia
    Brian R Ott
    Department of Clinical Neurosciences, Brown University, Providence, Rhode Island, USA
    J Geriatr Psychiatry Neurol 21:18-25. 2008
    ..Measurement of maze task performance appears to be useful in the assessment of older drivers at risk for hazardous driving...
  4. ncbi request reprint Open label, multicenter, 28-week extension study of the safety and tolerability of memantine in patients with mild to moderate Alzheimer's disease
    Brian R Ott
    The Alzheimer s Disease and Memory Disorders Center, Rhode Island Hospital APC 6, 593 Eddy Street, Providence, Rhode Island 02903, and Department of Psychiatry, Northwestern University, Chicago, IL 60611, USA
    J Neurol 254:351-8. 2007
    ..It is approved in the U.S. and Europe for the treatment of moderate to severe AD and is currently under investigation for mild to moderate AD...
  5. pmc Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer's disease
    Brian R Ott
    Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Alzheimers Dis 20:647-57. 2010
    ..The basis for the apparent effect of APOE epsilon4 genotype on the relationship of ventricular volume to Abeta and tau levels is unknown, but could involve altered CSF-blood-brain barrier function during the course of disease...
  6. pmc A longitudinal study of drivers with Alzheimer disease
    B R Ott
    Department of Clinical Neurosciences, Brown University, Providence, RI, USA
    Neurology 70:1171-8. 2008
    ..The goal of this study was to define the natural progression of driving impairment in persons who initially have very mild to mild dementia...
  7. ncbi request reprint Neuroimaging correlates of dementia rating scale performance at baseline and 12-month follow-up among patients with vascular dementia
    Lawrence H Sweet
    Brown University Medical School, Miriam Hospital, Providence, RI 20903, USA
    J Geriatr Psychiatry Neurol 16:240-4. 2003
    ..These findings indicate that although SH volume increases with disease progression, the relative impact of SH volume on cognitive status decreases among patients with advanced VaD...
  8. pmc Neuropsychological deficits associated with driving performance in Parkinson's and Alzheimer's disease
    Janet Grace
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA
    J Int Neuropsychol Soc 11:766-75. 2005
    ..Multifactorial measures (ROCF, Trails B) were useful in distinguishing safe from unsafe drivers in both patient groups...
  9. ncbi request reprint Clinical correlates of cognitive decline in vascular dementia
    Robert H Paul
    Brown Medical School, Providence, Rhode Island 20903, USA
    Cogn Behav Neurol 16:40-6. 2003
    ..To determine whether demographic data, dementia severity, functional status, whole brain volume (WBV), or subcortical hyperintensity volume (SH) predict subsequent cognitive decline in vascular dementia (VaD)...
  10. ncbi request reprint Is donepezil therapy associated with reduced mortality in nursing home residents with dementia?
    Mason C Gasper
    Department of Clinical Neurosciences, Brown University, Providence, Rhode Island, USA
    Am J Geriatr Pharmacother 3:1-7. 2005
    ..These broad-ranging, long-term effects may explain the recent finding that the use of a CEI among nursing home residents with dementia was associated with lower mortality...
  11. pmc Maze test performance and reported driving ability in early dementia
    Brian R Ott
    Department of Clinical Neurosciences, Brown University, Providence, Rhode Island, USA
    J Geriatr Psychiatry Neurol 16:151-5. 2003
    ..Computerized tests of maze performance offer promise as a screening tool to identify potential driving impairment among cognitively impaired elderly and demented drivers...
  12. ncbi request reprint Progressive morphometric and cognitive changes in vascular dementia
    John Gunstad
    Department of Psychiatry and Human Behavior, Brown Medical School, Miriam Hospital, Coro West Third Floor, 1 Hoppin St, Providence RI 02903, USA
    Arch Clin Neuropsychol 20:229-41. 2005
    ..Further research is needed to determine whether this observed decline is attributable to differential lesion distribution or statistical artifact...
  13. doi request reprint Effect of discontinuing cholinesterase inhibitor therapy on behavioral and mood symptoms in nursing home patients with dementia
    Lori A Daiello
    Department of Clinical Neurosciences, Alpert School of Medicine, Brown University, Providence, Rhode Island
    Am J Geriatr Pharmacother 7:74-83. 2009
    ..Cholinesterase inhibitors (CHEIs) ameliorate some types of behavioral symptoms in patients with Alzheimer's disease. However, there has been little previous study of the outcomes associated with discontinuing these medications...
