Research Topics
| J LauSummaryAffiliation: Rhode Island Hospital Country: USA Publications
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Detail Information
Publications
Comparison of evidence of treatment effects in randomized and nonrandomized studiesJ P Ioannidis
Division of Clinical Care Research, New England Medical Center, Box 63, 750 Washington St, Boston, MA 02111, USA
JAMA 286:821-30. 2001..There is substantial debate about whether the results of nonrandomized studies are consistent with the results of randomized controlled trials on the same topic...
Diagnosing acute cardiac ischemia in the emergency department: a systematic review of the accuracy and clinical effect of current technologiesJ Lau
Evidence Based Practice Center, Division of Clinical Care Research, New England Medical Center, Boston, MA 02111, USA
Ann Emerg Med 37:453-60. 2001..Accurate diagnosis and triage of patients with ACI in the emergency department should increase survival for these patients and reduce unnecessary hospital admissions...
Accuracy of imaging technologies in the diagnosis of acute cardiac ischemia in the emergency department: a meta-analysisJ P Ioannidis
Evidence-based Practice Center, Division of Clinical Care Research, New England Medical Center, Boston, MA 02115, USA
Ann Emerg Med 37:471-7. 2001..More evidence should be accumulated on their performance specifically in the ED setting...
Accuracy of biomarkers to diagnose acute cardiac ischemia in the emergency department: a meta-analysisE M Balk
Evidence-based Practice Center, Division of Clinical Care Research, New England Medical Center, Boston, MA 02115, USA
Ann Emerg Med 37:478-94. 2001..Further high-quality studies are needed on the clinical effect of using biomarkers for patients with ACI in the ED and on optimal timing of serial testing and in combination with other tests...
Accuracy and clinical effect of out-of-hospital electrocardiography in the diagnosis of acute cardiac ischemia: a meta-analysisJ P Ioannidis
Evidence-based Practice Center, Division of Clinical Care Research, New England Medical Center, Boston, MA 02115, USA
Ann Emerg Med 37:461-70. 2001..Out-of-hospital thrombolysis achieves time savings and improves short-term mortality, but the effect on long-term mortality is unknown...
Technical report: evidence for the diagnosis and treatment of acute uncomplicated sinusitis in children: a systematic overviewJ P Ioannidis
New England Medical Center Evidence-based Practice Center, Boston, Massachusetts, USA
Pediatrics 108:E57. 2001..Diagnostic modalities show poor concordance, and treatment options are based on inadequate data. More evidence is needed for defining the optimal treatment and diagnostic methods for this common condition...
Meta-analysis of diagnostic tests for acute sinusitisE A Engels
Division of Clinical Care Research, Department of Medicine, New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111, USA
J Clin Epidemiol 53:852-62. 2000..In conclusion, acute sinusitis is common among symptomatic patients. Radiography and clinical evaluation (especially risk scores) appear to provide useful information for diagnosis of sinusitis...
Summing up evidence: one answer is not always enoughJ Lau
Division of Clinical Care Research, New England Medical Center Hospitals, Boston, MA 02111, USA
Lancet 351:123-7. 1998..Here we take a more rounded approach to meta-analyses, arguing that their strengths outweigh their weaknesses, although the latter must not be brushed aside...
Strategies for diagnosing and treating suspected acute bacterial sinusitis: a cost-effectiveness analysisE M Balk
Evidence-based Practice Center, Division of Clinical Care Research, Tufts University School of Medicine, New England Medical Center, Boston, MA 02111, USA
J Gen Intern Med 16:701-11. 2001..Newer, expensive antibiotics are of limited value. Additional testing is not cost-effective. Further studies are needed to find an accurate,low-cost diagnostic test for acute bacterial sinusitis...
Balancing the benefits of primary angioplasty against the benefits of thrombolytic therapy for acute myocardial infarction: the importance of timingD M Kent
New England Medical Center Tufts University School of Medicine, Boston, Mass, USA
Eff Clin Pract 4:214-20. 2001..However, fewer than 20% of U.S. hospitals have facilities to perform PTCA and many clinicians must choose between immediate thrombolytic therapy and delayed PTCA...
