Research Topics
| Hubert H FernandezSummaryAffiliation: Rhode Island Country: USA Publications
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Publications
Treatment of psychosis in Parkinson's disease: safety considerationsHubert H Fernandez
Department of Clinical Neurosciences, Brown University School of Medicine, Providence, Rhode Island, USA
Drug Saf 26:643-59. 2003..Electroconvulsive treatment is generally reserved for the patient with psychotic depression who is unable to tolerate any pharmacological therapy...- Quetiapine for psychosis in Parkinson's disease versus dementia with Lewy bodiesHubert H Fernandez
Department of Clinical Neurosciences, Brown University School of Medicine, Providence, RI, USA
J Clin Psychiatry 63:513-5. 2002..Most clinicians perceive psychosis in dementia with Lewy bodies (DLB) as more difficult to treat than Parkinson's disease, yet there are no reports comparing the antipsychotic response between the 2 disorders... - Classification and treatment of tardive syndromesHubert H Fernandez
Department of Clinical Neurosciences, Brown University School of Medicine, Providence, Rhode Island, USA
Neurologist 9:16-27. 2003..Tardive syndromes are a group of delayed-onset abnormal involuntary movement disorders induced by a dopamine receptor blocking agent. There are several phenomenologically distinct types of TS... - Long-term outcome of quetiapine use for psychosis among Parkinsonian patientsHubert H Fernandez
Department of Clinical Neurosciences, Brown University School of Medicine, Providence, Rhode Island, USA
Mov Disord 18:510-4. 2003..6; 95% CI = 1.4-92.9). Also, patients who developed motor worsening while on quetiapine tended to be more demented (P = 0.07)... - Atypical antipsychotics in Parkinson-sensitive populationsJoseph H Friedman
Department of Clinical Neurosciences, Brown University School of Medicine, Providence, Rhode Island, USA
J Geriatr Psychiatry Neurol 15:156-70. 2002..Suggestions are made for future research to improve the interpretability of these studies... - Long-term outcome of clozapine use for psychosis in parkinsonian patientsHubert H Fernandez
Department of Clinical Neurosciences, Brown Uniersity School of Medicine, Providence, Rhode Island, USA
Mov Disord 19:831-3. 2004..Our data are more consistent with recently published long-term outcome data suggesting an improvement in the prognosis of parkinsonian patients with psychosis with the use of atypical antipsychotic agents such as clozapine... - Hemiballismus from a parietal stroke in a Parkinson patientMotasem Al-Yacoub
Department of Clinical Neurosciences, Brown University School of Medicine, Providence, RI, USA
Mov Disord 19:986-8. 2004..This suggests that HB itself, whether from a lesion in the subthalamic nucleus or elsewhere, is not what improves motor function in PD; instead, the physiological function of the damaged structure is the determining factor... - Botulinum toxin type B for gait freezing in Parkinson's diseaseHubert H Fernandez
Department of Clinical Neuroscience, Brown University School of Medicine, Providence, RI, USA
Med Sci Monit 10:CR282-4. 2004..Freezing of Gait (FOG) can be a serious problem in Parkinson's disease (PD) and is usually refractory to medical treatment. Botulinum toxin (BTX) type A has been reported to relieve FOG in small open label studies... - Parkinsonism in a nursing home: underrecognitionJoseph H Friedman
Division of Neurology, Memorial Hospital of Rhode Island, 111 Brewster St, Pawtucket, RI 02860, USA
J Geriatr Psychiatry Neurol 17:39-41. 2004..02). Only 1 patient with drug-induced parkinsonism and 3 residents with previously diagnosed Parkinson's disease had chart notes indicating that parkinsonism had been recognized... - Combating psychosis in Parkinson's disease patients: the use of antipsychotic drugsKelvin L Chou
Department of Clinical Neurosciences, Brown Medical School, Providence, Rhode Island, USA
Expert Opin Investig Drugs 15:339-49. 2006.... - REM behavior disorder and excessive daytime somnolence in Machado-Joseph disease (SCA-3)Joseph H Friedman
Department of Clinical Neurosciences, Brown University School of Medicine, Providence, Rhode Island 02860, USA
Mov Disord 18:1520-2. 2003..Our results support the previous observation that RBD-like behaviors are significantly increased in SCA-3... - Monozygotic twins discordant for Huntington disease after 7 yearsJoseph H Friedman
Department of Clinical Neurosciences, Brown University School of Medicine, Providence, RI, USA
Arch Neurol 62:995-7. 2005..We have identified increased cigarette use and longer exposure to various industrial toxins as potential explanations for the earlier onset in one twin... - Predictors of mortality among nursing home residents with a diagnosis of Parkinson's diseaseHubert H Fernandez
Department of Clinical Neurosciences, Brown University School of Medicine, Providence, RI, USA
