D M Kent

Summary

Affiliation: Rhode Island Hospital
Country: USA

Publications

  1. ncbi request reprint The potential use of ECG-based prognostic instruments in clinical trials and cost-effectiveness analyses of new therapies in acute cardiac ischemia
    D M Kent
    Department of Medicine, New England Medical Center Tufts University School of Medicine, Boston, MA 02111, USA
    J Electrocardiol 33:263-8. 2000
  2. ncbi request reprint Suitable monitoring approaches to antiretroviral therapy in resource-poor settings: setting the research agenda
    David M Kent
    Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Clin Infect Dis 37:S13-24. 2003
  3. ncbi request reprint Are some patients likely to benefit from recombinant tissue-type plasminogen activator for acute ischemic stroke even beyond 3 hours from symptom onset?
    David M Kent
    Division of Clinical Care Research, Tufts New England Medical Center, Boston, Mass 02111, USA
    Stroke 34:464-7. 2003
  4. pmc Is primary angioplasty for some as good as primary angioplasty for all?
    David M Kent
    Received from the Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, Boston, Mass 02111, USA
    J Gen Intern Med 17:887-94. 2002
  5. ncbi request reprint An independently derived and validated predictive model for selecting patients with myocardial infarction who are likely to benefit from tissue plasminogen activator compared with streptokinase
    David M Kent
    Division of Clinical Care Research, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Med 113:104-11. 2002
  6. ncbi request reprint Balancing the benefits of primary angioplasty against the benefits of thrombolytic therapy for acute myocardial infarction: the importance of timing
    D M Kent
    New England Medical Center Tufts University School of Medicine, Boston, Mass, USA
    Eff Clin Pract 4:214-20. 2001
  7. ncbi request reprint Extent of early ischemic changes on computed tomography (CT) before thrombolysis: prognostic value of the Alberta Stroke Program Early CT Score in ECASS II
    Imanuel Dzialowski
    Department of Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Alberta, Canada
    Stroke 37:973-8. 2006
  8. pmc Multivariable risk prediction can greatly enhance the statistical power of clinical trial subgroup analysis
    Rodney A Hayward
    Department of Veterans Affairs, VA Center for Practice Management and Outcomes Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    BMC Med Res Methodol 6:18. 2006
  9. ncbi request reprint Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 37:2322-5. 2006
  10. ncbi request reprint Implantable or external defibrillators for individuals at increased risk of cardiac arrest: where cost-effectiveness hits fiscal reality
    Peter Cram
    University of Iowa College of Medicine, Iowa City, IA, USA
    Value Health 9:292-302. 2006

