Jorge J Castillo

Summary

Affiliation: Rhode Island Hospital
Country: USA

Publications

  1. pmc Diffuse large B-cell lymphoma in human T-lymphotropic virus type 1 carriers
    Brady E Beltran
    Department of Oncology and Radiotherapy, Edgardo Rebagliati Martins Hospital, Lima, Peru
    Leuk Res Treatment 2012:262363. 2012
  2. pmc The role of ofatumumab in the treatment of chronic lymphocytic leukemia resistant to previous therapies
    Jorge Castillo
    The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, The Miriam Hospital, Providence, RI, USA
    J Blood Med 1:1-8. 2010
  3. pmc Immunophenotypical Switch versus Tumor Heterogeneity in a Patient with HIV-Associated Diffuse Large B-Cell Lymphoma
    Jorge J Castillo
    Division of Hematology and Oncology, The Miriam Hospital, The Warren Alpert Medical School of Brown University, 164 Summit Avenue, Providence, RI 02906, USA
    Patholog Res Int 2011:563216. 2010
  4. doi Prognosis in primary effusion lymphoma is associated with the number of body cavities involved
    Jorge J Castillo
    Division of Hematology and Oncology, Department of Medicine, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI, USA
    Leuk Lymphoma 53:2378-82. 2012
  5. doi Similar outcomes in Asian and Western patients with diffuse large B-cell lymphoma treated with R-CHOP
    Jorge J Castillo
    Division of Hematology and Oncology, Rhode Island Hospital The Miriam Hospital, Providence, RI 02906, USA
    Leuk Res 37:386-91. 2013
  6. ncbi Cigarette smoking is associated with a small increase in the incidence of non-Hodgkin lymphoma: a meta-analysis of 24 observational studies
    Jorge J Castillo
    Division of Hematology and Oncology, The Warren Alpert Medical School of Brown University, The Miriam Hospital, Providence, RI 02906, USA
    Leuk Lymphoma 53:1911-9. 2012
  7. pmc Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies
    Jorge J Castillo
    Division of Hematology and Oncology, Rhode Island Hospital The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA
    Blood 119:4845-50. 2012
  8. doi Human immunodeficiency virus-associated plasmablastic lymphoma: poor prognosis in the era of highly active antiretroviral therapy
    Jorge J Castillo
    The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, The Miriam Hospital, Providence, RI, USA
    Cancer 118:5270-7. 2012
  9. doi No association between cigarette smoking and incidence of plasma cell myeloma: a meta-analysis of 17 observational studies
    Jorge J Castillo
    Division of Hematology and Oncology, The Warren Alpert Medical School of Brown University, Rhode Island Hospital The Miriam Hospital, Providence, RI, USA
    Am J Hematol 87:729-31. 2012
  10. doi Obesity but not overweight increases the incidence and mortality of leukemia in adults: a meta-analysis of prospective cohort studies
    Jorge J Castillo
    Division of Hematology and Oncology, The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA
    Leuk Res 36:868-75. 2012

Detail Information

Publications43

  1. pmc Diffuse large B-cell lymphoma in human T-lymphotropic virus type 1 carriers
    Brady E Beltran
    Department of Oncology and Radiotherapy, Edgardo Rebagliati Martins Hospital, Lima, Peru
    Leuk Res Treatment 2012:262363. 2012
    ..To the best of our knowledge, this is the first case series describing the characteristics of HTLV-1-positive DLBCL patients. The potential relationship between HTLV-1 and EBV should be further explored...
  2. pmc The role of ofatumumab in the treatment of chronic lymphocytic leukemia resistant to previous therapies
    Jorge Castillo
    The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, The Miriam Hospital, Providence, RI, USA
    J Blood Med 1:1-8. 2010
    ..Further research is necessary to further define the role of ofatumumab in the treatment of CLL...
  3. pmc Immunophenotypical Switch versus Tumor Heterogeneity in a Patient with HIV-Associated Diffuse Large B-Cell Lymphoma
    Jorge J Castillo
    Division of Hematology and Oncology, The Miriam Hospital, The Warren Alpert Medical School of Brown University, 164 Summit Avenue, Providence, RI 02906, USA
    Patholog Res Int 2011:563216. 2010
    ..This phenomenon was not associated with a superinfection with EBV or HHV-8...
