AWEWURA JACOB KWARA

Summary

Affiliation: Rhode Island Hospital
Country: USA

Publications

  1. ncbi request reprint Highly active antiretroviral therapy (HAART) in adults with tuberculosis: current status
    A Kwara
    Division of Infectious Diseases, Department of Medicine, Miriam Hospital Brown Medical School, Providence, Rhode Island 02926, USA
    Int J Tuberc Lung Dis 9:248-57. 2005
  2. ncbi request reprint Outcome of hospital admissions in HIV-infected children at the Korle Bu Teaching Hospital, Accra, Ghana
    A Kwara
    The Miriam Hospital, Providence, Rhode Island, RI 02906, USA
    West Afr J Med 29:379-83. 2010
  3. doi request reprint Paradoxically elevated efavirenz concentrations in HIV/tuberculosis-coinfected patients with CYP2B6 516TT genotype on rifampin-containing antituberculous therapy
    Awewura Kwara
    The Miriam Hospital, Providence, Rhode Island 02906, USA
    AIDS 25:388-90. 2011
  4. pmc Dose adjustment of the non-nucleoside reverse transcriptase inhibitors during concurrent rifampicin-containing tuberculosis therapy: one size does not fit all
    Awewura Kwara
    Warren Alpert Medical School of Brown University and The Miriam Hospital, Providence, Rhode Island 02906, USA
    Expert Opin Drug Metab Toxicol 6:55-68. 2010
  5. pmc CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients
    Awewura Kwara
    Warren Alpert Medical School of Brown University, Rhode Island, USA
    AIDS 23:2101-6. 2009
  6. pmc Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected Ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation
    Awewura Kwara
    Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Clin Pharmacol 49:1079-90. 2009
  7. pmc CYP2B6 (c.516G-->T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients
    Awewura Kwara
    The Miriam Hospital, Providence, RI 02906, USA
    Br J Clin Pharmacol 67:427-36. 2009
  8. pmc Pharmacokinetics of efavirenz when co-administered with rifampin in TB/HIV co-infected patients: pharmacogenetic effect of CYP2B6 variation
    Awewura Kwara
    The Miriam Hospital, 164 Summit Avenue, Providence, RI 02906, USA
    J Clin Pharmacol 48:1032-40. 2008
  9. doi request reprint Antiretroviral drug concentrations and HIV RNA in the genital tract of HIV-infected women receiving long-term highly active antiretroviral therapy
    Awewura Kwara
    Miriam Hospital, Providence, Rhode Island 02906, USA
    Clin Infect Dis 46:719-25. 2008
  10. ncbi request reprint Factors associated with failure to complete isoniazid treatment for latent tuberculosis infection in Rhode Island
    Awewura Kwara
    Department of Medicine, Miriam Hospital, RISE Building, Providence, RI 02906, USA
    Chest 133:862-8. 2008

Research Grants

Detail Information

Publications12

  1. ncbi request reprint Highly active antiretroviral therapy (HAART) in adults with tuberculosis: current status
    A Kwara
    Division of Infectious Diseases, Department of Medicine, Miriam Hospital Brown Medical School, Providence, Rhode Island 02926, USA
    Int J Tuberc Lung Dis 9:248-57. 2005
    ..Specific questions relating to optimal timing of concurrent HAART, challenges to concurrent HAART, optimal regimens and future considerations are discussed...
  2. ncbi request reprint Outcome of hospital admissions in HIV-infected children at the Korle Bu Teaching Hospital, Accra, Ghana
    A Kwara
    The Miriam Hospital, Providence, Rhode Island, RI 02906, USA
    West Afr J Med 29:379-83. 2010
    ..The burden of paediatric HIV infection remains high in resource-poor settings. Information on morbidity leading to hospitalisation as well as outcome is limited...
  3. doi request reprint Paradoxically elevated efavirenz concentrations in HIV/tuberculosis-coinfected patients with CYP2B6 516TT genotype on rifampin-containing antituberculous therapy
    Awewura Kwara
    The Miriam Hospital, Providence, Rhode Island 02906, USA
    AIDS 25:388-90. 2011
    ....
  4. pmc Dose adjustment of the non-nucleoside reverse transcriptase inhibitors during concurrent rifampicin-containing tuberculosis therapy: one size does not fit all
    Awewura Kwara
    Warren Alpert Medical School of Brown University and The Miriam Hospital, Providence, Rhode Island 02906, USA
    Expert Opin Drug Metab Toxicol 6:55-68. 2010
    ..Simultaneous highly active antiretroviral therapy during TB treatment is associated with substantial survival benefit but drug-drug interactions complicate NNRTI dosing...
  5. pmc CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients
    Awewura Kwara
    Warren Alpert Medical School of Brown University, Rhode Island, USA
    AIDS 23:2101-6. 2009
    ..In this study, we determined whether selected UGT2B7 polymorphisms could be used to enhance the prediction of efavirenz plasma concentrations from CYP2B6 and CYP2A6 genotypes...
  6. pmc Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected Ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation
    Awewura Kwara
    Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    J Clin Pharmacol 49:1079-90. 2009
    ..In conclusion, generic NRTI pharmacokinetics in HIV/TB-coinfected Ghanaians are similar to other populations, whereas the UGT2B7*1c polymorphism may explain in part relatively high interindividual variability in zidovudine clearance...
  7. pmc CYP2B6 (c.516G-->T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients
    Awewura Kwara
    The Miriam Hospital, Providence, RI 02906, USA
    Br J Clin Pharmacol 67:427-36. 2009
    ..The aim of this study was to determine whether polymorphisms in the CYP2A6 gene can be used to enhance the predictability of efavirenz concentrations in human immunodeficiency virus (HIV)-infected native African patients...
  8. pmc Pharmacokinetics of efavirenz when co-administered with rifampin in TB/HIV co-infected patients: pharmacogenetic effect of CYP2B6 variation
    Awewura Kwara
    The Miriam Hospital, 164 Summit Avenue, Providence, RI 02906, USA
    J Clin Pharmacol 48:1032-40. 2008
    ..516GT and GG genotypes. Our results indicate that CYP2B6 c.516TT genotype can be used to identify efavirenz poor metabolizers in patients co-treated with rifampin...
  9. doi request reprint Antiretroviral drug concentrations and HIV RNA in the genital tract of HIV-infected women receiving long-term highly active antiretroviral therapy
    Awewura Kwara
    Miriam Hospital, Providence, Rhode Island 02906, USA
    Clin Infect Dis 46:719-25. 2008
    ....
  10. ncbi request reprint Factors associated with failure to complete isoniazid treatment for latent tuberculosis infection in Rhode Island
    Awewura Kwara
    Department of Medicine, Miriam Hospital, RISE Building, Providence, RI 02906, USA
    Chest 133:862-8. 2008
    ..To aid the design of targeted adherence interventions, we investigated the factors associated with noncompletion of isoniazid (INH) therapy for LTBI...
  11. pmc Modest but variable effect of rifampin on steady-state plasma pharmacokinetics of efavirenz in healthy African-American and Caucasian volunteers
    Awewura Kwara
    Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Antimicrob Agents Chemother 55:3527-33. 2011
    ..Body weight and genetic factors will be important covariates in dosing algorithms...
  12. ncbi request reprint Manifestations and outcome of extra-pulmonary tuberculosis: impact of human immunodeficiency virus co-infection
    A Kwara
    Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, USA
    Int J Tuberc Lung Dis 9:485-93. 2005
    ..Metropolitan New Orleans...

Research Grants2