Stephen Gregory

Summary

Affiliation: Rhode Island Hospital
Country: USA

Publications

  1. pmc Dendritic cells, regulatory T cells and the pathogenesis of chronic hepatitis C
    Phyllis T Losikoff
    Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School at Brown University, Providence, RI, USA
    Virulence 3:610-20. 2012
  2. pmc Detoxified endotoxin vaccine (J5dLPS/OMP) protects mice against lethal respiratory challenge with Francisella tularensis SchuS4
    Stephen H Gregory
    Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 55 Claverick Street, Providence, RI 02903, USA
    Vaccine 28:2908-15. 2010
  3. pmc Epitope-based vaccination against pneumonic tularemia
    Stephen H Gregory
    Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, United States
    Vaccine 27:5299-306. 2009
  4. ncbi request reprint CD8+ T-cell-mediated response to Listeria monocytogenes taken up in the liver and replicating within hepatocytes
    S H Gregory
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence 02903, USA
    Immunol Rev 174:112-22. 2000
  5. ncbi request reprint Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections
    Stephen H Gregory
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence 02903, USA
    J Leukoc Biol 72:239-48. 2002
  6. ncbi request reprint Flt3 ligand pretreatment promotes protective immunity to Listeria monocytogenes
    S H Gregory
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cytokine 13:202-8. 2001
  7. ncbi request reprint Complementary adhesion molecules promote neutrophil-Kupffer cell interaction and the elimination of bacteria taken up by the liver
    Stephen H Gregory
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 168:308-15. 2002
  8. ncbi request reprint Neutrophils sequestered in the liver suppress the proinflammatory response of Kupffer cells to systemic bacterial infection
    Martin Holub
    Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University Providence, RI 02903, USA
    J Immunol 183:3309-16. 2009
  9. ncbi request reprint Differential effects of macrophage inflammatory chemokine-2 and keratinocyte-derived chemokine on hemorrhage-induced neutrophil priming for lung inflammation: assessment by adoptive cells transfer in mice
    Joanne L Lomas
    Shock Trauma Research Laboratories in the Division of Surgical Research, Department of Surgery, Rhode Island Hospital and Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Shock 19:358-65. 2003
  10. pmc In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice
    Doreen E Wesche-Soldato
    Division of Surgical Research, Department of Surgery, Brown University School of Medicine, Providence, RI, USA
    Blood 106:2295-301. 2005