Med Sci Monit 8:CR241-6. 2002..Minority groups have a reduced risk of death relative to white PD nursing home residents... - What we have learned about sleep disorders and psychosis after nearly two centuries of Parkinson's disease. Summary and conclusionsHubert H Fernandez
Department of Neurology, University of Florida, Gainesville, FL, USA
CNS Spectr 13:34-5. 2008 - Hypersexuality and paraphilia induced by selegiline in Parkinson's disease: report of 2 casesMichael A Shapiro
Department of Neurology, McKnight Brain Institute, University of Florida College of Medicine, P.O. Box 100236, Gainesville, FL 32610, USA
Parkinsonism Relat Disord 12:392-5. 2006..Social repercussions may prohibit patients and/or their families from volunteering such information... - Diagnostic criteria for psychosis in Parkinson's disease: report of an NINDS, NIMH work groupBernard Ravina
Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14620, USA
Mov Disord 22:1061-8. 2007..These criteria require validation and may be refined, but form a starting point for studies of the epidemiology and pathophysiology of PDPsy, and are a potential indication for therapy development... - When should levodopa therapy be initiated in patients with Parkinson's disease?Irene A C Halkias
Department of Neurology, University of Florida, Gainesville, Florida 32608, USA
Drugs Aging 24:261-73. 2007..However, because of levodopa's superior efficacy, when a rapid and sustained symptomatic improvement is required because of significant motor disability, levodopa may be used as the first-line agent regardless of age... 
Course, prognosis, and management of psychosis in Parkinson's disease: are current treatments really effective?Laura B Zahodne
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
CNS Spectr 13:26-33. 2008..An emerging treatment option is acetylcholinesterase inhibitors. This article reviews what is currently known about the course, prognosis, and treatment strategies in Parkinson's disease psychosis...- Monoamine oxidase-B inhibition in the treatment of Parkinson's diseaseHubert H Fernandez
Movement Disorders Center, University of Florida, McKnight Brain Institute, Gainesville, FL 32610, USA
Pharmacotherapy 27:174S-185S. 2007..A third agent with MAO-B inhibition properties, safinamide, is in phase III development. Although not yet approved, safinamide may offer the added advantage of combined MAO-B and dopamine reuptake inhibition... - Pearls in patient selection for deep brain stimulationRamon L Rodriguez
Department of Neurology, University of Florida Movement Disorders Center, McKnight Brain Institute, Gainesville, Florida, USA
Neurologist 13:253-60. 2007..General neurologists and even general practitioners may be called upon to screen potential candidates for DBS. The patient selection process plays an important role in this procedure... 
Scales to assess psychosis in Parkinson's disease: Critique and recommendationsHubert H Fernandez
Department of Neurology, McKnight Brain Institute University of Florida, Gainesville, Florida 32611, USA
Mov Disord 23:484-500. 2008..The CGIS is suggested as a secondary outcome scale to measure change and response to treatment over time...- Community and long-term care management of Parkinson's disease in the elderly: focus on monoamine oxidase type B inhibitorsJack J Chen
Movement Disorders Center, Schools of Medicine and Pharmacy, Loma Linda University, Loma Linda, California 92350, USA
Drugs Aging 24:663-80. 2007..The favourable safety profile of rasagiline in the elderly and its once-daily formulation may maximise drug adherence and improve outcomes... - The "chair test" to aid in the diagnosis of psychogenic gait disordersMichael S Okun
Department of Neurology, University of Florida, McKnight Brain Institute, Gainesville, Florida 32610, USA
Neurologist 13:87-91. 2007..To evaluate the chair test for diagnosis of psychogenic gait disorders... - Psychosis in Parkinson's diseaseDylan P Wint
Department of Psychiatry, McKnight Brain Institute/University of Florida, Gainesville 32610, USA
J Geriatr Psychiatry Neurol 17:127-36. 2004..An emerging treatment option is the use of acetylcholinesterase inhibitors. This article reviews what is known about the epidemiology, risk factors, pathophysiology, and treatment of PD-related psychosis... - Cognitive and behavioral features discriminate between Alzheimer's and Parkinson's diseaseDeborah A Cahn-Weiner
Memorial Hospital of Rhode Island and Brown Medical School, Pawtucket 02860, USA
Neuropsychiatry Neuropsychol Behav Neurol 15:79-87. 2002..To compare the cognitive and behavioral profiles of Alzheimer's disease (AD) and cognitively impaired patients with Parkinson's disease (PD) and to determine the individual measures that best discriminate the two patient groups... - Pharmacotherapy of dementia with Lewy bodiesHubert H Fernandez
Division of Neurology, Memorial Hospital of Rhode Island, 111 Brewster Street, Pawtucket, RI 02860, USA