  14. ncbi request reprint Preliminary study of the relationship between thyroid status and cognitive and neuropsychiatric functioning in euthyroid patients with Alzheimer dementia
    Robert A Stern
    Department of Neurology, Boston University School of Medicine, Robinson Suite 7800, 715 Albany Street, Boston, MA 02118, USA
    Cogn Behav Neurol 17:219-23. 2004
    ..To investigate whether variations within normal ranges of thyroid functioning are related to cognitive and neuropsychiatric functioning in Alzheimer disease (AD)...
  15. pmc Effects of cholinesterase inhibitors on visual attention in drivers with Alzheimer disease
    Lori A Daiello
    Department of Clinical Neurosciences, Brown University, Providence, USA
    J Clin Psychopharmacol 30:245-51. 2010
    ..We conducted a combined observational cohort and case-control study in patients with Alzheimer disease (AD) to assess the effects of acetylcholinesterase inhibitor (ChEI) treatment on cognitive functions important for driving...
  16. ncbi request reprint The relationship of subcortical MRI hyperintensities and brain volume to cognitive function in vascular dementia
    Ronald A Cohen
    Department of Psychiatry, Brown Medical School, Providence, Rhode Island, USA
    J Int Neuropsychol Soc 8:743-52. 2002
    ..That WBV emerged as a stronger correlate of dementia raises further questions regarding the cerebral mechanisms that contribute to the development of VaD...
  17. ncbi request reprint Tacrine therapy is associated with reduced mortality in nursing home residents with dementia
    Brian R Ott
    Department of Clinical Neurosciences, Center for Gerontology and Health Care Research, and Department of Community Health, Brown University, Providence, Rhode Island
    J Am Geriatr Soc 50:35-40. 2002
    ..To investigate the extent to which treatment with tacrine is associated with a reduction in mortality in nursing home residents with dementia...
  18. pmc Cerebral atrophy, apolipoprotein E varepsilon4, and rate of decline in everyday function among patients with amnestic mild cognitive impairment
    Ozioma C Okonkwo
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 6:404-11. 2010
    ..In this study, we investigated whether whole brain atrophy and apolipoprotein E (APOE) genotype are associated with the rate of functional decline in MCI...
  19. ncbi request reprint Patient versus informant perspectives of Quality of Life in Mild Cognitive Impairment and Alzheimer's disease
    Rebecca E Ready
    Department of Psychiatry, Brown Medical School, Providence, RI, USA
    Int J Geriatr Psychiatry 19:256-65. 2004
    ..Furthermore, there is little data to indicate whether or not mildly impaired patients can provide self-report QOL data or if informant reports are needed...
  20. pmc Dual-task conditions modulate the efficiency of selective attention mechanisms in Alzheimer's disease
    Elena K Festa
    Department of Cognitive, Linguistic and Psychological Sciences, Brown University, Street, Providence, RI 02912, USA
    Neuropsychologia 48:3252-61. 2010
    ..These findings not only increase our understanding of the nature of the attentional deficits in AD patients, but also have implications for understanding the processes mediating attention in neurologically intact individuals...
  21. ncbi request reprint Medical treatment of Alzheimer's disease: past, present, and future
    Brian R Ott
    Memorial Hospital Alzheimer s Disease and Memory Disorders Center, Pawtucket, RI, USA
    Med Health R I 85:210-2. 2002
  22. pmc Prediction of on-road driving performance in patients with early Alzheimer's disease
    Laura B Brown
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA
    J Am Geriatr Soc 53:94-8. 2005
    ..Physicians and family members frequently are asked to provide information about driving ability in patients with Alzheimer's disease (AD), yet there has been little research on the validity of their assessments of driving performance...
  23. pmc Clinician assessment of the driving competence of patients with dementia
    Brian R Ott
    Department of Clinical Neurosciences, Brown University, Providence, Rhode Island, USA
    J Am Geriatr Soc 53:829-33. 2005
    ..To determine the validity and reliability of clinician ratings of the driving competence of patients with mild dementia...
  24. ncbi request reprint Cognitive decline among female estrogen users in nursing homes
    Brian R Ott
    Department of Clinical Neurosciences, Brown University, Providence, Rhode Island, USA
    J Gerontol A Biol Sci Med Sci 57:M594-8. 2002
    ....