  4. doi Prognosis in primary effusion lymphoma is associated with the number of body cavities involved
    Jorge J Castillo
    Division of Hematology and Oncology, Department of Medicine, The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI, USA
    Leuk Lymphoma 53:2378-82. 2012
    ..04). In conclusion, our study suggests that the number and location of body cavities involved are prognostic in patients with PEL...
  5. doi Similar outcomes in Asian and Western patients with diffuse large B-cell lymphoma treated with R-CHOP
    Jorge J Castillo
    Division of Hematology and Oncology, Rhode Island Hospital The Miriam Hospital, Providence, RI 02906, USA
    Leuk Res 37:386-91. 2013
    ..The aim of this retrospective study is to compare characteristics, prognostic factors and outcomes of Asian and Western patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP)...
  6. ncbi Cigarette smoking is associated with a small increase in the incidence of non-Hodgkin lymphoma: a meta-analysis of 24 observational studies
    Jorge J Castillo
    Division of Hematology and Oncology, The Warren Alpert Medical School of Brown University, The Miriam Hospital, Providence, RI 02906, USA
    Leuk Lymphoma 53:1911-9. 2012
    ..In conclusion, there appears to be an increase in the odds of NHL in current female smokers...
  7. pmc Increased incidence of non-Hodgkin lymphoma, leukemia, and myeloma in patients with diabetes mellitus type 2: a meta-analysis of observational studies
    Jorge J Castillo
    Division of Hematology and Oncology, Rhode Island Hospital The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA
    Blood 119:4845-50. 2012
    ....
  8. doi Human immunodeficiency virus-associated plasmablastic lymphoma: poor prognosis in the era of highly active antiretroviral therapy
    Jorge J Castillo
    The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, The Miriam Hospital, Providence, RI, USA
    Cancer 118:5270-7. 2012
    ..The authors conducted a multi-institutional, retrospective study to describe characteristics and determine prognostic factors in HIV-associated PBL...
  9. doi No association between cigarette smoking and incidence of plasma cell myeloma: a meta-analysis of 17 observational studies
    Jorge J Castillo
    Division of Hematology and Oncology, The Warren Alpert Medical School of Brown University, Rhode Island Hospital The Miriam Hospital, Providence, RI, USA
    Am J Hematol 87:729-31. 2012
    ..In conclusion, our meta-analysis shows that there is no relationship between cigarette smoking and an increased incidence of PCM. Future studies should focus on other potential risk factors for PCM...
  10. doi Obesity but not overweight increases the incidence and mortality of leukemia in adults: a meta-analysis of prospective cohort studies
    Jorge J Castillo
    Division of Hematology and Oncology, The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI 02906, USA
    Leuk Res 36:868-75. 2012
    ..001), chronic myeloid leukemia (RR 1.16, 95% CI 1.04-1.30; p = 0.007) and acute lymphoblastic leukemia (RR 1.62, 95% CI 1.12-2.32; p = 0.009). The risk of incidence and mortality of leukemia in adults was consistently higher in obese men...
  11. pmc Diagnosis and management of hyponatremia in cancer patients
    Jorge J Castillo
    The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, The Miriam Hospital, 164 Summit Avenue, Providence, Rhode Island 02906, USA
    Oncologist 17:756-65. 2012
    ..By blocking AVP effects in the renal collecting duct, tolvaptan promotes aquaresis, leading to a controlled increase in serum sodium levels...
  12. doi The Hans algorithm is not prognostic in patients with diffuse large B-cell lymphoma treated with R-CHOP
    Jorge J Castillo
    Division of Hematology and Oncology, The Warren Alpert Medical School of Brown University, The Miriam Hospital, Providence, RI 02906, USA
    Leuk Res 36:413-7. 2012
    ..55, 95% CI 0.37-0.83; p<0.01) in the multivariate logistic regression analysis. Interestingly, Asian patients had higher proportion of GC DLBCL (p=0.01)...
