John E Donahue
Affiliation: Rhode Island Hospital
- Ecrg4 expression and its product augurin in the choroid plexus: impact on fetal brain development, cerebrospinal fluid homeostasis and neuroprogenitor cell response to CNS injuryAna Maria Gonzalez
College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
Fluids Barriers CNS 8:6. 2011..abstract:..
- Autopsy-proven Creutzfeldt-Jakob disease in a patient with a negative 14-3-3 assay and nonspecific EEG and MRIJ E Donahue
Division of Neuropathology, Department of Pathology, Rhode Island Hospital, Brown University School of Medicine, 593 Eddy Street, Providence, RI 02903, USA
Neurol Sci 24:411-3. 2004..The chances of all three diagnostic testing modalities to be negative in a single case of sporadic CJD are extremely remote. Autopsy with neuropathologic confirmation remains the only definitive way to make a diagnosis of CJD...
- Apolipoprotein E, amyloid-beta, and blood-brain barrier permeability in Alzheimer diseaseJohn E Donahue
Division of Neuropathology, Department of Pathology, Rhode Island Hospital, Providence, Rhode Island 02903, USA
J Neuropathol Exp Neurol 67:261-70. 2008..Therapeutic alternatives targeting apoE/Abeta and sealing a compromised BBB are under development for the treatment of AD...
- RAGE, LRP-1, and amyloid-beta protein in Alzheimer's diseaseJohn E Donahue
Department of Clinical Neurosciences, Rhode Island Hospital and Brown Medical School, Providence, RI 02903, USA
Acta Neuropathol 112:405-15. 2006..They also suggest that the proportion of amyloid within the brains of AD patients that is derived from the systemic circulation may be significant...
- Amyloid efflux transporter expression at the blood-brain barrier declines in normal agingGerald D Silverberg
Department of Neurosurgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
J Neuropathol Exp Neurol 69:1034-43. 2010..0004). These data indicate that alterations in LRP-1 and P-gp expression seem to contribute progressively to Aβ accumulation in aging...
- Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal agingGerald D Silverberg
Department of Clinical Neuroscience, Warren Alpert Medical School, Brown University and Aldrich Neurosurgery Research Laboratories, Rhode Island Hospital, Providence, Rhode Island, USA
J Neuropathol Exp Neurol 69:98-108. 2010..These data indicate an association between amyloid and microvessel RAGE during aging. An increase in capillary RAGE expression seems to play a role in the later Abeta accumulation but not in the initial increase...
- Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's diseaseMiles C Miller
Division of Neuropathology, Department of Pathology, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 593 Eddy Street APC 12 219, Providence, RI 02903, USA
Brain Res 1230:273-80. 2008..038). Our data suggest that microvascular RAGE levels increase in conjunction with the onset of AD, and continue to increase linearly as a function of AD pathologic severity (p < 0.0001)...
- Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer's diseaseBrian R Ott
Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
J Alzheimers Dis 20:647-57. 2010..The basis for the apparent effect of APOE epsilon4 genotype on the relationship of ventricular volume to Abeta and tau levels is unknown, but could involve altered CSF-blood-brain barrier function during the course of disease...
- Thyroid hormone levels in the prefrontal cortex of post-mortem brains of Alzheimer's disease patientsJennifer Duncan Davis
Warren Alpert Medical School of Brown University, Department of Psychiatry, Rhode Island Hospital, Providence, RI 02903, USA
Curr Aging Sci 1:175-81. 2008..Reduced conversion of T(4) to T(3) in AD may be associated with both AD pathology and the clinical presentation of dementia...
- Preoperative MRI evaluation of pituitary macroadenoma: imaging features predictive of successful transsphenoidal surgeryJerrold L Boxerman
Department of Diagnostic Imaging, Rhode Island Hospital, 593 Eddy St, Providence, RI 02903, USA
AJR Am J Roentgenol 195:720-8. 2010..The purpose of this study was to determine whether the preoperative MRI findings of enhanced diffusivity, macrocyst content, and internal hemorrhage in pituitary macroadenomas are predictive of successful transsphenoidal hypophysectomy...
- Visual vignette. ProlactinomaJane V Mayrin
Division of Endocrinology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
Endocr Pract 14:256. 2008
- Effects of ApoE Genotype on Blood-Brain Barrier Permeability and LRP-1 ExpressionJohn Donahue; Fiscal Year: 2007..Hopefully, this will lead eventually to treatment interventions to slow the progression and/or reverse the pathophysiology of BBB collapse in AD. ..