Expert Opin Pharmacother 4:2027-37. 2003.... - Rationale for current therapies in Parkinson's diseaseJanet Romrell
University of Florida, Department of Neurology, McKnight Brain Institute, PO Box 100236, Gainesville, FL 32610, USA
Expert Opin Pharmacother 4:1747-61. 2003..Even though there have been great advances in the medical options for symptomatic management of PD, there are still many unmet needs for this patient population... - Rebound psychosis: effect of discontinuation of antipsychotics in Parkinson's diseaseHubert H Fernandez
Department of Neurology, University of Florida McKnight Brain Institute, Movement Disorders Program, Gainesville, Florida 32610, USA
Mov Disord 20:104-5. 2005..In 3 patients the "rebound psychosis" was worse than the original psychotic episode and required subsequent higher antipsychotic medication doses... - Management of referred deep brain stimulation failures: a retrospective analysis from 2 movement disorders centersMichael S Okun
Department of Neurology, University of Florida, Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
Arch Neurol 62:1250-5. 2005..An attempt is made herein to evaluate the reasons for DBS failure in a series of such patients and to make recommendations to improve overall DBS outcomes... - Comprehensive screening of a North American Parkinson's disease cohort for LRRK2 mutationJanel Johnson
Laboratory of Neurogenetics, National Institute on Aging, Porter Neuroscience Research Center, National Institutes of Health, Bethesda, MD 20892, USA
Neurodegener Dis 4:386-91. 2007..Recently, mutations in LRRK2 encoding the protein dardarin have been linked to an autosomal dominant form of parkinsonism... - Apomorphine therapy in Parkinson's disease: a reviewIhtsham Ul Haq
Movement Disorders Program, University of Florida, Department of Neurology McKnight Brain Institute, 100 S Newell Drive, PO Box 100236, Gainesville, Florida 32610 0236, USA
Expert Opin Pharmacother 8:2799-809. 2007..In this review, the authors discuss the history, pharmacology, efficacy, safety and proper administration of apomorphine for treating 'off' states in Parkinson's disease, with a focus on intermittent subcutaneous administration... - Unrecognized parkinsonism in acute care medical patients receiving neurological consultationsJoseph H Friedman
J Gerontol A Biol Sci Med Sci 58:94-5. 2003 - Role of deep brain stimulation targeted to the pedunculopontine nucleus in Parkinson's diseaseChristopher Kenney
Expert Rev Neurother 7:585-9. 2007 - Taking a closer look at sleep problems and psychosis in Parkinson's disease. IntroductionHubert H Fernandez
Department of Neurology, University of Florida, Gainesville, FL 32610, USA
CNS Spectr 13:4-5. 2008 - 18F-Dopa vs dopamine transporter ligands in positron emission tomographic and single-photon emission computed tomographic scans for Parkinson diseaseHubert H Fernandez
Arch Neurol 59:1973; author reply 1973-4. 2002 - Efficacy and safety of purified botulinum toxin type A (Dysport) for the treatment of benign essential blepharospasm: a randomized, placebo-controlled, phase II trialDaniel Truong
The Parkinson s and Movement Disorder Institute, Orange Coast Memorial Medical Center, 9940 Talbert Ave 204, Fountain Valley, CA 92708, USA
Parkinsonism Relat Disord 14:407-14. 2008..The best balance of sustained efficacy and favorable safety profile was provided by 80 units of Dysport/eye in this study... - Clinical cases where lesion therapy was chosen over deep brain stimulationAmanda K Hooper
University of Florida, Movement Disorders Center, Gainesville, FL 32601, USA
Stereotact Funct Neurosurg 86:147-52. 2008..Lesion therapy represents a viable alternative and has several important advantages, including a decreased need for access to specialists and clinical follow-up, improved affordability, and a lower infection risk... - Aripiprazole for drug-induced psychosis in Parkinson disease: preliminary experienceHubert H Fernandez
Department of Neurology, University of Florida College of Medicine, Gainesville, FL 32610
Clin Neuropharmacol 27:4-5. 2004..Our preliminary experience with aripiprazole is mixed but not very encouraging. Controlled studies are needed to evaluate aripiprazole in parkinsonian patients... - Monamine oxidase inhibitors: current and emerging agents for Parkinson diseaseHubert H Fernandez
Movement Disorders Center, Department of Neurology, McKnight Brain Institute University of Florida, Gainesville, FL 32610, USA
Clin Neuropharmacol 30:150-68. 2007..Unlike selegiline, rasagiline is an aminoindan derivative with no amphetamine metabolites. A randomized clinical trial is underway to confirm preclinical and preliminary clinical data suggesting rasagiline has disease-modifying effects... - Identifying candidates for deep brain stimulation in Parkinson's disease: the role of the primary care physicianMichael S Okun
Department of Neurology, University of Florida Movement Disorders Center, McKnight Brain Institute, Gainesville, USA