Detail Information

Publications32

  1. ncbi request reprint The potential use of ECG-based prognostic instruments in clinical trials and cost-effectiveness analyses of new therapies in acute cardiac ischemia
    D M Kent
    Department of Medicine, New England Medical Center Tufts University School of Medicine, Boston, MA 02111, USA
    J Electrocardiol 33:263-8. 2000
    ..Additionally, using validated models in the planning and execution of clinical trials of new therapies can improve the power of the trial and help target the therapies to patients most likely to benefit...
  2. ncbi request reprint Suitable monitoring approaches to antiretroviral therapy in resource-poor settings: setting the research agenda
    David M Kent
    Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Clin Infect Dis 37:S13-24. 2003
    ....
  3. ncbi request reprint Are some patients likely to benefit from recombinant tissue-type plasminogen activator for acute ischemic stroke even beyond 3 hours from symptom onset?
    David M Kent
    Division of Clinical Care Research, Tufts New England Medical Center, Boston, Mass 02111, USA
    Stroke 34:464-7. 2003
    ....
  4. pmc Is primary angioplasty for some as good as primary angioplasty for all?
    David M Kent
    Received from the Division of Clinical Care Research, Department of Medicine, Tufts New England Medical Center, Boston, Mass 02111, USA
    J Gen Intern Med 17:887-94. 2002
    ..To investigate whether proper patient selection might allow most of the benefits of population-wide primary coronary angioplasty to be captured in a subgroup of high-risk patients...
  5. ncbi request reprint An independently derived and validated predictive model for selecting patients with myocardial infarction who are likely to benefit from tissue plasminogen activator compared with streptokinase
    David M Kent
    Division of Clinical Care Research, Department of Medicine, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Am J Med 113:104-11. 2002
    ..3% 30-day mortality, compared with a mortality of 7.3% among those treated with streptokinase, despite a greater risk of intracranial hemorrhage with tPA. However, in part because of its higher cost, tPA has not been adopted universally...
  6. ncbi request reprint Balancing the benefits of primary angioplasty against the benefits of thrombolytic therapy for acute myocardial infarction: the importance of timing
    D M Kent
    New England Medical Center Tufts University School of Medicine, Boston, Mass, USA
    Eff Clin Pract 4:214-20. 2001
    ..However, fewer than 20% of U.S. hospitals have facilities to perform PTCA and many clinicians must choose between immediate thrombolytic therapy and delayed PTCA...
  7. ncbi request reprint Extent of early ischemic changes on computed tomography (CT) before thrombolysis: prognostic value of the Alberta Stroke Program Early CT Score in ECASS II
    Imanuel Dzialowski
    Department of Clinical Neurosciences, Calgary Stroke Program, University of Calgary, Alberta, Canada
    Stroke 37:973-8. 2006
    ..We hypothesized that dichotomized ASPECTS predicts response to intravenous thrombolysis and incidence of secondary hemorrhage within 6 hours of stroke onset...
  8. pmc Multivariable risk prediction can greatly enhance the statistical power of clinical trial subgroup analysis
    Rodney A Hayward
    Department of Veterans Affairs, VA Center for Practice Management and Outcomes Research, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    BMC Med Res Methodol 6:18. 2006
    ..conventional subgroup analysis...
  9. ncbi request reprint Sex-based differences in the effect of intra-arterial treatment of stroke: analysis of the PROACT-2 study
    Michael D Hill
    Calgary Stroke Program, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
    Stroke 37:2322-5. 2006
    ..In a combined analysis of the tissue plasminogen activator clinical trials, a sex-by-treatment interaction was observed. We sought to confirm that observation in an independent data set...
  10. ncbi request reprint Implantable or external defibrillators for individuals at increased risk of cardiac arrest: where cost-effectiveness hits fiscal reality
    Peter Cram
    University of Iowa College of Medicine, Iowa City, IA, USA
    Value Health 9:292-302. 2006
    ..We used decision analysis to evaluate the clinical and economic trade-offs of AEDs, ICDs, and emergency medical services equipped with defibrillators (EMS-D) for reducing cardiac arrest mortality...
  11. ncbi request reprint The stroke-thrombolytic predictive instrument: a predictive instrument for intravenous thrombolysis in acute ischemic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Stroke 37:2957-62. 2006
    ..Therefore, we aimed to develop a Stroke-Thrombolytic Predictive Instrument (TPI) to aid physicians considering thrombolysis for stroke...
  12. ncbi request reprint Can multivariable risk-benefit profiling be used to select treatment-favorable patients for thrombolysis in stroke in the 3- to 6-hour time window?
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA
    Stroke 37:2963-9. 2006
    ..We sought to examine whether such a multivariate predictive instrument might be useful in selecting patients with a favorable risk-benefit treatment profile for therapy after 3 hours...
  13. ncbi request reprint Comparison of mortality benefit of immediate thrombolytic therapy versus delayed primary angioplasty for acute myocardial infarction
    David M Kent
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Am J Cardiol 99:1384-8. 2007
    ..Previous meta-regressions appear to have underestimated the PPCI-related delay that would nullify the incremental benefits of PPCI...
  14. doi request reprint The gender effect in stroke thrombolysis: of CASES, controls, and treatment-effect modification
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA
    Neurology 71:1080-3. 2008
    ..This nullification of the usual gender effect among rtPA-treated patients has not been confirmed...
  15. ncbi request reprint Gender differences in tPA-related arterial recanalization
    David M Kent
    Stroke 36:2529; author reply 2529-30. 2005
  16. ncbi request reprint In acute ischemic stroke, are asymptomatic intracranial hemorrhages clinically innocuous?
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, 750 Washington St, Box 63, Boston, Mass 02111, USA
    Stroke 35:1141-6. 2004
