Jianping Chen

Summary

Affiliation: Rhode Island College
Country: USA

Publications

  1. pmc Protein under-wrapping causes dosage sensitivity and decreases gene duplicability
    Han Liang
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 4:e11. 2008
  2. pmc Protein structure protection commits gene expression patterns
    Jianping Chen
    Program in Applied Physics, Rice Quantum Institute, Rice University, Houston, TX 77005, USA
    Genome Biol 9:R107. 2008
  3. doi request reprint Taming the induced folding of drug-targeted kinases
    Ariel Fernandez
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Trends Pharmacol Sci 30:66-71. 2009
  4. pmc Human capacitance to dosage imbalance: coping with inefficient selection
    Ariel Fernandez
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    Genome Res 19:2185-92. 2009
  5. ncbi request reprint Solvent-exposed backbone loosens the hydration shell of soluble folded proteins
    Ariel Fernandez
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    J Chem Phys 126:245103. 2007
  6. pmc An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic
    Ariel Fernandez
    Department of Bioengineering and Applied Physics Division, Rice Quantum Institute, Rice University, Houston, Texas 77005, USA
    J Clin Invest 117:4044-54. 2007
  7. pmc Molecular basis for specificity in the druggable kinome: sequence-based analysis
    Jianping Chen
    Program in Applied Physics and Rice Quantum Institute, Rice University, Houston, TX 77005, USA
    Bioinformatics 23:563-72. 2007
  8. ncbi request reprint The novel MGC13096 protein is correlated with proliferation
    Qiu Chen
    College of Life Sciences, Zhejiang University, Hangzhou, PR China
    Cell Biochem Funct 26:141-5. 2008
  9. ncbi request reprint Biochemical and HIV-1 coreceptor properties of K26R, a new CCR5 Variant in China's Sichuan population
    Liying Ma
    INSERM U543, CHU Pitie Salpetriere, 75013 Paris, France
    J Acquir Immune Defic Syndr 39:38-43. 2005
  10. ncbi request reprint Leaves of the Lamiaceae species Glechoma hederacea (ground ivy) contain a lectin that is structurally and evolutionary related to the legume lectins
    Weifang Wang
    Laboratory for Phytopathology and Plant Protection, Katholieke Universiteit Leuven, Willem de Croylaan 42, 3001 Leuven, Belgium
    Plant J 33:293-304. 2003

Collaborators

Detail Information

Publications10

  1. pmc Protein under-wrapping causes dosage sensitivity and decreases gene duplicability
    Han Liang
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 4:e11. 2008
    ..Our under-wrapping analysis of more than 12,000 protein structures strongly supports these predictions and further reveals that the effect of dosage sensitivity on gene duplicability decreases with increasing organismal complexity...
  2. pmc Protein structure protection commits gene expression patterns
    Jianping Chen
    Program in Applied Physics, Rice Quantum Institute, Rice University, Houston, TX 77005, USA
    Genome Biol 9:R107. 2008
    ..Yet, little effort has been devoted to tracing coordinating signals for expression correlations to the three-dimensional structures of gene products...
  3. doi request reprint Taming the induced folding of drug-targeted kinases
    Ariel Fernandez
    Department of Bioengineering, Rice University, Houston, TX 77005, USA
    Trends Pharmacol Sci 30:66-71. 2009
    ..This concept is validated by dynamically examining structural adaptations promoted by imatinib redesigns intended to control drug specificity...
  4. pmc Human capacitance to dosage imbalance: coping with inefficient selection
    Ariel Fernandez
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    Genome Res 19:2185-92. 2009
    ..The results may clarify the evolutionary etiology of aggregation-related diseases, since aggregation is often promoted by overexpression (a dosage imbalance) and aggregation propensity is associated with extreme packing deficiency...
  5. ncbi request reprint Solvent-exposed backbone loosens the hydration shell of soluble folded proteins
    Ariel Fernandez
    Department of Bioengineering, Rice University, Houston, Texas 77005, USA
    J Chem Phys 126:245103. 2007
    ..These bonds are poorly wrapped by surrounding nonpolar groups from the side chains and their dehydration is energetically favored...
  6. pmc An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic
    Ariel Fernandez
    Department of Bioengineering and Applied Physics Division, Rice Quantum Institute, Rice University, Houston, Texas 77005, USA
    J Clin Invest 117:4044-54. 2007
    ..These findings identify the reengineered imatinib as an agent to treat GISTs with curbed side effects and reveal a bottom-up approach to control drug specificity...
  7. pmc Molecular basis for specificity in the druggable kinome: sequence-based analysis
    Jianping Chen
    Program in Applied Physics and Rice Quantum Institute, Rice University, Houston, TX 77005, USA
    Bioinformatics 23:563-72. 2007
    ..This work answers the question for a sizable screened sample of the human pharmacokinome including targets with unreported structure...
  8. ncbi request reprint The novel MGC13096 protein is correlated with proliferation
    Qiu Chen
    College of Life Sciences, Zhejiang University, Hangzhou, PR China
    Cell Biochem Funct 26:141-5. 2008
    ....
  9. ncbi request reprint Biochemical and HIV-1 coreceptor properties of K26R, a new CCR5 Variant in China's Sichuan population
    Liying Ma
    INSERM U543, CHU Pitie Salpetriere, 75013 Paris, France
    J Acquir Immune Defic Syndr 39:38-43. 2005
    ..We observed that K26R displayed alteration in MIP1-beta/CCL4 and RANTES/CCL5 ligand binding and exhibited a slightly decrease for HIV coreceptor properties...
  10. ncbi request reprint Leaves of the Lamiaceae species Glechoma hederacea (ground ivy) contain a lectin that is structurally and evolutionary related to the legume lectins
    Weifang Wang
    Laboratory for Phytopathology and Plant Protection, Katholieke Universiteit Leuven, Willem de Croylaan 42, 3001 Leuven, Belgium
    Plant J 33:293-304. 2003
    ....