  25. pmc Driving and dementia: a review of the literature
    Laura B Brown
    Department of Psychiatry and Human Behavior, Brown Medical School, Rhode Island Hospital, Neuropsychology Program, 593 Eddy Street, Physician s Office Building, Providence, RI 02903, USA
    J Geriatr Psychiatry Neurol 17:232-40. 2004
    ..The approach of the physician to driving and dementia is addressed, including in-office screening, referral for on-road driving assessments, and the potential for physician reporting to state agencies...
  26. ncbi request reprint Amnestic behavior in dementia: symptoms to assist in early detection and diagnosis
    Rebecca E Ready
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Pawtucket, Rhode Island, USA
    J Am Geriatr Soc 51:32-7. 2003
    ..This study evaluated two amnestic behavior changes (repetitive questioning and repetitive actions) to determine their utility in screening for early dementia...
  27. ncbi request reprint A survey of voter participation by cognitively impaired elderly patients
    Brian R Ott
    Department of Clinical Neurosciences, Brown University, Providence, RI, USA
    Neurology 60:1546-8. 2003
    ..Actively voting persons had general knowledge about the election as evidenced by matching candidate photographs with name and party labels...
  28. ncbi request reprint The Cornell-Brown Scale for Quality of Life in dementia
    Rebecca E Ready
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island, USA
    Alzheimer Dis Assoc Disord 16:109-15. 2002
    ..Reliability and validity were not adversely affected by patient cognitive impairment. Thus, preliminary data indicate that the Cornell-Brown Scale for Quality of Life is a brief, easily administered, reliable, and valid measure of QOL...
  29. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  30. pmc Quality of Life measures for dementia
    Rebecca E Ready
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA
    Health Qual Life Outcomes 1:11. 2003
    ..It will also be important to identify factors that affect reports of QOL, determine the how perceived QOL affects decisions regarding the care of dementia patients, and evaluate interventions to increase patient QOL...
  31. ncbi request reprint The global deterioration scale: relationships to neuropsychological performance and activities of daily living in patients with vascular dementia
    Robert H Paul
    Department of Psychiatry and Human Behavior, Brown University School of Medicine, Miriam Hospital, Providence, Rhode Island, USA
    J Geriatr Psychiatry Neurol 15:50-4. 2002
    ..Further, the GDS score accurately classified 87% of the patients with VaD. These findings provide support for the validity of the GDS in general staging of dementia severity of VaD...
  32. ncbi request reprint Considering phasic alerting in Alzheimer's disease: comment on Tales et al. (2006)
    Elena K Festa
    Department of Psychology, Brown University, Providence, RI, USA
    Neuropsychology 20:757-60; discussion 761-2. 2006
    ..s conclusions and reaffirm their position that not considering interactions among attentional systems can lead to inaccurate characterizations of the mechanisms by which they operate...
  33. ncbi request reprint Interactions between phasic alerting and spatial orienting: effects of normal aging and Alzheimer's disease
    Elena Festa-Martino
    Department of Psychology, Brown University, Providence, RI, USA
    Neuropsychology 18:258-68. 2004
    ....
  34. ncbi request reprint Results of a randomized placebo-controlled study of memory training for mildly impaired Alzheimer's disease patients
    Deborah A Cahn-Weiner
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, Rhode Island, USA
    Appl Neuropsychol 10:215-23. 2003
    ....
  35. ncbi request reprint Insight and cognitive impairment: effects on quality-of-life reports from mild cognitive impairment and Alzheimer's disease patients
    Rebecca E Ready
    University of Massachusetts, Department of Psychology, Amherst 01003, USA
    Am J Alzheimers Dis Other Demen 21:242-8. 2006
    ..Thus, even when patient insight is intact, patient reports are unlikely to agree with caregiver reports. Patient and caregiver reports about patient QOL may represent 2 unique, yet potentially valid, perspectives...
  36. pmc Driving scenes test of the Neuropsychological Assessment Battery (NAB) and on-road driving performance in aging and very mild dementia
    Laura B Brown
    Department of Psychiatry and Human Behavior, Brown Medical School, USA
    Arch Clin Neuropsychol 20:209-15. 2005
    ..Thus, the new NAB Driving Scenes test appears to have good ecological validity for real-world driving ability in normal and very mildly demented older adults...
  37. ncbi request reprint Behavioral problems as predictors of functional abilities of vascular dementia patients
    Tricia M Zawacki
    Department of Psychology, Georgia State University, Atlanta, Georgia 30303, USA
    J Neuropsychiatry Clin Neurosci 14:296-302. 2002
    ..These findings highlight the importance of apathy as an independent factor associated with functional independence beyond general cognitive abilities...