  13. doi Rituximab in combination with chemotherapy versus chemotherapy alone in HIV-associated non-Hodgkin lymphoma: a pooled analysis of 15 prospective studies
    Jorge J Castillo
    Department of Medicine and Division of Hematology and Oncology, The Warren Alpert Medical School of Brown University, The Miriam Hospital, Providence, Rhode Island, USA
    Am J Hematol 87:330-3. 2012
    ..98-2.82; p = 0.06) and 2.19 (95% CI 1.68-2.86; p < 0.001), respectively. HIV-positive lymphoma patients treated with R-chemo had higher odds for CR and 2-year OS when compared to chemo but also had a higher proportion of HAART usage...
  14. pmc ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature
    Brady Beltran
    Department of Oncology and Radiotherapy, Edgardo Rebagliati Martins Hospital, Lima, Peru
    J Hematol Oncol 2:11. 2009
    ..The latest WHO classification of lymphomas recognizes ALK-DLBCL as a separate entity...
  15. doi CAL-101: a phosphatidylinositol-3-kinase p110-delta inhibitor for the treatment of lymphoid malignancies
    Jorge J Castillo
    The Miriam Hospital, Division of Hematology and Oncology, 164 Summit Ave, Providence, RI 02906, USA
    Expert Opin Investig Drugs 21:15-22. 2012
    ..The PI3K pathway seems to play a seminal role in the development of lymphoid malignancies. CAL-101 is a highly selective PI3K p110δ inhibitor currently undergoing clinical development...
  16. doi Plasmablastic lymphoma: a systematic review
    Jorge J Castillo
    The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, The Miriam Hospital, Providence, RI, USA
    ScientificWorldJournal 11:687-96. 2011
    ..Specific covered topics include new pathological markers for diagnosis, its association with Epstein-Barr virus, and the need of more intensive therapies...
  17. pmc EBV-positive diffuse large B-cell lymphoma in a human T-lymphotropic virus type 1 carrier
    Brady Beltran
    The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, The Miriam Hospital, Providence, RI, USA
    Infect Agent Cancer 4:10. 2009
    ..Furthermore, the immunodeficiency caused by the viral infections and chemotherapy may have played a role in developing life-threatening infectious complications...
  18. doi Meta-analysis of the association between cigarette smoking and incidence of Hodgkin's Lymphoma
    Jorge J Castillo
    The Warren Alpert Medical School of Brown University and The Miriam Hospital, Providence, RI, USA
    J Clin Oncol 29:3900-6. 2011
    ..Previous studies have suggested a relationship between smoking and Hodgkin's lymphoma (HL). The main objective of this study was to evaluate this potential association with a meta-analysis of observational studies...
  19. pmc Prognostic factors in chemotherapy-treated patients with HIV-associated Plasmablastic lymphoma
    Jorge J Castillo
    164 Summit Avenue, Fain Building, Providence, Rhode Island 02906, USA
    Oncologist 15:293-9. 2010
    ..PBL has a poor prognosis, but prognostic factors in patients who have received chemotherapy have not been adequately evaluated...
  20. doi Lymphopenia as a prognostic factor in patients with peripheral T-cell lymphoma, unspecified
    Jorge J Castillo
    The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, The Miriam Hospital, Providence, RI, USA
    Leuk Lymphoma 51:1822-8. 2010
    ..In multivariate analysis, lymphopenia and a PIT score>2 were the only independent poor prognostic factors, implying an important role of the patient's immune system in both response to therapy and survival...
  21. doi Clinical and pathological differences between human immunodeficiency virus-positive and human immunodeficiency virus-negative patients with plasmablastic lymphoma
    Jorge J Castillo
    The Warren Alpert Medical School of Brown University, The Miriam Hospital, Providence, RI, USA
    Leuk Lymphoma 51:2047-53. 2010
    ..In conclusion, HIV-positive and HIV-negative patients with PBL have different clinicopathological characteristics, including a better response to chemotherapy and longer survival in HIV-positive patients...
  22. pmc Epstein-barr virus-positive diffuse large B-cell lymphoma of the elderly: what we know so far
    Jorge J Castillo
    The Miriam Hospital, 164 Summit Avenue, Providence, Rhode Island 02906, USA
    Oncologist 16:87-96. 2011
    ....