Research Grants

Collaborators

Detail Information

Publications29

  1. pmc Dendritic cells, regulatory T cells and the pathogenesis of chronic hepatitis C
    Phyllis T Losikoff
    Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School at Brown University, Providence, RI, USA
    Virulence 3:610-20. 2012
    ..Overwhelming evidence suggests that the complex interaction of dendritic cells and regulatory T cells plays a critical role in the pathogenesis of chronic hepatitis C...
  2. pmc Detoxified endotoxin vaccine (J5dLPS/OMP) protects mice against lethal respiratory challenge with Francisella tularensis SchuS4
    Stephen H Gregory
    Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 55 Claverick Street, Providence, RI 02903, USA
    Vaccine 28:2908-15. 2010
    ..tularensis. The efficacy of J5dLPS/OMP vaccine suggests its potential utility in immunizing the general population against several different gram-negative select agents concurrently...
  3. pmc Epitope-based vaccination against pneumonic tularemia
    Stephen H Gregory
    Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, RI, United States
    Vaccine 27:5299-306. 2009
    ..These results demonstrate the efficacy of an epitope-based tularemia vaccine and suggest that such an approach might be widely applicable to the development of vaccines specific for intracellular bacterial pathogens...
  4. ncbi request reprint CD8+ T-cell-mediated response to Listeria monocytogenes taken up in the liver and replicating within hepatocytes
    S H Gregory
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence 02903, USA
    Immunol Rev 174:112-22. 2000
    ..Evidence demonstrating the perforin- and/or Fas ligand-dependent induction of caspase activity and the resultant apoptosis of Listeria-infected hepatocytes is discussed...
  5. ncbi request reprint Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections
    Stephen H Gregory
    Department of Medicine, Rhode Island Hospital and Brown University School of Medicine, Providence 02903, USA
    J Leukoc Biol 72:239-48. 2002
    ..We discuss the critical role of neutrophil-Kupffer cell interaction in innate host defenses and, conceivably, the development and expression of adaptive immunity in the liver...
  6. ncbi request reprint Flt3 ligand pretreatment promotes protective immunity to Listeria monocytogenes
    S H Gregory
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cytokine 13:202-8. 2001
    ..The latter finding supports a potential role for Flt3L in strategies to develop vaccines to intracellular pathogens...
  7. ncbi request reprint Complementary adhesion molecules promote neutrophil-Kupffer cell interaction and the elimination of bacteria taken up by the liver
    Stephen H Gregory
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 168:308-15. 2002
    ..Complement was not a factor; complement depletion affected neither the clearance of listeriae by Kupffer cells nor the antimicrobial activity expressed by infiltrating neutrophils...
  8. ncbi request reprint Neutrophils sequestered in the liver suppress the proinflammatory response of Kupffer cells to systemic bacterial infection
    Martin Holub
    Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University Providence, RI 02903, USA
    J Immunol 183:3309-16. 2009
    ..These findings document the critical role of neutrophils in moderating the proinflammatory response of Kupffer cells to bacteria taken up by the liver...
  9. ncbi request reprint Differential effects of macrophage inflammatory chemokine-2 and keratinocyte-derived chemokine on hemorrhage-induced neutrophil priming for lung inflammation: assessment by adoptive cells transfer in mice
    Joanne L Lomas
    Shock Trauma Research Laboratories in the Division of Surgical Research, Department of Surgery, Rhode Island Hospital and Brown University School of Medicine, Providence, Rhode Island 02903, USA
    Shock 19:358-65. 2003
    ..Taken together, these data demonstrate that Hem-induced priming of PMN not only mediates ALI in the mouse, but also that this process is differentially effected by MIP2 and KC, despite the fact that both signal through CXCR2...
  10. pmc In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice
    Doreen E Wesche-Soldato
    Division of Surgical Research, Department of Surgery, Brown University School of Medicine, Providence, RI, USA
    Blood 106:2295-301. 2005
    ..Indices of liver damage were also decreased. Finally, the injection of Fas or caspase-8 given not only 30 minutes but up to 12 hours after CLP significantly improved the survival of septic mice...
  11. pmc CD8+ T cells promote inflammation and apoptosis in the liver after sepsis: role of Fas-FasL
    Doreen E Wesche-Soldato
    Surgical Research, Aldrich 227, Rhode Island Hospital, Providence, RI 02903, USA
    Am J Pathol 171:87-96. 2007
    ..Thus, although truncating Fas-FasL signaling ameliorates many untoward effects of sepsis, the pathological mode of action is distinct at the tissue level...
  12. pmc The role of hepatic invariant NKT cells in systemic/local inflammation and mortality during polymicrobial septic shock
    Caroline K Hu
    Shock Trauma Research Laboratories, Division of Surgical Research, Department of Surgery, Rhode Island Hospital and Brown University School of Medicine, Providence, RI 02903, USA
    J Immunol 182:2467-75. 2009
    ..Together, these findings suggest that the activation of hepatic invariant NKT cells plays a critical role in regulating the innate immune/systemic inflammatory response and survival in a model of acute septic shock...
  13. pmc Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency
    Alfred Ayala
    Shock Trauma Research Laboratories, Aldrich 227, Division of Surgical Research, Brown University School of Medicine and Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Am J Pathol 161:2283-94. 2002
    ..Alternatively, the combined loss of FasL and TLR-4 did not inhibit the increase in MPO and exacerbated lung IL-6/MIP-2 levels even further...
  14. ncbi request reprint Listeria monocytogenes: clinical and experimental update
    Edward J Wing
    Department of Medicine, Brown University Medical School, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Infect Dis 185:S18-24. 2002
    ....
  15. pmc Improved antimicrobial host defense in mice following poly-(1,6)-β-D-glucopyranosyl-(1,3)-β-D-glucopyranose glucan treatment by a gender-dependent immune mechanism
