H E Resnick

..Diet has been related to several characteristics of metabolic syndrome (MSDR) and insulin resistance, which carry an increased risk for diabetes and heart disease...

..Whether IR and MS predict CVD independently of diabetes and other CVD risk factors is not known. This study examines whether IR and/or presence of MS are independently associated with CVD in nondiabetic American Indians (AI)...

..The associations of low (<0.90) and high (>1.40) ankle brachial index (ABI) with risk of all-cause and cardiovascular disease (CVD) mortality have not been examined in a population-based setting...

..To compare risk of all-cause and cardiovascular disease (CVD) mortality in people with a lower-extremity amputation (LEA) attributable to diabetes and people without an LEA...

..To define incidence and predictors of nontraumatic lower-extremity amputation (LEA) in a diverse cohort of American Indians with diabetes...

..To estimate the proportion of U.S. adults with diabetes who meet American Diabetes Association (ADA) clinical practice recommendations...

..To test the hypothesis that diabetes is independently associated with sleep-disordered breathing (SDB), and in particular that diabetes is associated with sleep abnormalities of a central, rather than obstructive, nature...

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..Although the OGTT may identify additional adults with more CVD risk factors than normals, these differences appear to be clustered among those who also have IFG...

..Interventions aimed at reducing the impact of diabetes-associated disability in old age may have the greatest impact among people with peripheral neuropathy...

..The high prevalence of IFG indicates that diabetes may become increasingly problematic in this population. Abdominal obesity in women may help explain why diabetes prevalence differs according to sex...

..To determine whether long term weight gain and weight loss are associated with subsequent risk of type 2 diabetes in overweight, non-diabetic adults...

..Further studies are needed to clarify the potential mediating role of diabetes on the apo E-PAD association...

..The magnitude of mortality risk associated with IPH is intermediate between diabetes and IFG. Because those with IPH are at high risk for diabetes, American Indians with IPH should be targeted for diabetes prevention...

..CONCLUSIONS: These findings highlight the importance of risk factors, such as high blood pressure and dyslipidaemia, in increasing CVD risk in those with diabetes...

..Thus, alcohol intake does not appear to be a determinant of diabetes risk in this population...

..CONCLUSIONS: This study suggests that non-HDL cholesterol index may be particularly useful in predicting CVD risk in patients with diabetes...

..To determine whether sensory and motor nerve function is associated cross-sectionally with quadriceps or ankle dorsiflexion strength in an older community-based population...

..However, the independent and potentially synergistic effects of these factors in old age are poorly described, especially among the oldest-old and among people with an existing disability...

..Fracture prevention needs to target specific risk factors found in older adults with DM...

..Diabetes has been defined as a coronary heart disease (CHD) risk equivalent, and more aggressive treatment goals have been proposed for diabetic patients...

..In conclusion, this enhanced calculator should be useful in estimating CHD risk in populations with high prevalence of diabetes and renal disease...

..The ability of estimated GFR (eGFR) to predict CVD events during 5-10 years of follow-up is assessed using data from the Strong Heart Study (SHS), a large cohort with a high prevalence of diabetes...

..Poor peripheral nerve function is prevalent in diabetes and older populations, and it has great potential to contribute to poor physical performance...

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..For both Scr and eGFR, the AV method provided the most favorable results in predicting CVD risk, regardless of the rate of missing data...

..Several of these factors are modifiable, and provide important targets for researchers, clinicians, and public health practitioners in their efforts to reduce the burden of disability in the older population...

..In the U.S. in 2004, one in four nursing home residents aged >or=65 years had diabetes, and diabetic residents had increased odds of several unfavorable outcomes that are important for care planning...

..However in 2004, 3 of every 10 US nursing home residents did not have documentation of advance care plans. Continued efforts are needed to promote the importance of advance care planning among US nursing home residents...