  23. doi Prognostic factors in patients with HIV-associated peripheral T-cell lymphoma: a multicenter study
    Jorge J Castillo
    Division of Hematology and Oncology, The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Am J Hematol 86:256-61. 2011
    ..HIV-associated PTCL presents predominantly in young men with low CD4(+) counts and high HIV viral loads. Both HIV-related and lymphoma-related factors were associated with OS...
  24. ncbi Ofatumumab, a second-generation anti-CD20 monoclonal antibody, for the treatment of lymphoproliferative and autoimmune disorders
    Jorge Castillo
    Brown University Warren Alpert Medical School, The Miriam Hospital, Division of Hematology and Oncology, Providence, RI 02906, USA
    Expert Opin Investig Drugs 18:491-500. 2009
    ..Ofatumumab is a new, fully human anti-CD20 antibody and has been shown to be effective and safe, but its role in these conditions is still unclear...
  25. doi HIV-associated plasmablastic lymphoma: lessons learned from 112 published cases
    Jorge Castillo
    Division of Hematology Oncology, The Miriam Hospital, Brown University Warren Alpert Medical School, Providence, Rhode Island 02906, USA
    Am J Hematol 83:804-9. 2008
    ..PBL is an aggressive B-cell lymphoma that presents in both oral and extra-oral sites of chronically HIV-infected immunosuppressed young men...
  26. ncbi Newer monoclonal antibodies for hematological malignancies
    Jorge Castillo
    Division of Hematology and Oncology, Rhode Island Hospital, Brown University Warren Alpert Medical School, Providence, RI 02906, USA
    Exp Hematol 36:755-68. 2008
    ....
  27. doi Association between red blood cell transfusions and development of non-Hodgkin lymphoma: a meta-analysis of observational studies
    Jorge J Castillo
    The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, The Miriam Hospital, Providence, RI 02906, USA
    Blood 116:2897-907. 2010
    ..Blood transfusions appear to increase the risk of developing NHL; however, the risk of CLL/SLL appears higher than for other NHL subtypes...
  28. doi EBV-positive diffuse large B-cell lymphoma of the elderly: a case series from Peru
    Brady E Beltran
    Department of Oncology and Radiotherapy, Edgardo Rebagliati Martins Hospital, Lima, Peru
    Am J Hematol 86:663-7. 2011
    ..Further studies are needed to investigate if rituximab-containing regimens are associated with better response and OS rates in EBV-positive DLBCL of the elderly...
  29. doi HIV-negative plasmablastic lymphoma: not in the mouth
    Jorge J Castillo
    The Warren Alpert Medical School of Brown University, Providence, RI
    Clin Lymphoma Myeloma Leuk 11:185-9. 2011
    ....
  30. doi Peripheral T-cell lymphoma with a regulatory T-cell phenotype: report of a nodal and an extranodal case from Peru
    Brady E Beltran
    Department of Oncology and Radiotherapy, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru
    Appl Immunohistochem Mol Morphol 20:196-200. 2012
    ..We conclude that peripheral T-cell lymphoma, not otherwise specified with a T reg phenotype may represent a distinct category of T-cell lymphoma with an aggressive clinical course and poor prognosis...
  31. doi Population-based prognostic factors for survival in patients with Burkitt lymphoma: an analysis from the Surveillance, Epidemiology, and End Results database
    Jorge J Castillo
    Division of Hematology and Oncology, Alpert Medical School of Brown University, Rhode Island Hospital The Miriam Hospital, Providence, Rhode Island
    Cancer 119:3672-9. 2013
    ..This study evaluated prognostic factors for survival in adult patients with BL and a potential outcome improvement over the past decade in a population-based cohort...
  32. ncbi Follicular lymphoma with leukemic phase at diagnosis: a series of seven cases and review of the literature
    Brady E Beltran
    Department of Oncology and Radiotherapy, Edgardo Rebagliati Martins Hospital, Lima, Peru
    Leuk Res 37:1116-9. 2013
    ..A discrepancy with previously reported cases of FL in leukemic phase raises the possibility of differences attributable to geographic regions. ..
  33. pmc Cellular immunotherapy for refractory hematological malignancies
    John L Reagan
    Division of Hematology Oncology, Rhode Island Hospital The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, USA
    J Transl Med 11:150. 2013
    ..The end goal of cellular therapy is not engraftment but instead is the purposeful rejection of donor cells so as to elicit a potent immune reaction that appears to break host tumor tolerance...