    Courtni T Newsome
    Department of Surgery, Division of Surgical Research, Rhode Island Hospital, Providence, RI 02903, USA
    Clin Vaccine Immunol 18:2043-9. 2011
    ..This therapy does not require prophylactic beta-glucan administration...
  16. ncbi request reprint Kupffer cells abrogate cholestatic liver injury in mice
    Stephan Gehring
    Department of Medicine, Rhode Island and Hasbro Children s Hospitals, Brown Medical School, Providence, Rhode Island, USA
    Gastroenterology 130:810-22. 2006
    ..Kupffer cells play a key role in modulating the inflammatory response observed in most animal models of liver injury. This study was performed to determine the role of Kupffer cells in the injury attending cholestasis...
  17. pmc Invariant natural killer T cells suppress the neutrophil inflammatory response in a mouse model of cholestatic liver damage
    Philip Wintermeyer
    Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Gastroenterology 136:1048-59. 2009
    ..These invariant NKT (iNKT) cells have been implicated in cholestatic liver injury...
  18. ncbi request reprint Diversity of Francisella tularensis Schu4 antigens recognized by T lymphocytes after natural infections in humans: identification of candidate epitopes for inclusion in a rationally designed tularemia vaccine
    Julie A McMurry
    EpiVax, Inc, Providence, RI 02903, USA
    Vaccine 25:3179-91. 2007
    ..These data can aid in the development of novel epitope-based and subunit tularemia vaccines...
  19. ncbi request reprint Tularemia vaccines - an overview
    Julie A McMurry
    EpiVax, Inc, Providence, RI 02903, USA
    Med Health R I 90:311-4. 2007
    ....
  20. ncbi request reprint Generation and characterization of an immunogenic dendritic cell population
    Stephan Gehring
    The Liver Research Center, Providence, Rhode Island 02903, USA The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    J Immunol Methods 332:18-30. 2008
    ..This approach combines three critical elements necessary for efficient DC-based immunization that include DC enrichment, maturation and antigen targeting...
  21. pmc Neutrophil depletion blocks early collagen degradation in repairing cholestatic rat livers
    Mark W Harty
    Department of Surgery, The Warren Alpert Medical School of Brown University, Hasbro Children s Hospital, Room 147, 593 Eddy Street, Providence, RI 02903, USA
    Am J Pathol 176:1271-81. 2010
    ....
  22. ncbi request reprint Type 1 interferon augments DNA-based vaccination against hepatitis C virus core protein
    Stephan Gehring
    The Liver Research Center, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island 02903, USA
    J Med Virol 75:249-57. 2005
    ....
  23. ncbi request reprint Repair after cholestatic liver injury correlates with neutrophil infiltration and matrix metalloproteinase 8 activity
    Mark W Harty
    Department of Surgery, Brown Medical School, Rhode Island and Hasbro Children s Hospitals, Providence 02903, USA
    Surgery 138:313-20. 2005
    ..We questioned whether these mechanisms of repair include changes in the inflammatory infiltrate and associated biological activity of matrix metalloproteinases (MMPs) 8 and 2...
  24. pmc Laser capture microdissection and genetic analysis of carbon-labeled Kupffer cells
    Stephan Gehring
    Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 55 Claverick Street, Providence, RI 02903, USA
    World J Gastroenterol 15:1708-18. 2009
    ..To develop a method of labeling and micro-dissecting mouse Kupffer cells within an extraordinarily short period of time using laser capture microdissection (LCM)...
  25. ncbi request reprint Vaccination with protein-transduced dendritic cells elicits a sustained response to hepatitis C viral antigens
    Noriyoshi Kuzushita
    The Liver Research Center, Department of Medicine, Rhode Island Hospital and Brown Medical School, Providence, 02903, USA
    Gastroenterology 130:453-64. 2006
    ..The administration of antigen-loaded dendritic cells offers a potential approach to induce high-level immunity against hepatitis C virus...
  26. pmc Generation of immune responses against hepatitis C virus by dendritic cells containing NS5 protein-coated microparticles
    Stephan Gehring
    The Liver Research Center, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02903, USA
    Clin Vaccine Immunol 16:163-71. 2009
    ..Thus, strategies that employ NS5-coated beads induce cellular immune responses in mice, which correlate well with the natural immune responses that occur in individuals who resolve HCV...
  27. ncbi request reprint Hepatic macrophages promote the neutrophil-dependent resolution of fibrosis in repairing cholestatic rat livers
    Mark W Harty
    Department of Surgery, The Warren Alpert Medical School of Brown University and Hasbro Children s Hospitals, Providence, RI 02903, USA
    Surgery 143:667-78. 2008
    ..We sought to determine the cellular and molecular requirements for repair after biliary decompression, focusing on the role of hepatic macrophages in regulating inflammation and matrix resolution...
  28. pmc Targeting the diverse immunological functions expressed by hepatic NKT cells
    Caroline C Duwaerts
    Rhode Island Hospital and The Warren Alpert Medical School at Brown University, Department of Medicine, Providence, RI 02903, USA
    Expert Opin Ther Targets 15:973-88. 2011
    ..Efforts are ongoing to develop α-galactosylceramide analogs that modulate iNKT cell activity and selectively promote IFN-γ or IL-4...
  29. pmc Host resistance of CD18 knockout mice against systemic infection with Listeria monocytogenes
    Huaizhu Wu
    Section of Atherosclerosis, Department of Medicine, Baylor College of Medicine, 6565 Fannin, Houston, TX 77030, USA
    Infect Immun 71:5986-93. 2003
    ..We propose that the absence of CD18 in the mice results in the priming of innate immunity, as evidenced by elevated cytokine expression, and neutrophilic leukocytosis, which augments antilisterial defense...

Research Grants2

  1. FRANCISELLA TULARENSIS: INNATE RESISTANCE TO IHALATION
    Stephen Gregory; Fiscal Year: 2004
    ..abstract_text> ..
  2. Neutrophil-macrophage Interactions Govern Liver Immunity
    Stephen H Gregory; Fiscal Year: 2010
    ..Consequently, they should provide valuable insights that enable the development of innovative strategies to improve treatment and prevent the devastating consequencesoften associated with septicemia and sepsis. ..