    ..We examined whether the occurrence of an asymptomatic intracranial hemorrhage affects functional outcome in patients with acute ischemic stroke (AIS) treated or not treated with recombinant tissue plasminogen activator (rt-PA)...
  17. ncbi request reprint Clinical trials in sub-Saharan Africa and established standards of care: a systematic review of HIV, tuberculosis, and malaria trials
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass
    JAMA 292:237-42. 2004
    ..The minimum standard of care required for participants in clinical trials conducted in resource-poor settings is a matter of controversy; international documents offer contradictory guidance...
  18. ncbi request reprint Testing therapies less effective than the best current standard: ethical beliefs in an international sample of researchers
    David M Kent
    Tufts New England Medical Center, Boston, USA
    Am J Bioeth 3:W11. 2003
    ..To test the range of beliefs regarding the ethics of testing, in resource poor settings, new therapies that are less efficacious but more affordable and feasible than the best current therapeutic standard...
  19. ncbi request reprint Tissue plasminogen activator was cost-effective compared to streptokinase in only selected patients with acute myocardial infarction
    David M Kent
    Clinical Research and Health Policy Studies, Tufts New England Medical Center Tufts University School of Medicine, 750 Washington Street, Box 63, Boston, MA 02111, USA
    J Clin Epidemiol 57:843-52. 2004
    ..We sought to explore the patient-specific cost-effectiveness in a community-based sample for a therapy for which the average cost-effectiveness in a clinical trial has been well-described...
  20. ncbi request reprint Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, 750 Washington Street, 63, Boston, MA, 02111, USA
    Stroke 36:62-5. 2005
    ..We explored whether sex might modify the effect of recombinant tissue plasminogen activator (rtPA) on outcomes in patients with acute ischemic stroke...
  21. ncbi request reprint "Clinical-CT mismatch" and the response to systemic thrombolytic therapy in acute ischemic stroke
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, USA
    Stroke 36:1695-9. 2005
    ..We explored this hypothesis using a combined database including 4 major clinical trials of intravenous (IV) thrombolytic therapy...
  22. ncbi request reprint Primary angioplasty or thrombolysis for acute myocardial infarction?
    David M Kent
    Lancet 361:78; author reply 78-9. 2003
  23. doi request reprint A percutaneous coronary intervention-thrombolytic predictive instrument to assist choosing between immediate thrombolytic therapy versus delayed primary percutaneous coronary intervention for acute myocardial infarction
    David M Kent
    Center for Cardiovascular Health Services Research, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:790-5. 2008
    ..Incorporated into electrocardiogram, it may assist targeting PCI to those who benefit most and identifying patients before hospitalization for whom a receiving hospital should prepare for PCI...
  24. doi request reprint Benchmarks and determinants of adherence to stroke performance measures
    Judith A Hinchey
    Stroke 39:1619-20. 2008
    ..Develop achievable benchmarks for 9 stroke performance measures (PM) and to identify organizational factors associated with adherence...
  25. ncbi request reprint A geospatial analysis of emergency transport and inter-hospital transfer in ST-segment elevation myocardial infarction
    Thomas W Concannon
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA
    Am J Cardiol 101:69-74. 2008
    ..In conclusion, the selection of high-benefit patients for transport or transfer to PCI-capable hospitals can reduce mortality while minimizing major shifts in hospital patient volumes...
  26. pmc Are "treatment" bare metal stents superior to "control" bare metal stents? A meta-analytic approach
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA 02111, USA
    Am Heart J 155:624-9, 629.e1-2. 2008
    ....
  27. ncbi request reprint Progression risk, urinary protein excretion, and treatment effects of angiotensin-converting enzyme inhibitors in nondiabetic kidney disease
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, 750 Washington Street 63, Boston, MA 02111, USA
    J Am Soc Nephrol 18:1959-65. 2007
    ..Patients with proteinuria <500 mg/d do not seem to benefit, even when at relatively high risk for progression...
  28. ncbi request reprint Reporting clinical trial results to inform providers, payers, and consumers
    Rodney A Hayward
    Department of Veterans Affairs VA Center for Practice Management and Outcomes Research, VA Ann Arbor Healthcare System, University of Michigan, USA
    Health Aff (Millwood) 24:1571-81. 2005
    ....
  29. ncbi request reprint New and dis-improved: on the evaluation and use of less effective, less expensive medical interventions
    David M Kent
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Med Decis Making 24:281-6. 2004
    ....
  30. ncbi request reprint Predicting nursing home admission: estimates from a 7-year follow-up of a nationally representative sample of older Americans
    Jane Banaszak-Holl
    Department of Health Management and Policy, School of Public Health, University of Michigan, Ann Arbor, 48109 2029, USA
    Alzheimer Dis Assoc Disord 18:83-9. 2004
    ..Interventions for individuals with dementia should impact the behavioral aspects of the condition and slow disease progression in addition to improving physical functioning...
  31. ncbi request reprint Differences in triage thresholds for patients presenting with possible acute coronary syndromes: more than meets the eye
    Catherine E Milch
    Institute for Clinical Research and Health Policy Studies, Center for Cardiovascular Health Services Research, Tufts New England Medical Center, Boston, MA 02111, USA
    J Investig Med 54:76-85. 2006
    ..Many studies have shown differences in cardiac care by racial/ethnic groups without accounting for institutional factors at the location of care...
  32. doi request reprint Statins, low-density lipoprotein cholesterol, and risk of cancer
    Alawi A Alsheikh-Ali
    Institute for Clinical Research and Health Policy Studies, Department of Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Am Coll Cardiol 52:1141-7. 2008
    ..We sought to assess whether statin-mediated reductions in low-density lipoprotein cholesterol (LDL-C) are associated with an increased risk of cancer...