  34. doi Different prognostic factors for survival in acute and lymphomatous adult T-cell leukemia/lymphoma
    Brady Beltran
    Department of Oncology and Radiotherapy, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru
    Leuk Res 35:334-9. 2011
    ..Adult T-cell leukemia/lymphoma (ATLL) is a clinically aggressive and heterogeneous entity; hence it is likely that different variants of ATLL have different prognostic factors...
  35. doi Management of hematological malignancies during pregnancy
    Tina Rizack
    Division of Hematology and Oncology, The Miriam Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island 02906, USA
    Am J Hematol 84:830-41. 2009
    ....
  36. doi Multiple myeloma-induced hyperammonemic encephalopathy: an entity associated with high in-patient mortality
    Anthony Pham
    Division of Hematology and Oncology, Mayo Clinic, Rochester, MN, USA
    Leuk Res 37:1229-32. 2013
    ..Hyperammonemic encephalopathy is a rare complication in MM and is associated with high in-patient mortality...
  37. doi Spontaneous regression of chronic lymphocytic leukemia to a monoclonal B-lymphocytosis or to a normal phenotype
    Peter S Nakhla
    Department of Medicine, Rhode Island Hospital, Providence, RI, USA
    Leuk Lymphoma 54:1647-51. 2013
    ..03). This difference in the duration of CLL prior to remission could be due to a possible distinct pathophysiology for these events...
  38. doi PCI-32765: a novel Bruton's tyrosine kinase inhibitor for the treatment of lymphoid malignancies
    Eric S Winer
    Division of Hematology Oncology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Expert Opin Investig Drugs 21:355-61. 2012
    ..The Bruton's tyrosine kinase (Btk) pathway is a downstream mediator of the B-cell receptor (BCR) pathway, which is crucial in B-cell production and maintenance, and a potential therapeutic target...
  39. doi Survival of patients with marginal zone lymphoma: analysis of the Surveillance, Epidemiology, and End Results database
    Adam J Olszewski
    Division of Hematology and Oncology, Memorial Hospital of Rhode Island, Pawtucket, RI 02860, USA
    Cancer 119:629-38. 2013
    ..The prognosis of patients with MALT lymphoma varies according to the anatomical site of origin...
  40. ncbi Ofatumumab as front-line therapy in untreated chronic lymphocytic leukemia
    John L Reagan
    Division of Hematology and Oncology, Rhode Island Hospital, Providence, RI, USA
    Future Oncol 10:1147-55. 2014
    ..Herein, we outline the efficacy and toxicities of ofatumumab alone and in combination for the front-line treatment of CLL. ..
  41. doi Why is my patient neutropenic?
    John L Reagan
    Division of Hematology and Oncology, The Miriam Hospital, The Warren Alpert Medical School of Brown University, 164 Summit Avenue, Providence, RI 02906, USA
    Hematol Oncol Clin North Am 26:253-66, vii. 2012
    ..This article outlines the most common causes of neutropenia and discusses differential diagnoses, treatment modalities, and the mechanisms by which neutropenia occurs...
  42. doi Ofatumumab for newly diagnosed and relapsed/refractory chronic lymphocytic leukemia
    John L Reagan
    Division of Hematology and Oncology, The Warren Alpert Medical School of Brown University, The Miriam Hospital, Providence, RI 02906, USA
    Expert Rev Anticancer Ther 11:151-60. 2011
    ..This article provides an overview of the current data supporting the use of ofatumumab for CLL and projects the future role of ofatumumab as monotherapy and combination therapy...
  43. ncbi Veltuzumab, an anti-CD20 mAb for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura
    Cannon Milani
    Brown University Warren Alpert Medical School, The Miriam Hospital, Division of Hematology and Oncology, 164 Summit Avenue, Providence, RI 02906, USA
    Curr Opin Mol Ther 11:200-7. 2009
    ..Prospective, randomized clinical trials are needed to clarify the role veltuzumab will play in a market where the therapy of B-cell lymphoproliferative disorders is dominated by rituximab...