John E Donahue

Summary

Affiliation: Rhode Island Hospital
Country: USA

Publications

  1. pmc Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury
    Ana Maria Gonzalez
    College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Fluids Barriers CNS 8:6. 2011
  2. ncbi request reprint Autopsy-proven Creutzfeldt-Jakob disease in a patient with a negative 14-3-3 assay and nonspecific EEG and MRI
    J E Donahue
    Division of Neuropathology, Department of Pathology, Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Neurol Sci 24:411-3. 2004
  3. doi request reprint Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease
    John E Donahue
    Division of Neuropathology, Department of Pathology, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Neuropathol Exp Neurol 67:261-70. 2008
  4. ncbi request reprint RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease
    John E Donahue
    Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    Acta Neuropathol 112:405-15. 2006
  5. doi request reprint Amyloid efflux transporter expression at the blood-brain barrier declines in normal aging
    Gerald D Silverberg
    Department of Neurosurgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
    J Neuropathol Exp Neurol 69:1034-43. 2010
  6. doi request reprint Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging
    Gerald D Silverberg
    Department of Clinical Neuroscience, Warren Alpert Medical School, Brown University and Aldrich Neurosurgery Research Laboratories, Rhode Island Hospital, Providence, Rhode Island, USA
    J Neuropathol Exp Neurol 69:98-108. 2010
  7. pmc Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease
    Miles C Miller
    Division of Neuropathology, Department of Pathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 593 Eddy Street APC 12 219, Providence, RI 02903, USA
    Brain Res 1230:273-80. 2008
  8. pmc Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer's disease
    Brian R Ott
    Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Alzheimers Dis 20:647-57. 2010
  9. pmc Thyroid hormone levels in the prefrontal cortex of post-mortem brains of Alzheimer's disease patients
    Jennifer Duncan Davis
    Warren Alpert Medical School of Brown University, Department of Psychiatry, Rhode Island Hospital, Providence, RI 02903, USA
    Curr Aging Sci 1:175-81. 2008
  10. doi request reprint Preoperative MRI evaluation of pituitary macroadenoma: imaging features predictive of successful transsphenoidal surgery
    Jerrold L Boxerman
    Department of Diagnostic Imaging, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    AJR Am J Roentgenol 195:720-8. 2010

Collaborators

Detail Information

Publications11

  1. pmc Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injury
    Ana Maria Gonzalez
    College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Fluids Barriers CNS 8:6. 2011
    ..abstract:..
  2. ncbi request reprint Autopsy-proven Creutzfeldt-Jakob disease in a patient with a negative 14-3-3 assay and nonspecific EEG and MRI
    J E Donahue
    Division of Neuropathology, Department of Pathology, Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
    Neurol Sci 24:411-3. 2004
    ..The chances of all three diagnostic testing modalities to be negative in a single case of sporadic CJD are extremely remote. Autopsy with neuropathologic confirmation remains the only definitive way to make a diagnosis of CJD...
  3. doi request reprint Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer disease
    John E Donahue
    Division of Neuropathology, Department of Pathology, Rhode Island Hospital, Providence, Rhode Island 02903, USA
    J Neuropathol Exp Neurol 67:261-70. 2008
    ..Therapeutic alternatives targeting apoE/Abeta and sealing a compromised BBB are under development for the treatment of AD...
  4. ncbi request reprint RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease
    John E Donahue
    Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
    Acta Neuropathol 112:405-15. 2006
    ..They also suggest that the proportion of amyloid within the brains of AD patients that is derived from the systemic circulation may be significant...
  5. doi request reprint Amyloid efflux transporter expression at the blood-brain barrier declines in normal aging
    Gerald D Silverberg
    Department of Neurosurgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
    J Neuropathol Exp Neurol 69:1034-43. 2010
    ..0004). These data indicate that alterations in LRP-1 and P-gp expression seem to contribute progressively to Aβ accumulation in aging...
  6. doi request reprint Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging
    Gerald D Silverberg
    Department of Clinical Neuroscience, Warren Alpert Medical School, Brown University and Aldrich Neurosurgery Research Laboratories, Rhode Island Hospital, Providence, Rhode Island, USA
    J Neuropathol Exp Neurol 69:98-108. 2010
    ..These data indicate an association between amyloid and microvessel RAGE during aging. An increase in capillary RAGE expression seems to play a role in the later Abeta accumulation but not in the initial increase...
  7. pmc Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease
    Miles C Miller
    Division of Neuropathology, Department of Pathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 593 Eddy Street APC 12 219, Providence, RI 02903, USA
    Brain Res 1230:273-80. 2008
    ..038). Our data suggest that microvascular RAGE levels increase in conjunction with the onset of AD, and continue to increase linearly as a function of AD pathologic severity (p < 0.0001)...
  8. pmc Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer's disease
    Brian R Ott
    Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Alzheimers Dis 20:647-57. 2010
    ..The basis for the apparent effect of APOE epsilon4 genotype on the relationship of ventricular volume to Abeta and tau levels is unknown, but could involve altered CSF-blood-brain barrier function during the course of disease...
  9. pmc Thyroid hormone levels in the prefrontal cortex of post-mortem brains of Alzheimer's disease patients
    Jennifer Duncan Davis
    Warren Alpert Medical School of Brown University, Department of Psychiatry, Rhode Island Hospital, Providence, RI 02903, USA
    Curr Aging Sci 1:175-81. 2008
    ..Reduced conversion of T(4) to T(3) in AD may be associated with both AD pathology and the clinical presentation of dementia...
  10. doi request reprint Preoperative MRI evaluation of pituitary macroadenoma: imaging features predictive of successful transsphenoidal surgery
    Jerrold L Boxerman
    Department of Diagnostic Imaging, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
    AJR Am J Roentgenol 195:720-8. 2010
    ..The purpose of this study was to determine whether the preoperative MRI findings of enhanced diffusivity, macrocyst content, and internal hemorrhage in pituitary macroadenomas are predictive of successful transsphenoidal hypophysectomy...
  11. ncbi request reprint Visual vignette. Prolactinoma
    Jane V Mayrin
    Division of Endocrinology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Endocr Pract 14:256. 2008

Research Grants2

  1. Effects of ApoE Genotype on Blood-Brain Barrier Permeability and LRP-1 Expression
    John Donahue; Fiscal Year: 2007
    ..Hopefully, this will lead eventually to treatment interventions to slow the progression and/or reverse the pathophysiology of BBB collapse in AD. ..