Evolution of treatment effects over time: empirical insight from recursive cumulative metaanalysesJ Ioannidis
Division of Clinical Care Research, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
Proc Natl Acad Sci U S A 98:831-6. 2001..Early wide oscillations in the evolution of the treatment effect for specific interventions may sometimes signal further major changes in the future...
Efficacy of quinolone prophylaxis in neutropenic cancer patients: a meta-analysisE A Engels
Tupper Research Institute, Department of Medicine, New England Medical Center, Boston, MA 02111, USA
J Clin Oncol 16:1179-87. 1998..To perform a meta-analysis to estimate the efficacy of quinolone antibiotics in preventing infections, fevers, and deaths among cancer patients neutropenic following chemotherapy...
Typhoid fever vaccines: a meta-analysis of studies on efficacy and toxicityE A Engels
Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
BMJ 316:110-6. 1998..To estimate the efficacy and toxicity of typhoid fever vaccines...
Effect of biocompatibility of hemodialysis membranes on mortality in acute renal failure: a meta-analysisB L Jaber
Department of Medicine, New England Medical Center Hospitals, Boston, MA 02111, USA
Clin Nephrol 57:274-82. 2002....
The Kidney Disease: improving Global Outcomes website: comparison of guidelines as a tool for harmonizationH Vanbelleghem
University Hospital, Gent, Belgium
Kidney Int 71:1054-61. 2007..The tables displayed on the website offer a basis for structuring this process, a procedure which has recently been initiated by a body composed of the five guideline development groups...
Efficacy of Haemophilus influenzae type b vaccination of children: a meta-analysisC O Obonyo
Centre for Vector Biology and Control Research, Kenya Medical Research Institute, PO Box 1578, Kisumu, 40100, Kenya
Eur J Clin Microbiol Infect Dis 25:90-7. 2006....
Introduction to cumulative meta-analysis in dentistry: lessons learned from undertaking a cumulative meta-analysis in periodontologyD R Moles
Eastman Dental Institute for Oral Health Care Science, University College London, London, WC1X 8LD, UK
J Dent Res 84:345-9. 2005..This represents a potential source of bias. Investigators are encouraged to consider their trials as part of an information continuum and to report sufficient detail to permit the trials' incorporation into subsequent syntheses...
A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarctionE M Antman
Department of Medicine, Brigham and Women's Hospital, Boston, MA
JAMA 268:240-8. 1992....
Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for lower respiratory tract infectionsD G Contopoulos-Ioannidis
Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
J Antimicrob Chemother 48:691-703. 2001....
Meta-analysis of randomized controlled trials on the comparative efficacy and safety of azithromycin against other antibiotics for upper respiratory tract infectionsJ P Ioannidis
Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece
J Antimicrob Chemother 48:677-89. 2001..Convenience of dosing should be balanced against the increased cost of this regimen for the treatment of these common infections, where often no antibiotic may be indicated at all...
Evidence on interventions to reduce medical errors: an overview and recommendations for future researchJ P Ioannidis
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
J Gen Intern Med 16:325-34. 2001..Evidence on reduction of medical errors needs to be better categorized, replicated, and tested in study designs maximizing protection from bias. Emphasis should be placed on serious errors...
Completeness of safety reporting in randomized trials: an evaluation of 7 medical areasJ P Ioannidis
Clinical Trials and Evidence-Based Medicine Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
JAMA 285:437-43. 2001..Current standards for safety reporting in randomized trials should be revised to address this inadequacy...
Maternal obesity and risk of cesarean delivery: a meta-analysisS Y Chu
Division of Reproductive Health, Centers for Disease Control and Prevention, Mailstop K23, 1600 Clifton Road, Atlanta, GA 30333, USA
Obes Rev 8:385-94. 2007..The meta-regression found no evidence that these estimates were affected by selected study characteristics. Our findings provide a quantitative estimate of the risk of cesarean delivery associated with high maternal body mass...