..CONCLUSIONS: In adults aged 20 to 59 years in the United States, self-reported fatigue is associated with higher body mass index, higher waist circumference, and a reduced likelihood of getting recommended levels of physical activity...

..No relation between calcium intake and BMI or PBF was observed in NHANES III participants. Our data may be used to develop nutritional interventions aimed at weight control in culturally appropriate clinical trials...

..01) and higher hip BMD for each race-gender group (p < or = 0.01). Type 2 diabetes was associated with a 4-5% higher total hip BMD in all race-gender groups of elderly adults, independent of body composition and fasting insulin levels...

..Poor peripheral nerve function may directly affect bone...

..To define the prevalence of documented sleep apnea in US nursing home (NH) residents and to examine characteristics associated with sleep apnea in this population...

..This analysis evaluates clinical peripheral arterial disease among generally healthy women in the Women's Health Initiative randomized trial of estrogen plus progestin...

..Provision of appropriate staff training may be a key to expanding EoL program participation in skilled nursing...

..To understand key characteristics of the leadership team, and to examine if differences in these factors exist between for-profit (FP) and not-for-profit (NFP) nursing homes (NHs)...

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..To determine whether older women with diabetes have an increased risk of falls and whether known risk factors for falls account for any increased risk...

..Consumption of long-chain omega-3 FAs from marine sources may improve certain MS components, and thus may reduce risk for cardiovascular disease. High consumption of saturated FAs and trans-FAs may have an adverse effect on MS...

..Furthermore, MS may carry a risk beyond that of single risk factors. Identifying MS in American Indians and treating the factors that comprise it may reduce risk of both diabetes and cardiovascular disease in this population...

..Although hypopneas constitute a majority of disordered breathing events, significant controversy remains about the best criteria used to define these events...

..This study examined the relative predictive power of fasting and 2-hour glucose level on cardiovascular event risk...

..S. population of adults with diabetes and shows that for American Indians with diabetes, programs to decrease SFA and increase fiber intakes are warranted...

..The goal of this study was to determine if the haptoglobin phenotype was predictive of cardiovascular disease (CVD) in diabetic mellitus (DM)...

..Therefore, abnormal LV geometry and function are related to the MS. Increased BP is the component of the MS most strongly associated with cardiac markers of preclinical disease, even in the absence of traditionally defined hypertension...

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..To compare polysomnographic recordings obtained in the home and laboratory setting...

..These findings could be due to the absence of association or to survivor bias in these cross-sectional analyses...

..We investigated the prevalence of sleepiness as well as factors associated with sleepiness in individuals with moderate to severe sleep-disordered breathing (apnea-hypopnea index > or = 15)...

..These findings have implications for SDB screening and treatment. Distinguishing between hypertensive subtypes reveals a stronger association between SDB and hypertension for those aged <60 years than previously reported...

..This review summarizes findings from large studies examining this issue and accentuates the importance of carrying out additional well-designed research...

..Activation of peroxisome proliferator-activated receptor-gamma by thiazolidinediones (TZDs) results in lower bone mass in mice...

..We examined the effect of C-reactive protein (CRP) and interleukin-6 (IL-6) on the incident mobility limitation in older adults with and without diabetes...

..This study assesses the relationship between usual sleep duration and hypertension in a community-based cohort...

..A program of regular vigorous physical activity of at least 3 h per week may be a useful adjunctive treatment modality for SDB, but this association needs confirmation with a prospective clinical trial...

..The results of this study suggest that SDB is independently associated with glucose intolerance and insulin resistance and may lead to type 2 diabetes mellitus...

..This study analyzed which definition of the metabolic syndrome is more predictive of cardiovascular events in both diabetic and nondiabetic members of a population-based sample...

..However, it is not known whether disordered breathing events with oxyhemoglobin desaturation less than 4% are associated with clinical sequelae such as abnormalities in fasting glycemia...

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..We evaluated the relationship between MAC, AV sclerosis, and first stroke events in a population-based cohort...

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