Geriatrics 62:18-24. 2007..Potential candidates who score well on this questionnaire can be referred for presurgical multidisciplinary evaluation at an experienced DBS implanting center... - The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populationsSonja W Scholz
Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Building 35, Room 1A 1012, Bethesda, MD 20892, USA
Neurosci Lett 395:227-9. 2006..No association between genotypes in codon 129 and IPD was detected in three distinct populations, suggesting that this PRNP polymorphism has no direct influence on the susceptibility to IPD... - Testosterone therapy in men with Parkinson disease: results of the TEST-PD StudyMichael S Okun
Department of Neurology, University of Florida Movement Disorders Center, McKnight Brain Institute, Gainesville, FL 32610, USA
Arch Neurol 63:729-35. 2006..Previously, we reported that testosterone deficiency is more common in patients with PD compared with age-matched control subjects, and we also reported in 2 small open-label studies that some nonmotor symptoms responded favorably to TT... - Diabetes mellitus among parkinsonian patients treated chronically with clozapineHubert H Fernandez
Department of Neurology, University of Florida, Gainesville, FL, USA
Parkinsonism Relat Disord 10:439-41. 2004..3% for ages > or = 60 years). In this small study, parkinsonian patients on long-term, low dose clozapine were not at increased risk for developing DM. Larger controlled prospective studies are needed to confirm this... - Lessons learned in deep brain stimulation for movement and neuropsychiatric disordersFrank M Skidmore
Department of Neurology, McKnight Brain Institute, University of Florida College of Medicine in Gainesville, 32610, USA
CNS Spectr 11:521-36. 2006..Also discussed are the emerging targets, what is known about the cognitive sequelae of DBS, and what has been learned about the complications and therapeutic failures... - Deep brain stimulation of the internal segment of the globus pallidus in delayed runaway dyskinesiaJohn Graff-Radford
Department of Neurology, University of Florida Movement Disorders Center, University of Florida, Gainesville, FL, USA
Arch Neurol 63:1181-4. 2006..CONCLUSION: This case highlights the delayed development of runaway dyskinesia after a period without medication as an important potential long-term adverse effect of embryonic cell transplantation in patients with Parkinson disease... - Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of dataHon Chung Fung
Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
Lancet Neurol 5:911-6. 2006.... - Laterality, region, and type of motor dysfunction correlate with cognitive impairment in Parkinson's diseaseLindsy N Williams
Department of Neurology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
Mov Disord 22:141-5. 2007..22, t(105) = -1.95, P = 0.054. We therefore found that right-sided symptoms (for laterality), axial symptoms (for region), and bradykinesia (for type of symptoms) were the best predictors of cognitive function... - Analysis of the PINK1 gene in a large cohort of cases with Parkinson diseaseEkaterina Rogaeva
Centre for Research in Neurodegenerative Diseases and Division of Neurology, Department of Medicine, Toronto Western Hospital, University of Toronto, Ontario, Canada
Arch Neurol 61:1898-904. 2004..Mutations in the PTEN-induced kinase (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease... - Deep brain stimulation and the role of the neuropsychologistMichael S Okun
Department of Neurology, Movement Disorders Center, University of Florida, Gainesville, FL 32610, USA
Clin Neuropsychol 21:162-89. 2007..Additionally, this article will review all aspects of the DBS procedure that can result in mood, cognitive, and behavioral effects and what role(s) the neuropsychologist should play in screening and follow-up... - Tardive dyskinesiaKarla Soares Weiser
Enhance Reviews, Kfar Saba, Israel
Semin Neurol 27:159-69. 2007..None of the trials pooled on these reviews found a definitive therapy for TD. Clinicians faced with conditions such as TD should carefully weigh the risks and benefits involved with any given intervention... - Abnormal affective startle modulation in individuals with psychogenic [corrected] movement disorderPaul J Seignourel
Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida, USA
Mov Disord 22:1265-71. 2007..Abnormal affective startle modulation may be used to help distinguish between malingering and PMD. Future studies using larger samples are needed to better understand the role of emotions in conversion disorder... - Distribution of motor impairment influences quality of life in Parkinson's diseaseKim C Stewart
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida 32611, USA
Mov Disord 23:1466-8. 2008..Patients with greater UE and LE motor impairments had lower QoL scores. However, LE impairments had a greater influence than UE impairments across all QoL measures...