  38. ncbi request reprint The neuropsychological profile of vascular cognitive impairment--no dementia: comparisons to patients at risk for cerebrovascular disease and vascular dementia
    Kelly Davis Garrett
    Department of Psychiatry and Human Behavior, Brown Medical School, USA
    Arch Clin Neuropsychol 19:745-57. 2004
    ..The current findings suggest that poor cognitive flexibility and verbal retrieval in the context of preserved function in other domains may characterize the prodromal stage of VaD...
  39. ncbi request reprint Apathy and executive dysfunction in mild cognitive impairment and Alzheimer disease
    Rebecca E Ready
    Brown Medical School Department of Psychiatry, Memorial Hospital of Rhode Island, Medical Rehabilitation, Pawtucket, RI 02860, USA
    Am J Geriatr Psychiatry 11:222-8. 2003
    ..Apathy, executive dysfunction, and disinhibition are common in AD, but these behaviors have not been studied in MCI...
  40. doi request reprint Integrating patient and informant reports on the Cornell-Brown Quality-of-Life Scale
    Rebecca E Ready
    Department of Psychology, University of Massachusetts, Amherst, MA 01003, USA
    Am J Alzheimers Dis Other Demen 22:528-34. 2007
    ..This study contributes to a growing line of research that recommends integrating patient and informant perspectives to achieve the most complete assessment of quality of life...
  41. ncbi request reprint Validity of informant reports about AD and MCI patients' memory
    Rebecca E Ready
    University Center for Social and Urban Research, University of Pittsburgh, 121 University Place, Room 513, Pittsburgh, PA 15260, USA
    Alzheimer Dis Assoc Disord 18:11-6. 2004
    ..Results of this study will aid in selecting informants who can provide the most accurate data about memory disorder patients and will aid in the development of protocols for clinical trials for dementia prevention and treatment...
  42. ncbi request reprint Memantine treatment in mild to moderate Alzheimer disease: a 24-week randomized, controlled trial
    Elaine R Peskind
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine and Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Seattle, WA 98108, USA
    Am J Geriatr Psychiatry 14:704-15. 2006
    ..The objective of this study was to compare the efficacy and safety of the moderate-affinity, uncompetitive N-methyl-d-aspartate receptor antagonist, memantine, versus placebo in patients with mild to moderate Alzheimer disease (AD)...
  43. ncbi request reprint Factor structure of patient and caregiver ratings on the dementia quality of life instrument
    Rebecca E Ready
    Department of Psychology, The University of Massachusetts, Amherst, MA 01003, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 14:144-54. 2007
    ..Thus, data from patients demonstrated a factor structure that was highly consistent with caregiver report data and conformed to meaningful psychological constructs...
  44. ncbi request reprint Memantine treatment of cognitive symptoms in mild to moderate Alzheimer disease: secondary analyses from a placebo-controlled randomized trial
    Nunzio Pomara
    Nathan S Kline Institute and New York University School of Medicine, Orangeburg, NY 10962, USA
    Alzheimer Dis Assoc Disord 21:60-4. 2007
    ....
  45. ncbi request reprint Driving safety among older adults
    Melissa M Amick
    Memorial Hospital of RI, Department of Medical Rehabilitation, Pawtucket 02860, USA
    Med Health R I 91:146-8. 2008
  46. ncbi request reprint Mortality in donepezil-treated patients
    Brian R Ott
    J Am Geriatr Soc 52:1412-3; author reply 1413. 2004
  47. ncbi request reprint Pharmacotherapy of dementia with Lewy bodies
    Hubert H Fernandez
    Division of Neurology, Memorial Hospital of Rhode Island, 111 Brewster Street, Pawtucket, RI 02860, USA
    Expert Opin Pharmacother 4:2027-37. 2003
    ....
  48. ncbi request reprint Cognitive and behavioral features discriminate between Alzheimer's and Parkinson's disease
    Deborah A Cahn-Weiner
    Memorial Hospital of Rhode Island and Brown Medical School, Pawtucket 02860, USA
    Neuropsychiatry Neuropsychol Behav Neurol 15:79-87. 2002
    ..To compare the cognitive and behavioral profiles of Alzheimer's disease (AD) and cognitively impaired patients with Parkinson's disease (PD) and to determine the individual measures that best discriminate the two patient groups...
  49. pmc High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
    Paul S Aisen
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Dr, M C 0949, La Jolla, CA 92093, USA
    JAMA 300:1774-83. 2008
    ..Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline...